Clinical investigation of CAR T cells for solid tumors: Lessons learned and future directions von Bagley, Stephen J., O’Rourke, Donald M.

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Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α von Wang, Qirui, He, Zhenqiang, Huang, Menggui, Liu, Tianrun, Wang, Yanling, Xu, Haineng, Duan, Hao, Ma, Peihong, Zhang, Lin, Zamvil, Scott S., Hidalgo, Juan, Zhang, Zhenfeng, O’Rourke, Donald M., Dahmane, Nadia, Brem, Steven, Mou, Yonggao, Gong, Yanqing, Fan, Yi

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PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma von Liu, Tianrun, Ma, Wenjuan, Xu, Haineng, Huang, Menggui, Zhang, Duo, He, Zhenqiang, Zhang, Lin, Brem, Steven, O’Rourke, Donald M., Gong, Yanqing, Mou, Yonggao, Zhang, Zhenfeng, Fan, Yi

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Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma von Akbari, Hamed, Macyszyn, Luke, Da, Xiao, Bilello, Michel, Wolf, Ronald L., Martinez-Lage, Maria, Biros, George, Alonso-Basanta, Michelle, O'Rourke, Donald M., Davatzikos, Christos

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A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity von Jacob, Fadi, Salinas, Ryan D., Zhang, Daniel Y., Nguyen, Phuong T.T., Schnoll, Jordan G., Wong, Samuel Zheng Hao, Thokala, Radhika, Sheikh, Saad, Saxena, Deeksha, Prokop, Stefan, Liu, Di-ao, Qian, Xuyu, Petrov, Dmitriy, Lucas, Timothy, Chen, H. Isaac, Dorsey, Jay F., Christian, Kimberly M., Binder, Zev A., Nasrallah, MacLean, Brem, Steven, O’Rourke, Donald M., Ming, Guo-li, Song, Hongjun

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Glioblastoma: The Current State of Biology and Therapeutic Strategies von Binder, Zev A, O'Rourke, Donald M

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CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges von Bagley, Stephen J, Desai, Arati S, Linette, Gerald P, June, Carl H, O'Rourke, Donald M

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Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1 von Rathore, Saima, Akbari, Hamed, Rozycki, Martin, Abdullah, Kalil G., Nasrallah, MacLean P., Binder, Zev A., Davuluri, Ramana V., Lustig, Robert A., Dahmane, Nadia, Bilello, Michel, O’Rourke, Donald M., Davatzikos, Christos

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Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results von Bagley, Stephen J., Logun, Meghan, Fraietta, Joseph A., Wang, Xin, Desai, Arati S., Bagley, Linda J., Nabavizadeh, Ali, Jarocha, Danuta, Martins, Rene, Maloney, Eileen, Lledo, Lester, Stein, Carly, Marshall, Amy, Leskowitz, Rachel, Jadlowsky, Julie K., Christensen, Shannon, Oner, Bike Su, Plesa, Gabriela, Brennan, Andrea, Gonzalez, Vanessa, Chen, Fang, Sun, Yusha, Gladney, Whitney, Barrett, David, Nasrallah, MacLean P., Hwang, Wei-Ting, Ming, Guo-Li, Song, Hongjun, Siegel, Donald L., June, Carl H., Hexner, Elizabeth O., Binder, Zev A., O’Rourke, Donald M.

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Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development von Binder, Zev A., Thorne, Amy Haseley, Bakas, Spyridon, Wileyto, E. Paul, Bilello, Michel, Akbari, Hamed, Rathore, Saima, Ha, Sung Min, Zhang, Logan, Ferguson, Cole J., Dahiya, Sonika, Bi, Wenya Linda, Reardon, David A., Idbaih, Ahmed, Felsberg, Joerg, Hentschel, Bettina, Weller, Michael, Bagley, Stephen J., Morrissette, Jennifer J.D., Nasrallah, MacLean P., Ma, Jianhui, Zanca, Ciro, Scott, Andrew M., Orellana, Laura, Davatzikos, Christos, Furnari, Frank B., O'Rourke, Donald M.

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Circulating Glioma Cells Exhibit Stem Cell-like Properties von Liu, Tianrun, Xu, Haineng, Huang, Menggui, Ma, Wenjuan, Saxena, Deeksha, Lustig, Robert A, Alonso-Basanta, Michelle, Zhang, Zhenfeng, O'Rourke, Donald M, Zhang, Lin, Gong, Yanqing, Kao, Gary D, Dorsey, Jay F, Fan, Yi

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IDH mutation impairs histone demethylation and results in a block to cell differentiation von Lu, Chao, Ward, Patrick S., Kapoor, Gurpreet S., Rohle, Dan, Turcan, Sevin, Abdel-Wahab, Omar, Edwards, Christopher R., Khanin, Raya, Figueroa, Maria E., Melnick, Ari, Wellen, Kathryn E., O’Rourke, Donald M., Berger, Shelley L., Chan, Timothy A., Levine, Ross L., Mellinghoff, Ingo K., Thompson, Craig B.

