BCL-2 protein family: attractive targets for cancer therapy von Kaloni, Deeksha, Diepstraten, Sarah T, Strasser, Andreas, Kelly, Gemma L

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The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs von Diepstraten, Sarah T., Anderson, Mary Ann, Czabotar, Peter E., Lessene, Guillaume, Strasser, Andreas, Kelly, Gemma L.

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Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias von Thijssen, Rachel, Diepstraten, Sarah T., Moujalled, Donia, Chew, Edward, Flensburg, Christoffer, Shi, Melissa X., Dengler, Michael A., Litalien, Veronique, MacRaild, Sarah, Chen, Maoshan, Anstee, Natasha S., Reljić, Boris, Gabriel, Sarah S., Djajawi, Tirta M., Riffkin, Chris D., Aubrey, Brandon J., Chang, Catherine, Tai, Lin, Xu, Zhen, Morley, Thomas, Pomilio, Giovanna, Bruedigam, Claudia, Kallies, Axel, Stroud, David A., Bajel, Ashish, Kluck, Ruth M., Lane, Steven W., Schoumacher, Marie, Banquet, Sébastien, Majewski, Ian J., Strasser, Andreas, Roberts, Andrew W., Huang, David C.S., Brown, Fiona C., Kelly, Gemma L., Wei, Andrew H.

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The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells von Wang, Zilu, Hu, Huimin, Heitink, Luuk, Rogers, Kelly, You, Yue, Tan, Tao, Suen, Connie Li Wai, Garnham, Alex, Chen, Hao, Lieschke, Elizabeth, Diepstraten, Sarah T., Chang, Catherine, Chen, Tianwei, Moujalled, Diane, Sutherland, Kate, Lessene, Guillaume, Sieber, Oliver M., Visvader, Jane, Kelly, Gemma L., Strasser, Andreas

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Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance von Deng, Yexuan, Diepstraten, Sarah T., Potts, Margaret A., Giner, Göknur, Trezise, Stephanie, Ng, Ashley P., Healey, Gerry, Kane, Serena R., Cooray, Amali, Behrens, Kira, Heidersbach, Amy, Kueh, Andrew J., Pal, Martin, Wilcox, Stephen, Tai, Lin, Alexander, Warren S., Visvader, Jane E., Nutt, Stephen L., Strasser, Andreas, Haley, Benjamin, Zhao, Quan, Kelly, Gemma L., Herold, Marco J.

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A Drosophila chemical screen reveals synergistic effect of MEK and DGKα inhibition in Ras-driven cancer von La Marca, John E, Ely, Robert W, Diepstraten, Sarah T, Burke, Peter, Kelly, Gemma L, Humbert, Patrick O, Richardson, Helena E

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Author Correction: Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance von Deng, Yexuan, Diepstraten, Sarah T., Potts, Margaret A., Giner, Göknur, Trezise, Stephanie, Ng, Ashley P., Healey, Gerry, Kane, Serena R., Cooray, Amali, Behrens, Kira, Heidersbach, Amy, Kueh, Andrew J., Pal, Martin, Wilcox, Stephen, Tai, Lin, Alexander, Warren S., Visvader, Jane E., Nutt, Stephen L., Strasser, Andreas, Haley, Benjamin, Zhao, Quan, Kelly, Gemma L., Herold, Marco J.

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Don’t fear the reaper: The role of regulated cell death in tumorigenesis and BH3-mimetics for cancer therapy von La Marca, John E., Kelly, Gemma L., Strasser, Andreas, Diepstraten, Sarah T.

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BCL-W makes only minor contributions to MYC-driven lymphoma development von Diepstraten, Sarah T., La Marca, John E., Chang, Catherine, Young, Savannah, Strasser, Andreas, Kelly, Gemma L.

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Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs von Diepstraten, Sarah T., Young, Savannah, La Marca, John E., Wang, Zilu, Kluck, Ruth M., Strasser, Andreas, Kelly, Gemma L.

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Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers von Diepstraten, Sarah T., Yuan, Yin, La Marca, John E., Young, Savannah, Chang, Catherine, Whelan, Lauren, Ross, Aisling M., Fischer, Karla C., Pomilio, Giovanna, Morris, Rhiannon, Georgiou, Angela, Litalien, Veronique, Brown, Fiona C., Roberts, Andrew W., Strasser, Andreas, Wei, Andrew H., Kelly, Gemma L.

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Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses von La Marca, John E., Aubrey, Brandon J., Yang, Bruce, Chang, Catherine, Wang, Zilu, Kueh, Andrew, Tai, Lin, Wilcox, Stephen, Milla, Liz, Heinzel, Susanne, Vremec, David, Whelan, Lauren, König, Christina, Kaloni, Deeksha, Voss, Anne K., Strasser, Andreas, Diepstraten, Sarah T., Herold, Marco J., Kelly, Gemma L.

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Modelling human haemoglobin switching von Diepstraten, Sarah T., Hart, Adam H.

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Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death von Domostegui, Ana, Peddigari, Suresh, Mercer, Carol A., Iannizzotto, Flavia, Rodriguez, Marta L., Garcia-Cajide, Marta, Amador, Virginia, Diepstraten, Sarah T., Kelly, Gemma L., Salazar, Ramón, Kozma, Sara C., Kusnadi, Eric P., Kang, Jian, Gentilella, Antonio, Pearson, Richard B., Thomas, George, Pelletier, Joffrey

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Correction to: The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells von Wang, Zilu, Hu, Huimin, Heitink, Luuk, Rogers, Kelly, You, Yue, Tan, Tao, Suen, Connie Li Wai, Garnham, Alex, Chen, Hao, Lieschke, Elizabeth, Diepstraten, Sarah T., Chang, Catherine, Chen, Tianwei, Moujalled, Diane, Sutherland, Kate, Lessene, Guillaume, Sieber, Oliver M., Visvader, Jane, Kelly, Gemma L., Strasser, Andreas

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Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1 von Aubrey, Brandon J., Brennan, Margs S., Diepstraten, Sarah T., Wang, Zilu, Chang, Catherine, Herold, Marco J., Strasser, Andreas, Kelly, Gemma L.

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Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development von Aubrey, Brandon J, Janic, Ana, Chen, Yunshun, Chang, Catherine, Lieschke, Elizabeth C, Diepstraten, Sarah T, Kueh, Andrew J, Bernardini, Jonathan P, Dewson, Grant, O'Reilly, Lorraine A, Whitehead, Lachlan, Voss, Anne K, Smyth, Gordon K, Strasser, Andreas, Kelly, Gemma L

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Strip and Cka negatively regulate JNK signalling during Drosophila spermatogenesis von La Marca, John E, Diepstraten, Sarah T, Hodge, Amy L, Wang, Hongyan, Hart, Adam H, Richardson, Helena E, Somers, W Gregory

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MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3+ regulatory T cells von Teh, Charis E., Robbins, Alissa K., Henstridge, Darren C., Dewson, Grant, Diepstraten, Sarah T., Kelly, Gemma, Febbraio, Mark A., Gabriel, Sarah S., O’Reilly, Lorraine A., Strasser, Andreas, Gray, Daniel H. D.

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BCL-W is dispensable for the sustained survival of select Burkitt lymphoma and diffuse large B-cell lymphoma cell lines von Diepstraten, Sarah T., Chang, Catherine, Tai, Lin, Gong, Jia-nan, Lan, Ping, Dowell, Alexander C., Taylor, Graham S., Strasser, Andreas, Kelly, Gemma L.

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