A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220 von Hou, Panpan, Wu, Chao, Wang, Yuchen, Qi, Rui, Bhavanasi, Dheeraj, Zuo, Zhixiang, Dos Santos, Cedric, Chen, Shuliang, Chen, Yu, Zheng, Hong, Wang, Hong, Perl, Alexander, Guo, Deyin, Huang, Jian

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SIRT1 Activation by a c-MYC Oncogenic Network Promotes the Maintenance and Drug Resistance of Human FLT3-ITD Acute Myeloid Leukemia Stem Cells von Li, Ling, Osdal, Tereza, Ho, Yinwei, Chun, Sookhee, McDonald, Tinisha, Agarwal, Puneet, Lin, Allen, Chu, Su, Qi, Jing, Li, Liang, Hsieh, Yao-Te, Dos Santos, Cedric, Yuan, Hongfeng, Ha, Trung-Quang, Popa, Mihaela, Hovland, Randi, Bruserud, Øystein, Gjertsen, Bjørn Tore, Kuo, Ya-Huei, Chen, Wenyong, Lain, Sonia, McCormack, Emmet, Bhatia, Ravi

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Biomarkers associated with blinatumomab outcomes in acute lymphoblastic leukemia von Wei, Andrew H., Ribera, Josep-Maria, Larson, Richard A., Ritchie, David, Ghobadi, Armin, Chen, Yuqi, Anderson, Abraham, Dos Santos, Cedric E., Franklin, Janet, Kantarjian, Hagop

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Phase 1b/2 study of blinatumomab in Japanese adults with relapsed/refractory acute lymphoblastic leukemia von Kiyoi, Hitoshi, Morris, Joan D., Oh, Iekuni, Maeda, Yoshinobu, Minami, Hironobu, Miyamoto, Toshihiro, Sakura, Toru, Iida, Hiroatsu, Tuglus, Catherine A., Chen, Yuqi, Dos Santos, Cedric, Kalabus, James, Anderson, Abraham, Hata, Tomoko, Nakashima, Yasuhiro, Kobayashi, Yukio

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A phase 1b study of blinatumomab in Japanese children with relapsed/refractory B-cell precursor acute lymphoblastic leukemia von Horibe, Keizo, Morris, Joan D., Tuglus, Catherine A., Dos Santos, Cedric, Kalabus, James, Anderson, Abraham, Goto, Hiroaki, Ogawa, Chitose

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Treatment of Acute Myeloid Leukemia in Elderly Patients—A Therapeutic Dilemma von Mamdani, Hirva, MD, Santos, Cedric Dos, PhD, Konig, Heiko, MD, PhD

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Immune checkpoints PVR and PVRL2 are prognostic markers in AML and their blockade represents a new therapeutic option von Stamm, Hauke, Klingler, Felix, Grossjohann, Eva-Maria, Muschhammer, Jana, Vettorazzi, Eik, Heuser, Michael, Mock, Ulrike, Thol, Felicitas, Vohwinkel, Gabi, Latuske, Emily, Bokemeyer, Carsten, Kischel, Roman, Dos Santos, Cedric, Stienen, Sabine, Friedrich, Matthias, Lutteropp, Michael, Nagorsen, Dirk, Wellbrock, Jasmin, Fiedler, Walter

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1q amplification and PHF19 expressing high-risk cells are associated with relapsed/refractory multiple myeloma von Johnson, Travis S., Sudha, Parvathi, Liu, Enze, Becker, Nathan, Robertson, Sylvia, Blaney, Patrick, Morgan, Gareth, Chopra, Vivek S., Dos Santos, Cedric, Nixon, Michael, Huang, Kun, Suvannasankha, Attaya, Zaid, Mohammad Abu, Abonour, Rafat, Walker, Brian A.

