PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow von Hopkins, Todd A, Ainsworth, William B, Ellis, Paul A, Donawho, Cherrie K, DiGiammarino, Enrico L, Panchal, Sanjay C, Abraham, Vivek C, Algire, Mikkel A, Shi, Yan, Olson, Amanda M, Johnson, Eric F, Wilsbacher, Julie L, Maag, David

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Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors von Hopkins, Todd A, Shi, Yan, Rodriguez, Luis E, Solomon, Larry R, Donawho, Cherrie K, DiGiammarino, Enrico L, Panchal, Sanjay C, Wilsbacher, Julie L, Gao, Wenqing, Olson, Amanda M, Stolarik, DeAnne F, Osterling, Donald J, Johnson, Eric F, Maag, David

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Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies von Bui, Mai H, Lin, Xiaoyu, Albert, Daniel H, Li, Leiming, Lam, Lloyd T, Faivre, Emily J, Warder, Scott E, Huang, Xiaoli, Wilcox, Denise, Donawho, Cherrie K, Sheppard, George S, Wang, Le, Fidanze, Steve, Pratt, John K, Liu, Dachun, Hasvold, Lisa, Uziel, Tamar, Lu, Xin, Kohlhapp, Fred, Fang, Guowei, Elmore, Steven W, Rosenberg, Saul H, McDaniel, Keith F, Kati, Warren M, Shen, Yu

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ABBV-176, a PRLR antibody drug conjugate with a potent DNA-damaging PBD cytotoxin and enhanced activity with PARP inhibition von Anderson, Mark G, Zhang, Qian, Rodriguez, Luis E, Hecquet, Claudie M, Donawho, Cherrie K, Ansell, Peter J, Reilly, Edward B

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Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer von Penning, Thomas D, Zhu, Gui-Dong, Gandhi, Viraj B, Gong, Jianchun, Liu, Xuesong, Shi, Yan, Klinghofer, Vered, Johnson, Eric F, Donawho, Cherrie K, Frost, David J, Bontcheva-Diaz, Velitchka, Bouska, Jennifer J, Osterling, Donald J, Olson, Amanda M, Marsh, Kennan C, Luo, Yan, Giranda, Vincent L

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Empowering therapeutic antibodies with IFN-α for cancer immunotherapy von Guo, Jun, Xiao, Yu, Iyer, Ramesh, Lu, Xin, Lake, Marc, Ladror, Uri, Harlan, John, Samanta, Tanushree, Tomlinson, Medha, Bukofzer, Gail, Donawho, Cherrie, Shoemaker, Alex, Huang, Tzu-Hsuan

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Iniparib Nonselectively Modifies Cysteine-Containing Proteins in Tumor Cells and Is Not a Bona Fide PARP Inhibitor von XUESONG LIU, YAN SHI, XU, Allison J, LAYER, Ramesh, HARLAN, John E, SOLOMON, Larry R, DONAWHO, Cherrie K, PENNING, Thomas D, JOHNSON, Eric F, SHOEMAKER, Alexander R, MAAG, David X, PALMA, Joann P, PATTERSON, Melanie J, ELLIS, Paul A, SURBER, Bruce W, READY, Damien B, SONI, Niru B, LADROR, Uri S

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ABT-888 Confers Broad In vivo Activity in Combination with Temozolomide in Diverse Tumors von PALMA, Joann P, WANG, Yi-Chun, ZHU, Gui-Dong, PENNING, Thomas D, GIRANDA, Vincent L, ROSENBERG, Saul H, FROST, David J, DONAWHO, Cherrie K, RODRIGUEZ, Luis E, MONTGOMERY, Debra, ELLIS, Paul A, BUKOFZER, Gail, NIQUETTE, Amanda, XUESONG LIU, YAN SHI, LASKO, Loren

