A First-Time-in-Human Study of GSK2636771, a Phosphoinositide 3 Kinase Beta-Selective Inhibitor, in Patients with Advanced Solid Tumors von Mateo, Joaquin, Ganji, Gopinath, Lemech, Charlotte, Burris, Howard A, Han, Sae-Won, Swales, Karen, Decordova, Shaun, DeYoung, M Phillip, Smith, Deborah A, Kalyana-Sundaram, Shanker, Wu, Jiuhua, Motwani, Monica, Kumar, Rakesh, Tolson, Jerry M, Rha, Sun Young, Chung, Hyun Cheol, Eder, Joseph P, Sharma, Sunil, Bang, Yung-Jue, Infante, Jeffrey R, Yan, Li, de Bono, Johann S, Arkenau, Hendrik-Tobias

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Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1 von Najafov, Ayaz, Sommer, Eeva M, Axten, Jeffrey M, Deyoung, M Phillip, Alessi, Dario R

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Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis von Horak, Peter, Crawford, Andrew R, Vadysirisack, Douangsone D, Nash, Zachary M, DeYoung, M. Phillip, Sgroi, Dennis, Ellisen, Leif W

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A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma von van Brummelen, Emilie M. J., Levchenko, Evgeny, Dómine, Manuel, Fennell, Dean A., Kindler, Hedy L., Viteri, Santiago, Gadgeel, Shirish, López, Pilar Garrido, Kostorov, Vladimir, Morgensztern, Daniel, Orlov, Sergey, Zauderer, Marjorie G., Vansteenkiste, Johan F., Baker-Neblett, Katherine, Vasquez, James, Wang, Xiaowei, Bellovin, David I., Schellens, Jan H. M., Yan, Li, Mitrica, Ionel, DeYoung, M. Phillip, Trigo, José

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An open-label phase IB study to evaluate GSK3052230 in combination with paclitaxel and carboplatin, or docetaxel, in FGFR1-amplified non-small cell lung cancer von Morgensztern, Daniel, Karaseva, Nina, Felip, Enriqueta, Delgado, Ignacio, Burdaeva, Olga, Dómine, Manuel, Lara, Primo, Paik, Paul K., Lassen, Ulrik, Orlov, Sergey, Trigo, José, Shomova, Marina, Baker-Neblett, Katherine, Vasquez, James, Wang, Xiaowei, Yan, Li, Mitrica, Ionel, DeYoung, M. Phillip, Garrido, Pilar

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Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230 von Blackwell, Christina, Sherk, Christian, Fricko, Maggie, Ganji, Gopinath, Barnette, Mary, Hoang, Bao, Tunstead, James, Skedzielewski, Tina, Alsaid, Hasan, Jucker, Beat M, Minthorn, Elisabeth, Kumar, Rakesh, DeYoung, M Phillip

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Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity von Concha, Nestor O., Smallwood, Angela, Bonnette, William, Totoritis, Rachel, Zhang, Guofeng, Federowicz, Kelly, Yang, Jingsong, Qi, Hongwei, Chen, Stephanie, Campobasso, Nino, Choudhry, Anthony E., Shuster, Leanna E., Evans, Karen A., Ralph, Jeff, Sweitzer, Sharon, Heerding, Dirk A., Buser, Carolyn A., Su, Dai-Shi, DeYoung, M. Phillip

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Activating Inducible T-cell Costimulator Yields Antitumor Activity Alone and in Combination with Anti-PD-1 Checkpoint Blockade von Yadavilli, Sapna, Waight, Jeremy D., Brett, Sara, Bi, Meixia, Zhang, Tianqian, Liu, Yao-Bin, Ellis, Catherine, Turner, David C., Hahn, Ashleigh, Shi, Hong, Seestaller-Wehr, Laura, Jing, Junping, Xie, Qing, Shaik, Jafar Sadik, Ji, Xiao, Gagnon, Robert, Fieles, William, Hook, Laura, Grant, Steven, Hopley, Stephanie, DeYoung, M. Phillip, Blackwell, Christina, Chisamore, Michael, Biddlecombe, Robert, Figueroa, David J., Hopson, Christopher B., Srinivasan, Roopa, Smothers, James, Maio, Michele, Rischin, Danny, Olive, Daniel, Paul, Elaine, Mayes, Patrick A., Hoos, Axel, Ballas, Marc

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Discovery of JNJ-88549968, a Novel, First-in-Class CALRmutxCD3 T-Cell Redirecting Antibody for the Treatment of Myeloproliferative Neoplasms von Kuchnio, Anna, Samakai, Elsie, Hug, Eva, Balmaña, Meritxell, Janssen, Lut, Amorim, Ricardo, Cornelissen, Ivo, Majoros, Andrea, Broux, Michaël, Taneja, Isha, Torti, Vince, Agic, Azra, Moritsch, Stefan, Benedetti, Filippo, Rosebrock, Felix, Packman, Kathryn, Arts, Janine, Patel, Sonal, Lomas, Oliver Christopher, Deyoung, M. Phillip, Zagrijtschuk, Oleh, Elsayed, Yusri, Constantinescu, Stefan, Kralovics, Robert, Philippar, Ulrike

