Vitamin in the Crosshairs: Targeting Pantothenate and Coenzyme A Biosynthesis for New Antituberculosis Agents von Butman, Hailey S, Kotzé, Timothy J, Dowd, Cynthia S, Strauss, Erick

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Identification of a Nitroimidazo-Oxazine-Specific Protein Involved in PA-824 Resistance in Mycobacterium tuberculosis von Manjunatha, Ujjini H., Boshoff, Helena, Dowd, Cynthia S., Zhang, Liang, Albert, Thomas J., Norton, Jason E., Daniels, Lacy, Dick, Thomas, Pang, Siew Siew, Barry, Clifton E.

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Substrate specificity of the deazaflavin‐dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles von Gurumurthy, Meera, Mukherjee, Tathagata, Dowd, Cynthia S., Singh, Ramandeep, Niyomrattanakit, Pornwaratt, Tay, Jo Ann, Nayyar, Amit, Lee, Yong Sok, Cherian, Joseph, Boshoff, Helena I., Dick, Thomas, Barry, Clifton E., Manjunatha, Ujjini H.

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Potent, specific MEPicides for treatment of zoonotic staphylococci von Edwards, Rachel L, Heueck, Isabel, Lee, Soon Goo, Shah, Ishaan T, Miller, Justin J, Jezewski, Andrew J, Mikati, Marwa O, Wang, Xu, Brothers, Robert C, Heidel, Kenneth M, Osbourn, Damon M, Burnham, Carey-Ann D, Alvarez, Sophie, Fritz, Stephanie A, Dowd, Cynthia S, Jez, Joseph M, Odom John, Audrey R

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Structure-guided microbial targeting of antistaphylococcal prodrugs von Miller, Justin J, Shah, Ishaan T, Hatten, Jayda, Barekatain, Yasaman, Mueller, Elizabeth A, Moustafa, Ahmed M, Edwards, Rachel L, Dowd, Cynthia S, Hoops, Geoffrey C, Johnson, R Jeremy, Planet, Paul J, Muller, Florian L, Jez, Joseph M, Odom John, Audrey R

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MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis von Edwards, Rachel L., Brothers, Robert C., Wang, Xu, Maron, Maxim I., Ziniel, Peter D., Tsang, Patricia S., Kraft, Thomas E., Hruz, Paul W., Williamson, Kim C., Dowd, Cynthia S., John, Audrey R. Odom

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Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacy von McKenney, Elizabeth S, Sargent, Michelle, Khan, Hameed, Uh, Eugene, Jackson, Emily R, San Jose, Géraldine, Couch, Robin D, Dowd, Cynthia S, van Hoek, Monique L

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Phosphonate prodrugs: an overview and recent advances von Heidel, Kenneth M, Dowd, Cynthia S

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Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase) von Haymond, Amanda, Johny, Chinchu, Dowdy, Tyrone, Schweibenz, Brandon, Villarroel, Karen, Young, Richard, Mantooth, Clark J, Patel, Trishal, Bases, Jessica, San Jose, Geraldine, Jackson, Emily R, Dowd, Cynthia S, Couch, Robin D

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Mechanism of Action of N -Acyl and N -Alkoxy Fosmidomycin Analogs: Mono- and Bisubstrate Inhibition of IspC from Plasmodium falciparum , a Causative Agent of Malaria von Girma, Misgina B, Ball, Haley S, Wang, Xu, Brothers, Robert C, Jackson, Emily R, Meyers, Marvin J, Dowd, Cynthia S, Couch, Robin D

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The Role of MmpL8 in Sulfatide Biogenesis and Virulence of Mycobacterium tuberculosis von Domenech, Pilar, Reed, Michael B, Dowd, Cynthia S, Manca, Claudia, Kaplan, Gilla, Barry, 3rd, Clifton E

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Synthetic Fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-d-xylulose 5-phosphate Reductoisomerase or Plasmodium falciparum growth in vitro von Chofor, René, Risseeuw, Martijn D P, Pouyez, Jenny, Johny, Chinchu, Wouters, Johan, Dowd, Cynthia S, Couch, Robin D, Van Calenbergh, Serge

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The Methylerythritol Phosphate Pathway: Promising Drug Targets in the Fight against Tuberculosis von Wang, Xu, Dowd, Cynthia S

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B Cell Signaling Is Regulated by Induced Palmitoylation of CD81 von Cherukuri, Anu, Carter, Robert H, Brooks, Stephen, Bornmann, William, Finn, Ronald, Dowd, Cynthia S, Pierce, Susan K

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Phosphoryl prodrugs: characteristics to improve drug development von Kirby, Samuel A., Dowd, Cynthia S.

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Structure−Activity Relationships at the 5-Position of Thiolactomycin:  An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuber... von KIM, Pilho, ZHANG, Yong-Mei, SHENOY, Gautham, NGUYEN, Quynh-Anh, BOSHOFF, Helena I., MANJUNATHA, Ujjini H., GOODWIN, Michael B., LONSDALE, John, PRICE, Allen C., MILLER, Darcie J., DUNCAN, Ken, WHITE, Stephen W., ROCK, Charles O., BARRY, Clifton E., DOWD, Cynthia S.

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PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release von Singh, Ramandeep, Manjunatha, Ujjini, Boshoff, Helena I.M, Ha, Young Hwan, Niyomrattanakit, Pornwaratt, Ledwidge, Richard, Dowd, Cynthia S, Lee, Ill Young, Kim, Pilho, Zhang, Liang, Kang, Sunhee, Keller, Thomas H, Jiricek, Jan, Barry, Clifton E. 3rd

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Mycobacterium leprae Is Naturally Resistant to PA-824 von MANJUNATHA, Ujjini H, LAHIRI, Ramanuj, RANDHAWA, Baljit, DOWD, Cynthia S, KRAHENBUHL, James L, BARRY, Clifton E

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MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria von Wang, Xu, Edwards, Rachel L, Ball, Haley, Johnson, Claire, Haymond, Amanda, Girma, Misgina, Manikkam, Michelle, Brothers, Robert C, McKay, Kyle T, Arnett, Stacy D, Osbourn, Damon M, Alvarez, Sophie, Boshoff, Helena I, Meyers, Marvin J, Couch, Robin D, Odom John, Audrey R, Dowd, Cynthia S

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Inhibition of DXR in the MEP pathway with lipophilic N -alkoxyaryl FR900098 analogs von Bague, Darean, Wang, Ruiqin, Hodge, Dana, Mikati, Marwa O, Roma, Jose S, Boshoff, Helena I, Dailey, Allyson L, Girma, Misgina, Couch, Robin D, Odom John, Audrey R, Dowd, Cynthia S

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