Recent Advances in the Discovery and Delivery of TLR7/8 Agonists as Vaccine Adjuvants von Dowling, David J

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An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity von Borriello, Francesco, Poli, Valentina, Shrock, Ellen, Spreafico, Roberto, Liu, Xin, Pishesha, Novalia, Carpenet, Claire, Chou, Janet, Di Gioia, Marco, McGrath, Marisa E., Dillen, Carly A., Barrett, Nora A., Lacanfora, Lucrezia, Franco, Marcella E., Marongiu, Laura, Iwakura, Yoichiro, Pucci, Ferdinando, Kruppa, Michael D., Ma, Zuchao, Lowman, Douglas W., Ensley, Harry E., Nanishi, Etsuro, Saito, Yoshine, O’Meara, Timothy R., Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Dowling, David J., Frieman, Matthew, Elledge, Stephen J., Levy, Ofer, Irvine, Darrell J., Ploegh, Hidde L., Williams, David L., Zanoni, Ivan

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The TLR5 Agonist Flagellin Shapes Phenotypical and Functional Activation of Lung Mucosal Antigen Presenting Cells in Neonatal Mice von Sharma, Pankaj, Levy, Ofer, Dowling, David J.

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Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses von Dowling, David J., PhD, Scott, Evan A., PhD, Scheid, Annette, MD, Bergelson, Ilana, BSc, Joshi, Sweta, PhD, Pietrasanta, Carlo, MD, Brightman, Spencer, BA, Sanchez-Schmitz, Guzman, MSc, PhD, Van Haren, Simon D., PhD, Ninković, Jana, PhD, Kats, Dina, BSc, Guiducci, Cristiana, PhD, de Titta, Alexandre, PhD, Bonner, Daniel K., PhD, Hirosue, Sachiko, PhD, Swartz, Melody A., PhD, Hubbell, Jeffrey A., PhD, Levy, Ofer, MD, PhD

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Precision Vaccine Development: Cues From Natural Immunity von Barman, Soumik, Soni, Dheeraj, Brook, Byron, Nanishi, Etsuro, Dowling, David J

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Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization von van Haren, Simon D, Dowling, David J, Foppen, Willemina, Christensen, Dennis, Andersen, Peter, Reed, Steven G, Hershberg, Robert M, Baden, Lindsey R, Levy, Ofer

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BCG as a Case Study for Precision Vaccine Development: Lessons From Vaccine Heterogeneity, Trained Immunity, and Immune Ontogeny von Angelidou, Asimenia, Diray-Arce, Joann, Conti, Maria Giulia, Smolen, Kinga K., van Haren, Simon Daniel, Dowling, David J., Husson, Robert N., Levy, Ofer

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The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes von Ganapathi, Lakshmi, Van Haren, Simon, Dowling, David J, Bergelson, Ilana, Shukla, Nikunj M, Malladi, Subbalakshmi S, Balakrishna, Rajalakshmi, Tanji, Hiromi, Ohto, Umeharu, Shimizu, Toshiyuki, David, Sunil A, Levy, Ofer

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Ontogeny of early life immunity von Dowling, David J, Levy, Ofer

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Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways von Philbin, Victoria J., DPhil, Dowling, David J., PhD, Gallington, Leighanne C., BSc, Cortés, Guadalupe, PhD, Tan, Zhen, MD, Suter, Eugénie E., MA, Chi, Kevin W., BA, Shuckett, Ariel, MPH, Stoler-Barak, Liat, MSc, Tomai, Mark, PhD, Miller, Richard L., PhD, Mansfield, Keith, DVM, Levy, Ofer, MD, PhD

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Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination von Dowling, David J., Barman, Soumik, Smith, Alyson J., Borriello, Francesco, Chaney, Danielle, Brightman, Spencer E., Melhem, Gandolina, Brook, Byron, Menon, Manisha, Soni, Dheeraj, Schüller, Simone, Siram, Karthik, Nanishi, Etsuro, Bazin, Hélène G., Burkhart, David J., Levy, Ofer, Evans, Jay T.

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Neonatal monocytes demonstrate impaired homeostatic extravasation into a microphysiological human vascular model von Sanchez-Schmitz, Guzman, Morrocchi, Elena, Cooney, Mitchell, Soni, Dheeraj, Khatun, Rahima, Palma, Paolo, Dowling, David J., Levy, Ofer

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The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes von Dowling, David J, Tan, Zhen, Prokopowicz, Zofia M, Palmer, Christine D, Matthews, Maura-Ann H, Dietsch, Gregory N, Hershberg, Robert M, Levy, Ofer

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Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn... von Speer, Esther M, Dowling, David J, Xu, Jianjin, Ozog, Lukasz S, Mathew, Jaime A, Chander, Avinash, Yin, Donglei, Levy, Ofer

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Precision Vaccinology Approaches for the Development of Adjuvanted Vaccines Targeted to Distinct Vulnerable Populations von Lee, Branden, Nanishi, Etsuro, Levy, Ofer, Dowling, David J

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Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization von Borriello, Francesco, Pietrasanta, Carlo, Lai, Jacqueline C Y, Walsh, Lois M, Sharma, Pankaj, O'Driscoll, David N, Ramirez, Juan, Brightman, Spencer, Pugni, Lorenza, Mosca, Fabio, Burkhart, David J, Dowling, David J, Levy, Ofer

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Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference von Soni, Dheeraj, Van Haren, Simon D., Idoko, Olubukola T., Evans, Jay T., Diray-Arce, Joann, Dowling, David J., Levy, Ofer

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Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn von Scheid, Annette, Borriello, Francesco, Pietrasanta, Carlo, Christou, Helen, Diray-Arce, Joann, Pettengill, Matthew A, Joshi, Sweta, Li, Ning, Bergelson, Ilana, Kollmann, Tobias, Dowling, David J, Levy, Ofer

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Major Secretory Antigens of the Helminth Fasciola hepatica Activate a Suppressive Dendritic Cell Phenotype That Attenuates Th17 Cells but Fails To Activate Th2 Immune Responses von Dowling, David J, Hamilton, Clare M, Donnelly, Sheila, La Course, James, Brophy, Peter M, Dalton, John, O'Neill, Sandra M

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A Precision Adjuvant Approach to Enhance Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines Optimized for Immunologically Distinct Vulnerable Populations von Dowling, David J, Levy, Ofer

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