Discovery and Structure−Activity Relationship of Quinuclidine Benzamides as Agonists of α7 Nicotinic Acetylcholine Receptors von Bodnar, Alice L, Cortes-Burgos, Luz A, Cook, Karen K, Dinh, Dac M, Groppi, Vincent E, Hajos, Mihaly, Higdon, Nicole R, Hoffmann, William E, Hurst, Raymond S, Myers, Jason K, Rogers, Bruce N, Wall, Theron M, Wolfe, Mark L, Wong, Erik

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Discovery of N‑((3R,4R)‑4-Fluoro-1-(6-((3-methoxy-1-methyl‑1H‑pyrazol-4-yl)amino)-9-methyl‑9H‑purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Desi... von Planken, Simon, Behenna, Douglas C, Nair, Sajiv K, Johnson, Theodore O, Nagata, Asako, Almaden, Chau, Bailey, Simon, Ballard, T. Eric, Bernier, Louise, Cheng, Hengmiao, Cho-Schultz, Sujin, Dalvie, Deepak, Deal, Judith G, Dinh, Dac M, Edwards, Martin P, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle, Kania, Robert S, Kath, John C, Matthews, Jean, Murray, Brion W, Niessen, Sherry, Orr, Suvi T. M, Pairish, Mason, Sach, Neal W, Shen, Hong, Shi, Manli, Solowiej, James, Tran, Khanh, Tseng, Elaine, Vicini, Paolo, Wang, Yuli, Weinrich, Scott L, Zhou, Ru, Zientek, Michael, Liu, Longqing, Luo, Yiqin, Xin, Shuibo, Zhang, Chengyi, Lafontaine, Jennifer

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Design, Synthesis, and Evaluation of NO-Donor Containing Carbonic Anhydrase Inhibitors To Lower Intraocular Pressure von Huang, Qinhua, Rui, Eugene Y, Cobbs, Morena, Dinh, Dac M, Gukasyan, Hovhannes J, Lafontaine, Jennifer A, Mehta, Saurabh, Patterson, Brian D, Rewolinski, David A, Richardson, Paul F, Edwards, Martin P

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Positive Allosteric Modulator of the Human 5-HT2C Receptor von Im, Wha Bin, Chio, Christopher L, Alberts, Glen L, Dinh, Dac M

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Conformationally-restricted cyclic sulfones as potent and selective mTOR kinase inhibitors von Liu, Kevin K.-C., Bailey, Simon, Dinh, Dac M., Lam, Hieu, Li, Chunze, Wells, Peter A., Yin, Min-Jean, Zou, Aihua

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Dopamine D3 Receptor Antagonists. 1. Synthesis and Structure−Activity Relationships of 5,6-Dimethoxy-N-alkyl- and N-Alkylaryl-Substituted 2-Aminoindans von Haadsma-Svensson, Susanne R, Cleek, Kerry A, Dinh, Dac M, Duncan, J. Neil, Haber, Christopher L, Huff, Rita M, Lajiness, Mary E, Nichols, Nanette F, Smith, Martin W, Svensson, Kjell A, Zaya, Matt J, Carlsson, Arvid, Lin, Chiu-Hong

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Apolipoprotein A-I as a Marker of Angiographically Assessed Coronary-Artery Disease von Maciejko, James J, Holmes, David R, Kottke, Bruce A, Zinsmeister, Alan R, Dinh, Dac M, Mao, Simon J. T

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Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D4 receptor von SCHLACHTER, S. K, POEL, T. J, LAWSON, C. F, DINH, D. M, LAJINESS, M. E, ROMERO, A. G, REES, S. A, DUNCAN, J. N, SMITH, M. W

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PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models von Zou, Helen Y., Friboulet, Luc, Kodack, David P., Engstrom, Lars D., Li, Qiuhua, West, Melissa, Tang, Ruth W., Wang, Hui, Tsaparikos, Konstantinos, Wang, Jinwei, Timofeevski, Sergei, Katayama, Ryohei, Dinh, Dac M., Lam, Hieu, Lam, Justine L., Yamazaki, Shinji, Hu, Wenyue, Patel, Bhushankumar, Bezwada, Divya, Frias, Rosa L., Lifshits, Eugene, Mahmood, Sidra, Gainor, Justin F., Affolter, Timothy, Lappin, Patrick B., Gukasyan, Hovhannes, Lee, Nathan, Deng, Shibing, Jain, Rakesh K., Johnson, Ted W., Shaw, Alice T., Fantin, Valeria R., Smeal, Tod

