Discovery of Thieno[3,2‑d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3 von Disch, Jeremy S, Evindar, Ghotas, Chiu, Cynthia H, Blum, Charles A, Dai, Han, Jin, Lei, Schuman, Eli, Lind, Kenneth E, Belyanskaya, Svetlana L, Deng, Jianghe, Coppo, Frank, Aquilani, Leah, Graybill, Todd L, Cuozzo, John W, Lavu, Siva, Mao, Cheney, Vlasuk, George P, Perni, Robert B

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Discovery of oxazolo[4,5- b]pyridines and related heterocyclic analogs as novel SIRT1 activators von Bemis, Jean E., Vu, Chi B., Xie, Roger, Nunes, Joseph J., Ng, Pui Yee, Disch, Jeremy S., Milne, Jill C., Carney, David P., Lynch, Amy V., Jin, Lei, Smith, Jesse J., Lavu, Siva, Iffland, Andre, Jirousek, Michael R., Perni, Robert B.

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Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators von Hubbard, Basil P., Gomes, Ana P., Dai, Han, Li, Jun, Case, April W., Considine, Thomas, Riera, Thomas V., Lee, Jessica E., Yen E, Sook, Lamming, Dudley W., Pentelute, Bradley L., Schuman, Eli R., Stevens, Linda A., Ling, Alvin J. Y., Armour, Sean M., Michan, Shaday, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Blum, Charles A., Disch, Jeremy S., Ng, Pui Yee, Howitz, Konrad T., Rolo, Anabela P., Hamuro, Yoshitomo, Moss, Joel, Perni, Robert B., Ellis, James L., Vlasuk, George P., Sinclair, David A.

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Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening von Disch, Jeremy S, Duffy, Jennifer M, Lee, Esther C. Y, Gikunju, Diana, Chan, Betty, Levin, Benjamin, Monteiro, Michael I, Talcott, Sarah A, Lau, Anthony C, Zhou, Fei, Kozhushnyan, Anton, Westlund, Neil E, Mullins, Patrick B, Yu, Yan, von Rechenberg, Moritz, Zhang, Junyi, Arnautova, Yelena A, Liu, Yanbin, Zhang, Ying, McRiner, Andrew J, Keefe, Anthony D, Kohlmann, Anna, Clark, Matthew A, Cuozzo, John W, Huguet, Christelle, Arora, Shilpi

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Discovery of Nanomolar DCAF1 Small Molecule Ligands von Li, Alice Shi Ming, Kimani, Serah, Wilson, Brian, Noureldin, Mahmoud, González-Álvarez, Héctor, Mamai, Ahmed, Hoffer, Laurent, Guilinger, John P., Zhang, Ying, von Rechenberg, Moritz, Disch, Jeremy S., Mulhern, Christopher J., Slakman, Belinda L., Cuozzo, John W., Dong, Aiping, Poda, Gennady, Mohammed, Mohammed, Saraon, Punit, Mittal, Manish, Modh, Pratik, Rathod, Vaibhavi, Patel, Bhashant, Ackloo, Suzanne, Santhakumar, Vijayaratnam, Szewczyk, Magdalena M, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Marcellus, Richard, Guié, Marie-Aude, Keefe, Anthony D., Brown, Peter J., Halabelian, Levon, Al-awar, Rima, Vedadi, Masoud

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Crystallographic structure of a small molecule SIRT1 activator-enzyme complex von Dai, Han, Case, April W., Riera, Thomas V., Considine, Thomas, Lee, Jessica E., Hamuro, Yoshitomo, Zhao, Huizhen, Jiang, Yong, Sweitzer, Sharon M., Pietrak, Beth, Schwartz, Benjamin, Blum, Charles A., Disch, Jeremy S., Caldwell, Richard, Szczepankiewicz, Bruce, Oalmann, Christopher, Yee Ng, Pui, White, Brian H., Casaubon, Rebecca, Narayan, Radha, Koppetsch, Karsten, Bourbonais, Francis, Wu, Bo, Wang, Junfeng, Qian, Dongming, Jiang, Fan, Mao, Cheney, Wang, Minghui, Hu, Erding, Wu, Joe C., Perni, Robert B., Vlasuk, George P., Ellis, James L.