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Characterization of ABT-806, a Humanized Tumor-Specific Anti-EGFR Monoclonal Antibody von Reilly, Edward B, Phillips, Andrew C, Buchanan, Fritz G, Kingsbury, Gillian, Zhang, Yumin, Meulbroek, Jonathan A, Cole, Todd B, DeVries, Peter J, Falls, Hugh D, Beam, Christine, Gu, Jinming, Digiammarino, Enrico L, Palma, Joann P, Donawho, Cherrie K, Goodwin, Neal C, Scott, Andrew M

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Synthesis and Evaluation of a New Generation of Orally Efficacious Benzimidazole-Based Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors as Anticancer Agents von Tong, Yunsong, Bouska, Jennifer J, Ellis, Paul A, Johnson, Eric F, Leverson, Joel, Liu, Xuesong, Marcotte, Patrick A, Olson, Amanda M, Osterling, Donald J, Przytulinska, Magdalena, Rodriguez, Luis E, Shi, Yan, Soni, Nirupama, Stavropoulos, Jason, Thomas, Sheela, Donawho, Cherrie K, Frost, David J, Luo, Yan, Giranda, Vincent L, Penning, Thomas D

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Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization von Shah, O. Jameel, Lin, Xiaoyu, Li, Leiming, Huang, Xiaoli, Li, Junling, Anderson, Mark G., Tang, Hua, Rodriguez, Luis E., Warder, Scott E., McLoughlin, Shaun, Chen, Jun, Palma, Joann, Glaser, Keith B., Donawho, Cherrie K., Fesik, Stephen W., Shen, Yu, Hunter, Tony

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ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models von DONAWHO, Cherrie K, YAN LUO, FERGUSON, Debra C, GHOREISHI-HAACK, Nayereh S, GRIMM, David R, GUAN, Ran, HAN, Edward K, HOLLEY-SHANKS, Rhonda R, HRISTOV, Boris, IDLER, Kenneth B, JARVIS, Ken, JOHNSON, Eric F, YANPING LUO, KLEINBERG, Lawrence R, KLINGHOFER, Vered, LASKO, Loren M, XUESONG LIU, MARSH, Kennan C, MCGONIGAL, Thomas P, MEULBROEK, Jonathan A, OLSON, Amanda M, PALMA, Joann P, RODRIGUEZ, Luis E, PENNING, Thomas D, YAN SHI, STAVROPOULOS, Jason A, TSURUTANI, Alan C, ZHU, Gui-Dong, ROSENBERG, Saul H, GIRANDA, Vincent L, FROST, David J, BAUCH, Joy L, BOUSKA, Jennifer J, BONTCHEVA-DIAZ, Velitchka D, COX, Bryan F, DEWEESE, Theodore L, DILLEHAY, Larry E

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Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer von Zhu, Gui-Dong, Gong, Jianchun, Gandhi, Viraj B., Liu, Xuesong, Shi, Yan, Johnson, Eric F., Donawho, Cherrie K., Ellis, Paul A, Bouska, Jennifer J., Osterling, Donald J., Olson, Amanda M., Park, Chang, Luo, Yan, Shoemaker, Alexander, Giranda, Vincent L., Penning, Thomas D.

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Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer von Penning, Thomas D, Zhu, Gui-Dong, Gandhi, Viraj B, Gong, Jianchun, Thomas, Sheela, Lubisch, Wilfried, Grandel, Roland, Wernet, Wolfgang, Park, Chang H, Fry, Elizabeth H, Liu, Xuesong, Shi, Yan, Klinghofer, Vered, Johnson, Eric F, Donawho, Cherrie K, Frost, David J, Bontcheva-Diaz, Velitchka, Bouska, Jennifer J, Olson, Amanda M, Marsh, Kennan C, Luo, Yan, Rosenberg, Saul H, Giranda, Vincent L