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2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: New templates for 5-HT2C agonists von ENNIS, Michael D, HOFFMAN, Robert L, SVENSSON, Kjell A, MCCALL, Robert B, HABER, Christopher L, KAGEY, Michelle L, DINH, Dac M, GHAZAL, Nabil B, OLSON, Rebecca M, KNAUER, Christopher S, CHIO, Chris L, HYSLOP, Deborah K, CAMPBELL, Jeffery E, FITZGERALD, Lawrence W, NICHOLS, Nanette F

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Discovery of 1‑{(3R,4R)‑3-[({5-Chloro-2-[(1-methyl‑1H‑pyrazol-4-yl)amino]‑7H‑pyrrolo[2,3‑d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Pote... von Cheng, Hengmiao, Nair, Sajiv K, Murray, Brion W, Almaden, Chau, Bailey, Simon, Baxi, Sangita, Behenna, Doug, Cho-Schultz, Sujin, Dalvie, Deepak, Dinh, Dac M, Edwards, Martin P, Feng, Jun Li, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle D, Jackson-Fisher, Amy, Jalaie, Mehran, Johnson, Ted O, Kania, Robert S, Kephart, Susan, Lafontaine, Jennifer, Lunney, Beth, Liu, Kevin K.-C, Liu, Zhengyu, Matthews, Jean, Nagata, Asako, Niessen, Sherry, Ornelas, Martha A, Orr, Suvi T. M, Pairish, Mason, Planken, Simon, Ren, Shijian, Richter, Daniel, Ryan, Kevin, Sach, Neal, Shen, Hong, Smeal, Tod, Solowiej, Jim, Sutton, Scott, Tran, Khanh, Tseng, Elaine, Vernier, William, Walls, Marlena, Wang, Shuiwang, Weinrich, Scott L, Xin, Shuibo, Xu, Haiwei, Yin, Min-Jean, Zientek, Michael, Zhou, Ru, Kath, John C

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Design and Synthesis of Seco-oxysterol Analogs as Potential Inhibitors of 3-Hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) Reductase Gene Transcription von Larsen, Scott D, Spilman, Charles H, Yagi, Yoshi, Dinh, Dac M, Hart, Karen L, Hess, Gerard F

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Cholesterol-lowering bile acid-binding agents: novel lipophilic polyamines von Thomas, Edward W, Cudahy, Michele M, Spilman, Charles H, Dinh, Dac M, Watkins, Tommie L, Vidmar, Thomas J

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Discovery of N -((3 R ,4 R )-4-Fluoro-1-(6-((3-methoxy-1-methyl-1 H -pyrazol-4-yl)amino)-9-methyl-9 H -purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based... von Planken, Simon, Behenna, Douglas C., Nair, Sajiv K., Johnson, Theodore O., Nagata, Asako, Almaden, Chau, Bailey, Simon, Ballard, T. Eric, Bernier, Louise, Cheng, Hengmiao, Cho-Schultz, Sujin, Dalvie, Deepak, Deal, Judith G., Dinh, Dac M., Edwards, Martin P., Ferre, Rose Ann, Gajiwala, Ketan S., Hemkens, Michelle, Kania, Robert S., Kath, John C., Matthews, Jean, Murray, Brion W., Niessen, Sherry, Orr, Suvi T. M., Pairish, Mason, Sach, Neal W., Shen, Hong, Shi, Manli, Solowiej, James, Tran, Khanh, Tseng, Elaine, Vicini, Paolo, Wang, Yuli, Weinrich, Scott L., Zhou, Ru, Zientek, Michael, Liu, Longqing, Luo, Yiqin, Xin, Shuibo, Zhang, Chengyi, Lafontaine, Jennifer

