Integrated Genomic Analysis of Hürthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes von Ganly, Ian, Makarov, Vladimir, Deraje, Shyamprasad, Dong, YiYu, Reznik, Ed, Seshan, Venkatraman, Nanjangud, Gouri, Eng, Stephanie, Bose, Promita, Kuo, Fengshen, Morris, Luc G.T., Landa, Inigo, Carrillo Albornoz, Pedro Blecua, Riaz, Nadeem, Nikiforov, Yuri E., Patel, Kepal, Umbricht, Christopher, Zeiger, Martha, Kebebew, Electron, Sherman, Eric, Ghossein, Ronald, Fagin, James A., Chan, Timothy A.

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Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy von Inoue-Yamauchi, Akane, Jeng, Paul S., Kim, Kwanghee, Chen, Hui-Chen, Han, Song, Ganesan, Yogesh Tengarai, Ishizawa, Kota, Jebiwott, Sylvia, Dong, Yiyu, Pietanza, Maria C., Hellmann, Matthew D., Kris, Mark G., Hsieh, James J., Cheng, Emily H.

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The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma von Nargund, Amrita M., Pham, Can G., Dong, Yiyu, Wang, Patricia I., Osmangeyoglu, Hatice U., Xie, Yuchen, Aras, Omer, Han, Song, Oyama, Toshinao, Takeda, Shugaku, Ray, Chelsea E., Dong, Zhenghong, Berge, Mathieu, Hakimi, A. Ari, Monette, Sebastien, Lekaye, Carl L., Koutcher, Jason A., Leslie, Christina S., Creighton, Chad J., Weinhold, Nils, Lee, William, Tickoo, Satish K., Wang, Zhong, Cheng, Emily H., Hsieh, James J.

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Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets von Chen, Ying-Bei, Xu, Jianing, Skanderup, Anders Jacobsen, Dong, Yiyu, Brannon, A. Rose, Wang, Lu, Won, Helen H., Wang, Patricia I., Nanjangud, Gouri J., Jungbluth, Achim A., Li, Wei, Ojeda, Virginia, Hakimi, A. Ari, Voss, Martin H., Schultz, Nikolaus, Motzer, Robert J., Russo, Paul, Cheng, Emily H., Giancotti, Filippo G., Lee, William, Berger, Michael F., Tickoo, Satish K., Reuter, Victor E., Hsieh, James J.

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Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin von Xu, Jianing, Pham, Can G, Albanese, Steven K, Dong, Yiyu, Oyama, Toshinao, Lee, Chung-Han, Rodrik-Outmezguine, Vanessa, Yao, Zhan, Han, Song, Chen, David, Parton, Daniel L, Chodera, John D, Rosen, Neal, Cheng, Emily H, Hsieh, James J

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Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection von Sinha, Rileen, Winer, Andrew G., Chevinsky, Michael, Jakubowski, Christopher, Chen, Ying-Bei, Dong, Yiyu, Tickoo, Satish K., Reuter, Victor E., Russo, Paul, Coleman, Jonathan A., Sander, Chris, Hsieh, James J., Hakimi, A. Ari

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ΔNp63 Inhibits Oxidative Stress-Induced Cell Death, Including Ferroptosis, and Cooperates with the BCL-2 Family to Promote Clonogenic Survival von Wang, Gary X., Tu, Ho-Chou, Dong, Yiyu, Skanderup, Anders Jacobsen, Wang, Yufeng, Takeda, Shugaku, Ganesan, Yogesh Tengarai, Han, Song, Liu, Han, Hsieh, James J., Cheng, Emily H.

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Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts von Kim, Kwanghee, Hu, Wenhuo, Audenet, François, Almassi, Nima, Hanrahan, Aphrothiti J., Murray, Katie, Bagrodia, Aditya, Wong, Nathan, Clinton, Timothy N., Dason, Shawn, Mohan, Vishnu, Jebiwott, Sylvia, Nagar, Karan, Gao, Jianjiong, Penson, Alex, Hughes, Chris, Gordon, Benjamin, Chen, Ziyu, Dong, Yiyu, Watson, Philip A., Alvim, Ricardo, Elzein, Arijh, Gao, Sizhi P., Cocco, Emiliano, Santin, Alessandro D., Ostrovnaya, Irina, Hsieh, James J., Sagi, Irit, Pietzak, Eugene J., Hakimi, A. Ari, Rosenberg, Jonathan E., Iyer, Gopa, Vargas, Herbert A., Scaltriti, Maurizio, Al-Ahmadie, Hikmat, Solit, David B., Coleman, Jonathan A.

