IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment von Manore, Sara G, Doheny, Daniel L, Wong, Grace L, Lo, Hui-Wen

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STAT family of transcription factors in breast cancer: Pathogenesis and therapeutic opportunities and challenges von Wong, Grace L., Manore, Sara G., Doheny, Daniel L., Lo, Hui-Wen

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Breast cancer extracellular vesicles-derived miR-1290 activates astrocytes in the brain metastatic microenvironment via the FOXA2→CNTF axis to promote progression of brain metastas... von Sirkisoon, Sherona R., Wong, Grace L., Aguayo, Noah R., Doheny, Daniel L., Zhu, Dongqin, Regua, Angelina T., Arrigo, Austin, Manore, Sara G., Wagner, Calvin, Thomas, Alexandra, Singh, Ravi, Xing, Fei, Jin, Guangxu, Watabe, Kounosuke, Lo, Hui-Wen

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Correction: Regua et al. TrkA Interacts with and Phosphorylates STAT3 to Enhance Gene Transcription and Promote Breast Cancer Stem Cells in Triple-Negative and HER2-Enriched Breast... von Regua, Angelina T, Aguayo, Noah R, Jalboush, Sara Abu, Doheny, Daniel L, Manore, Sara G, Zhu, Dongqin, Wong, Grace L, Arrigo, Austin, Wagner, Calvin J, Yu, Yang, Thomas, Alexandra, Chan, Michael D, Ruiz, Jimmy, Jin, Guangxu, Strowd, Roy, Sun, Peiqing, Lin, Jiayuh, Lo, Hui-Wen

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TrkA Interacts with and Phosphorylates STAT3 to Enhance Gene Transcription and Promote Breast Cancer Stem Cells in Triple-Negative and HER2-Enriched Breast Cancers von Regua, Angelina T., Aguayo, Noah R., Jalboush, Sara Abu, Doheny, Daniel L., Manore, Sara G., Zhu, Dongqin, Wong, Grace L., Arrigo, Austin, Wagner, Calvin J., Yu, Yang, Thomas, Alexandra, Chan, Michael D., Ruiz, Jimmy, Jin, Guangxu, Strowd, Roy, Sun, Peiqing, Lin, Jiayuh, Lo, Hui-Wen

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Editor's Highlight: Development of an In vitro Assay Measuring Uterine-Specific Estrogenic Responses for Use in Chemical Safety Assessment von Miller, Michelle M, Alyea, Rebecca A, LeSommer, Caroline, Doheny, Daniel L, Rowley, Sean M, Childs, Kristin M, Balbuena, Pergentino, Ross, Susan M, Dong, Jian, Sun, Bin, Andersen, Melvin A, Clewell, Rebecca A

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Editor's Highlight: Screening ToxCast Prioritized Chemicals for PPARG Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis von Foley, Briana, Doheny, Daniel L, Black, Michael B, Pendse, Salil N, Wetmore, Barbara A, Clewell, Rebecca A, Andersen, Melvin E, Deisenroth, Chad

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Abstract 2866: Truncated glioma-associated oncogene homolog 1 (tGLI1) is an actionable therapeutic target in breast cancer brain metastases von Doheny, Daniel L., Sirkisoon, Sherona R., Rimkus, Tadas, Zhu, Dongqin, Aguayo, Noah R., Anguelov, Marlyn, Manore, Sara, Xing, Fei, Metheny-Barlow, Linda, Watabe, Kounosuke, Thomas, Alexandra, Masters, Adrianna Henson, Strowd, Roy E., Lo, Hui-Wen

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Abstract 5025: Antifungal ketoconazole inhibits tumor-specific transcription factor tGLI1 leading to suppression of breast cancer stem cells and brain metastasis von Doheny, Daniel L., Sirkisoon, Sherona R., Rimkus, Tadas, Zhu, Dongqin, Aguayo, Noah R., Harrison, Alexandria, Anguelov, Marlyn, Manore, Sara, Xing, Fei, Metheny-Barlow, Linda J., Watabe, Kounosuke, Thomas, Alexandra, Masters, Adrianna Henson, Strowd, Roy, Lo, Hui-Wen

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Abstract 1979: JAK2/STAT3 and TrkA pathways are frequently co-activated in triple-negative and HER2-enriched breast cancers and the co-activation correlates with an increased poten... von Regua, Angelina T., Aguayo, Noah R., Jalboush, Sara Abu, Doheny, Daniel L., Manore, Sara G., Zhu, Dongqin, Wong, Grace L., Arrigo, Austin, Wagner, Calvin J., Yu, Yang, Baylon, Karen, Thomas, Alexandra, Chan, Michael D., Ruiz, Jimmy, Jin, Guangxu, Strowd, Roy E., Sun, Peiqing, Metheny-Barlow, Linda J., Lin, Jiayuh, Lo, Hui-Wen

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Abstract 92: tGLI1 and IL-6/IL-6R/GP130/STAT3 pathways cooperate to promote breast cancer stem cells and are co-activated in HER2-enriched and triple-negative breast cancers von Manore, Sara G., Doheny, Daniel L., Zhu, Dongqin, Wong, Grace L., Regua, Angelina T., Arrigo, Austin, Wagner, Calvin J., Najjar, Mariana, Lo, Hui-Wen

