Am I ready for CRISPR? A user's guide to genetic screens von Doench, John G.

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CRISPR screens for functional interrogation of immunity von Shi, Hao, Doench, John G., Chi, Hongbo

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Design and analysis of CRISPR–Cas experiments von Hanna, Ruth E., Doench, John G.

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Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map von Smith, Ian, Greenside, Peyton G, Natoli, Ted, Lahr, David L, Wadden, David, Tirosh, Itay, Narayan, Rajiv, Root, David E, Golub, Todd R, Subramanian, Aravind, Doench, John G

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Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation von Doench, John G, Hartenian, Ella, Graham, Daniel B, Tothova, Zuzana, Hegde, Mudra, Smith, Ian, Sullender, Meagan, Ebert, Benjamin L, Xavier, Ramnik J, Root, David E

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Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities von Sanson, Kendall R., Hanna, Ruth E., Hegde, Mudra, Donovan, Katherine F., Strand, Christine, Sullender, Meagan E., Vaimberg, Emma W., Goodale, Amy, Root, David E., Piccioni, Federica, Doench, John G.

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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma von Chapuy, Bjoern, McKeown, Michael R., Lin, Charles Y., Monti, Stefano, Roemer, Margaretha G.M., Qi, Jun, Rahl, Peter B., Sun, Heather H., Yeda, Kelly T., Doench, John G., Reichert, Elaine, Kung, Andrew L., Rodig, Scott J., Young, Richard A., Shipp, Margaret A., Bradner, James E.

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DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells von He, Yizhou Joseph, Meghani, Khyati, Caron, Marie-Christine, Yang, Chunyu, Ronato, Daryl A., Bian, Jie, Sharma, Anchal, Moore, Jessica, Niraj, Joshi, Detappe, Alexandre, Doench, John G., Legube, Gaelle, Root, David E., D’Andrea, Alan D., Drané, Pascal, De, Subhajyoti, Konstantinopoulos, Panagiotis A., Masson, Jean-Yves, Chowdhury, Dipanjan

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Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway von Evavold, Charles L., Hafner-Bratkovič, Iva, Devant, Pascal, D’Andrea, Jasmin M., Ngwa, Elsy M., Boršić, Elvira, Doench, John G., LaFleur, Martin W., Sharpe, Arlene H., Thiagarajah, Jay R., Kagan, Jonathan C.

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Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells von Shalem, Ophir, Sanjana, Neville E., Hartenian, Ella, Shi, Xi, Scott, David A., Mikkelsen, Tarjei S., Heckl, Dirk, Ebert, Benjamin L., Root, David E., Doench, John G., Zhang, Feng

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Genetic screens and functional genomics using CRISPR/Cas9 technology von Hartenian, Ella, Doench, John G

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A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis von Zou, Yilong, Palte, Michael J., Deik, Amy A., Li, Haoxin, Eaton, John K., Wang, Wenyu, Tseng, Yuen-Yi, Deasy, Rebecca, Kost-Alimova, Maria, Dančík, Vlado, Leshchiner, Elizaveta S., Viswanathan, Vasanthi S., Signoretti, Sabina, Choueiri, Toni K., Boehm, Jesse S., Wagner, Bridget K., Doench, John G., Clish, Clary B., Clemons, Paul A., Schreiber, Stuart L.

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Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin von Wijshake, Tobias, Zou, Zhongju, Chen, Beibei, Zhong, Lin, Xiao, Guanghua, Xie, Yang, Doench, John G., Bennett, Lynda, Levine, Beth

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A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation von Arroyo, Jason D., Jourdain, Alexis A., Calvo, Sarah E., Ballarano, Carmine A., Doench, John G., Root, David E., Mootha, Vamsi K.

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Cas9 activates the p53 pathway and selects for p53-inactivating mutations von Enache, Oana M., Rendo, Veronica, Abdusamad, Mai, Lam, Daniel, Davison, Desiree, Pal, Sangita, Currimjee, Naomi, Hess, Julian, Pantel, Sasha, Nag, Anwesha, Thorner, Aaron R., Doench, John G., Vazquez, Francisca, Beroukhim, Rameen, Golub, Todd R., Ben-David, Uri

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Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis von Zou, Yilong, Li, Haoxin, Graham, Emily T., Deik, Amy A., Eaton, John K., Wang, Wenyu, Sandoval-Gomez, Gerardo, Clish, Clary B., Doench, John G., Schreiber, Stuart L.

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Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 von Doench, John G, Fusi, Nicolo, Sullender, Meagan, Hegde, Mudra, Vaimberg, Emma W, Donovan, Katherine F, Smith, Ian, Tothova, Zuzana, Wilen, Craig, Orchard, Robert, Virgin, Herbert W, Listgarten, Jennifer, Root, David E

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Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens von Hegde, Mudra, Strand, Christine, Hanna, Ruth E, Doench, John G

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Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity von Brestoff, Jonathan R., Wilen, Craig B., Moley, John R., Li, Yongjia, Zou, Wei, Malvin, Nicole P., Rowen, Marina N., Saunders, Brian T., Ma, Hongming, Mack, Madison R., Hykes, Barry L., Balce, Dale R., Orvedahl, Anthony, Williams, Jesse W., Rohatgi, Nidhi, Wang, Xiaoyan, McAllaster, Michael R., Handley, Scott A., Kim, Brian S., Doench, John G., Zinselmeyer, Bernd H., Diamond, Michael S., Virgin, Herbert W., Gelman, Andrew E., Teitelbaum, Steven L.

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Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death von Balsa, Eduardo, Perry, Elizabeth A., Bennett, Christopher F., Jedrychowski, Mark, Gygi, Steven P., Doench, John G., Puigserver, Pere

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