Brexanolone as adjunctive therapy in super‐refractory status epilepticus von Rosenthal, Eric S., Claassen, Jan, Wainwright, Mark S., Husain, Aatif M., Vaitkevicius, Henrikas, Raines, Shane, Hoffmann, Ethan, Colquhoun, Helen, Doherty, James J., Kanes, Stephen J.

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25-Hydroxycholesterol amplifies microglial IL-1 beta production in an apoE isoform-dependent manner von Wong, Man Ying, Lewis, Michael, Doherty, James J., Shi, Yang, Cashikar, Anil G., Amelianchik, Anna, Tymchuk, Svitlana, Sullivan, Patrick M., Qian, Mingxing, Covey, Douglas F., Petsko, Gregory A., Holtzman, David M., Paul, Steven M., Luo, Wenjie

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Stimulus-specific adaptation in auditory cortex is an NMDA-independent process distinct from the sensory novelty encoded by the mismatch negativity von Farley, Brandon J, Quirk, Michael C, Doherty, James J, Christian, Edward P

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Preventing Phosphorylation of the GABAAR β3 Subunit Compromises the Behavioral Effects of Neuroactive Steroids von Vien, Thuy N., Ackley, Michael A., Doherty, James J., Moss, Stephen J., Davies, Paul A.

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Trial of SAGE-217 in Patients with Major Depressive Disorder von Gunduz-Bruce, Handan, Silber, Christopher, Kaul, Inder, Rothschild, Anthony J, Riesenberg, Robert, Sankoh, Abdul J, Li, Haihong, Lasser, Robert, Zorumski, Charles F, Rubinow, David R, Paul, Steven M, Jonas, Jeffrey, Doherty, James J, Kanes, Stephen J

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Neuroactive Steroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model von Modgil, Amit, Vien, Thuy N, Ackley, Michael A, Doherty, James J, Moss, Stephen J, Davies, Paul A

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Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator von Althaus, Alison L., Ackley, Michael A., Belfort, Gabriel M., Gee, Steven M., Dai, Jing, Nguyen, David P., Kazdoba, Tatiana M., Modgil, Amit, Davies, Paul A., Moss, Stephen J., Salituro, Francesco G., Hoffmann, Ethan, Hammond, Rebecca S., Robichaud, Albert J., Quirk, Michael C., Doherty, James J.

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Oxysterols Modulate the Acute Effects of Ethanol on Hippocampal N-Methyl-D-Aspartate Receptors, Long-Term Potentiation, and Learning von Izumi, Yukitoshi, Mennerick, Steven J., Doherty, James J., Zorumski, Charles F.

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Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA(A) receptor positive allosteric modulator von Althaus, Alison L., Ackley, Michael A., Belfort, Gabriel M., Gee, Steven M., Dai, Jing, Nguyen, David P., Kazdoba, Tatiana M., Modgil, Amit, Davies, Paul A., Moss, Stephen J., Salituro, Francesco G., Hoffmann, Ethan, Hammond, Rebecca S., Robichaud, Albert J., Quirk, Michael C., Doherty, James J.

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Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano‑1H‑pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric... von Martinez Botella, Gabriel, Salituro, Francesco G, Harrison, Boyd L, Beresis, Richard T, Bai, Zhu, Blanco, Maria-Jesus, Belfort, Gabriel M, Dai, Jing, Loya, Carlos M, Ackley, Michael A, Althaus, Alison L, Grossman, Scott J, Hoffmann, Ethan, Doherty, James J, Robichaud, Albert J

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The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors von Paul, Steven M, Doherty, James J, Robichaud, Albert J, Belfort, Gabriel M, Chow, Brian Y, Hammond, Rebecca S, Crawford, Devon C, Linsenbardt, Andrew J, Shu, Hong-Jin, Izumi, Yukitoshi, Mennerick, Steven J, Zorumski, Charles F

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Endogenous and synthetic neuroactive steroids evoke sustained increases in the efficacy of GABAergic inhibition via a protein kinase C-dependent mechanism von Modgil, Amit, Parakala, Manasa L., Ackley, Michael A., Doherty, James J., Moss, Stephen J., Davies, Paul A.

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AZD8529, a positive allosteric modulator at the mGluR2 receptor, does not improve symptoms in schizophrenia: A proof of principle study von Litman, Robert E, Smith, Mark A, Doherty, James J, Cross, Alan, Raines, Shane, Gertsik, Lev, Zukin, Stephen R

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Pharmacological characterization of SAGE‐718, a novel positive allosteric modulator of N‐methyl‐d‐aspartate receptors von Beckley, Jacob T., Aman, Teresa K., Ackley, Michael A., Kazdoba, Tatiana M., Lewis, Michael C., Smith, Anne C., Farley, Brandon J., Dai, Jing, Deats, Wayne, Hoffmann, Ethan, Robichaud, Albert J., Doherty, James J., Quirk, Michael C.

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SAGE-718: A First-in-Class N‑Methyl‑d‑Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment von Hill, Matthew D., Blanco, Maria-Jesus, Salituro, Francesco G., Bai, Zhu, Beckley, Jacob T., Ackley, Michael A., Dai, Jing, Doherty, James J., Harrison, Boyd L., Hoffmann, Ethan C., Kazdoba, Tatiana M., Lanzetta, David, Lewis, Michael, Quirk, Michael C., Robichaud, Albert J.

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Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABA A receptors von Parakala, Manasa L, Zhang, Yihui, Modgil, Amit, Chadchankar, Jayashree, Vien, Thuy N, Ackley, Michael A, Doherty, James J, Davies, Paul A, Moss, Stephen J

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Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABAA receptors von Parakala, Manasa L., Zhang, Yihui, Modgil, Amit, Chadchankar, Jayashree, Vien, Thuy N., Ackley, Michael A., Doherty, James J., Davies, Paul A., Moss, Stephen J.

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Novel neuroactive steroids as positive allosteric modulators of NMDA receptors: mechanism, site of action, and rescue pharmacology on GRIN variants associated with neurological con... von Tang, Weiting, Beckley, Jacob T., Zhang, Jin, Song, Rui, Xu, Yuchen, Kim, Sukhan, Quirk, Michael C., Robichaud, Albert J., Diaz, Eva Sarai, Myers, Scott J., Doherty, James J., Ackley, Michael A., Traynelis, Stephen F., Yuan, Hongjie

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A Selective Allosteric Potentiator of the M1 Muscarinic Acetylcholine Receptor Increases Activity of Medial Prefrontal Cortical Neurons and Restores Impairments in Reversal Learnin... von Shirey, Jana K, Brady, Ashley E, Jones, Paulianda J, Davis, Albert A, Bridges, Thomas M, Kennedy, J. Phillip, Jadhav, Satyawan B, Menon, Usha N, Xiang, Zixiu, Watson, Mona L, Christian, Edward P, Doherty, James J, Quirk, Michael C, Snyder, Dean H, Lah, James J, Levey, Allan I, Nicolle, Michelle M, Lindsley, Craig W, Conn, P. Jeffrey

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Long-Term Depression in Hippocampal Interneurons: Joint Requirement for Pre- and Postsynaptic Events von Laezza, Fernanda, Doherty, James J., Dingledine, Raymond

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