Exchange listing of ETFS: key concerns in the 19b-4 process von Haskin, Benjamin J, Burns, James R, Doench, James E

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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma von Chapuy, Bjoern, McKeown, Michael R., Lin, Charles Y., Monti, Stefano, Roemer, Margaretha G.M., Qi, Jun, Rahl, Peter B., Sun, Heather H., Yeda, Kelly T., Doench, John G., Reichert, Elaine, Kung, Andrew L., Rodig, Scott J., Young, Richard A., Shipp, Margaret A., Bradner, James E.

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Mutational processes shape the landscape of TP53 mutations in human cancer von Giacomelli, Andrew O., Yang, Xiaoping, Lintner, Robert E., McFarland, James M., Duby, Marc, Kim, Jaegil, Howard, Thomas P., Takeda, David Y., Ly, Seav Huong, Kim, Eejung, Gannon, Hugh S., Hurhula, Brian, Sharpe, Ted, Goodale, Amy, Fritchman, Briana, Steelman, Scott, Vazquez, Francisca, Tsherniak, Aviad, Aguirre, Andrew J., Doench, John G., Piccioni, Federica, Roberts, Charles W. M., Meyerson, Matthew, Getz, Gad, Johannessen, Cory M., Root, David E., Hahn, William C.

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Massively parallel assessment of human variants with base editor screens von Hanna, Ruth E., Hegde, Mudra, Fagre, Christian R., DeWeirdt, Peter C., Sangree, Annabel K., Szegletes, Zsofia, Griffith, Audrey, Feeley, Marissa N., Sanson, Kendall R., Baidi, Yossef, Koblan, Luke W., Liu, David R., Neal, James T., Doench, John G.

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Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity von Griffin, Gabriel K., Wu, Jingyi, Iracheta-Vellve, Arvin, Patti, James C., Hsu, Jeffrey, Davis, Thomas, Dele-Oni, Deborah, Du, Peter P., Halawi, Aya G., Ishizuka, Jeffrey J., Kim, Sarah Y., Klaeger, Susan, Knudsen, Nelson H., Miller, Brian C., Nguyen, Tung H., Olander, Kira E., Papanastasiou, Malvina, Rachimi, Suzanna, Robitschek, Emily J., Schneider, Emily M., Yeary, Mitchell D., Zimmer, Margaret D., Jaffe, Jacob D., Carr, Steven A., Doench, John G., Haining, W. Nicholas, Yates, Kathleen B., Manguso, Robert T., Bernstein, Bradley E.

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Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries von Misek, Sean A., Fultineer, Aaron, Kalfon, Jeremie, Noorbakhsh, Javad, Boyle, Isabella, Roy, Priyanka, Dempster, Joshua, Petronio, Lia, Huang, Katherine, Saadat, Alham, Green, Thomas, Brown, Adam, Doench, John G., Root, David E., McFarland, James M., Beroukhim, Rameen, Boehm, Jesse S.

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Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway von Viswanathan, Vasanthi S., Ryan, Matthew J., Dhruv, Harshil D., Gill, Shubhroz, Eichhoff, Ossia M., Seashore-Ludlow, Brinton, Kaffenberger, Samuel D., Eaton, John K., Shimada, Kenichi, Aguirre, Andrew J., Viswanathan, Srinivas R., Chattopadhyay, Shrikanta, Tamayo, Pablo, Yang, Wan Seok, Rees, Matthew G., Chen, Sixun, Boskovic, Zarko V., Javaid, Sarah, Huang, Cherrie, Wu, Xiaoyun, Tseng, Yuen-Yi, Roider, Elisabeth M., Gao, Dong, Cleary, James M., Wolpin, Brian M., Mesirov, Jill P., Haber, Daniel A., Engelman, Jeffrey A., Boehm, Jesse S., Kotz, Joanne D., Hon, Cindy S., Chen, Yu, Hahn, William C., Levesque, Mitchell P., Doench, John G., Berens, Michael E., Shamji, Alykhan F., Clemons, Paul A., Stockwell, Brent R., Schreiber, Stuart L.

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Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations von Chandrasekaran, Srinivas Niranj, Cimini, Beth A., Goodale, Amy, Miller, Lisa, Kost-Alimova, Maria, Jamali, Nasim, Doench, John G., Fritchman, Briana, Skepner, Adam, Melanson, Michelle, Kalinin, Alexandr A., Arevalo, John, Haghighi, Marzieh, Caicedo, Juan C., Kuhn, Daniel, Hernandez, Desiree, Berstler, James, Shafqat-Abbasi, Hamdah, Root, David E., Swalley, Susanne E., Garg, Sakshi, Singh, Shantanu, Carpenter, Anne E.

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Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs von Jutzi, Jonas S, Marneth, Anna E, Ciboddo, Michele, Guerra-Moreno, Angel, Jiménez-Santos, María José, Kosmidou, Anastasia, Dressman, James W, Liang, Hongyan, Hamel, Rebecca, Lozano, Patricia, Rumi, Elisa, Doench, John G, Gotlib, Jason, Krishnan, Anandi, Elf, Shannon, Al-Shahrour, Fátima, Mullally, Ann

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Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis von Zhao, Baobing, Keerthivasan, Ganesan, Mei, Yang, Yang, Jing, McElherne, James, Wong, Piu, Doench, John G, Feng, Gang, Root, David E, Ji, Peng

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DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia von Chen, Chun-Wei, Koche, Richard P, Sinha, Amit U, Deshpande, Aniruddha J, Zhu, Nan, Eng, Rowena, Doench, John G, Xu, Haiming, Chu, Scott H, Qi, Jun, Wang, Xi, Delaney, Christopher, Bernt, Kathrin M, Root, David E, Hahn, William C, Bradner, James E, Armstrong, Scott A