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Discovery of a selective c-MET inhibitor with a novel binding mode von Collie, Gavin W., Barlind, Louise, Bazzaz, Sana, Börjesson, Ulf, Dale, Ian L., Disch, Jeremy S., Habeshian, Sevan, Jetson, Rachael, Khurana, Puneet, Madin, Andrew, Michaelides, Iacovos N., Peng, Ling, Snijder, Arjan, Stubbs, Christopher J.

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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes von Milne, Jill C., Lambert, Philip D., Schenk, Simon, Carney, David P., Smith, Jesse J., Gagne, David J., Jin, Lei, Boss, Olivier, Perni, Robert B., Vu, Chi B., Bemis, Jean E., Xie, Roger, Disch, Jeremy S., Ng, Pui Yee, Nunes, Joseph J., Lynch, Amy V., Yang, Hongying, Galonek, Heidi, Israelian, Kristine, Choy, Wendy, Iffland, Andre, Lavu, Siva, Medvedik, Oliver, Sinclair, David A., Olefsky, Jerrold M., Jirousek, Michael R., Elliott, Peter J., Westphal, Christoph H.

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A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins von Ackloo, Suzanne, Li, Fengling, Szewczyk, Magda, Seitova, Almagul, Loppnau, Peter, Zeng, Hong, Xu, Jin, Ahmad, Shabbir, Arnautova, Yelena A, Baghaie, A. J., Beldar, Serap, Bolotokova, Albina, Centrella, Paolo A., Chau, Irene, Clark, Matthew A., Cuozzo, John W., Dehghani-Tafti, Saba, Disch, Jeremy S., Dong, Aiping, Dumas, Antoine, Feng, Jianwen A., Ghiabi, Pegah, Gibson, Elisa, Gilmer, Justin, Goldman, Brian, Green, Stuart R, Guié, Marie-Aude, Guilinger, John P., Harms, Nathan, Herasymenko, Oleksandra, Houliston, Scott, Hutchinson, Ashley, Kearnes, Steven, Keefe, Anthony D., Kimani, Serah W., Kramer, Trevor, Kutera, Maria, Kwak, Haejin A., Lento, Cristina, Li, Yanjun, Liu, Jenny, Loup, Joachim, Machado, Raquel A. C., Mulhern, Christopher J., Perveen, Sumera, Righetto, Germanna L., Riley, Patrick, Shrestha, Suman, Sigel, Eric A., Silva, Madhushika, Sintchak, Michael D., Slakman, Belinda L., Taylor, Rhys D., Thompson, James, Torng, Wen, Underkoffler, Carl, von Rechenberg, Moritz, Walsh, Ryan T., Watson, Ian, Wilson, Derek J., Wolf, Esther, Yadav, Manisha, Yazdi, Aliakbar K., Zhang, Junyi, Zhang, Ying, Santhakumar, Vijayaratnam, Edwards, Aled M., Barsyte-Lovejoy, Dalia, Schapira, Matthieu, Brown, Peter J., Halabelian, Levon, Arrowsmith, Cheryl H.

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Generating Selective Leads for Mer Kinase InhibitorsExample of a Comprehensive Lead-Generation Strategy von Nissink, J. Willem M, Bazzaz, Sana, Blackett, Carolyn, Clark, Matthew A, Collingwood, Olga, Disch, Jeremy S, Gikunju, Diana, Goldberg, Kristin, Guilinger, John P, Hardaker, Elizabeth, Hennessy, Edward J, Jetson, Rachael, Keefe, Anthony D, McCoull, William, McMurray, Lindsay, Olszewski, Allison, Overman, Ross, Pflug, Alexander, Preston, Marian, Rawlins, Philip B, Rivers, Emma, Schimpl, Marianne, Smith, Paul, Truman, Caroline, Underwood, Elizabeth, Warwicker, Juli, Winter-Holt, Jon, Woodcock, Simon, Zhang, Ying

