A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures von Dinnon, Kenneth H., Leist, Sarah R., Schäfer, Alexandra, Edwards, Caitlin E., Martinez, David R., Montgomery, Stephanie A., West, Ande, Yount, Boyd L., Hou, Yixuan J., Adams, Lily E., Gully, Kendra L., Brown, Ariane J., Huang, Emily, Bryant, Matthew D., Choong, Ingrid C., Glenn, Jeffrey S., Gralinski, Lisa E., Sheahan, Timothy P., Baric, Ralph S.

Volltext

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo von Hou, Yixuan J, Chiba, Shiho, Halfmann, Peter, Ehre, Camille, Kuroda, Makoto, Dinnon, 3rd, Kenneth H, Leist, Sarah R, Schäfer, Alexandra, Nakajima, Noriko, Takahashi, Kenta, Lee, Rhianna E, Mascenik, Teresa M, Graham, Rachel, Edwards, Caitlin E, Tse, Longping V, Okuda, Kenichi, Markmann, Alena J, Bartelt, Luther, de Silva, Aravinda, Margolis, David M, Boucher, Richard C, Randell, Scott H, Suzuki, Tadaki, Gralinski, Lisa E, Kawaoka, Yoshihiro, Baric, Ralph S

Volltext

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801 von Wahl, Angela, Gralinski, Lisa E., Johnson, Claire E., Yao, Wenbo, Kovarova, Martina, Dinnon, Kenneth H., Liu, Hongwei, Madden, Victoria J., Krzystek, Halina M., De, Chandrav, White, Kristen K., Gully, Kendra, Schäfer, Alexandra, Zaman, Tanzila, Leist, Sarah R., Grant, Paul O., Bluemling, Gregory R., Kolykhalov, Alexander A., Natchus, Michael G., Askin, Frederic B., Painter, George, Browne, Edward P., Jones, Corbin D., Pickles, Raymond J., Baric, Ralph S., Garcia, J. Victor

Volltext

Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection von Edwards, Caitlin E., Yount, Boyd L., Graham, Rachel L., Leist, Sarah R., Hou, Yixuan J., Dinnon, Kenneth H., Sims, Amy C., Swanstrom, Jesica, Gully, Kendra, Scobey, Trevor D., Cooley, Michelle R., Currie, Caroline G., Randell, Scott H., Baric, Ralph S.

Volltext

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase von Brown, Ariane J., Won, John J., Graham, Rachel L., Dinnon, Kenneth H., Sims, Amy C., Feng, Joy Y., Cihlar, Tomas, Denison, Mark R., Baric, Ralph S., Sheahan, Timothy P.

Volltext

Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection von Menachery, Vineet D, Dinnon, 3rd, Kenneth H, Yount, Jr, Boyd L, McAnarney, Eileen T, Gralinski, Lisa E, Hale, Andrew, Graham, Rachel L, Scobey, Trevor, Anthony, Simon J, Wang, Lingshu, Graham, Barney, Randell, Scott H, Lipkin, W Ian, Baric, Ralph S

Volltext

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice von Leist, Sarah R., Dinnon, Kenneth H., Schäfer, Alexandra, Tse, Longping V., Okuda, Kenichi, Hou, Yixuan J., West, Ande, Edwards, Caitlin E., Sanders, Wes, Fritch, Ethan J., Gully, Kendra L., Scobey, Trevor, Brown, Ariane J., Sheahan, Timothy P., Moorman, Nathaniel J., Boucher, Richard C., Gralinski, Lisa E., Montgomery, Stephanie A., Baric, Ralph S.

Volltext

Stabilized coronavirus spike stem elicits a broadly protective antibody von Hsieh, Ching-Lin, Werner, Anne P., Leist, Sarah R., Stevens, Laura J., Falconer, Ester, Goldsmith, Jory A., Chou, Chia-Wei, Abiona, Olubukola M., West, Ande, Westendorf, Kathryn, Muthuraman, Krithika, Fritch, Ethan J., Dinnon, Kenneth H., Schäfer, Alexandra, Denison, Mark R., Chappell, James D., Baric, Ralph S., Graham, Barney S., Corbett, Kizzmekia S., McLellan, Jason S.

Volltext

A highly immunogenic and effective measles virus-based Th1-biased COVID-19 vaccine von Hörner, Cindy, Schürmann, Christoph, Auste, Arne, Ebenig, Aileen, Muraleedharan, Samada, Dinnon, Kenneth H., Scholz, Tatjana, Herrmann, Maike, Schnierle, Barbara S., Baric, Ralph S., Mühlebach, Michael D.

