A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer von de Sousa e Melo, Felipe, Kurtova, Antonina V., Harnoss, Jonathan M., Kljavin, Noelyn, Hoeck, Joerg D., Hung, Jeffrey, Anderson, Jeffrey Eastham, Storm, Elaine E., Modrusan, Zora, Koeppen, Hartmut, Dijkgraaf, Gerrit J. P., Piskol, Robert, de Sauvage, Frederic J.

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A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition von Biehs, Brian, Dijkgraaf, Gerrit J. P., Piskol, Robert, Alicke, Bruno, Boumahdi, Soufiane, Peale, Franklin, Gould, Stephen E., de Sauvage, Frederic J.

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Recurrent R-spondin fusions in colon cancer von Seshagiri, Somasekar, Stawiski, Eric W., Durinck, Steffen, Modrusan, Zora, Storm, Elaine E., Conboy, Caitlin B., Chaudhuri, Subhra, Guan, Yinghui, Janakiraman, Vasantharajan, Jaiswal, Bijay S., Guillory, Joseph, Ha, Connie, Dijkgraaf, Gerrit J. P., Stinson, Jeremy, Gnad, Florian, Huntley, Melanie A., Degenhardt, Jeremiah D., Haverty, Peter M., Bourgon, Richard, Wang, Weiru, Koeppen, Hartmut, Gentleman, Robert, Starr, Timothy K., Zhang, Zemin, Largaespada, David A., Wu, Thomas D., de Sauvage, Frederic J.

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Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma von Sharpe, Hayley J., Pau, Gregoire, Dijkgraaf, Gerrit J., Basset-Seguin, Nicole, Modrusan, Zora, Januario, Thomas, Tsui, Vickie, Durham, Alison B., Dlugosz, Andrzej A., Haverty, Peter M., Bourgon, Richard, Tang, Jean Y., Sarin, Kavita Y., Dirix, Luc, Fisher, David C., Rudin, Charles M., Sofen, Howard, Migden, Michael R., Yauch, Robert L., de Sauvage, Frederic J.

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Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance von DIJKGRAAF, Gerrit J. P, ALICKE, Bruno, SCALES, Suzie J, GOULD, Stephen E, YAUCH, Robert L, DE SAUVAGE, Frederic J, WEINMANN, Lasse, JANUARIO, Thomas, WEST, Kristina, MODRUSAN, Zora, BURDICK, Dan, GOLDSMITH, Richard, ROBARGE, Kirk, SUTHERLIN, Dan

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Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma von Yauch, Robert L., Dijkgraaf, Gerrit J. P., Alicke, Bruno, Januario, Thomas, Ahn, Christina P., Holcomb, Thomas, Pujara, Kanan, Stinson, Jeremy, Callahan, Christopher A., Tang, Tracy, Bazan, J. Fernando, Kan, Zhengyan, Seshagiri, Somasekar, Hann, Christine L., Gould, Stephen E., Low, Jennifer A., Rudin, Charles M., de Sauvage, Frederic J.

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A Role for Matrix Metalloproteinases in Regulating Mammary Stem Cell Function via the Wnt Signaling Pathway von Kessenbrock, Kai, Dijkgraaf, Gerrit J.P., Lawson, Devon A., Littlepage, Laurie E., Shahi, Payam, Pieper, Ursula, Werb, Zena

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PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition von METCALFE, Ciara, ALICKE, Bruno, CROW, Ailey, LAMOUREUX, Marlea, DIJKGRAAF, Gerrit J. P, PEALE, Franklin, GOULD, Stephen E, DE SAUVAGE, Frederic J

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Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity von Partanen, Johanna I., Tervonen, Topi A., Myllynen, Mikko, Lind, Essi, Imai, Misa, Katajisto, Pekka, Dijkgraaf, Gerrit J. P., Kovanen, Panu E., Mäkelä, Tomi P., Werb, Zena, Klefström, Juha

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Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer von Welm, Bryan E, Dijkgraaf, Gerrit J P, Bledau, Anita S, Welm, Alana L, Werb, Zena

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Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression von Pozniak, Christine D., Langseth, Abraham J., Dijkgraaf, Gerrit J. P., Choe, Youngshik, Werb, Zena, Pleasure, Samuel J.

