A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide‑1 Receptor von Griffith, David A., Edmonds, David J., Fortin, Jean-Philippe, Kalgutkar, Amit S., Kuzmiski, J. Brent, Loria, Paula M., Saxena, Aditi R., Bagley, Scott W., Buckeridge, Clare, Curto, John M., Derksen, David R., Dias, João M., Griffor, Matthew C., Han, Seungil, Jackson, V. Margaret, Landis, Margaret S., Lettiere, Daniel, Limberakis, Chris, Liu, Yuhang, Mathiowetz, Alan M., Patel, Jayesh C., Piotrowski, David W., Price, David A., Ruggeri, Roger B., Tess, David A.

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Characterization of [125I]GLP-1(9-36), a novel radiolabeled analog of the major metabolite of glucagon-like peptide 1 to a receptor distinct from GLP1-R and function of the peptide... von Kuc, Rhoda E., Maguire, Janet J., Siew, Keith, Patel, Sheena, Derksen, David R., Margaret Jackson, V., O'Shaughnessey, Kevin M., Davenport, Anthony P.

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Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type... von Pfefferkorn, Jeffrey A, Guzman-Perez, Angel, Litchfield, John, Aiello, Robert, Treadway, Judith L, Pettersen, John, Minich, Martha L, Filipski, Kevin J, Jones, Christopher S, Tu, Meihua, Aspnes, Gary, Risley, Hud, Bian, Jianwei, Stevens, Benjamin D, Bourassa, Patricia, D’Aquila, Theresa, Baker, Levenia, Barucci, Nicole, Robertson, Alan S, Bourbonais, Francis, Derksen, David R, MacDougall, Margit, Cabrera, Over, Chen, Jing, Lapworth, Amanda Lee, Landro, James A, Zavadoski, William J, Atkinson, Karen, Haddish-Berhane, Nahor, Tan, Beijing, Yao, Lili, Kosa, Rachel E, Varma, Manthena V, Feng, Bo, Duignan, David B, El-Kattan, Ayman, Murdande, Sharad, Liu, Shenping, Ammirati, Mark, Knafels, John, DaSilva-Jardine, Paul, Sweet, Laurel, Liras, Spiros, Rolph, Timothy P

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Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide‑1 Receptor (GLP-1R) Agonists von Hoang, Huy N, Song, Kun, Hill, Timothy A, Derksen, David R, Edmonds, David J, Kok, W. Mei, Limberakis, Chris, Liras, Spiros, Loria, Paula M, Mascitti, Vincent, Mathiowetz, Alan M, Mitchell, Justin M, Piotrowski, David W, Price, David A, Stanton, Robert V, Suen, Jacky Y, Withka, Jane M, Griffith, David A, Fairlie, David P

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Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling von Plisson, Fabien, Hill, Timothy A., Mitchell, Justin M., Hoang, Huy N., de Araujo, Aline D., Xu, Weijun, Cotterell, Adam, Edmonds, David J., Stanton, Robert V., Derksen, David R., Loria, Paula M., Griffith, David A., Price, David A., Liras, Spiros, Fairlie, David P.

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Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists von Swedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Durek, Thomas, Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Liras, Spiros, Price, David A., Craik, David J.

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Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro von Swedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Price, David A., Liras, Spiros, Craik, David J.

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The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus von Pfefferkorn, Jeffrey A., Tu, Meihua, Filipski, Kevin J., Guzman-Perez, Angel, Bian, Jianwei, Aspnes, Gary E., Sammons, Matthew F., Song, Wei, Li, Jian-Cheng, Jones, Christopher S., Patel, Leena, Rasmusson, Tim, Zeng, Dongxiang, Karki, Kapil, Hamilton, Michael, Hank, Richard, Atkinson, Karen, Litchfield, John, Aiello, Robert, Baker, Levenia, Barucci, Nicole, Bourassa, Patricia, Bourbounais, Francis, D’Aquila, Theresa, Derksen, David R., MacDougall, Margit, Robertson, Alan

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Optimization of amide-based EP3 receptor antagonists von Lee, Esther C.Y., Futatsugi, Kentaro, Arcari, Joel T., Bahnck, Kevin, Coffey, Steven B., Derksen, David R., Kalgutkar, Amit S., Loria, Paula M., Sharma, Raman

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Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia von Stevens, Benjamin D., Litchfield, John, Pfefferkorn, Jeffrey A., Atkinson, Karen, Perreault, Christian, Amor, Paul, Bahnck, Kevin, Berliner, Martin A., Calloway, Jessica, Carlo, Anthony, Derksen, David R., Filipski, Kevin J., Gumkowski, Mike, Jassal, Charanjeet, MacDougall, Margit, Murphy, Brendan, Nkansah, Paul, Pettersen, John, Rotter, Charles, Zhang, Yan