Volltext

Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as a live virus vaccine candidate von Sun, Weina, Leist, Sarah R., McCroskery, Stephen, Liu, Yonghong, Slamanig, Stefan, Oliva, Justine, Amanat, Fatima, Schäfer, Alexandra, Dinnon, Kenneth H., García-Sastre, Adolfo, Krammer, Florian, Baric, Ralph S., Palese, Peter

Volltext

Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection von Geng, Qibin, Tai, Wanbo, Baxter, Victoria K, Shi, Juan, Wan, Yushun, Zhang, Xiujuan, Montgomery, Stephanie A, Taft-Benz, Sharon A, Anderson, Elizabeth J, Knight, Audrey C, Dinnon, Kenneth H, Leist, Sarah R, Baric, Ralph S, Shang, Jian, Hong, Sung-Wook, Drelich, Aleksandra, Tseng, Chien-Te K, Jenkins, Marc, Heise, Mark, Du, Lanying, Li, Fang

Volltext

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice von Pruijssers, Andrea J., George, Amelia S., Schäfer, Alexandra, Leist, Sarah R., Gralinksi, Lisa E., Dinnon, Kenneth H., Yount, Boyd L., Agostini, Maria L., Stevens, Laura J., Chappell, James D., Lu, Xiaotao, Hughes, Tia M., Gully, Kendra, Martinez, David R., Brown, Ariane J., Graham, Rachel L., Perry, Jason K., Du Pont, Venice, Pitts, Jared, Ma, Bin, Babusis, Darius, Murakami, Eisuke, Feng, Joy Y., Bilello, John P., Porter, Danielle P., Cihlar, Tomas, Baric, Ralph S., Denison, Mark R., Sheahan, Timothy P.

Volltext

An Immunocompetent Mouse Model of Zika Virus Infection von Gorman, Matthew J., Caine, Elizabeth A., Zaitsev, Konstantin, Begley, Matthew C., Weger-Lucarelli, James, Uccellini, Melissa B., Tripathi, Shashank, Morrison, Juliet, Yount, Boyd L., Dinnon, Kenneth H., Rückert, Claudia, Young, Michael C., Zhu, Zhe, Robertson, Shelly J., McNally, Kristin L., Ye, Jing, Cao, Bin, Mysorekar, Indira U., Ebel, Gregory D., Baric, Ralph S., Best, Sonja M., Artyomov, Maxim N., Garcia-Sastre, Adolfo, Diamond, Michael S.

Volltext

MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis von Menachery, Vineet D, Mitchell, Hugh D, Cockrell, Adam S, Gralinski, Lisa E, Yount, Jr, Boyd L, Graham, Rachel L, McAnarney, Eileen T, Douglas, Madeline G, Scobey, Trevor, Beall, Anne, Dinnon, 3rd, Kenneth, Kocher, Jacob F, Hale, Andrew E, Stratton, Kelly G, Waters, Katrina M, Baric, Ralph S

Volltext

Mouse Adapted SARS-CoV-2 (MA10) Viral Infection Induces Neuroinflammation in Standard Laboratory Mice von Amruta, Narayanappa, Ismael, Saifudeen, Leist, Sarah R, Gressett, Timothy E, Srivastava, Akhilesh, Dinnon, 3rd, Kenneth H, Engler-Chiurazzi, Elizabeth B, Maness, Nicholas J, Qin, Xuebin, Kolls, Jay K, Baric, Ralph S, Bix, Gregory

Volltext

SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung von Routhu, Nanda Kishore, Cheedarla, Narayanaiah, Bollimpelli, Venkata Satish, Gangadhara, Sailaja, Edara, Venkata Viswanadh, Lai, Lilin, Sahoo, Anusmita, Shiferaw, Ayalnesh, Styles, Tiffany M., Floyd, Katharine, Fischinger, Stephanie, Atyeo, Caroline, Shin, Sally A., Gumber, Sanjeev, Kirejczyk, Shannon, Dinnon, Kenneth H., Shi, Pei-Yong, Menachery, Vineet D., Tomai, Mark, Fox, Christopher B., Alter, Galit, Vanderford, Thomas H., Gralinski, Lisa, Suthar, Mehul S., Amara, Rama Rao

Volltext

Shortening of Zika virus CD-loop reduces neurovirulence while preserving antigenicity von Dinnon Iii, Kenneth H, Gallichotte, Emily N, Fritch, Ethan J, Menachery, Vineet D, Baric, Ralph S

Volltext

COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge von DiPiazza, Anthony T., Leist, Sarah R., Abiona, Olubukola M., Moliva, Juan I., Werner, Anne, Minai, Mahnaz, Nagata, Bianca M., Bock, Kevin W., Phung, Emily, Schäfer, Alexandra, Dinnon, Kenneth H., Chang, Lauren A., Loomis, Rebecca J., Boyoglu-Barnum, Seyhan, Alvarado, Gabriela S., Sullivan, Nancy J., Edwards, Darin K., Morabito, Kaitlyn M., Mascola, John R., Carfi, Andrea, Corbett, Kizzmekia S., Moore, Ian N., Baric, Ralph S., Graham, Barney S., Ruckwardt, Tracy J.

Volltext

Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines von Menachery, Vineet D, Gralinski, Lisa E, Mitchell, Hugh D, Dinnon, 3rd, Kenneth H, Leist, Sarah R, Yount, Jr, Boyd L, McAnarney, Eileen T, Graham, Rachel L, Waters, Katrina M, Baric, Ralph S

Volltext

A Newcastle Disease Virus (NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective Inactivated SARS-CoV-2 Vaccine von Sun, Weina, McCroskery, Stephen, Liu, Wen-Chun, Leist, Sarah R, Liu, Yonghong, Albrecht, Randy A, Slamanig, Stefan, Oliva, Justine, Amanat, Fatima, Schäfer, Alexandra, Dinnon, 3rd, Kenneth H, Innis, Bruce L, García-Sastre, Adolfo, Krammer, Florian, Baric, Ralph S, Palese, Peter

Volltext