The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia von Stein, Eytan M., Garcia-Manero, Guillermo, Rizzieri, David A., Tibes, Raoul, Berdeja, Jesus G., Savona, Michael R., Jongen-Lavrenic, Mojca, Altman, Jessica K., Thomson, Blythe, Blakemore, Stephen J., Daigle, Scott R., Waters, Nigel J., Suttle, A. Benjamin, Clawson, Alicia, Pollock, Roy, Krivtsov, Andrei, Armstrong, Scott A., DiMartino, Jorge, Hedrick, Eric, Löwenberg, Bob, Tallman, Martin S.

Volltext

A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies von Rasco, Drew W, Papadopoulos, Kyriakos P, Pourdehnad, Michael, Gandhi, Anita K, Hagner, Patrick R, Li, Yan, Wei, Xin, Chopra, Rajesh, Hege, Kristen, DiMartino, Jorge, Shih, Kent

Volltext

Combination of azacitidine and enasidenib enhances leukemic cell differentiation and cooperatively hypomethylates DNA von MacBeth, Kyle J., Chopra, Vivek S., Tang, Lin, Zheng, Bing, Avanzino, Brian, See, Wendy L., Schwickart, Martin, Figueroa, Maria E., Quek, Lynn, DiMartino, Jorge F.

Volltext

PB1889: KB‐LANRA 1001: A PHASE 1B/2 STUDY ON SAFETY, PK, PD, AND PRELIMINARY EFFICACY OF THE SELECTIVE SYK INHIBITOR LANRAPLENIB IN COMBINATION WITH THE FLT3 INHIBITOR GILTERITINIB... von Patel, Anand, Michaelis, Laura, Schiller, Gary, Swords, Ronan, Morris, Lawrence E., Carvajal, Luis A., Bray, Gordon, Olek, Elizabeth A., Cutler, Richard, Dimartino, Jorge, Stein, Eytan

Volltext

Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia von Wei, Junping, Wunderlich, Mark, Fox, Catherine, Alvarez, Sara, Cigudosa, Juan C., Wilhelm, Jamie S., Zheng, Yi, Cancelas, Jose A., Gu, Yi, Jansen, Michael, DiMartino, Jorge F., Mulloy, James C.

Volltext

MLL rearrangements in haematological malignancies: lessons from clinical and biological studies von DiMartino, Jorge F., Cleary, Michael L.

Volltext

The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10 von DiMartino, Jorge F., Ayton, Paul M., Chen, Everett H., Naftzger, Clarissa C., Young, Bryan D., Cleary, Michael L.

Volltext

A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL von DiMartino, Jorge F., Miller, Trissa, Ayton, Paul M., Landewe, Theresa, Hess, Jay L., Cleary, Michael L., Shilatifard, Ali

Volltext

The Combination of Lanraplenib, a Selective SYK Inhibitor, and Gilteritinib, a FLT3 Inhibitor, Targets Aberrant Proliferation and Differentiation Blockade in Acute Myeloid Leukemia von Carvajal, Luis A., McKeown, Michael R., Hood, Tressa, Guo, Linlin, Lin, Charles Y., DiMartino, Jorge F.

Volltext

The TALE Homeodomain Protein Pbx2 Is Not Essential for Development and Long-Term Survival von Selleri, Licia, DiMartino, Jorge, van Deursen, Jan, Brendolan, Andrea, Sanyal, Mrinmoy, Boon, Elles, Capellini, Terence, Smith, Kevin S., Rhee, Joon, Pöpperl, Heike, Grosveld, Gerard, Cleary, Michael L.

Volltext

SYK Inhibitors, Entospletinib and Lanraplenib, Show Potent Anti-Leukemic Activity in Combination with Targeted Agents von Carvajal, Luis A., McKeown, Michael, Hood, Tressa, Kumar, Pavan, Saffran, Douglas C., DiMartino, Jorge

Volltext

Responses in patients with AML and treated with entospletinib monotherapy von Lin, Tara L., Cutler, Richard E., Olek, Elizabeth, Carvajal, Luis A., DiMartino, Jorge F., Walker, Alison R.

Volltext

The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver von DiMartino, Jorge F., Selleri, Licia, Traver, David, Firpo, Meri T., Rhee, Joon, Warnke, Roger, O'Gorman, Stephen, Weissman, Irving L., Cleary, Michael L.

Volltext

Combined Single Cell Flow Cytometry and Imaging Analyses Reveal Immunomodulatory Effects Exerted By Targeted Phospho-SYK Inhibitors with Elevated Sensitivity in NPM1 Mutated AML von Robinson, Bridget A, Sergeev, Philipp, Kosaka, Yoko, Jacob, Thomas, Kaempf, Andy, Lind, Evan F., Tognon, Cristina, Carvajal, Luis A., DiMartino, Jorge F., Heckman, Caroline A., Vu, Tania Q

Volltext

Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome von Leung, Kevin K., Nguyen, Aaron, Shi, Tao, Tang, Lin, Ni, Xiaochun, Escoubet, Laure, MacBeth, Kyle J., DiMartino, Jorge, Wells, James A.

Volltext

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Entospletinib in Combination with Intensive Induction and Consolidation Chemother... von Byrd, John C., Cortes, Jorge E., Minden, Mark D., Oellerich, Thomas, Stein, Eytan M., Elder, Jenna, Kumar, Pavan, Bray, Gordon, DiMartino, Jorge, Stock, Wendy

Volltext

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Entospletinib in Combination with Intensive Induction and Consolidation Chemother... von Byrd, John C., Cortes, Jorge E., Minden, Mark D., Oellerich, Thomas, Stein, Eytan M., Elder, Jenna, Kumar, Pavan, Bray, Gordon, DiMartino, Jorge, Stock, Wendy

Volltext

KB-Lanra 1001: A Phase 1b/2 Study of Safety, PK, PD, and Preliminary Efficacy of the Selective SYK Inhibitor Lanraplenib in Combination with the FLT3 Inhibitor Gilteritinib in FLT3... von Arnan, Monteserrat, Patel, Anand Ashwin, Esteve, Jordi, Morris, Lawrence, Schiller, Gary J., Swords, Ronan T., Alonso-Dominguez, Juan M., Michaelis, Laura C., Daver, Naval, Carvajal, Luis A., Bray, Gordon, Olek, Elizabeth, Cutler, Richard E., DiMartino, Jorge F., Stein, Eytan M.

Volltext

The Novel Profiling Relative Inhibition Simultaneously in Mixtures (PRISM) Platform Identifies Synergistic Activity of Lanraplenib and Ruxolitinib in Hematological Malignancies von Pandey, Akanksha, Carvajal, Luis A., Boghossian, Andrew S, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Hood, Tressa, Guo, Linlin, Hopkins, Tamara D, Obholzer, Nikolaus, McKeown, Michael R., DiMartino, Jorge F., Lin, Charles Y.

Volltext

Abstract P5-08-05: Preclinical activity of KB-0742, an oral, highly selective, CDK9 inhibitor, in cell lines and in MYC-high expressing, patient-derived models of multiple breast c... von Saffran, Douglas C., Day, Melinda A.L., Rioux, Nathalie, Chen, Tom, Lee, Christina, Amara, Suha Naffar-Abu, Freeman, David B., Hood, Tressa, Lin, Charles Y., Kumar, Pavan, DiMartino, Jorge

Volltext