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The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents von Dos Santos, Cedric, McDonald, Tinisha, Ho, Yin Wei, Liu, Hongjun, Lin, Allen, Forman, Stephen J., Kuo, Ya-Huei, Bhatia, Ravi

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Leukemia cell–targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity von Hossain, Dewan Md Sakib, Dos Santos, Cedric, Zhang, Qifang, Kozlowska, Anna, Liu, Hongjun, Gao, Chan, Moreira, Dayson, Swiderski, Piotr, Jozwiak, Agnieszka, Kline, Justin, Forman, Stephen, Bhatia, Ravi, Kuo, Ya-Huei, Kortylewski, Marcin

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CD33/CD3-bispecific T-cell engaging (BiTE®) antibody construct targets monocytic AML myeloid-derived suppressor cells von Jitschin, Regina, Saul, Domenica, Braun, Martina, Tohumeken, Sehmus, Völkl, Simon, Kischel, Roman, Lutteropp, Michael, Dos Santos, Cedric, Mackensen, Andreas, Mougiakakos, Dimitrios

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Cytokines increase engraftment of human acute myeloid leukemia cells in immunocompromised mice but not engraftment of human myelodysplastic syndrome cells von Krevvata, Maria, Shan, Xiaochuan, Zhou, Chenghui, Dos Santos, Cedric, Habineza Ndikuyeze, Georges, Secreto, Anthony, Glover, Joshua, Trotman, Winifred, Brake-Silla, Gisela, Nunez-Cruz, Selene, Wertheim, Gerald, Ra, Hyun-Jeong, Griffiths, Elizabeth, Papachristou, Charalampos, Danet-Desnoyers, Gwenn, Carroll, Martin

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Immune microenvironment characteristics in multiple myeloma progression from transcriptome profiling von Wang, Jin, Hu, Yi, Hamidi, Habib, Dos Santos, Cedric, Zhang, Jingyu, Punnoose, Elizabeth, Li, Wenjin

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Clinical Outcomes in Patients with FLT3-ITD-Mutated Relapsed/Refractory Acute Myelogenous Leukemia Undergoing Hematopoietic Stem Cell Transplantation after Quizartinib or Salvage C... von Ganguly, Siddhartha, Cortes, Jorge E., Krämer, Alwin, Levis, Mark J., Martinelli, Giovanni, Perl, Alexander E., Russell, Nigel H., Arunachalam, Meena, Santos, Cedric Dos, Gammon, Guy, Lesegretain, Arnaud, Mires, Derek E., Pham, Hoang, Wang, Yibin, Khaled, Samer K.

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A quantitative method for detection of circulating fms related tyrosine kinase 3 (FLT-3) in acute myeloid leukemia (AML) patients von Cook, Kevin D., Finger, Elizabeth C., Santos, Cedric Dos, Rock, Dan A.

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Polo-like kinase 1 is overexpressed in acute myeloid leukemia and its inhibition preferentially targets the proliferation of leukemic cells von Renner, Annelies G., Dos Santos, Cédric, Recher, Christian, Bailly, Christian, Créancier, Laurent, Kruczynski, Anna, Payrastre, Bernard, Manenti, Stéphane

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Antileukemic activity of rapamycin in acute myeloid leukemia von Récher, Christian, Beyne-Rauzy, Odile, Demur, Cécile, Chicanne, Gaëtan, Dos Santos, Cédric, Mas, Véronique Mansat-De, Benzaquen, David, Laurent, Guy, Huguet, Françoise, Payrastre, Bernard

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Signal Transduction Inhibitors as Promising Anticancer Agents von Kumar, Raj, Dos Santos, Cedric, Ahluwalia, Tarunveer Singh, Singh, Sandeep

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A functional link between Polo-like kinase 1 and the mammalian Target-Of-Rapamycin pathway? von Renner, Annelies G., Créancier, Laurent, Dos Santos, Cédric, Fialin, Camille, Recher, Christian, Bailly, Christian, Kruczynski, Anna, Payrastre, Bernard, Manenti, Stéphane

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A critical role for Lyn in acute myeloid leukemia von Dos Santos, Cédric, Demur, Cécile, Bardet, Valérie, Prade-Houdellier, Nais, Payrastre, Bernard, Récher, Christian

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