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Identification, Characterization, and Implications of Species-Dependent Plasma Protein Binding for the Oral Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) von Giannetti, Anthony M, Wong, Harvey, Dijkgraaf, Gerrit J. P, Dueber, Erin C, Ortwine, Daniel F, Bravo, Brandon J, Gould, Stephen E, Plise, Emile G, Lum, Bert L, Malhi, Vikram, Graham, Richard A

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Complex regulation of ADAR-mediated RNA-editing across tissues von Huntley, Melanie A, Lou, Melanie, Goldstein, Leonard D, Lawrence, Michael, Dijkgraaf, Gerrit J P, Kaminker, Joshua S, Gentleman, Robert

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Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway von Castanedo, Georgette M., Wang, Shumei, Robarge, Kirk D., Blackwood, Elizabeth, Burdick, Daniel, Chang, Christine, Dijkgraaf, Gerrit J.P., Gould, Stephen, Gunzner, Janet, Guichert, Oivin, Halladay, Jason, Khojasteh, Cyrus, Lee, Leslie, Marsters, James C., Murray, Lesley, Peterson, David, Plise, Emile, Salphati, Laurent, de Sauvage, Frederic J., Wong, Susan, Sutherlin, Daniel P.

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A Saccharomyces cerevisiae Genome-Wide Mutant Screen for Altered Sensitivity to K1 Killer Toxin von Page, Nicolas, Gerard-Vincent, Manon, Menard, Patrice, Beaulieu, Maude, Azuma, Masayuki, Dijkgraaf, Gerrit J. P, Li, Huijuan, Marcoux, Jose, Nguyen, Thuy, Dowse, Tim, Sdicu, Anne-Marie, Bussey, Howard

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The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression von Littlepage, Laurie E, Adler, Adam S, Kouros-Mehr, Hosein, Huang, Guiqing, Chou, Jonathan, Krig, Sheryl R, Griffith, Obi L, Korkola, James E, Qu, Kun, Lawson, Devon A, Xue, Qing, Sternlicht, Mark D, Dijkgraaf, Gerrit J P, Yaswen, Paul, Rugo, Hope S, Sweeney, Colleen A, Collins, Colin C, Gray, Joe W, Chang, Howard Y, Werb, Zena

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Disruption of stem cell niche–confined R-spondin 3 expression leads to impaired hematopoiesis von Kurtova, Antonina V., Heinlein, Melanie, Haas, Simon, Velten, Lars, Dijkgraaf, Gerrit J. P., Storm, Elaine E., Kljavin, Noelyn M., Boumahdi, Soufiane, Himmels, Patricia, Herault, Aurelie, Mancini, Andrew, Koeppen, Hartmut, Dail, Monique, Yan, Qingxiang, Zhang, Jianhuan, Koch, Ute, Radtke, Freddy, Modrusan, Zora, Metcalfe, Ciara, Piskol, Robert, de Sauvage, Frederic J.

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Mutations in Fks1p affect the cell wall content of β‐1,3‐ and β‐1,6‐glucan in Saccharomyces cerevisiae von Dijkgraaf, Gerrit J. P., Abe, Mitsuhiro, Ohya, Yoshikazu, Bussey, Howard

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Abstract LB-136: Characterization of residual Basal Cell Carcinoma after vismodegib treatment von Biehs, Brian, Dijkgraaf, Gerrit J., Alicke, Bruno, Peale, Franklin, Gould, Stephen E., Sauvage, Frederic J. de

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A distinct role for Lgr^sup 5+^ stem cells in primary and metastatic colon cancer von e Melo, Felipe de Sousa, Kurtova, Antonina V, Harnoss, Jonathan M, Kljavin, Noelyn, Hoeck, Joerg D, Hung, Jeffrey, Anderson, Jeffrey Eastham, Storm, Elaine E, Modrusan, Zora, Koeppen, Hartmut, Dijkgraaf, Gerrit J P, Piskol, Robert, de Sauvage, Frederic J

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