246 PARP inhibitors trap PARP1 onto damaged DNA via catalytic inhibition and not by an allosteric mechanism von Hopkins, T, Solomon, L, Shi, Y, Rodriguez, L, Donawho, C, DiGiammarino, E, Panchal, S, Olson, A, Stolarik, D, Osterling, D, Gao, W, Johnson, E, Maag, D

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A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer von Kriwacki, Richard W, DiGiammarino, Enrico L, Lee, Amanda S, Cadwell, Craig, Zhang, Weixing, Bothner, Brian, Ribeiro, Raul C, Zambetti, Gerard

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Cooperative Signals Governing ARF-Mdm2 Interaction and Nucleolar Localization of the Complex von Weber, Jason D., Kuo, Mei-Ling, Bothner, Brian, DiGiammarino, Enrico L., Kriwacki, Richard W., Roussel, Martine F., Sherr, Charles J.

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Defining the molecular basis of Arf and Hdm2 interactions von Bothner, B, Lewis, W S, DiGiammarino, E L, Weber, J D, Bothner, S J, Kriwacki, R W

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571 Quantitative ligand and receptor binding studies reveal IL-36 activation mode von Todorovic, V., Zhou, L., Kakavas, S., Wang, L., Sielaff, B., Sadhukhan, R., Richardson, P.L., DiGiammarino, E., Sun, C., Scott, V.E.

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Cloning, Overexpression, and Purification of Aminoglycoside Antibiotic Nucleotidyltransferase (2‘ ‘)-Ia:  Conformational Studies with Bound Substrates von Ekman, D. R, DiGiammarino, E. L, Wright, E, Witter, E. D, Serpersu, E. H

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Inhibition of p300/CBP Suppresses Castration-Resistant Prostate Cancer

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Solution Studies of Isepamicin and Conformational Comparisons between Isepamicin and Butirosin A When Bound to an Aminoglycoside 6‘-N-Acetyltransferase Determined by NMR Spectrosco... von DiGiammarino, Enrico L, Draker, Kari-ann, Wright, Gerard D, Serpersu, Engin H

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Aminoglycoside antibiotics bound to aminoglycoside-detoxifying enzymes and RNA adopt similar conformations von Cox, J R, Ekman, D R, DiGiammarino, E L, Akal-Strader, A, Serpersu, E H

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Reversible Amyloid Formation by the p53 Tetramerization Domain and a Cancer-associated Mutant von Lee, Amanda S., Galea, Charles, DiGiammarino, Enrico L., Jun, Bokkyoo, Murti, Gopal, Ribeiro, Raul C., Zambetti, Gerard, Schultz, Christian P., Kriwacki, Richard W.

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High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target von Chen, Liqing, DiGiammarino, Enrico, Zhou, Xiaoyin E, Wang, Yujun, Toh, Diana, Hodge, Thomas W, Meehan, Edward J

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Solution Structure of the p53 Regulatory Domain of the p19Arf Tumor Suppressor Protein von DiGiammarino, Enrico L, Filippov, Igor, Weber, Jason D, Bothner, Brian, Kriwacki, Richard W

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Conformations of antibiotics in active sites of aminoglycoside-detoxifying enzymes von Serpersu, E H, Cox, J R, DiGiammarino, E L, Mohler, M L, Ekman, D R, Akal-Strader, A, Owston, M

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Purification, crystallization and preliminary X-ray analysis of Caenorhabditis elegans ubiquitin-conjugation enzyme M7.1 von Gavira, José A., Claxton, Derek P., Wang, Jenny H., Toh, Diana, Meehan, Edward J., DiGiammarino, Enrico L.

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Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors von Hopkins, Todd A, Shi, Yan, Rodriguez, Luis E, Solomon, Larry R, Donawho, Cherrie K, DiGiammarino, Enrico L, Panchal, Sanjay C, Wilsbacher, Julie L, Gao, Wenqing, Olson, Amanda M, Stolarik, DeAnne F, Osterling, Donald J, Johnson, Eric F, Maag, David

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ABT-165, a Dual Variable Domain Immunoglobulin (DVD-Ig) Targeting DLL4 and VEGF, Demonstrates Superior Efficacy and Favorable Safety Profiles in Preclinical Models von Li, Yingchun, Hickson, Jonathan A, Ambrosi, Dominic J, Haasch, Deanna L, Foster-Duke, Kelly D, Eaton, Lucia J, DiGiammarino, Enrico L, Panchal, Sanjay C, Jiang, Fang, Mudd, Sarah R, Zhang, Catherine, Akella, Surekha S, Gao, Wenqing, Ralston, Sherry L, Naumovski, Louie, Gu, Jijie, Morgan-Lappe, Susan E

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Hexavalent TRAIL Fusion Protein Eftozanermin Alfa Optimally Clusters Apoptosis-Inducing TRAIL Receptors to Induce On-Target Antitumor Activity in Solid Tumors von Phillips, Darren C, Buchanan, Fritz G, Cheng, Dong, Solomon, Larry R, Xiao, Yu, Xue, John, Tahir, Stephen K, Smith, Morey L, Zhang, Haichao, Widomski, Deborah, Abraham, Vivek C, Xu, Nan, Liu, Zhihong, Zhou, Li, DiGiammarino, Enrico, Lu, Xin, Rudra-Ganguly, Nandini, Trela, Bruce, Morgan-Lappe, Susan E

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Ligand association rates to the inner-variable-domain of a dual-variable-domain immunoglobulin are significantly impacted by linker design von DiGiammarino, Enrico L., Harlan, John E., Walter, Karl A., Ladror, Uri S., Edalji, Rohinton P., Hutchins, Charles W., Lake, Marc R., Greischar, Amy J., Liu, Junjian, Ghayur, Tariq, Jakob, Clarissa G.

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Rationale for the combination of veliparib with platinum-based chemotherapy von Maag, David, Solomon, Larry, Hopkins, Todd, Bukhofzer, Gail, Shi, Yan, Donawho, Cherrie, Zhu, Gui-Dong, Rodriguez, Luis E, Penning, Thomas, DiGiammarino, Enrico, Panchal, Sanjay C, Johnson, Eric Feral

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High Resolution Crystal Structure of Human Rab9 GTPase von Chen, Liqing, DiGiammarino, Enrico, Zhou, Xiaoyin E., Wang, Yujun, Toh, Diana, Hodge, Thomas W., Meehan, Edward J.

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