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Pyrimidone-based series of glucokinase activators with alternative donor–acceptor motif von Filipski, Kevin J., Guzman-Perez, Angel, Bian, Jianwei, Perreault, Christian, Aspnes, Gary E., Didiuk, Mary T., Dow, Robert L., Hank, Richard F., Jones, Christopher S., Maguire, Robert J., Tu, Meihua, Zeng, Dongxiang, Liu, Shenping, Knafels, John D., Litchfield, John, Atkinson, Karen, Derksen, David R., Bourbonais, Francis, Gajiwala, Ketan S., Hickey, Michael, Johnson, Theodore O., Humphries, Paul S., Pfefferkorn, Jeffrey A.

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Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxami... von Pfefferkorn, Jeffrey A., Guzman-Perez, Angel, Oates, Peter J., Litchfield, John, Aspnes, Gary, Basak, Arindrajit, Benbow, John, Berliner, Martin A., Bian, Jianwei, Choi, Chulho, Freeman-Cook, Kevin, Corbett, Jeffrey W., Didiuk, Mary, Dunetz, Joshua R., Filipski, Kevin J., Hungerford, William M., Jones, Christopher S., Karki, Kapil, Ling, Anthony, Li, Jian-Cheng, Patel, Leena, Perreault, Christian, Risley, Hud, Saenz, James, Song, Wei, Tu, Meihua, Aiello, Robert, Atkinson, Karen, Barucci, Nicole, Beebe, David, Bourassa, Patricia, Bourbounais, Francis, Brodeur, Anne M., Burbey, Rena, Chen, Jing, D'Aquila, Theresa, Derksen, David R., Haddish-Berhane, Nahor, Huang, Cong, Landro, James, Lee Lapworth, Amanda, MacDougall, Margit, Perregaux, David, Pettersen, John, Robertson, Alan, Tan, Beijing, Treadway, Judith L., Liu, Shenping, Qiu, Xiayang, Knafels, John, Ammirati, Mark, Song, Xi, DaSilva-Jardine, Paul, Liras, Spiros, Sweet, Laurel, Rolph, Timothy P.

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Corrigendum to “The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of Type 2 diabetes mellitus” [Bioorg. Med. Chem. Lett. 22 (... von Pfefferkorn, Jeffrey A., Tu, Meihua, Filipski, Kevin J., Guzman-Perez, Angel, Bian, Jianwei, Aspnes, Gary E., Sammons, Matthew F., Song, Wei, Li, Jian-Cheng, Jones, Christopher S., Patel, Leena, Rasmusson, Tim, Zeng, Dongxiang, Karki, Kapil, Hamilton, Michael, Hank, Richard, Atkinson, Karen, Litchfield, John, Aiello, Robert, Baker, Levenia, Barucci, Nicole, Bourassa, Patricia, Bourbonais, Francis, D’Aquila, Theresa, Derksen, David R., MacDougall, Margit, Robertson, Alan

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Optimizing glucokinase activator binding kinetics to lower in vivo hypoglycemia risk von Borzilleri, Kris A., Pfefferkorn, Jeffrey A., Guzman-Perez, Angel, Liu, Shenping, Qiu, Xiayang, Chrunyk, Boris A., Song, Xi, Tu, Meihua, Filipski, Kevin J., Aiello, Robert, Derksen, David R., Bourbonais, Francis J., Landro, James, Bourassa, Patricia, D'Aquila, Theresa, Baker, Levenia, Barrucci, Nicole, Litchfield, John, Atkinson, Karen, Rolph, Timothy P., Withka, Jane M.

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Discovery of ( S )-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1 H -imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating... von Pfefferkorn, Jeffrey A., Guzman-Perez, Angel, Litchfield, John, Aiello, Robert, Treadway, Judith L., Pettersen, John, Minich, Martha L., Filipski, Kevin J., Jones, Christopher S., Tu, Meihua, Aspnes, Gary, Risley, Hud, Bian, Jianwei, Stevens, Benjamin D., Bourassa, Patricia, D’Aquila, Theresa, Baker, Levenia, Barucci, Nicole, Robertson, Alan S., Bourbonais, Francis, Derksen, David R., MacDougall, Margit, Cabrera, Over, Chen, Jing, Lapworth, Amanda Lee, Landro, James A., Zavadoski, William J., Atkinson, Karen, Haddish-Berhane, Nahor, Tan, Beijing, Yao, Lili, Kosa, Rachel E., Varma, Manthena V., Feng, Bo, Duignan, David B., El-Kattan, Ayman, Murdande, Sharad, Liu, Shenping, Ammirati, Mark, Knafels, John, DaSilva-Jardine, Paul, Sweet, Laurel, Liras, Spiros, Rolph, Timothy P.