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Characterization of JNJ-80948543, a Novel CD79bxCD20xCD3 Trispecific T-Cell Redirecting Antibody for the Treatment of B-Cell Non-Hodgkin Lymphoma von Kuchnio, Anna, Yang, Danlin, Vloemans, Nele, Lowenstein, Cassandra, Cornelissen, Ivo, Amorim, Ricardo, Han, Chao, Sukumaran, Siddharth, Janssen, Lut, Suls, Toon, Bekkers, Mariette, Lasorsa, Elena, Fontana, Lorena, Medeiros, Nicole, Wu, Bingyuan, Chen, Jun, Feldkamp, Michael, Wu, Sheng-Jiun, Habte, Habtom, Krayer, John, Holland, Cam, Deyoung, M. Phillip, Elsayed, Yusri A, Philippar, Ulrike

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Open-Label Pilot Study of Genetically Engineered NY-ESO-1 Specific T Cells (GSK3377794) Alone or in Combination with Pembrolizumab in Relapsed and Refractory Multiple Myeloma von Nishihori, Taiga, Kaufman, Jonathan L., Hoffman, James E., Blouch, Kristin, Pandit, Sunil, Butler, Emily, Jain, Amit, Wu, Yuehui, DeYoung, M. Phillip, Hasan, Aisha N., Rapoport, Aaron P.

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A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma von van Brummelen, Emilie M.J, Levchenko, Evgeny, Domine, Manuel, Fennell, Dean A, Kindler, Hedy L, Viteri, Santiago, Gadgeel, Shirish, Garrido Lopez, Pilar, Kostorov, Vladimir, Morgensztern, Daniel, Orlov, Sergey, Zauderer, Marjorie G, Vansteenkiste, Johan F, Baker-Neblett, Katherine, Vasquez, James, Wang, Xiaowei, Bellovin, David, Schellens, Jan H.M, Yan, Li, Mitrica, Ionel, DeYoung, M. Phillip, Trigo, Jose

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Abstract 5449: FP-1039/GSK3052230, an FGF ligand trap, enhances VEGF antagonist therapy in preclinical models of RCC and HCC von Bellovin, David I., Palencia, Servando, Hestir, Kevin, Lee, Ernestine, DeYoung, M. Phillip, Brennan, Thomas, Los, Gerrit, Baker, Kevin

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Abstract LB-42: PDK1 knockdown selectively inhibits growth of cancer cells harboring activating mutations involved in MAPK signaling von DeYoung, M. Phillip, Gardiner, Christine M., Chadderton, Antony R., Medina, Jesus R., Axten, Jeffrey M., Rabindran, Sridhar K.

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Abstract IA22: Targeting inducible T cell co-stimulator (ICOS) promotes effector T cell function and antitumor response von Mayes, Patrick A., Yadavilli, Sapna, Liu, Yao-Bin, Bi, Meixia, Zhang, Tianqian, Sendeyo, Kelhia, Willoughby, Jane, Seestaller-Wehr, Laura, Hahn, Ashleigh, Bhattacharya, Sabyasachi, DeYoung, M. Phillip, Blackwell, Christina, Shi, Hong, Killian, David, Adam, Michael, Zhang, Shu-Yun, Jing, Junping, Hopson, Chris, Marodon, Gilles, Cragg, Mark S., Hoos, Axel

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Abstract LB-116: GSK2334470: A potent and highly selective inhibitor of PDK1 von Axten, Jeffrey M., Medina, Jesus R., Shu, Arthur, Li, William H., Feng, Yanhong, DeYoung, M. Phillip, Gardiner, Christine M., Chadderton, Antony R., Dumble, Melissa, Liu, Qi, Rabindran, Sridhar

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Open-Label Pilot Study of Genetically Engineered NY-ESO-1 Specific T Cells (GSK3377794) Alone or in Combination with Pembrolizumab in Relapsed and Refractory Multiple Myeloma von Nishihori, Taiga, Kaufman, Jonathan L., Hoffman, James E., Blouch, Kristin, Pandit, Sunil, Butler, Emily, Jain, Amit, Wu, Yuehui, DeYoung, M. Phillip, Hasan, Aisha N., Farsaci, Benedetto, Chisamore, Michael, Rapoport, Aaron P.

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How Robust Is the p Factor? Using Multitrait-Multimethod Modeling to Inform the Meaning of General Factors of Youth Psychopathology von Watts, Ashley L., Makol, Bridget A., Palumbo, Isabella M., De Los Reyes, Andres, Olino, Thomas M., Latzman, Robert D., DeYoung, Colin G., Wood, Phillip K., Sher, Kenneth J.

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p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis von Rocco, James W., Leong, Chee-Onn, Kuperwasser, Nicolas, DeYoung, Maurice Phillip, Ellisen, Leif W.

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Genetic diversity of Guatemalan climbing bean collections von Tobar Piñón, María Gabriela, Mafi Moghaddam, Samira, Lee, Rian K., Villatoro Mérida, Julio C., DeYoung, David J., Reyes, Byron A., Maredia, Mywish, Osorno, Juan M., McClean, Phillip E.

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