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Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds von Ramos, Ashley L., Goedken, Eric R., Frank, Kristine E., Argiriadi, Maria A., Bazzaz, Sana, Bian, Zhiguo, Brown, Jesse T. C., Centrella, Paolo A., Chen, Hui-Ju, Disch, Jeremy S., Donner, Pamela L., Duignan, David B., Gikunju, Diana, Greszler, Stephen N., Guié, Marie-Aude, Habeshian, Sevan, Hartl, Hajnalka E., Hein, Christopher D., Hutchins, Charles W., Jetson, Rachael, Keefe, Anthony D., Khan, Hasan, Li, Huan-Qiu, Olszewski, Allison, Ortiz Cardona, Benjamin J., Osuma, Augustine, Panchal, Sanjay C., Phelan, Ryan, Qiu, Wei, Shotwell, J. Brad, Shrestha, Anurupa, Srikumaran, Myron, Su, Zhi, Sun, Chaohong, Upadhyay, Anup K., Wood, Michael D., Wu, Haihong, Zhang, Ruijie, Zhang, Ying, Zhao, Gang, Zhu, Haizhong, Webster, Matthew P.

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Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators von Vu, Chi B, Bemis, Jean E, Disch, Jeremy S, Ng, Pui Yee, Nunes, Joseph J, Milne, Jill C, Carney, David P, Lynch, Amy V, Smith, Jesse J, Lavu, Siva, Lambert, Philip D, Gagne, David J, Jirousek, Michael R, Schenk, Simon, Olefsky, Jerrold M, Perni, Robert B

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Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism von Hubbard, Basil P, Loh, Christine, Gomes, Ana P, Li, Jun, Lu, Quinn, Doyle, Taylor LG, Disch, Jeremy S, Armour, Sean M, Ellis, James L, Vlasuk, George P, Sinclair, David A

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Nickel(II) Cyclidenes with Appended Ethylpyridine Receptor Centers as Molecular Tweezers for Dicarboxylic Acids von Disch, Jeremy S, Staples, Richard J, Concolino, Thomas E, Haas, Terry E, Rybak-Akimova, Elena V

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Abstract 5346: Discovery of new targeted protein degraders using DNA-encoded chemistry von Keefe, Anthony D., Disch, Jeremy S., Duffy, Jennifer, Lee, Esther C., Gikunju, Diana, Chan, Betty, Levin, Benjamin D., Monteiro, Michael I., Talcott, Sarah A., Lau, Anthony, Zhou, Fei, Kozhushnyan, Anton, Westlund, Neil E., Mullins, Patrick B., Yu, Yan, von Rechenberg, Moritz, Zhang, Junyi, Arnautova, Yelena, Liu, Yanbin, Zhang, Ying, McRiner, Andrew J., Kohlmann, Anna, Clark, Matthew A., Cuozzo, John W., Huguet, Christelle, Arora, Shilpi

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Reactions at the azomethine CN bonds in the nickel( ii ) and copper( ii ) complexes of pyridine-containing Schiff-base macrocyclic ligands von Herrera, Aida M., Kalayda, Ganna V., Disch, Jeremy S., Wikstrom, Jeffrey P., Korendovych, Ivan V., Staples, Richard J., Campana, Charles F., Nazarenko, Alexander Y., Haas, Terry E., Rybak-Akimova, Elena V.

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SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS von BLUM CHARLES A, DISCH JEREMY S, SPRINGER STEPHANIE K

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THIENO[3,2-D]PYRIMIDINE-6-CARBOXAMIDES AND ANALOGUES AS SIRTUIN MODULATORS von EVINDAR GHOTAS, BLUM CHARLES A, DISCH JEREMY S, PERNI ROBERT B

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2-Phenyl-N-(2-(6-(pyrrolidin-1-ylmethyl)thiazolo[5,4-b]pyridin-2-yl)phenyl)thiazole-4-carboxamide derivatives von DISCH, JEREMY, S, OALMANN, CHRISTOPHER

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aza-heterociclos substituídos bicíclicos e análogos como moduladores de sirtuina von CHARLES A. BLUM, STEPHANIE K. SPRINGER, JEREMY S. DISCH

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