Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation von Rothbart, Scott B, Dickson, Bradley M, Ong, Michelle S, Krajewski, Krzysztof, Houliston, Scott, Kireev, Dmitri B, Arrowsmith, Cheryl H, Strahl, Brian D

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Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7 von Lamb, Kelsey N., Bsteh, Daniel, Dishman, Sarah N., Moussa, Hagar F., Fan, Huitao, Stuckey, Jacob I., Norris, Jacqueline L., Cholensky, Stephanie H., Li, Dongxu, Wang, Jingkui, Sagum, Cari, Stanton, Benjamin Z., Bedford, Mark T., Pearce, Kenneth H., Kenakin, Terry P., Kireev, Dmitri B., Wang, Gang Greg, James, Lindsey I., Bell, Oliver, Frye, Stephen V.

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Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a von Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M, Wasney, Gregory A, Dong, Aiping, Barsyte, Dalia, Kozieradzki, Ivona, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Kireev, Dmitri B, Jadhav, Ajit, Herold, J. Martin, Frye, Stephen V, Arrowsmith, Cheryl H, Brown, Peter J, Simeonov, Anton, Vedadi, Masoud, Jin, Jian

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A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization von Dilworth, David, Hanley, Ronan P., Ferreira de Freitas, Renato, Allali-Hassani, Abdellah, Zhou, Mengqi, Mehta, Naimee, Marunde, Matthew R., Ackloo, Suzanne, Carvalho Machado, Raquel Arminda, Khalili Yazdi, Aliakbar, Owens, Dominic D. G., Vu, Victoria, Nie, David Y., Alqazzaz, Mona, Marcon, Edyta, Li, Fengling, Chau, Irene, Bolotokova, Albina, Qin, Su, Lei, Ming, Liu, Yanli, Szewczyk, Magdalena M., Dong, Aiping, Kazemzadeh, Sina, Abramyan, Tigran, Popova, Irina K., Hall, Nathan W., Meiners, Matthew J., Cheek, Marcus A., Gibson, Elisa, Kireev, Dmitri, Greenblatt, Jack F., Keogh, Michael-C., Min, Jinrong, Brown, Peter J., Vedadi, Masoud, Arrowsmith, Cheryl H., Barsyte-Lovejoy, Dalia, James, Lindsey I., Schapira, Matthieu

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Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines von Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M, Wigle, Tim J, Wasney, Gregory A, Dong, Aiping, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Norris, Jacqueline L, Kireev, Dmitri B, Jadhav, Ajit, Herold, J. Martin, Janzen, William P, Arrowsmith, Cheryl H, Frye, Stephen V, Brown, Peter J, Simeonov, Anton, Vedadi, Masoud, Jin, Jian

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In silico fragment-based discovery of CIB1-directed anti-tumor agents by FRASE-bot von An, Yi, Lim, Jiwoong, Glavatskikh, Marta, Wang, Xiaowen, Norris-Drouin, Jacqueline, Hardy, P. Brian, Leisner, Tina M., Pearce, Kenneth H., Kireev, Dmitri

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MERTK activation drives osimertinib resistance in EGFR-mutant non-small cell lung cancer von Yan, Dan, Huelse, Justus M, Kireev, Dmitri, Tan, Zikang, Chen, Luxiao, Goyal, Subir, Wang, Xiaodong, Frye, Stephen V, Behera, Madhusmita, Schneider, Frank, Ramalingam, Suresh S, Owonikoko, Taofeek, Earp, H Shelton, DeRyckere, Deborah, Graham, Douglas K

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Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins von Rectenwald, Justin M, Guduru, Shiva Krishna Reddy, Dang, Zhao, Collins, Leonard B, Liao, Yi-En, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Kaufmann, Kyle W, Hammond, Scott M, Kireev, Dmitri B, Frye, Stephen V, Pearce, Kenneth H

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Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain von James, Lindsey I, Barsyte-Lovejoy, Dalia, Zhong, Nan, Krichevsky, Liubov, Korboukh, Victoria K, Herold, J Martin, MacNevin, Christopher J, Norris, Jacqueline L, Sagum, Cari A, Tempel, Wolfram, Marcon, Edyta, Guo, Hongbo, Gao, Cen, Huang, Xi-Ping, Duan, Shili, Emili, Andrew, Greenblatt, Jack F, Kireev, Dmitri B, Jin, Jian, Janzen, William P, Brown, Peter J, Bedford, Mark T, Arrowsmith, Cheryl H, Frye, Stephen V