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Abstract 130: PF-06463922, a novel next generation ALK/ROS1 inhibitor, overcomes resistance to 1st and 2nd generation ALK inhibitors in pre-clinical models von Friboulet, Luc, Zou, Helen, Kodack, David P., Engstrom, Lars D., Li, Qiuhua, West, Melissa, Tang, Ruth W., Wang, Hui, Tsaparikos, Konstantinos, Wang, Jinwei, Timofeevski, Sergei, Dinh, Dac M., Lam, Hieu, Lam, Justine L., Yamazaki, Shinji, Hu, Wenyue, Patel, Bhushankumar, Bezwada, Divya, Mahmood, Sidra, Lifshits, Eugene, Affolter, Timothy, Lappin, Patrick B., Gukasyan, Hovhannes, Lee, Nathan, Deng, Shibing, Jain, Rakesh K., Johnson, Ted W., Shaw, Alice T., Fantin, Valeria R., Smeal, Tod

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PF-06463922, an ALK/ROS1 inhibitor, overcomes resistance to 1st and 2nd generation ALK inhibitors in pre-clinical models von Zou, Helen Y., Friboulet, Luc, Kodack, David P., Engstrom, Lars D., Li, Qiuhua, West, Melissa, Tang, Ruth W., Wang, Hui, Tsaparikos, Konstantinos, Wang, Jinwei, Timofeevski, Sergei, Katayama, Ryohei, Dinh, Dac M., Lam, Hieu, Lam, Justine L., Yamazaki, Shinji, Hu, Wenyue, Patel, Bhushankumar, Bezwada, Divya, Frias, Rosa L., Lifshits, Eugene, Mahmood, Sidra, Gainor, Justin F., Affolter, Timothy, Lappin, Patrick B., Gukasyan, Hovhannes, Lee, Nathan, Deng, Shibing, Jain, Rakesh K, Johnson, Ted W., Shaw, Alice T., Fantin, Valeria R., Smeal, Tod

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Abstract C253: PF-06463922, a novel brain-penetrating small molecule inhibitor of ALK/ROS1 with potent activity against a broad spectrum of ALK resistant mutations in preclinical m... von Zou, Helen Y., Engstrom, Lars R., Li, Qiuhua, West Lu, Melissa, Tang, Ruth Wei, Wang, Hui, Tsaparikos, Konstantinos, Wang, Jinwei, Timofeevski, Sergei, Dinh, Dac M., Lam, Hieu, Lam, Justine, Yamazaki, Shinji, Hu, Wenyue, Affolter, Timothy, Lappin, Patrick B., Gukasyan, Hovhannes, Lee, Nathan, Tursi, Jennifer M., Johnson, Ted W., Fantin, Valeria, Smeal, Tod

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Synthesis and hypocholesterolemic activity of 6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-diones, novel inhibitors of acylCoA: cholesterol O-acyltransferase von Larsen, Scott D, Spilman, Charles H, Bell, Frank P, Dinh, Dac M, Martinborough, Esther, Wilson, Gracella J

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Abstract LB-390: Antitumor efficacy of crizotinib (PF-02341066), a potent and selective ALK and c-Met RTK inhibitor, in EML4-ALK driven NSCLC tumors in vitro and in vivo von Zou, Helen Y., Li, Qiuhua, Lee, Joseph, Engstrom, Lars, Lu, Melissa West, Young, Alex, Timofeevski, Sergei, Dinh, Dac M., Yamazaki, Shinji, Lam, Justine, Feng, Zheng, Nickel, Jeffrey, Lappin, Patrick B., Nichols, Tim, Wong, Anthony, Snider, Brittany, Gukasyan, Hovhannes, Bender, Steve, Zabludoff, Sonya, Smeal, Tod, Christensen, James R.

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Corrigendum to “Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: Structure-based drug design, synthesis, and biological evaluation” [Bioorg. Med. Chem. 18... von Vernier, William F., Chong, Wesley K.M., Rewolinski, David A., Greasley, Samantha E., Pauly, Thomas A., Shaw, Morena N., Dinh, Dac M., Ferre, Rose Ann A., Meador, James W., Nukui, Seiji, Ornelas, Martha A., Paz, Robert L., Reyner, Eric L.

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