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Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers von Wang, Jianbo, Day, Ryan, Dong, Yiyu, Weintraub, Steven J, Michel, Loren

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Synthetic Lethality through Combined Notch-Epidermal Growth Factor Receptor Pathway Inhibition in Basal-Like Breast Cancer von YIYU DONG, AIMIN LI, JIANBO WANG, WEBER, Jason D, MICHEL, Loren S

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PUMA and BIM are required for oncogene inactivation-induced apoptosis von Bean, Gregory R, Ganesan, Yogesh Tengarai, Dong, Yiyu, Takeda, Shugaku, Liu, Han, Chan, Po M, Huang, Yafen, Chodosh, Lewis A, Zambetti, Gerard P, Hsieh, James J-D, Cheng, Emily H-Y

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Molecular characterization of sarcomatoid clear cell renal cell carcinoma unveils new candidate oncogenic drivers von Malouf, Gabriel G., Flippot, Ronan, Dong, Yiyu, Dinatale, Renzo G., Chen, Ying-Bei, Su, Xiaoping, Compérat, Eva, Rouprêt, Morgan, Mano, Roy, Blum, Kyle A., Yao, Hui, Mouawad, Roger, Spano, Jean-Philippe, Khayat, David, Karam, Jose A., Ho, Thai H., Tickoo, Satish K., Russo, Paul, Hsieh, James J., Tannir, Nizar M., Hakimi, Abraham A.

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HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma von Takeda, Shugaku, Liu, Han, Sasagawa, Satoru, Dong, Yiyu, Trainor, Paul A, Cheng, Emily H, Hsieh, James J

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A Pharmacologic Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth von CHEN, David Y, LEE, Yishan, OH, Kyoung J, KORSMEYER, Stanley J, HERMONE, Ann, GUSSIO, Richard, SHOEMAKER, Robert H, CHENG, Emily H.-Y, HSIEH, James J.-D, VAN TINE, Brian A, SEARLEMAN, Adam C, WESTERGARD, Todd D, HAN LIU, TU, Ho-Chou, TAKEDA, Shugaku, YIYU DONG, PIWNICA-WORMS, David R

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A dual-modal PET/near infrared fluorescent nanotag for long-term immune cell tracking von Harmsen, Stefan, Medine, Emin Ilker, Moroz, Maxim, Nurili, Fuad, Lobo, Jose, Dong, Yiyu, Turkekul, Mezruh, Pillarsetty, Naga Vara Kishore, Ting, Richard, Ponomarev, Vladimir, Akin, Oguz, Aras, Omer

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Obtaining and analysis of flanking sequences from T-DNA transformants of Arabidopsis von Qin, Genji, Kang, Dingming, Dong, Yiyu, Shen, Yunping, Zhang, Li, Deng, Xiaohui, Zhang, Yao, Li, Song, Chen, Nan, Niu, Weiran, Chen, Cong, Liu, Peicheng, Chen, Haodong, Li, Jigang, Ren, Yanfei, Gu, Hongya, Deng, XingWang, Qu, Li-Jia, Chen, Zhangliang

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Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived ccRCC Xenograft Models von Dong, Yiyu, Eskandari, Roozbeh, Ray, Chelsea, Granlund, Kristin L, Santos-Cunha, Lidia Dos, Miloushev, Vesselin Z, Tee, Sui Seng, Jeong, Sangmoo, Aras, Omer, Chen, Ying-Bei, Cheng, Emily H, Hsieh, James J, Keshari, Kayvan R

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SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes von Xie, Yuchen, Sahin, Merve, Sinha, Sonali, Wang, Yufeng, Nargund, Amrita M, Lyu, Yang, Han, Song, Dong, Yiyu, Hsieh, James J, Leslie, Christina S, Cheng, Emily H

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Targeting the mTOR Pathway in Hurthle Cell Carcinoma Results in Potent Anti-Tumor Activity von Dong, Yiyu, Gong, Yongxing, Kuo, Fengshen, Makarov, Vladimir, Reznik, Ed, Nanjangud, Gouri J., Aras, Omer, Zhao, Huiyong, Qu, Rui, Fagin, James A., Sherman, Eric J., Xu, Bin, Ghossein, Ronald, Chan, Timothy A., Ganly, Ian

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Targeting the mTOR Pathway in Hurthle Cell Carcinoma Results in Potent Antitumor Activity von Dong, Yiyu, Gong, Yongxing, Kuo, Fengshen, Makarov, Vladimir, Reznik, Ed, Nanjangud, Gouri J, Aras, Omer, Zhao, Huiyong, Qu, Rui, Fagin, James A, Sherman, Eric J, Xu, Bin, Ghossein, Ronald, Chan, Timothy A, Ganly, Ian

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