Matched Molecular Pair Analysis in drug discovery von Dossetter, Alexander G., Griffen, Edward J., Leach, Andrew G.

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A statistical analysis of in vitro human microsomal metabolic stability of small phenyl group substituents, leading to improved design sets for parallel SAR exploration of a chemic... von Dossetter, Alexander G.

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Chemists: AI Is Here; Unite To Get the Benefits von Griffen, Edward J, Dossetter, Alexander G, Leach, Andrew G

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Highly Enantio- and Diastereoselective Hetero-Diels-Alder Reactions Catalyzed by New Chiral Tridentate Chromium(III) Catalysts von Dossetter, Alexander G., Jamison, Timothy F., Jacobsen, Eric N.

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Can we accelerate medicinal chemistry by augmenting the chemist with Big Data and artificial intelligence? von Griffen, Edward J., Dossetter, Alexander G., Leach, Andrew G., Montague, Shane

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Mapping Ligand-Shape Space for Protein–Ligand Systems: Distinguishing Key-in-Lock and Hand-in-Glove Proteins von Zarnecka, Joanna, Lukac, Iva, Messham, Stephen J, Hussin, Alhusein, Coppola, Francesco, Enoch, Steven J, Dossetter, Alexander G, Griffen, Edward J, Leach, Andrew G

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An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer von Colley, Helen E, Muthana, Munitta, Danson, Sarah J, Jackson, Lucinda V, Brett, Matthew L, Harrison, Joanne, Coole, Sean F, Mason, Daniel P, Jennings, Luke R, Wong, Melanie, Tulasi, Vamshi, Norman, Dennis, Lockey, Peter M, Williams, Lynne, Dossetter, Alexander G, Griffen, Edward J, Thompson, Mark J

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Catalytic Enantioselective Intermolecular Cycloadditions of 2-Diazo-3,6-Diketoester-Derived Carbonyl Ylides with Alkene Dipolarophiles von Hodgson, David M., Brückl, Tobias, Glen, Rebecca, Labande, Agnès H., Selden, Deborah A., Dossetter, Alexander G., Redgrave, Alison J., Halpern, Jack

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Turbocharging Matched Molecular Pair Analysis: Optimizing the Identification and Analysis of Pairs von Lukac, Iva, Zarnecka, Joanna, Griffen, Edward J, Dossetter, Alexander G, St-Gallay, Stephen A, Enoch, Steven J, Madden, Judith C, Leach, Andrew G

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Optimization of Brain Penetrant 11β-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet-Induced Obese Mice von Goldberg, Frederick W, Dossetter, Alexander G, Scott, James S, Robb, Graeme R, Boyd, Scott, Groombridge, Sam D, Kemmitt, Paul D, Sjögren, Tove, Gutierrez, Pablo Morentin, deSchoolmeester, Joanne, Swales, John G, Turnbull, Andrew V, Wild, Martin J

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Anomalous Intramolecular C−H Insertion Reactions of Rhodium Carbenoids:  Factors Influencing the Reaction Course and Mechanistic Implications von Clark, J. Stephen, Dossetter, Alexander G, Wong, Yung-Sing, Townsend, Robert J, Whittingham, William G, Russell, C. Adam

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Identification, Optimization, and Pharmacology of Acylurea GHS-R1a Inverse Agonists von McCoull, William, Barton, Peter, Brown, Alastair J. H, Bowker, Suzanne S, Cameron, Jennifer, Clarke, David S, Davies, Robert D. M, Dossetter, Alexander G, Ertan, Anne, Fenwick, Mark, Green, Clive, Holmes, Jane L, Martin, Nathaniel, Masters, David, Moore, Jane E, Newcombe, Nicholas J, Newton, Claire, Pointon, Helen, Robb, Graeme R, Sheldon, Christopher, Stokes, Stephen, Morgan, David

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Pharmacokinetic Benefits of 3,4-Dimethoxy Substitution of a Phenyl Ring and Design of Isosteres Yielding Orally Available Cathepsin K Inhibitors von Crawford, James J, Kenny, Peter W, Bowyer, Jonathan, Cook, Calum R, Finlayson, Jonathan E, Heyes, Christine, Highton, Adrian J, Hudson, Julian A, Jestel, Anja, Krapp, Stephan, Martin, Scott, MacFaul, Philip A, McDermott, Benjamin P, McGuire, Thomas M, Morley, Andrew D, Morris, Jeffrey J, Page, Ken M, Ribeiro, Lyn Rosenbrier, Sawney, Helen, Steinbacher, Stefan, Smith, Caroline, Dossetter, Alexander G

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The discovery of benzanilides as c-Met receptor tyrosine kinase inhibitors by a directed screening approach von Allen, Joanne V., Bardelle, Catherine, Blades, Kevin, Buttar, Dave, Chapman, Louise, Colclough, Nicola, Dossetter, Alexander G., Garner, Andrew P., Girdwood, Alan, Lambert, Christine, Leach, Andrew G., Law, Brian, Major, John, Plant, Helen, Slater, Anthony M.

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Stereoselective Construction of the Tricyclic Core of Neoliacinic Acid von Clark, J. Stephen, Baxter, Carl A, Dossetter, Alexander G, Poigny, Stéphane, Castro, José L, Whittingham, William G

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Chemists: AI Is Here; Unite To Get the Benefits von Griffen, Edward J, Dossetter, Alexander G, Leach, Andrew G

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Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity von McCoull, William, Barton, Peter, Broo, Anders, Brown, Alastair J. H., Clarke, David S., Coope, Gareth, Davies, Robert D. M., Dossetter, Alexander G., Kelly, Elizabeth E., Knerr, Laurent, MacFaul, Philip, Holmes, Jane L., Martin, Nathaniel, Moore, Jane E., Morgan, David, Newton, Claire, Österlund, Krister, Robb, Graeme R., Rosevere, Eleanor, Selmi, Nidhal, Stokes, Stephen, Svensson, Tor S., Ullah, Victoria B. K., Williams, Emma J.

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Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition von Dossetter, Alexander G., Bowyer, Jonathan, Cook, Calum R., Crawford, James J., Finlayson, Jonathan E., Heron, Nicola M., Heyes, Christine, Highton, Adrian J., Hudson, Julian A., Jestel, Anja, Krapp, Stephan, MacFaul, Philip A., McGuire, Thomas M., Morley, Andrew D., Morris, Jeffrey J., Page, Ken M., Ribeiro, Lyn Rosenbrier, Sawney, Helen, Steinbacher, Stefan, Smith, Caroline

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(1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor f... von Dossetter, Alexander G, Beeley, Howard, Bowyer, Jonathan, Cook, Calum R, Crawford, James J, Finlayson, Jonathan E, Heron, Nicola M, Heyes, Christine, Highton, Adrian J, Hudson, Julian A, Jestel, Anja, Kenny, Peter W, Krapp, Stephan, Martin, Scott, MacFaul, Philip A, McGuire, Thomas M, Gutierrez, Pablo Morentin, Morley, Andrew D, Morris, Jeffrey J, Page, Ken M, Ribeiro, Lyn Rosenbrier, Sawney, Helen, Steinbacher, Stefan, Smith, Caroline, Vickers, Madeleine

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Mapping Ligand-Shape Space for Protein–Ligand Systems: Distinguishing Key-in-Lock and Hand-in-Glove Proteins von Zarnecka, Joanna, Lukac, Iva, Messham, Stephen J, Hussin, Alhusein, Coppola, Francesco, Enoch, Steven J, Dossetter, Alexander G, Griffen, Edward J, Leach, Andrew G

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