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Abstract 1039: TrkA and JAK2-STAT3 pathway crosstalk promotes breast cancer stem cells in HER2-enriched and triple-negative breast cancers von Regua, Angelina T., Zhu, Dongqin, Doheny, Daniel L., Wong, Grace L., Manore, Sara G., Wagner, Calvin J., Arrigo, Austin, Najjar, Mariana, Lo, Hui-Wen

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Abstract 2354: Astrocytes activated by tGLI1-expressing breast cancer brain metastases upregulate CNTF to activate astrocytes and promote breast cancer stem cells von Wong, Grace L., Sirkisoon, Sherona R., Aguayo, Noah R., Doheny, Daniel L., Zhu, Dongqin, Regua, Angelina T., Arrigo, Austin, Manore, Sara G., Wagner, Calvin J., Thomas, Alexandra, Singh, Ravi, Xing, Fei, Jin, Guangxu, Watabe, Kounosuke, Lo, Hui-Wen

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Hedgehog Signaling and Truncated GLI1 in Cancer von Doheny, Daniel, Manore, Sara G., Wong, Grace L., Lo, Hui-Wen

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Quality control and quality assurance in genotypic data for genome-wide association studies von Laurie, Cathy C., Doheny, Kimberly F., Mirel, Daniel B., Pugh, Elizabeth W., Bierut, Laura J., Bhangale, Tushar, Boehm, Frederick, Caporaso, Neil E., Cornelis, Marilyn C., Edenberg, Howard J., Gabriel, Stacy B., Harris, Emily L., Hu, Frank B., Jacobs, Kevin B., Kraft, Peter, Landi, Maria Teresa, Lumley, Thomas, Manolio, Teri A., McHugh, Caitlin, Painter, Ian, Paschall, Justin, Rice, John P., Rice, Kenneth M., Zheng, Xiuwen, Weir, Bruce S.

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The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers von Amos, Christopher I, Dennis, Joe, Wang, Zhaoming, Byun, Jinyoung, Schumacher, Fredrick R, Gayther, Simon A, Casey, Graham, Hunter, David J, Sellers, Thomas A, Gruber, Stephen B, Dunning, Alison M, Michailidou, Kyriaki, Fachal, Laura, Doheny, Kimberly, Spurdle, Amanda B, Li, Yafang, Xiao, Xiangjun, Romm, Jane, Pugh, Elizabeth, Coetzee, Gerhard A, Hazelett, Dennis J, Bojesen, Stig E, Caga-Anan, Charlisse, Haiman, Christopher A, Kamal, Ahsan, Luccarini, Craig, Tessier, Daniel, Vincent, Daniel, Bacot, François, Van Den Berg, David J, Nelson, Stefanie, Demetriades, Stephen, Goldgar, David E, Couch, Fergus J, Forman, Judith L, Giles, Graham G, Conti, David V, Bickeböller, Heike, Risch, Angela, Waldenberger, Melanie, Brüske-Hohlfeld, Irene, Hicks, Belynda D, Ling, Hua, McGuffog, Lesley, Lee, Andrew, Kuchenbaecker, Karoline, Soucy, Penny, Manz, Judith, Cunningham, Julie M, Butterbach, Katja, Kote-Jarai, Zsofia, Kraft, Peter, FitzGerald, Liesel, Lindström, Sara, Adams, Marcia, McKay, James D, Phelan, Catherine M, Benlloch, Sara, Kelemen, Linda E, Brennan, Paul, Riggan, Marjorie, O'Mara, Tracy A, Shen, Hongbing, Shi, Yongyong, Thompson, Deborah J, Goodman, Marc T, Nielsen, Sune F, Berchuck, Andrew, Laboissiere, Sylvie, Schmit, Stephanie L, Shelford, Tameka, Edlund, Christopher K, Taylor, Jack A, Field, John K, Park, Sue K, Offit, Kenneth, Thomassen, Mads, Schmutzler, Rita, Ottini, Laura, Hung, Rayjean J, Marchini, Jonathan, Amin Al Olama, Ali, Peters, Ulrike, Eeles, Rosalind A, Seldin, Michael F, Gillanders, Elizabeth, Seminara, Daniela, Antoniou, Antonis C, Pharoah, Paul D P, Chenevix-Trench, Georgia, Chanock, Stephen J, Simard, Jacques, Easton, Douglas F

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TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment von Sirkisoon, Sherona R., Carpenter, Richard L., Rimkus, Tadas, Doheny, Daniel, Zhu, Dongqin, Aguayo, Noah R., Xing, Fei, Chan, Michael, Ruiz, Jimmy, Metheny-Barlow, Linda J., Strowd, Roy, Lin, Jiayuh, Regua, Angelina T., Arrigo, Austin, Anguelov, Marlyn, Pasche, Boris, Debinski, Waldemar, Watabe, Kounosuke, Lo, Hui-Wen

