A molecular map of murine lymph node blood vascular endothelium at single cell resolution von Brulois, Kevin, Rajaraman, Anusha, Szade, Agata, Nordling, Sofia, Bogoslowski, Ania, Dermadi, Denis, Rahman, Milladur, Kiefel, Helena, O’Hara, Edward, Koning, Jasper J., Kawashima, Hiroto, Zhou, Bin, Vestweber, Dietmar, Red-Horse, Kristy, Mebius, Reina E., Adams, Ralf H., Kubes, Paul, Pan, Junliang, Butcher, Eugene C.

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Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon von Dermadi, Denis, Valo, Satu, Ollila, Saara, Soliymani, Rabah, Sipari, Nina, Pussila, Marjaana, Sarantaus, Laura, Linden, Jere, Baumann, Marc, Nyström, Minna

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Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils von Takeda, Akira, Hollmén, Maija, Dermadi, Denis, Pan, Junliang, Brulois, Kevin Francis, Kaukonen, Riina, Lönnberg, Tapio, Boström, Pia, Koskivuo, Ilkka, Irjala, Heikki, Miyasaka, Masayuki, Salmi, Marko, Butcher, Eugene C., Jalkanen, Sirpa

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An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice von Nikkanen, Joni, Leong, Yew Ann, Krause, William C, Dermadi, Denis, Maschek, J Alan, Van Ry, Tyler, Cox, James E, Weiss, Ethan J, Gokcumen, Omer, Chawla, Ajay, Ingraham, Holly A

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A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature von Xiang, Menglan, Grosso, Rubén Adrián, Takeda, Akira, Pan, Junliang, Bekkhus, Tove, Brulois, Kevin, Dermadi, Denis, Nordling, Sofia, Vanlandewijck, Michael, Jalkanen, Sirpa, Ulvmar, Maria H, Butcher, Eugene C

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A 6-mRNA host response classifier in whole blood predicts outcomes in COVID-19 and other acute viral infections von Buturovic, Ljubomir, Zheng, Hong, Tang, Benjamin, Lai, Kevin, Kuan, Win Sen, Gillett, Mark, Santram, Rahul, Shojaei, Maryam, Almansa, Raquel, Nieto, Jose Ángel, Muñoz, Sonsoles, Herrero, Carmen, Antonakos, Nikolaos, Koufargyris, Panayiotis, Kontogiorgi, Marina, Damoraki, Georgia, Liesenfeld, Oliver, Wacker, James, Midic, Uros, Luethy, Roland, Rawling, David, Remmel, Melissa, Coyle, Sabrina, Liu, Yiran E., Rao, Aditya M., Dermadi, Denis, Toh, Jiaying, Jones, Lara Murphy, Donato, Michele, Khatri, Purvesh, Giamarellos-Bourboulis, Evangelos J., Sweeney, Timothy E.

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Single-Cell Sequencing of Mouse Thymocytes Reveals Mutational Landscape Shaped by Replication Errors, Mismatch Repair, and H3K36me3 von Aska, Elli-Mari, Dermadi, Denis, Kauppi, Liisa

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Inferring direction of associations between histone modifications using a neural processes-based framework von Ganesan, Ananthakrishnan, Dermadi, Denis, Kalesinskas, Laurynas, Donato, Michele, Sowers, Rosalie, Utz, Paul J., Khatri, Purvesh

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Inherited cancer predisposition sensitizes colonic mucosa to address Western diet effects and putative cancer-predisposing changes on mouse proteome von Đermadi, Denis, Valo, Satu, Pussila, Marjaana, Reyhani, Nima, Sarantaus, Laura, Lalowski, Maciej, Baumann, Marc, Nyström, Minna

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Exploration of Cell Development Pathways through High-Dimensional Single Cell Analysis in Trajectory Space von Dermadi, Denis, Bscheider, Michael, Bjegovic, Kristina, Lazarus, Nicole H., Szade, Agata, Hadeiba, Husein, Butcher, Eugene C.

