Coordinated Activation of Toll-Like Receptor8 (TLR8) and NLRP3 by the TLR8 Agonist, VTX-2337, Ignites Tumoricidal Natural Killer Cell Activity von Dietsch, Gregory N, Lu, Hailing, Yang, Yi, Morishima, Chihiro, Chow, Laura Q, Disis, Mary L, Hershberg, Robert M

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The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes von Dowling, David J, Tan, Zhen, Prokopowicz, Zofia M, Palmer, Christine D, Matthews, Maura-Ann H, Dietsch, Gregory N, Hershberg, Robert M, Levy, Ofer

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Phase Ib Trial of the Toll-like Receptor 8 Agonist, Motolimod (VTX-2337), Combined with Cetuximab in Patients with Recurrent or Metastatic SCCHN von Chow, Laura Q M, Morishima, Chihiro, Eaton, Keith D, Baik, Christina S, Goulart, Bernardo H, Anderson, Leslie N, Manjarrez, Kristi L, Dietsch, Gregory N, Bryan, James Kyle, Hershberg, Robert M, Disis, Mary L, Martins, Renato G

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Motolimod effectively drives immune activation in advanced cancer patients von Dietsch, Gregory N.

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VTX-2337 Is a Novel TLR8 Agonist That Activates NK Cells and Augments ADCC von HAILING LU, DIETSCH, Gregory N, DISIS, Mary L, HERSHBERG, Robert M, MATTHEWS, Maura-Ann H, YI YANG, GHANEKAR, Smita, INOKUMA, Margaret, SUNI, Maria, MAINO, Vernon C, HENDERSON, Katherine E, HOWBERT, James Jeffry

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Late-Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337) von Dietsch, Gregory N, Randall, Tressa D, Gottardo, Raphael, Northfelt, Donald W, Ramanathan, Ramesh K, Cohen, Peter A, Manjarrez, Kristi L, Newkirk, Mona, Bryan, James Kyle, Hershberg, Robert M

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A phase I dose-finding study of the novel Toll-like receptor 8 agonist VTX-2337 in adult subjects with advanced solid tumors or lymphoma von Northfelt, Donald W, Ramanathan, Ramesh K, Cohen, Peter A, Von Hoff, Daniel D, Weiss, Glen J, Dietsch, Gregory N, Manjarrez, Kristi L, Randall, Tressa D, Hershberg, Robert M

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Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity von Elavazhagan, Saranya, Fatehchand, Kavin, Santhanam, Vikram, Fang, Huiqing, Ren, Li, Gautam, Shalini, Reader, Brenda, Mo, Xiaokui, Cheney, Carolyn, Briercheck, Edward, Vasilakos, John P, Dietsch, Gregory N, Hershberg, Robert M, Caligiuri, Michael, Byrd, John C, Butchar, Jonathan P, Tridandapani, Susheela

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Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination von Fatehchand, Kavin, Ren, Li, Elavazhagan, Saranya, Fang, Huiqing, Mo, Xiaokui, Vasilakos, John P., Dietsch, Gregory N., Hershberg, Robert M., Tridandapani, Susheela, Butchar, Jonathan P.

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Characterization of the Inflammatory Response to a Highly Selective PDE4 Inhibitor in the Rat and the Identification of Biomarkers that Correlate with Toxicity von Dietsch, Gregory N., Dipalma, Chris R., Eyre, Russell J., Pham, Tuan Q., Poole, Karen M., Pefaur, Noah B., Welch, William D., Trueblood, Esther, Kerns, William D., Kanaly, Suzanne T.

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VTX‐1463, a novel TLR‐8 agonist, attenuates nasal congestion after ragweed challenge in sensitized beagle dogs von Royer, Christopher M., Rudolph, Karin, Dietsch, Gregory N., Hershberg, Robert M., Barrett, Edward G.

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The role of recombinant platelet-activating factor acetylhydrolase in a neonatal rat model of necrotizing enterocolitis von CAPLAN, M. S, LICKERMAN, M, ADLER, L, DIETSCH, G. N, YU, A

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Recombinant Human Platelet-Activating Factor- Acetylhydrolase Inhibits Airway Inflammation and Hyperreactivity in Mouse Asthma Model von Henderson, William R., Jr, Lu, Jiangyang, Poole, Karen M, Dietsch, Gregory N, Chi, Emil Y

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TLR8 ligation induces apoptosis of monocytic myeloid‐derived suppressor cells von Dang, Yushe, Rutnam, Zina J., Dietsch, Gregory, Lu, Hailing, Yang, Yi, Hershberg, Robert, Disis, Mary L.

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TLR8 stimulation enhances cetuximab-mediated natural killer cell lysis of head and neck cancer cells and dendritic cell cross-priming of EGFR-specific CD8+ T cells von Stephenson, Ryan M., Lim, Chwee Ming, Matthews, Maura, Dietsch, Gregory, Hershberg, Robert, Ferris, Robert L.

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Inhibition of experimental vasospasm with anti-intercellular adhesion molecule-1 monoclonal antibody in rats von Oshiro, E M, Hoffman, P A, Dietsch, G N, Watts, M C, Pardoll, D M, Tamargo, R J

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Lipopolysaccharide downregulates FcγRIIb via MARCH3-mediated ubiquitination von Butchar, Jonathan P, Fatehchand, Kavin, Ren, Li, Elavazhagan, Saranya, Fang, Huiqing, Mo, Xiaokui, Vasilakos, John P, Dietsch, Gregory N, Hershberg, Robert M, Tridandapani, Susheela

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Active8: A randomized, double-blind, placebo-controlled study of chemotherapy plus cetuximab in combination with VTX-2337 in patients with recurrent or metastatic squamous cell car... von Cohen, Ezra E.W., Ferris, Robert L., Gash, Kelly, Manjarrez, Kristi, Dietsch, Gregory, Hershberg, Robert Mark, Bryan, James Kyle

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Abstract 4738: TLR8 stimulation enhances cetuximab-mediated natural killer cell lysis of head and neck cancer cells and dendritic cell cross priming of EGFR-specific CD8+ T cells von Stephenson, Ryan M., Lim, Chwee Ming, Matthews, Maura, Dietsch, Gregory, Hershberg, Robert, Ferris, Robert L.

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TLR7/8 agonists enhance FcγR in CLL patient monocytes (TUM7P.958) von Elavazhagan, Saranya, Shah, Prexy, Fatehchand, Kavin, Patel, Hemal, Cheney, Carolyn, Muthusamy, Natarajan, Vasilakos, John, Matthews, Maura-Ann, Dietsch, Gregory, Hershberg, Robert, Byrd, John, Tridandapani, Susheela, Butchar, Jonathan

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