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Chromodomain Ligand Optimization via Target-Class Directed Combinatorial Repurposing von Barnash, Kimberly D, Lamb, Kelsey N, Stuckey, Jacob I, Norris, Jacqueline L, Cholensky, Stephanie H, Kireev, Dmitri B, Frye, Stephen V, James, Lindsey I

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Reprogramming CBX8-PRC1 function with a positive allosteric modulator von Suh, Junghyun L., Bsteh, Daniel, Hart, Bryce, Si, Yibo, Weaver, Tyler M., Pribitzer, Carina, Lau, Roy, Soni, Shivani, Ogana, Heather, Rectenwald, Justin M., Norris, Jacqueline L., Cholensky, Stephanie H., Sagum, Cari, Umana, Jessica D., Li, Dongxu, Hardy, Brian, Bedford, Mark T., Mumenthaler, Shannon M., Lenz, Heinz-Josef, Kim, Yong-Mi, Wang, Gang Greg, Pearce, Ken H., James, Lindsey I., Kireev, Dmitri B., Musselman, Catherine A., Frye, Stephen V., Bell, Oliver

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Small-Molecule Ligands of Methyl-Lysine Binding Proteins: Optimization of Selectivity for L3MBTL3 von James, Lindsey I, Korboukh, Victoria K, Krichevsky, Liubov, Baughman, Brandi M, Herold, J. Martin, Norris, Jacqueline L, Jin, Jian, Kireev, Dmitri B, Janzen, William P, Arrowsmith, Cheryl H, Frye, Stephen V

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Small-Molecule Ligands of Methyl-Lysine Binding Proteins von Herold, J. Martin, Wigle, Tim J, Norris, Jacqueline L, Lam, Robert, Korboukh, Victoria K, Gao, Cen, Ingerman, Lindsey A, Kireev, Dmitri B, Senisterra, Guillermo, Vedadi, Masoud, Tripathy, Ashutosh, Brown, Peter J, Arrowsmith, Cheryl H, Jin, Jian, Janzen, William P, Frye, Stephen V

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Discovery of selective activators of PRC2 mutant EED-I363M von Suh, Junghyun L., Barnash, Kimberly D., Abramyan, Tigran M., Li, Fengling, The, Juliana, Engelberg, Isabelle A., Vedadi, Masoud, Brown, Peter J., Kireev, Dmitri B., Arrowsmith, Cheryl H., James, Lindsey I., Frye, Stephen V.

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Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors von Zhang, Weihe, Zhang, Dehui, Stashko, Michael A, DeRyckere, Deborah, Hunter, Debra, Kireev, Dmitri, Miley, Michael J, Cummings, Christopher, Lee, Minjung, Norris-Drouin, Jacqueline, Stewart, Wendy M, Sather, Susan, Zhou, Yingqiu, Kirkpatrick, Gregory, Machius, Mischa, Janzen, William P, Earp, H. Shelton, Graham, Douglas K, Frye, Stephen V, Wang, Xiaodong

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A simulation model of heterochromatin formation at submolecular detail von Williams, Michael R., Xiaokang, Yan, Hathaway, Nathaniel A., Kireev, Dmitri

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Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1 von Suh, Junghyun L, Watts, Brian, Stuckey, Jacob I, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Dickson, Bradley M, An, Yi, Mathea, Sebastian, Salah, Eidarus, Knapp, Stefan, Khan, Abid, Adams, Alexander T, Strahl, Brian D, Sagum, Cari A, Bedford, Mark T, James, Lindsey I, Kireev, Dmitri B, Frye, Stephen V

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Discovery of Macrocyclic Pyrimidines as MerTK‐Specific Inhibitors von McIver, Andrew L., Zhang, Weihe, Liu, Qingyang, Jiang, Xinpeng, Stashko, Michael A., Nichols, James, Miley, Michael J., Norris‐Drouin, Jacqueline, Machius, Mischa, DeRyckere, Deborah, Wood, Edgar, Graham, Douglas K., Earp, H. Shelton, Kireev, Dmitri, Frye, Stephen V., Wang, Xiaodong

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Correction to “Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID subunit 1” von Suh, Junghyun L, Watts, Brian, Stuckey, Jacob I, Norris-Drouin, Jacqueline L, Cholensky, Stephanie H, Dickson, Bradley M, An, Yi, Mathea, Sebastian, Salah, Eidarus, Knapp, Stefan, Khan, Abid, Adams, Alexander T, Strahl, Brian D, Sagum, Cari A, Bedford, Mark T, James, Lindsey I, Kireev, Dmitri B, Frye, Stephen V

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Structure-Based Virtual Screening of Commercially Available Compound Libraries von Kireev, Dmitri

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