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Optimizing glucokinase activator binding kinetics to lower in vivo hypoglycemia riskElectronic supplementary information (ESI) available: SPR profiles for compounds 6 and 15, KD an... von Borzilleri, Kris A, Pfefferkorn, Jeffrey A, Guzman-Perez, Angel, Liu, Shenping, Qiu, Xiayang, Chrunyk, Boris A, Song, Xi, Tu, Meihua, Filipski, Kevin J, Aiello, Robert, Derksen, David R, Bourbonais, Francis J, Landro, James, Bourassa, Patricia, D'Aquila, Theresa, Baker, Levenia, Barrucci, Nicole, Litchfield, John, Atkinson, Karen, Rolph, Timothy P, Withka, Jane M

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Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzo f uran-4-yloxy)pyrimidine-2-carboxa... von Pfefferkorn, Jeffrey A, Guzman-Perez, Angel, Oates, Peter J, Litchfield, John, Aspnes, Gary, Basak, Arindrajit, Benbow, John, Berliner, Martin A, Bian, Jianwei, Choi, Chulho, Freeman-Cook, Kevin, Corbett, Jeffrey W, Didiuk, Mary, Dunetz, Joshua R, Filipski, Kevin J, Hungerford, William M, Jones, Christopher S, Karki, Kapil, Ling, Anthony, Li, Jian-Cheng, Patel, Leena, Perreault, Christian, Risley, Hud, Saenz, James, Song, Wei, Tu, Meihua, Aiello, Robert, Atkinson, Karen, Barucci, Nicole, Beebe, David, Bourassa, Patricia, Bourbounais, Francis, Brodeur, Anne M, Burbey, Rena, Chen, Jing, D'Aquila, Theresa, Derksen, David R, Haddish-Berhane, Nahor, Huang, Cong, Landro, James, Lee Lapworth, Amanda, MacDougall, Margit, Perregaux, David, Pettersen, John, Robertson, Alan, Tan, Beijing, Treadway, Judith L, Liu, Shenping, Qiu, Xiayang, Knafels, John, Ammirati, Mark, Song, Xi, DaSilva-Jardine, Paul, Liras, Spiros, Sweet, Laurel, Rolph, Timothy P

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A passive mutualistic interaction promotes the evolution of spatial structure within microbial populations von Marchal, Marie, Goldschmidt, Felix, Derksen-Müller, Selina N, Panke, Sven, Ackermann, Martin, Johnson, David R

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Treat-to-target in systemic lupus erythematosus: recommendations from an international task force von van Vollenhoven, Ronald F, Mosca, Marta, Bertsias, George, Isenberg, David, Kuhn, Annegret, Lerstrøm, Kirsten, Aringer, Martin, Bootsma, Hendrika, Boumpas, Dimitrios, Bruce, Ian N, Cervera, Ricard, Clarke, Ann, Costedoat-Chalumeau, Nathalie, Czirják, László, Derksen, Ronald, Dörner, Thomas, Gordon, Caroline, Graninger, Winfried, Houssiau, Frédéric, Inanc, Murat, Jacobsen, Søren, Jayne, David, Jedryka-Goral, Anna, Levitsky, Adrian, Levy, Roger, Mariette, Xavier, Morand, Eric, Navarra, Sandra, Neumann, Irmgard, Rahman, Anisur, Rovenský, Jozef, Smolen, Josef, Vasconcelos, Carlos, Voskuyl, Alexandre, Voss, Anne, Zakharova, Helena, Zoma, Asad, Schneider, Matthias

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A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS) von van Vollenhoven, R, Voskuyl, A, Bertsias, G, Aranow, C, Aringer, M, Arnaud, L, Askanase, A, Balazova, P, Bonfa, E, Bootsma, H, Boumpas, D, Bruce, I, Cervera, R, Clarke, A, Coney, C, Costedoat-Chalumeau, N, Czirjak, L, Derksen, R, Doria, A, Dorner, T, Fischer-Betz, R, Fritsch-Stork, R, Gordon, C, Graninger, W, Gyori, N, Houssiau, F, Isenberg, D, Jacobsen, S, Jayne, D, Kuhn, A, Le Guern, V, Lerstrom, K, Levy, R, Machado-Ribeiro, F, Mariette, X, Missaykeh, J, Morand, E, Mosca, M, Inanc, M, Navarra, S, Neumann, I, Olesinska, M, Petri, M, Rahman, A, Rekvig, OP, Rovensky, J, Shoenfeld, Y, Smolen, J, Tincani, A, Urowitz, M, van Leeuw, B, Vasconcelos, C, Voss, A, Werth, VP, Zakharova, H, Zoma, A, Schneider, M, Ward, M

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