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Potentiation of Temozolomide Cytotoxicity by Poly(ADP)Ribose Polymerase Inhibitor ABT-888 Requires a Conversion of Single-Stranded DNA Damages to Double-Stranded DNA Breaks von Liu, Xuesong, Shi, Yan, Guan, Ran, Donawho, Cherrie, Luo, Yanping, Palma, Joann, Zhu, Gui-Dong, Johnson, Eric F, Rodriguez, Luis E, Ghoreishi-Haack, Nayereh, Jarvis, Ken, Hradil, Vincent P, Colon-Lopez, Milagros, Cox, Bryan F, Klinghofer, Vered, Penning, Thomas, Rosenberg, Saul H, Frost, David, Giranda, Vincent L, Luo, Yan

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Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig von Bardwell, Philip D., Staron, Matthew M., Liu, Junjian, Tao, Qingfeng, Scesney, Susanne, Bukofzer, Gail, Rodriguez, Luis E., Choi, Chee-Ho, Wang, Jennifer, Chang, Qing, Dong, Feng, Donawho, Cherrie, Wang, Jieyi, Grinnell, Christine M., Tarcsa, Edit, Hutchins, Charles, Ghayur, Tariq, Gu, Jijie

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The PARP Inhibitor, ABT-888 Potentiates Temozolomide: Correlation with Drug Levels and Reduction in PARP Activity In Vivo von PALMA, Joann P, RODRIGUEZ, Luis E, XUESONG LIU, OLSON, Amanda, SALTARELLI, Mary J, YAN SHI, STAVROPOULOS, Jason A, ZHU, Gui-Dong, PENNING, Thomas D, YAN LUO, GIRANDA, Vincent L, ROSENBERG, Saul H, BONTCHEVA-DIAZ, Velitchka D, FROST, David J, DONAWHO, Cherrie K, BOUSKA, Jennifer J, BUKOFZER, Gail, COLON-LOPEZ, Milagros, RAN GUAN, JARVIS, Kenneth, JOHNSON, Eric F, KLINGHOFER, Vered

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Preclinical Characterization of ABT-348, a Kinase Inhibitor Targeting the Aurora, Vascular Endothelial Growth Factor Receptor/Platelet-Derived Growth Factor Receptor, and Src Kinas... von Glaser, Keith B., Li, Junling, Marcotte, Patrick A., Magoc, Terrance J., Guo, Jun, Reuter, David R., Tapang, Paul, Wei, Ru-Qi, Pease, Lori J., Bui, Mai H., Chen, Zehan, Frey, Robin R., Johnson, Eric F., Osterling, Donald J., Olson, Amanda M., Bouska, Jennifer J., Luo, Yanping, Curtin, Michael L., Donawho, Cherrie K., Michaelides, Michael R., Tse, Chris, Davidsen, Steven K., Albert, Daniel H.

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Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases von Curtin, Michael L., Robin Heyman, H., Frey, Robin R., Marcotte, Patrick A., Glaser, Keith B., Jankowski, James R., Magoc, Terrance J., Albert, Daniel H., Olson, Amanda M., Reuter, David R., Bouska, Jennifer J., Montgomery, Debra A., Palma, Joann P., Donawho, Cherrie K., Stewart, Kent D., Tse, Chris, Michaelides, Michael R.

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Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor von Albert, Daniel H, Tapang, Paul, Magoc, Terrance J, Pease, Lori J, Reuter, David R, Wei, Ru-Qi, Li, Junling, Guo, Jun, Bousquet, Peter F, Ghoreishi-Haack, Nayereh S, Wang, Baole, Bukofzer, Gail T, Wang, Yi-Chun, Stavropoulos, Jason A, Hartandi, Kresna, Niquette, Amanda L, Soni, Nirupama, Johnson, Eric F, McCall, J Owen, Bouska, Jennifer J, Luo, Yanping, Donawho, Cherrie K, Dai, Yujia, Marcotte, Patrick A, Glaser, Keith B, Michaelides, Michael R, Davidsen, Steven K

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