Metabotropic glutamate receptors as targets for new antipsychotic drugs: Historical perspective and critical comparative assessment von Wierońska, Joanna M, Zorn, Stevin H, Doller, Dario, Pilc, Andrzej

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The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies von Wierońska, Joanna M., Sławińska, Anna, Łasoń-Tyburkiewicz, Magdalena, Gruca, Piotr, Papp, Mariusz, Zorn, Stevin H., Doller, Darío, Kłeczek, Natalia, Noworyta-Sokołowska, Karolina, Gołembiowska, Krystyna, Pilc, Andrzej

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Synergy between l-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: Implications for Parkinson's disease treatment and dyskinesia von Bennouar, Khaled-Ezaheir, Uberti, Michelle A., Melon, Christophe, Bacolod, Maria D., Jimenez, Hermogenes N., Cajina, Manuel, Kerkerian-Le Goff, Lydia, Doller, Darío, Gubellini, Paolo

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Tricyclic Thiazolopyrazole Derivatives as Metabotropic Glutamate Receptor 4 Positive Allosteric Modulators von Hong, Sang-Phyo, Liu, Kevin G, Ma, Gil, Sabio, Michael, Uberti, Michelle A, Bacolod, Maria D, Peterson, John, Zou, Zack Z, Robichaud, Albert J, Doller, Darío

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Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1) Antagonists as Novel Antithrombotic Agents von Chackalamannil, Samuel, Xia, Yan, Greenlee, William J, Clasby, Martin, Doller, Darìo, Tsai, Hsingan, Asberom, Theodros, Czarniecki, Michael, Ahn, Ho-Sam, Boykow, George, Foster, Carolyn, Agans-Fantuzzi, Jacqueline, Bryant, Matthew, Lau, Janice, Chintala, Madhu

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Dusting off old blueprints: Is it time to reconsider metabotropic glutamate receptor 2 for therapeutic drug development? von Bespalov, Anton, Lütjens, Robert, Doller, Dario

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Discovery and structure–activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators von Zhou, Hao, Topiol, Sidney W., Grenon, Michel, Jimenez, Hermogenes N., Uberti, Michelle A., Smith, Daniel G., Brodbeck, Robbin M., Chandrasena, Gamini, Pedersen, Henrik, Madsen, Jens Christian, Doller, Darío, Li, Guiying

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The selective functionalization of saturated hydrocarbons: Gif chemistry von Barton, Derek H. R, Doller, Dario

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The “Century of Biology” and the Evolving Role of Medicinal Chemists in Neuroscience von Doller, Dario

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Chemical Biology at Lundbeck: Enhancing CNS drug discovery research von Doller, Dario

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4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators von Jimenez, Hermogenes N., Liu, Kevin G., Hong, Sang-Phyo, Reitman, Michael S., Uberti, Michelle A., Bacolod, Maria D., Cajina, Manuel, Nattini, Megan, Sabio, Michael, Doller, Darío

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Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands von Li, Guiying, Zhou, Hao, Jiang, Yu, Keim, Holger, Topiol, Sidney W., Poda, Suresh B., Ren, Yong, Chandrasena, Gamini, Doller, Darío

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Himbacine analogs as muscarinic receptor antagonists––effects of tether and heterocyclic variations von Chackalamannil, Samuel, Doller, Darı́o, McQuade, Robert, Ruperto, Vilma

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The design, synthesis and structure–activity relationships of 1-aryl-4-aminoalkylisoquinolines: A novel series of CRF-1 receptor antagonists von Yoon, Taeyoung, De Lombaert, Stéphane, Brodbeck, Robbin, Gulianello, Michael, Chandrasekhar, Jayaraman, Horvath, Raymond F., Ge, Ping, Kershaw, Mark T., Krause, James E., Kehne, John, Hoffman, Diane, Doller, Darío, Hodgetts, Kevin J.

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Discovery of N-(1-Ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98−2): An Orally Active Corticotropin Releasing Factor-1 (CRF-1... von Hodgetts, Kevin J, Ge, Ping, Yoon, Taeyoung, Lombaert, Stéphane De, Brodbeck, Robbin, Gulianello, Michael, Kieltyka, Andrzej, Horvath, Raymond F, Kehne, John H, Krause, James E, Maynard, George D, Hoffman, Diane, Lee, Younglim, Fung, Laurence, Doller, Dario

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Quality of Research Tools

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6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators von Weiss, Jesse M., Jimenez, Hermogenes N., Li, Guiying, April, Myriam, Uberti, Michelle A., Bacolod, Maria D., Brodbeck, Robb M., Doller, Darío

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Himbacine derived thrombin receptor antagonists: Discovery of a new tricyclic core von Clasby, Martin C., Chackalamannil, Samuel, Czarniecki, Michael, Doller, Darío, Eagen, Keith, Greenlee, William J., Lin, Yan, Tagat, Jayaram R., Tsai, Hsingan, Xia, Yan, Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline, Boykow, George, Chintala, Madhu, Hsieh, Yunsheng, McPhail, Andrew T.

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Metabolism-Based Identification of a Potent Thrombin Receptor Antagonist von Clasby, Martin C, Chackalamannil, Samuel, Czarniecki, Michael, Doller, Dario, Eagen, Keith, Greenlee, William, Kao, Grace, Lin, Yan, Tsai, Hsingan, Xia, Yan, Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline, Boykow, George, Chintala, Madhu, Foster, Carolyn, Smith-Torhan, April, Alton, Kevin, Bryant, Matthew, Hsieh, Yunsheng, Lau, Janice, Palamanda, Jairam

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Allosteric Modalities for Membrane-Bound Receptors: Insights from Drug Hunting for Brain Diseases von Coughlin, Quinn, Hopper, Allen T, Blanco, Maria-Jesus, Tirunagaru, Vijaya, Robichaud, Albert J, Doller, Dario

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