The Structural Biology of Bcl-xL von Lee, Erinna F., Fairlie, W. Douglas

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BECLIN1: Protein Structure, Function and Regulation von Tran, Sharon, Fairlie, W. Douglas, Lee, Erinna F.

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Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis von Czabotar, Peter E., Westphal, Dana, Dewson, Grant, Ma, Stephen, Hockings, Colin, Fairlie, W. Douglas, Lee, Erinna F., Yao, Shenggen, Robin, Adeline Y., Smith, Brian J., Huang, David C.S., Kluck, Ruth M., Adams, Jerry M., Colman, Peter M.

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Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia von Glaser, Stefan P, Lee, Erinna F, Trounson, Evelyn, Bouillet, Philippe, Wei, Andrew, Fairlie, W Douglas, Izon, David J, Zuber, Johannes, Rappaport, Amy R, Herold, Marco J, Alexander, Warren S, Lowe, Scott W, Robb, Lorraine, Strasser, Andreas

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BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival von Lee, Erinna F., Harris, Tiffany J., Tran, Sharon, Evangelista, Marco, Arulananda, Surein, John, Thomas, Ramnac, Celeste, Hobbs, Chloe, Zhu, Haoran, Gunasingh, Gency, Segal, David, Behren, Andreas, Cebon, Jonathan, Dobrovic, Alexander, Mariadason, John M., Strasser, Andreas, Rohrbeck, Leona, Haass, Nikolas K., Herold, Marco J., Fairlie, W. Douglas

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Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53 von Kelly, Gemma L, Grabow, Stephanie, Glaser, Stefan P, Fitzsimmons, Leah, Aubrey, Brandon J, Okamoto, Toru, Valente, Liz J, Robati, Mikara, Tai, Lin, Fairlie, W Douglas, Lee, Erinna F, Lindstrom, Mikael S, Wiman, Klas G, Huang, David C S, Bouillet, Philippe, Rowe, Martin, Rickinson, Alan B, Herold, Marco J, Strasser, Andreas

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Osteosarcoma cells depend on MCL-1 for survival, and osteosarcoma metastases respond to MCL-1 antagonism plus regorafenib in vivo von Ji, Yanhao, Harris, Michael A, Newton, Lucas M, Harris, Tiffany J, Fairlie, W Douglas, Lee, Erinna F, Hawkins, Christine J

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Membrane-bound Fas ligand only is essential for Fas-induced apoptosis von O’ Reilly, Lorraine A., Tai, Lin, Lee, Lily, Kruse, Elizabeth A., Grabow, Stephanie, Fairlie, W. Douglas, Haynes, Nicole M., Tarlinton, David M., Zhang, Jian-Guo, Belz, Gabrielle T., Smyth, Mark J., Bouillet, Philippe, Robb, Lorraine, Strasser, Andreas

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Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer von Berger, Stephanie, Procko, Erik, Margineantu, Daciana, Lee, Erinna F, Shen, Betty W, Zelter, Alex, Silva, Daniel-Adriano, Chawla, Kusum, Herold, Marco J, Garnier, Jean-Marc, Johnson, Richard, MacCoss, Michael J, Lessene, Guillaume, Davis, Trisha N, Stayton, Patrick S, Stoddard, Barry L, Fairlie, W Douglas, Hockenbery, David M, Baker, David

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Combination of bazedoxifene with chemotherapy and SMAC-mimetics for the treatment of colorectal cancer von Dmello, Rhynelle S., Palmieri, Michelle, Thilakasiri, Pathum S., Doughty, Larissa, Nero, Tracy L., Poh, Ashleigh R., To, Sarah Q., Lee, Erinna F., Douglas Fairlie, W., Mielke, Lisa, Parker, Michael W., Poon, Ivan K. H., Batlle, Eduard, Ernst, Matthias, Chand, Ashwini L.

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Structural insights into the degradation of Mcl-1 induced by BH3 domains von Czabotar, Peter E, Lee, Erinna F, van Delft, Mark F, Day, Catherine L, Smith, Brian J, Huang, David C.S, Fairlie, W. Douglas, Hinds, Mark G, Colman, Peter M

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Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax von Fletcher, Jamie I, Meusburger, Sarina, Hawkins, Christine J, Riglar, David T, Lee, Erinna F, Fairlie, W. Douglas, Huang, David C.S, Adams, Jerry M

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Physiological restraint of Bak by Bcl-xL is essential for cell survival von Lee, Erinna F, Grabow, Stephanie, Chappaz, Stephane, Dewson, Grant, Hockings, Colin, Kluck, Ruth M, Debrincat, Marlyse A, Gray, Daniel H, Witkowski, Matthew T, Evangelista, Marco, Pettikiriarachchi, Anne, Bouillet, Philippe, Lane, Rachael M, Czabotar, Peter E, Colman, Peter M, Smith, Brian J, Kile, Benjamin T, Fairlie, W Douglas

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High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL von Lee, Erinna F, Sadowsky, Jack D, Smith, Brian J, Czabotar, Peter E, Peterson-Kaufman, Kimberly J, Colman, Peter M, Gellman, Samuel H, Fairlie, W. Douglas

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Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands von Lee, Erinna F., Czabotar, Peter E., Yang, Hong, Sleebs, Brad E., Lessene, Guillaume, Colman, Peter M., Smith, Brian J., Fairlie, W.Douglas

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Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells von Carrington, Emma M., Zhang, Jian-Guo, Sutherland, Robyn M., Vikstrom, Ingela B., Brady, Jamie L., Soo, Priscilla, Vremec, David, Allison, Cody, Lee, Erinna F., Fairlie, W. Douglas, Bouillet, Philippe, Grabow, Stephanie, Ottina, Eleonora, Herold, Marco J., Pellegrini, Marc, Huang, David C. S., Tarlinton, David M., Strasser, Andreas, Lew, Andrew M., Zhan, Yifan

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Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl‑XL von Sleebs, Brad E, Kersten, Wilhemus J. A, Kulasegaram, Sanji, Nikolakopoulos, George, Hatzis, Effie, Moss, Rebecca M, Parisot, John P, Yang, Hong, Czabotar, Peter E, Fairlie, W. Douglas, Lee, Erinna F, Adams, Jerry M, Chen, Lin, van Delft, Mark F, Lowes, Kym N, Wei, Andrew, Huang, David C.S, Colman, Peter M, Street, Ian P, Baell, Jonathan B, Watson, Keith, Lessene, Guillaume

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BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking von Tran, Sharon, Juliani, Juliani, Harris, Tiffany J., Evangelista, Marco, Ratcliffe, Julian, Ellis, Sarah L., Baloyan, David, Reehorst, Camilla M., Nightingale, Rebecca, Luk, Ian Y., Jenkins, Laura J., Ghilas, Sonia, Yakou, Marina H., Inguanti, Chantelle, Johnson, Chad, Buchert, Michael, Lee, James C., De Cruz, Peter, Duszyc, Kinga, Gleeson, Paul A., Kile, Benjamin T., Mielke, Lisa A., Yap, Alpha S., Mariadason, John M., Fairlie, W. Douglas, Lee, Erinna F.

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Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes von Lee, Erinna F, Clarke, Oliver B, Evangelista, Marco, Feng, Zhiping, Speed, Terence P, Tchoubrieva, Elissaveta B, Strasser, Andreas, Kalinna, Bernd H, Colman, Peter M, Fairlie, W. Douglas

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Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers von Fairlie, W Douglas, Lee, Erinna F

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