Discovery of N 2‑(4-Amino-cyclohexyl)-9-cyclopentyl‑N 6‑(4-morpholin-4-ylmethyl-phenyl)-9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3... von Gucký, Tomáš, Řezníčková, Eva, Radošová Muchová, Tereza, Jorda, Radek, Klejová, Zuzana, Malínková, Veronika, Berka, Karel, Bazgier, Václav, Ajani, Haresh, Lepšík, Martin, Divoký, Vladimír, Kryštof, Vladimír

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Deep Molecular Response Achieved with Chemotherapy, Dasatinib and Interferon α in Patients with Lymphoid Blast Crisis of Chronic Myeloid Leukaemia von Vráblová, Lucia, Divoký, Vladimír, Kořalková, Pavla, Poláková, Kateřina Machová, Kriegová, Eva, Janská, Romana, Grohmann, Jan, Holzerová, Milena, Papajík, Tomáš, Faber, Edgar

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Hemoglobinopathies von Indrák, Karel, Divoká, Martina, Pospíšilová, Dagmar, Čermák, Jaroslav, Beličková, Monika, Horváthová, Monika, Divoký, Vladimír

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Oxidative DNA Damage, Inflammatory Signature, and Altered Erythrocytes Properties in Diamond-Blackfan Anemia von Kapralova, Katarina, Jahoda, Ondrej, Koralkova, Pavla, Gursky, Jan, Lanikova, Lucie, Pospisilova, Dagmar, Divoky, Vladimir, Horvathova, Monika

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Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl- N6-(4-morpholin-4-ylmethyl-phenyl)- 9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3... von Gucký, Tomáš, Řezníčková, Eva, Radošová Muchová, Tereza, Jorda, Radek, Klejová, Zuzana, Malínková, Veronika, Berka, Karel, Bazgier, Václav, Ajani, Haresh, Lepšík, Martin, Divoký, Vladimír, Kryštof, Vladimír

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The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis von Ghashghaeinia, Mehrdad, Koralkova, Pavla, Giustarini, Daniela, Mojzikova, Renata, Fehrenbacher, Birgit, Dreischer, Peter, Schaller, Martin, Mrowietz, Ulrich, Martínez-Ruiz, Antonio, Wieder, Thomas, Divoky, Vladimir, Rossi, Ranieri, Lang, Florian, Köberle, Martin

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Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development von Yoon, Donghoon, Pastore, Yves D., Divoky, Vladimir, Liu, Enli, Mlodnicka, Agnieszka E., Rainey, Karin, Ponka, Premysl, Semenza, Gregg L., Schumacher, Armin, Prchal, Josef T.

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Oxidative stress as a therapeutic perspective for ATM-deficient chronic lymphocytic leukemia patients von Navrkalova, Veronika, Kafkova, Leona Raskova, Divoky, Vladimir, Pospisilova, Sarka

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Cdk2 Inhibition Prolongs G1 Phase Progression in Mouse Embryonic Stem Cells von Koledova, Zuzana, Kafkova, Leona Raskova, Calabkova, Lenka, Krystof, Vladimir, Dolezel, Petr, Divoky, Vladimir

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DMT1-Mutant Erythrocytes have Shortened Life Span, Accelerated Glycolysis and Increased Oxidative Stress von Zidova, Zuzana, Kapralova, Katarina, Koralkova, Pavla, Mojzikova, Renata, Dolezal, Dalibor, Divoky, Vladimir, Horvathova, Monika

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MLL-ENL Inhibits Polycomb Repressive Complex 1 to Achieve Efficient Transformation of Hematopoietic Cells von Maethner, Emanuel, Garcia-Cuellar, Maria-Paz, Breitinger, Constanze, Takacova, Sylvia, Divoky, Vladimir, Hess, Jay L., Slany, Robert K.

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Hepcidin levels in Diamond-Blackfan anemia reflect erythropoietic activity and transfusion dependency von Pospisilova, Dagmar, Holub, Dusan, Zidova, Zuzana, Sulovska, Lucie, Houda, Jiri, Mihal, Vladimir, Hadacova, Ivana, Radova, Lenka, Dzubak, Petr, Hajduch, Marian, Divoky, Vladimir, Horvathova, Monika

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Erythropoietin-driven signaling ameliorates the survival defect of DMT1-mutant erythroid progenitors and erythroblasts von HORVATHOVA, Monika, KAPRALOVA, Katarina, ZIDOVA, Zuzana, DOLEZAL, Dalibor, POSPISILOVA, Dagmar, DIVOKYL, Vladimir

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Expression of Jak2 R1063H Leads to Altered Epor/Tpor Signaling, Changes in HSC Fitness and Represents Increased Risk of Thrombosis von Kropackova, Veronika, Gursky, Jan, Balounova, Jana, Korinek, Vladimir, Divoky, Vladimir, Lanikova, Lucie

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Functional consequences of the human DMT1 (SLC11A2) mutation on protein expression and iron uptake von Priwitzerova, Monika, Nie, Guangjun, Sheftel, Alex D., Pospisilova, Dagmar, Divoky, Vladimir, Ponka, Prem

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Metabolomic Profiling Confirms the Key Role of Oxidative Stress in the Pathophysiology of Diamond-Blackfan Anemia von Jahoda, Ondrej, Dobesova, Dana, Hlusickova Kapralova, Katarina, Kurekova, Simona, Pospisilova, Dagmar, Divoky, Vladimir, Friedecky, David, Horvathova, Monika

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Accelerated Progression in Lower-Risk Myelodysplastic Neoplasms: Attenuated Cell Cycle, DNA Damage Response, and Augmented Oncogenic Transcriptome Signatures von Kaisrlikova, Monika, Lenertová, Zuzana, Koralkova, Pavla, Trsová, Iva, Kundrat, David, Dostalova Merkerova, Michaela, Votavova, Hana, Krejcik, Zdenek, Jonasova, Anna, Cermak, Jaroslav, Divoky, Vladimir, Belickova, Monika

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Targeting of SFK and G6PD Contributes to Anti-Leukemic Activity of Novel FLT3 Trisubstituted Purine Inhibitors: Effective Therapeutic Approach for AML with FLT3 Mutations von Koralkova, Pavla, Niederlova, Nikola, Hradilova, Iveta, Gursky, Jan, Cudova, Barbora, Urbankova, Helena, Reznickova, Eva, Gucky, Tomas, Myslivcova, Denisa, Belickova, Monika, Krystof, Vladimir, Divoky, Vladimir

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Aging-Related Changes in Erythropoietic Activity and Iron Metabolism in a Mouse Model of Congenital Erythrocytosis with Human Gain-of-Function Erythropoietin Receptor von Kralova, Barbora, Jahoda, Ondrej, Song, Jihyun, Hlusickova Kapralova, Katarina, Sochorcova, Lucie, Prchal, Josef T., Divoky, Vladimir, Horvathova, Monika

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Intermittent dosage of imatinib mesylate in CML patients with a history of significant hematologic toxicity after standard dosing von Faber, Edgar, Naušová, Jitka, Jarošová, Marie, Egorin, Merrill J., Holzerová, Milena, Ro manová, Šárka, Marešová, Ivana, Divoký, Vladimír, Indrák, Karel

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