The evolution of thalidomide and its IMiD derivatives as anticancer agents von Bartlett, J. Blake, Dredge, Keith, Dalgleish, Angus G

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PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models von Dredge, K, Hammond, E, Handley, P, Gonda, T J, Smith, M T, Vincent, C, Brandt, R, Ferro, V, Bytheway, I

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The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy von Dredge, K., Hammond, E., Davis, K., Li, C. P., Liu, L., Johnstone, K., Handley, P., Wimmer, N., Gonda, T. J., Gautam, A., Ferro, V., Bytheway, I.

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Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects von DREDGE, K, MARRIOTT, J. B, MACDONALD, C. D, MAN, H-W, CHEN, R, MULLER, G. W, STIRLING, D, DALGLEISH, A. G

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Phase I study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced... von BARTLETT, J. B, MICHAE, A, ZELDIS, J, DALGLEISH, A. G, CLARKE, I. A, DREDGE, K, NICHOLSON, S, KRISTELEIT, H, POLYCHRONIS, A, PANDHA, H, MULLER, G. W, STIRLING, Dl

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Abstract 1: The novel heparin sulfate (HS) mimetic PG545 shows strong synergism when combined with cisplatin and paclitaxel in preclinical ovarian cancer models von Freyer, L, Teoman, A, von Bismarck, A, Dredge, K, Shridhar, V

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Protective Antitumor Immunity Induced by a Costimulatory Thalidomide Analog in Conjunction with Whole Tumor Cell Vaccination Is Mediated by Increased Th1-Type Immunity von Dredge, Keith, Marriott, J. Blake, Todryk, Stephen M, Muller, George W, Chen, Roger, Stirling, David I, Dalgleish, Angus G

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Thalidomide and its analogues have distinct and opposing effects on TNF‐α and TNFR2 during co‐stimulation of both CD4+ and CD8+ T cells von MARRIOTT, J. B., CLARKE, I. A., DREDGE, K., MULLER, G., STIRLING, D., DALGLEISH, A. G.

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polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer von Dredge, K, Kink, J. A, Johnson, R. M, Bytheway, I, Marton, L. J

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The dual angiogenesis/metastasis inhibitor PG545 inhibits growth factor-induced cell migration and invasion in vitro and tumor growth in vivo of ovarian cancer cells von Giri, S, Winterhoff, B, Maguire, J, Teoman, A, Dredge, K, Shridhar, V

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Adjuvants and the promotion of Th1-type cytokines in tumour immunotherapy von DREDGE, Keith, MARRIOTT, J. Blake, TODRYK, Stephen M, DALGLEISH, Angus G

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Orally administered lenalidomide (CC-5013) is anti-angiogenic in vivo and inhibits endothelial cell migration and Akt phosphorylation in vitro von Dredge, Keith, Horsfall, Rebecca, Robinson, Simon P., Zhang, Ling-Hua, Lu, Ling, Tang, Yang, Shirley, Michael A., Muller, George, Schafer, Peter, Stirling, David, Dalgleish, Angus G., Bartlett, J. Blake

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Vitamin D receptor‐dependent antitumour effects of 1,25‐dihydroxyvitamin D3 and two synthetic analogues in three in vivo models of prostate cancer von Oades, G.M., Dredge, K., Kirby, R.S., Colston, K.W.

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Vitamin D receptor‐dependent antitumour effects of 1,25‐dihydroxyvitamin D 3 and two synthetic analogues in three in vivo models of prostate cancer von Oades, G.M., Dredge, K., Kirby, R.S., Colston, K.W.

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A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase-dependent apoptosis is associated with altered expression of bcl-2 family proteins von MARRIOTT, J. Blake, CLARKE, Ian A, DALGLEISH, Angus G, CZAJKA, Anna, DREDGE, Keith, CHILDS, Kay, MAN, Hon-Wah, SCHAFER, Peter, GOVINDA, Sowmya, MULLER, George W, STIRLING, David I

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Thalidomide analogs as emerging anti-cancer drugs von Dredge, Keith, Dalgleish, Angus G, Marriott, J Blake

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Nova-1 Regulates Neuron-Specific Alternative Splicing and Is Essential for Neuronal Viability von Jensen, Kirk B, Dredge, B.Kate, Stefani, Giovanni, Zhong, Ru, Buckanovich, Ronald J, Okano, Hirotaka J, Yang, Yolanda Y.L, Darnell, Robert B

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Nova autoregulation reveals dual functions in neuronal splicing von Dredge, B Kate, Stefani, Giovanni, Engelhard, Caitlin C, Darnell, Robert B

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Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression von Harkin, Andrew, Kelly, John P, McNamara, Mairead, Connor, Thomas J, Dredge, Keith, Redmond, Anna, Leonard, Brian E

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Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV‑2 by Disrupting the Spike–ACE2 Interaction von Guimond, Scott E., Mycroft-West, Courtney J., Gandhi, Neha S., Tree, Julia A., Le, Thuy T., Spalluto, C. Mirella, Humbert, Maria V., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Wand, Matthew, Nyström, Kristina, Said, Joanna, Setoh, Yin Xiang, Amarilla, Alberto A., Modhiran, Naphak, Sng, Julian D. J., Chhabra, Mohit, Young, Paul R., Rawle, Daniel J., Lima, Marcelo A., Yates, Edwin A., Karlsson, Richard, Miller, Rebecca L., Chen, Yen-Hsi, Bagdonaite, Ieva, Yang, Zhang, Stewart, James, Nguyen, Dung, Laidlaw, Stephen, Hammond, Edward, Dredge, Keith, Wilkinson, Tom M. A., Watterson, Daniel, Khromykh, Alexander A., Suhrbier, Andreas, Carroll, Miles W., Trybala, Edward, Bergström, Tomas, Ferro, Vito, Skidmore, Mark A., Turnbull, Jeremy E.

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