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Genetic analyses of diverse populations improves discovery for complex traits von Wojcik, Genevieve L., Graff, Mariaelisa, Nishimura, Katherine K., Tao, Ran, Haessler, Jeffrey, Gignoux, Christopher R., Highland, Heather M., Patel, Yesha M., Sorokin, Elena P., Avery, Christy L., Belbin, Gillian M., Bien, Stephanie A., Cheng, Iona, Cullina, Sinead, Hodonsky, Chani J., Hu, Yao, Huckins, Laura M., Jeff, Janina, Justice, Anne E., Kocarnik, Jonathan M., Lim, Unhee, Lin, Bridget M., Lu, Yingchang, Nelson, Sarah C., Park, Sung-Shim L., Poisner, Hannah, Preuss, Michael H., Richard, Melissa A., Schurmann, Claudia, Setiawan, Veronica W., Sockell, Alexandra, Vahi, Karan, Verbanck, Marie, Vishnu, Abhishek, Walker, Ryan W., Young, Kristin L., Zubair, Niha, Acuña-Alonso, Victor, Ambite, Jose Luis, Barnes, Kathleen C., Boerwinkle, Eric, Bottinger, Erwin P., Bustamante, Carlos D., Caberto, Christian, Canizales-Quinteros, Samuel, Conomos, Matthew P., Deelman, Ewa, Do, Ron, Doheny, Kimberly, Fernández-Rhodes, Lindsay, Fornage, Myriam, Hailu, Benyam, Heiss, Gerardo, Henn, Brenna M., Hindorff, Lucia A., Jackson, Rebecca D., Laurie, Cecelia A., Laurie, Cathy C., Li, Yuqing, Lin, Dan-Yu, Moreno-Estrada, Andres, Nadkarni, Girish, Norman, Paul J., Pooler, Loreall C., Reiner, Alexander P., Romm, Jane, Sabatti, Chiara, Sandoval, Karla, Sheng, Xin, Stahl, Eli A., Stram, Daniel O., Thornton, Timothy A., Wassel, Christina L., Wilkens, Lynne R., Winkler, Cheryl A., Yoneyama, Sachi, Buyske, Steven, Haiman, Christopher A., Kooperberg, Charles, Le Marchand, Loic, Loos, Ruth J. F., Matise, Tara C., North, Kari E., Peters, Ulrike, Kenny, Eimear E., Carlson, Christopher S.

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Detectable clonal mosaicism from birth to old age and its relationship to cancer von Laurie, Cathy C, Laurie, Cecelia A, Rice, Kenneth, Doheny, Kimberly F, Zelnick, Leila R, McHugh, Caitlin P, Ling, Hua, Hetrick, Kurt N, Pugh, Elizabeth W, Amos, Chris, Wei, Qingyi, Wang, Li-e, Lee, Jeffrey E, Barnes, Kathleen C, Hansel, Nadia N, Mathias, Rasika, Daley, Denise, Beaty, Terri H, Scott, Alan F, Ruczinski, Ingo, Scharpf, Rob B, Bierut, Laura J, Hartz, Sarah M, Landi, Maria Teresa, Freedman, Neal D, Goldin, Lynn R, Ginsburg, David, Li, Jun, Desch, Karl C, Strom, Sara S, Blot, William J, Signorello, Lisa B, Ingles, Sue A, Chanock, Stephen J, Berndt, Sonja I, Le Marchand, Loic, Henderson, Brian E, Monroe, Kristine R, Heit, John A, de Andrade, Mariza, Armasu, Sebastian M, Regnier, Cynthia, Lowe, William L, Hayes, M Geoffrey, Marazita, Mary L, Feingold, Eleanor, Murray, Jeffrey C, Melbye, Mads, Feenstra, Bjarke, Kang, Jae H, Wiggs, Janey L, Jarvik, Gail P, McDavid, Andrew N, Seshan, Venkatraman E, Mirel, Daniel B, Crenshaw, Andrew, Sharopova, Nataliya, Wise, Anastasia, Shen, Jess, Crosslin, David R, Levine, David M, Zheng, Xiuwen, Udren, Jenna I, Bennett, Siiri, Nelson, Sarah C, Gogarten, Stephanie M, Conomos, Matthew P, Heagerty, Patrick, Manolio, Teri, Pasquale, Louis R, Haiman, Christopher A, Caporaso, Neil, Weir, Bruce S

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Genome-wide association scan of dental caries in the permanent dentition von Wang, Xiaojing, Shaffer, John R, Zeng, Zhen, Begum, Ferdouse, Vieira, Alexandre R, Noel, Jacqueline, Anjomshoaa, Ida, Cuenco, Karen T, Lee, Myoung-Keun, Beck, James, Boerwinkle, Eric, Cornelis, Marilyn C, Hu, Frank B, Crosslin, David R, Laurie, Cathy C, Nelson, Sarah C, Doheny, Kimberly F, Pugh, Elizabeth W, Polk, Deborah E, Weyant, Robert J, Crout, Richard, McNeil, Daniel W, Weeks, Daniel E, Feingold, Eleanor, Marazita, Mary L

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