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Immune landscapes associated with different glioblastoma molecular subtypes von Martinez-Lage, Maria, Lynch, Timothy M, Bi, Yingtao, Cocito, Carolina, Way, Gregory P, Pal, Sharmistha, Haller, Josephine, Yan, Rachel E, Ziober, Amy, Nguyen, Aivi, Kandpal, Manoj, O'Rourke, Donald M, Greenfield, Jeffrey P, Greene, Casey S, Davuluri, Ramana V, Dahmane, Nadia

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A Randomized Double-Blind Placebo-Controlled Phase II Trial of Dendritic Cell Vaccine ICT-107 in Newly Diagnosed Patients with Glioblastoma von Wen, Patrick Y, Reardon, David A, Armstrong, Terri S, Phuphanich, Surasak, Aiken, Robert D, Landolfi, Joseph C, Curry, William T, Zhu, Jay-Jiguang, Glantz, Michael, Peereboom, David M, Markert, James M, LaRocca, Renato, O'Rourke, Donald M, Fink, Karen, Kim, Lyndon, Gruber, Michael, Lesser, Glenn J, Pan, Edward, Kesari, Santosh, Muzikansky, Alona, Pinilla, Clemencia, Santos, Radleigh G, Yu, John S

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Histopathology‐validated machine learning radiographic biomarker for noninvasive discrimination between true progression and pseudo‐progression in glioblastoma von Akbari, Hamed, Rathore, Saima, Bakas, Spyridon, Nasrallah, MacLean P., Shukla, Gaurav, Mamourian, Elizabeth, Rozycki, Martin, Bagley, Stephen J., Rudie, Jeffrey D., Flanders, Adam E., Dicker, Adam P., Desai, Arati S., O’Rourke, Donald M., Brem, Steven, Lustig, Robert, Mohan, Suyash, Wolf, Ronald L., Bilello, Michel, Martinez‐Lage, Maria, Davatzikos, Christos

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Autologous Heat Shock Protein Peptide Vaccination for Newly Diagnosed Glioblastoma: Impact of Peripheral PD-L1 Expression on Response to Therapy von Bloch, Orin, Lim, Michael, Sughrue, Michael E, Komotar, Ricardo J, Abrahams, John M, O'Rourke, Donald M, D'Ambrosio, Anthony, Bruce, Jeffrey N, Parsa, Andrew T

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Clinical measures, radiomics, and genomics offer synergistic value in AI-based prediction of overall survival in patients with glioblastoma von Fathi Kazerooni, Anahita, Saxena, Sanjay, Toorens, Erik, Tu, Danni, Bashyam, Vishnu, Akbari, Hamed, Mamourian, Elizabeth, Sako, Chiharu, Koumenis, Costas, Verginadis, Ioannis, Verma, Ragini, Shinohara, Russell T., Desai, Arati S., Lustig, Robert A., Brem, Steven, Mohan, Suyash, Bagley, Stephen J., Ganguly, Tapan, O’Rourke, Donald M., Bakas, Spyridon, Nasrallah, MacLean P., Davatzikos, Christos

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In Vivo Detection of EGFRvIII in Glioblastoma via Perfusion Magnetic Resonance Imaging Signature Consistent with Deep Peritumoral Infiltration: The φ -Index von Bakas, Spyridon, Akbari, Hamed, Pisapia, Jared, Martinez-Lage, Maria, Rozycki, Martin, Rathore, Saima, Dahmane, Nadia, O'Rourke, Donald M, Davatzikos, Christos

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Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques von Macyszyn, Luke, Akbari, Hamed, Pisapia, Jared M, Da, Xiao, Attiah, Mark, Pigrish, Vadim, Bi, Yingtao, Pal, Sharmistha, Davuluri, Ramana V, Roccograndi, Laura, Dahmane, Nadia, Martinez-Lage, Maria, Biros, George, Wolf, Ronald L, Bilello, Michel, O'Rourke, Donald M, Davatzikos, Christos

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EGFR, the Lazarus target for precision oncology in glioblastoma von Lin, Benjamin, Ziebro, Julia, Smithberger, Erin, Skinner, Kasey R, Zhao, Eva, Cloughesy, Timothy F, Binder, Zev A, O'Rourke, Donald M, Nathanson, David A, Furnari, Frank B, Miller, C Ryan

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