The Melanocortin-4 Receptor Is Expressed in Enteroendocrine L Cells and Regulates the Release of Peptide YY and Glucagon-like Peptide 1 In Vivo von Panaro, Brandon L., Tough, Iain R., Engelstoft, Maja S., Matthews, Robert T., Digby, Gregory J., Møller, Cathrine L., Svendsen, Berit, Gribble, Fiona, Reimann, Frank, Holst, Jens J., Holst, Birgitte, Schwartz, Thue W., Cox, Helen M., Cone, Roger D.

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GPR109A Is a G-protein―Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon von THANGARAJU, Muthusamy, CRESCI, Gail A, PRASAD, Puttur D, GANAPATHY, Vadivel, KEBIN LIU, ANANTH, Sudha, GNANAPRAKASAM, Jaya P, BROWNING, Darren D, MELLINGER, John D, SMITH, Sylvia B, DIGBY, Gregory J, LAMBERT, Nevin A

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G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons von Ghamari-Langroudi, Masoud, Digby, Gregory J., Sebag, Julien A., Millhauser, Glenn L., Palomino, Rafael, Matthews, Robert, Gillyard, Taneisha, Panaro, Brandon L., Tough, Iain R., Cox, Helen M., Denton, Jerod S., Cone, Roger D.

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The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers von Hollins, Bettye, Kuravi, Sudhakiranmayi, Digby, Gregory J., Lambert, Nevin A.

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Some G Protein Heterotrimers Physically Dissociate in Living Cells von Digby, Gregory J., Lober, Robert M., Sethi, Pooja R., Lambert, Nevin A.

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Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders von Digby, Gregory J, Shirey, Jana K, Conn, P Jeffrey

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Differential dissociation of G protein heterotrimers von Digby, Gregory J., Sethi, Pooja R., Lambert, Nevin A.

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Development of a highly selective, orally bioavailable and CNS penetrant M₁ agonist derived from the MLPCN probe ML071 von Lebois, Evan P, Digby, Gregory J, Sheffler, Douglas J, Melancon, Bruce J, Tarr, James C, Cho, Hyekyung P, Miller, Nicole R, Morrison, Ryan, Bridges, Thomas M, Xiang, Zixiu, Scott Daniels, J, Wood, Michael R, Conn, P. Jeffrey, Lindsley, Craig W

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Point Mutation to Gαi Selectively Blocks GoLoco Motif Binding: DIRECT EVIDENCE FOR Gα·GoLoco COMPLEXES IN MITOTIC SPINDLE DYNAMICS von Willard, Francis S, Zheng, Zhen, Guo, Juan, Digby, Gregory J, Kimple, Adam J, Conley, Jason M, Johnston, Christopher A, Bosch, Dustin, Willard, Melinda D, Watts, Val J, Lambert, Nevin A, Ikeda, Stephen R, Du, Quansheng, Siderovski, David P

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Further exploration of M1 allosteric agonists: Subtle structural changes abolish M1 allosteric agonism and result in pan-mAChR orthosteric antagonism von Sheffler, Douglas J., Sevel, Christian, Le, Uyen, Lovell, Kimberly M., Tarr, James C., Carrington, Sheridan J.S., Cho, Hyekyung P., Digby, Gregory J., Niswender, Colleen M., Conn, P. Jeffrey, Hopkins, Corey R., Wood, Michael R., Lindsley, Craig W.

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Chemical Modification of the M1 Agonist VU0364572 Reveals Molecular Switches in Pharmacology and a Bitopic Binding Mode von Digby, Gregory J, Utley, Thomas J, Lamsal, Atin, Sevel, Christian, Sheffler, Douglas J, Lebois, Evan P, Bridges, Thomas M, Wood, Michael R, Niswender, Colleen M, Lindsley, Craig W, Conn, P. Jeffrey

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Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models von Digby, Gregory J, Noetzel, Meredith J, Bubser, Michael, Utley, Thomas J, Walker, Adam G, Byun, Nellie E, Lebois, Evan P, Xiang, Zixiu, Sheffler, Douglas J, Cho, Hyekyung P, Davis, Albert A, Nemirovsky, Natali E, Mennenga, Sarah E, Camp, Bryan W, Bimonte-Nelson, Heather A, Bode, Jacob, Italiano, Kimberly, Morrison, Ryan, Daniels, J Scott, Niswender, Colleen M, Olive, M Foster, Lindsley, Craig W, Jones, Carrie K, Conn, P Jeffrey

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Novel Positive Allosteric Modulators Bias Acetylcholine Signaling at Human M 4 Muscarinic Receptors von Klein, Michael Thomas, Digby, Gregory, Niswender, Colleen, Tarr, Christopher, Poslusney, Michael, Melancon, Bruce, Wood, Michael, Lindsley, Craig, Conn, P. Jeffrey

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G-protein independent coupling of the MC4R to Kir 7.1 in hypothalamic neurons von Ghamari-Langroudi, Masoud, Digby, Gregory J., Sebag, Julien A., Millhauser, Glenn L., Palomino, Rafael, Matthews, Robert, Gillyard, Taneisha, Panaro, Brandon L., Tough, Iain R., Cox, Helen M., Denton, Jerod S., Cone, Roger D.

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Development of a highly selective, orally bioavailable and CNS penetrant M 1 agonist derived from the MLPCN probe ML071 von Lebois, Evan P., Digby, Gregory J., Sheffler, Douglas J., Melancon, Bruce J., Tarr, James C., Cho, Hyekyung P., Miller, Nicole R., Morrison, Ryan, Bridges, Thomas M., Xiang, Zixiu, Scott Daniels, J., Wood, Michael R., Jeffrey Conn, P., Lindsley, Craig W.

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Chemical Modification of the M 1 Agonist VU0364572 Reveals Molecular Switches in Pharmacology and a Bitopic Binding Mode von Digby, Gregory J., Utley, Thomas J., Lamsal, Atin, Sevel, Christian, Sheffler, Douglas J., Lebois, Evan P., Bridges, Thomas M., Wood, Michael R., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey

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Rapid Binding of Gβγ Dimers to the c-terminus of GRK3 von Hollins, Bettye, Kuravi, Sudhakiranmayi, Digby, Gregory J., Lambert, Nevin A.

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Measuring arrestin binding to G Protein Coupled Receptors: BRET and recruitment assays tell different stories von Gimenez, Luis E, Digby, Gregory J, Weaver, Charles D., Conn, P. Jefffrey, Gurevich, Vsevolod V.

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Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disordersThis article is part of a Molecular BioSystems themed issue on Chemical Genomics.Ele... von Digby, Gregory J, Shirey, Jana K, Conn, P. Jeffrey

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Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disordersw von Digby, Gregory J., Shirey, Jana K., Conn, P. Jeffrey

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