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Cancer-predicting gene expression changes in colonic mucosa of Western diet fed Mlh1+/- mice von Pussila, Marjaana, Sarantaus, Laura, Dermadi Bebek, Denis, Valo, Satu, Reyhani, Nima, Ollila, Saara, Päivärinta, Essi, Peltomäki, Päivi, Mutanen, Marja, Nyström, Minna

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Ancestry-based differences in the immune phenotype are associated with lupus activity von Slight-Webb, Samantha, Thomas, Kevin, Smith, Miles, Wagner, Catriona A, Macwana, Susan, Bylinska, Aleksandra, Donato, Michele, Dvorak, Mai, Chang, Sarah E, Kuo, Alex, Cheung, Peggie, Kalesinskas, Laurynas, Ganesan, Ananthakrishnan, Dermadi, Denis, Guthridge, Carla J, DeJager, Wade, Wright, Christian, Foecke, Mariko H, Merrill, Joan T, Chakravarty, Eliza, Arriens, Cristina, Maecker, Holden T, Khatri, Purvesh, Utz, Paul J, James, Judith A, Guthridge, Joel M

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Mechanisms of pathogenicity in human MSH2 missense mutants von Ollila, Saara, Dermadi Bebek, Denis, Jiricny, Josef, Nyström, Minna

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Uncertain pathogenicity of MSH2 variants N127S and G322D challenges their classification von Ollila, Saara, Bebek, Denis Dermadi, Greenblatt, Marc, Nyström, Minna

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Single cell trajectories reveal a developmental sequence from angiogenic capillary progenitors to mature high endothelial cells von Brulois, Kevin, Rajaraman, Anusha, Szade, Agata, Nordling, Sofia, Takeda, Akira, Jalkanen, Sirpa, Dermadi, Denis, Pan, Junliang, Butcher, Eugene

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Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity across viruses von Zheng, Hong, Rao, Aditya M., Dermadi, Denis, Toh, Jiaying, Murphy Jones, Lara, Donato, Michele, Liu, Yiran, Su, Yapeng, Dai, Cheng L., Kornilov, Sergey A., Karagiannis, Minas, Marantos, Theodoros, Hasin-Brumshtein, Yehudit, He, Yudong D., Giamarellos-Bourboulis, Evangelos J., Heath, James R., Khatri, Purvesh

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A Single‐Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature von Xiang, Menglan, Grosso, Rubén, Takeda, Akira, Pan, Junliang, Bekkhus, Tove, Brulois, Kevin, Dermadi, Denis, Nordling, Sofia, Vanlandewijck, Michael, Jalkanen, Sirpa, Butcher, Eugene

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Air Pollution and Pregnancy: Insights into Immune Response, Histone Modifications, and Cytokine Signatures von Jung, Youn Soo, Ha, Ji Won, Aguilera, Juan, Kaushik, Abhinav, Cansdale, Stuart, Yang, Emily, Dermadi, Denis, Lurmann, Fred, Lutzker, Liza, Hammond, Katharine, Balmes, John, Noth, Elizabeth, Eisen, Ellen, Aghaeepour, Nima, Shaw, Gary, Waldrop, Anne, Khatri, Purvesh, Utz, Paul, Rosenburg-Hasson, Yael, Maecker, Holden, Burt, Trevor, Johnson, Mary, Nadeau, Kari

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Mass-Cytometry-Based Quantification of Global Histone Post-Translational Modifications at Single-Cell Resolution Across Peripheral Immune Cells in IBD von Bai, Lawrence, Dermadi, Denis, Kalesinskas, Laurynas, Dvorak, Mai, Chang, Sarah E, Ganesan, Ananthakrishnan, Rubin, Samuel J S, Kuo, Alex, Cheung, Peggie, Donato, Michele, Utz, Paul J, Habtezion, Aida, Khatri, Purvesh

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Abstract B18: Western diet-fed mice with inherited cancer predisposition reveal early epigenetic changes and protein markers for colon oncogenesis von Bebek, Denis Dermadi, Valo, Satu, Pussila, Marjaana, Reyhani, Nima, Sarantaus, Laura, Nystrom, Minna

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