Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical Specificities von Teyra, Joan, Huang, Haiming, Jain, Shobhit, Guan, Xinyu, Dong, Aiping, Liu, Yanli, Tempel, Wolfram, Min, Jinrong, Tong, Yufeng, Kim, Philip M., Bader, Gary D., Sidhu, Sachdev S.

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The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain von Min, Jinrong, Xu, Chao, Bian, Chuanbing, Lam, Robert, Dong, Aiping

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Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4 von Liu, Yanli, Qin, Su, Chen, Tsai-Yu, Lei, Ming, Dhar, Shilpa S., Ho, Jolene Caifeng, Dong, Aiping, Loppnau, Peter, Li, Yanjun, Lee, Min Gyu, Min, Jinrong

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Structure and Biochemical Functions of SIRT6 von Pan, Patricia W., Feldman, Jessica L., Devries, Mark K., Dong, Aiping, Edwards, Aled M., Denu, John M.

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A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells von Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Liu, Feng, Rival-Gervier, Sylvie, Allali-Hassani, Abdellah, Labrie, Viviane, Wigle, Tim J, DiMaggio, Peter A, Wasney, Gregory A, Siarheyeva, Alena, Dong, Aiping, Tempel, Wolfram, Wang, Sun-Chong, Chen, Xin, Chau, Irene, Mangano, Thomas J, Huang, Xi-ping, Simpson, Catherine D, Pattenden, Samantha G, Norris, Jacqueline L, Kireev, Dmitri B, Tripathy, Ashutosh, Edwards, Aled, Roth, Bryan L, Janzen, William P, Garcia, Benjamin A, Petronis, Arturas, Ellis, James, Brown, Peter J, Frye, Stephen V, Arrowsmith, Cheryl H, Jin, Jian

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Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations von Wu, Hong, Zeng, Hong, Dong, Aiping, Li, Fengling, He, Hao, Senisterra, Guillermo, Seitova, Alma, Duan, Shili, Brown, Peter J, Vedadi, Masoud, Arrowsmith, Cheryl H, Schapira, Matthieu

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Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase von Xiong, Yan, Li, Fengling, Babault, Nicolas, Dong, Aiping, Zeng, Hong, Wu, Hong, Chen, Xin, Arrowsmith, Cheryl H, Brown, Peter J, Liu, Jing, Vedadi, Masoud, Jin, Jian

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(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells von Barsyte-Lovejoy, Dalia, Li, Fengling, Oudhoff, Menno J., Tatlock, John H., Dong, Aiping, Zeng, Hong, Wu, Hong, Freeman, Spencer A., Schapira, Matthieu, Senisterra, Guillermo A., Kuznetsova, Ekaterina, Marcellus, Richard, Allali-Hassani, Abdellah, Kennedy, Steven, Lambert, Jean-Philippe, Couzens, Amber L., Aman, Ahmed, Gingras, Anne-Claude, Al-Awar, Rima, Fish, Paul V., Gerstenberger, Brian S., Roberts, Lee, Benn, Caroline L., Grimley, Rachel L., Braam, Mitchell J. S., Rossi, Fabio M. V., Sudol, Marius, Brown, Peter J., Bunnage, Mark E., Owen, Dafydd R., Zaph, Colby, Vedadi, Masoud, Arrowsmith, Cheryl H.

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TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma von Nakayama, Kazuhide, Szewczyk, Magdalena M, Dela Sena, Carlo, Wu, Hong, Dong, Aiping, Zeng, Hong, Li, Fengling, de Freitas, Renato Ferreira, Eram, Mohammad S, Schapira, Matthieu, Baba, Yuji, Kunitomo, Mihoko, Cary, Douglas R, Tawada, Michiko, Ohashi, Akihiro, Imaeda, Yasuhiro, Saikatendu, Kumar Singh, Grimshaw, Charles E, Vedadi, Masoud, Arrowsmith, Cheryl H, Barsyte-Lovejoy, Dalia, Kiba, Atsushi, Tomita, Daisuke, Brown, Peter J

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Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins von Kamps, Jos J.A.G., Huang, Jiaxin, Poater, Jordi, Xu, Chao, Pieters, Bas J.G.E., Dong, Aiping, Min, Jinrong, Sherman, Woody, Beuming, Thijs, Matthias Bickelhaupt, F., Li, Haitao, Mecinović, Jasmin

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Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP von Liu, Yanli, Lau, Johnathan, Li, Weiguo, Tempel, Wolfram, Li, Li, Dong, Aiping, Narula, Ashrut, Qin, Su, Min, Jinrong

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Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1) von Getlik, Matthäus, Smil, David, Zepeda-Velázquez, Carlos, Bolshan, Yuri, Poda, Gennady, Wu, Hong, Dong, Aiping, Kuznetsova, Ekaterina, Marcellus, Richard, Senisterra, Guillermo, Dombrovski, Ludmila, Hajian, Taraneh, Kiyota, Taira, Schapira, Matthieu, Arrowsmith, Cheryl H, Brown, Peter J, Vedadi, Masoud, Al-awar, Rima

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Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9 von Wu, Hong, Mathioudakis, Nikolas, Diagouraga, Boubou, Dong, Aiping, Dombrovski, Ludmila, Baudat, Frédéric, Cusack, Stephen, de Massy, Bernard, Kadlec, Jan

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Structural Basis of the Recruitment of Ubiquitin-specific Protease USP15 by Spliceosome Recycling Factor SART3 von Zhang, Qi, Harding, Rachel, Hou, Feng, Dong, Aiping, Walker, John R., Bteich, Joseph, Tong, Yufeng

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Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19 von Dong, Cheng, Nakagawa, Reiko, Oyama, Kyohei, Yamamoto, Yusuke, Zhang, Weilian, Dong, Aiping, Li, Yanjun, Yoshimura, Yuriko, Kamiya, Hiroyuki, Nakayama, Jun-ichi, Ueda, Jun, Min, Jinrong

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Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a von Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M, Wasney, Gregory A, Dong, Aiping, Barsyte, Dalia, Kozieradzki, Ivona, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Kireev, Dmitri B, Jadhav, Ajit, Herold, J. Martin, Frye, Stephen V, Arrowsmith, Cheryl H, Brown, Peter J, Simeonov, Anton, Vedadi, Masoud, Jin, Jian

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Defining efficient enzyme–cofactor pairs for bioorthogonal profiling of protein methylation von Islam, Kabirul, Chen, Yuling, Wu, Hong, Bothwell, Ian R., Blum, Gil J., Zeng, Hong, Dong, Aiping, Zheng, Weihong, Min, Jinrong, Deng, Haiteng, Luo, Minkui

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Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines von Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M, Wigle, Tim J, Wasney, Gregory A, Dong, Aiping, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Norris, Jacqueline L, Kireev, Dmitri B, Jadhav, Ajit, Herold, J. Martin, Janzen, William P, Arrowsmith, Cheryl H, Frye, Stephen V, Brown, Peter J, Simeonov, Anton, Vedadi, Masoud, Jin, Jian

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A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors von Deng, Youchao, Song, Xiaosheng, Iyamu, Iredia D., Dong, Aiping, Min, Jinrong, Huang, Rong

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Structural Basis of Inhibition of the Human NAD+-Dependent Deacetylase SIRT5 by Suramin von Schuetz, Anja, Min, Jinrong, Antoshenko, Tatiana, Wang, Chia-Lin, Allali-Hassani, Abdellah, Dong, Aiping, Loppnau, Peter, Vedadi, Masoud, Bochkarev, Alexey, Sternglanz, Rolf, Plotnikov, Alexander N.

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