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Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer von Bondeson, Daniel P, Paolella, Brenton R, Asfaw, Adhana, Rothberg, Michael V, Skipper, Thomas A, Langan, Carly, Mesa, Gabriel, Gonzalez, Alfredo, Surface, Lauren E, Ito, Kentaro, Kazachkova, Mariya, Colgan, William N, Warren, Allison, Dempster, Joshua M, Krill-Burger, John M, Ericsson, Maria, Tang, Andrew A, Fung, Iris, Chambers, Emily S, Abdusamad, Mai, Dumont, Nancy, Doench, John G, Piccioni, Federica, Root, David E, Boehm, Jesse, Hahn, William C, Mannstadt, Michael, McFarland, James M, Vazquez, Francisca, Golub, Todd R

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Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells von Vu, Ly P, Prieto, Camila, Amin, Elianna M, Chhangawala, Sagar, Krivtsov, Andrei, Calvo-Vidal, M Nieves, Chou, Timothy, Chow, Arthur, Minuesa, Gerard, Park, Sun Mi, Barlowe, Trevor S, Taggart, James, Tivnan, Patrick, Deering, Raquel P, Chu, Lisa P, Kwon, Jeong-Ah, Meydan, Cem, Perales-Paton, Javier, Arshi, Arora, Gönen, Mithat, Famulare, Christopher, Patel, Minal, Paietta, Elisabeth, Tallman, Martin S, Lu, Yuheng, Glass, Jacob, Garret-Bakelman, Francine E, Melnick, Ari, Levine, Ross, Al-Shahrour, Fatima, Järås, Marcus, Hacohen, Nir, Hwang, Alexia, Garippa, Ralph, Lengner, Christopher J, Armstrong, Scott A, Cerchietti, Leandro, Cowley, Glenn S, Root, David, Doench, John, Leslie, Christina, Ebert, Benjamin L, Kharas, Michael G

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Targeting oncoproteins with a positive selection assay for protein degraders von Koduri, Vidyasagar, Duplaquet, Leslie, Lampson, Benjamin L, Wang, Adam C, Sabet, Amin H, Ishoey, Mette, Paulk, Joshiawa, Teng, Mingxing, Harris, Isaac S, Endress, Jennifer E, Liu, Xiaoxi, Dasilva, Ethan, Paulo, Joao A, Briggs, Kimberly J, Doench, John G, Ott, Christopher J, Zhang, Tinghu, Donovan, Katherine A, Fischer, Eric S, Gygi, Steven P, Gray, Nathanael S, Bradner, James, Medin, Jeffrey A, Buhrlage, Sara J, Oser, Matthew G, Kaelin, Jr, William G

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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma von Chapuy, Bjoern, McKeown, Michael R., Lin, Charles Y., Monti, Stefano, Roemer, Margaretha G.M., Qi, Jun, Rahl, Peter B., Sun, Heather H., Yeda, Kelly T., Doench, John G., Reichert, Elaine, Kung, Andrew L., Rodig, Scott J., Young, Richard A., Shipp, Margaret A., Bradner, James E.

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Abstract IA13: RNA regulators and the control of self-renewal von Vu, Ly, Prieto, Camila, Amin, Eliana M., Minuesa, Gerard, Chhangawala, Sagar, Vidal, Maria C., Krivtsov, Andrei, Chou, Timothy, Chow, Arthur, Barlowe, Trevor, Taggart, James, Tivnan, Patrick, Deering, Raquel P., Chu, Lisa P., Gonen, Mithat, Figueroa, Maria E., Paietta, Elisabeth, Tallman, Martin S., Melnick, Ari, Levine, Ross, Al-Shahrour, Fatima, Jaras, Marcus, Hacohen, Nir, Hwang, Alexia, Garippa, Ralph, Lengner, Christopher, Armstrong, Scott, Cowley, Glenn S., Root, David, Doench, John, Cerchietti, Leandro, Leslie, Christina, Ebert, Benjamin L., Kharas, Michael G.

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Abstract 1028: Phosphate dysregulation as a novel therapeutic strategy in ovarian and uterine cancers von Bondeson, Daniel, Paolella, Brenton, Asfaw, Adhana, Rothberg, Michael, Skipper, Thomas, Mesa, Gabriel, Gonzalez, Alfredo, Surface, Lauren E., Ito, Kentaro, Kazachkova, Mariya, Colgan, William N., Warren, Allie, Dempster, Joshua, Krill-Burger, J Michael, Ericsson, Maria, Tang, Andrew, Fung, Iris, Chambers, Emily S., Abdusamad, Mai, Dumont, Nancy, Doench, John, Piccioni, Federica, Root, David, Boehm, Jesse, Hahn, William C., Mannstadt, Michael, McFarland, James, Vazquez, Francisca, Golub, Todd

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RNA Binding Protein Syncrip Regulates the Leukemia Stem Cell Program von Vu, Ly P., Prieto, Camila, Amin, Elianna, Minuesa, Gerard, Chhangawala, Sagar, Vidal, Maria J, Krivtsov, Andrei V., Chou, Tim, Barlowe, Trevor, Taggart, James, Tivnan, Patrick, Deering, Raquel P., Gonen, Mithat, Figueroa, Maria E, Paietta, Elisabeth, Tallman, Martin S., Melnick, Ari, Levine, Ross L., Al-Shahrour, Fatima, Järås, Marcus, Chu, Lisa, Garippa, Ralph, Lengner, Christopher, Armstrong, Scott A., Cowley, Glenn, Root, David, Doench, John G, Cerchietti, Leandro, Leslie, Christina, Ebert, Benjamin, Kharas, Michael G.

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