Endogenous dopamine release in the human brain as a pharmacodynamic biomarker: evaluation of the new GPR139 agonist TAK-041 with [C-11]PHNO PET von Rabiner, Eugenii A., Uz, Tolga, Mansur, Ayla, Brown, Terry, Chen, Grace, Wu, Jingtao, Atienza, Joy, Schwarz, Adam J., Yin, Wei, Lewis, Yvonne, Searle, Graham E., Dennison, Jeremy M. T. J., Passchier, Jan, Gunn, Roger N., Tauscher, Johannes

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Pharmacokinetics and ADME Characterization of Intravenous and Oral [ 14 C]-Linerixibat in Healthy Male Volunteers von Zamek-Gliszczynski, Maciej J, Kenworthy, David, Bershas, David A, Sanghvi, Mitesh, Pereira, Adrian I, Mudunuru, Jennypher, Crossman, Lee, Pirhalla, Jill L, Thorpe, Karl M, Dennison, Jeremy M T J, McLaughlin, Megan M, Allinder, Matthew, Swift, Brandon, O'Connor-Semmes, Robin L, Young, Graeme C

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ONO‐7684 a novel oral FXIa inhibitor: Safety, tolerability, pharmacokinetics and pharmacodynamics in a first‐in‐human study von Beale, Dominic, Dennison, Jeremy, Boyce, Malcolm, Mazzo, Francesca, Honda, Naoki, Smith, Paul, Bruce, Mark

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Oral gepotidacin versus nitrofurantoin in patients with uncomplicated urinary tract infection (EAGLE-2 and EAGLE-3): two randomised, controlled, double-blind, double-dummy, phase 3... von Wagenlehner, Florian, Perry, Caroline R, Hooton, Thomas M, Scangarella-Oman, Nicole E, Millns, Helen, Powell, Marcy, Jarvis, Emily, Dennison, Jeremy, Sheets, Amanda, Butler, Deborah, Breton, John, Janmohamed, Salim

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Safety and immunogenicity of a two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in adults in Europe (EBOVAC2): a randomised, observer-blind, participant-blind... von Pollard, Andrew J, Launay, Odile, Lelievre, Jean-Daniel, Lacabaratz, Christine, Grande, Sophie, Goldstein, Neil, Robinson, Cynthia, Gaddah, Auguste, Bockstal, Viki, Wiedemann, Aurelie, Leyssen, Maarten, Luhn, Kerstin, Richert, Laura, Bétard, Christine, Gibani, Malick M, Clutterbuck, Elizabeth A, Snape, Matthew D, Levy, Yves, Thiebaut, Rodolphe, McShane, Christopher, Callendret, Benoit, Dincq, Stephanie, Ferrault, Camille, Chai, Siew Pin, Gyselen, Maire Paule, van Looveren, Marleen, van Ballert, Sylvia, de Cnodder, Tinne, Roza, Len, Forcheh, Chiara, Stevens, Kate, Mastrandrea, Carmela, de Ridder, Sanne, Gundluru, Rachana, Swales, Nathalie, Errijegers, Vanessa, Willems, Wouter, Roorda, Veronika, Orzabal, Nicola, Assenberg, Magdalena, Vialatte, Karine, Remblier, Frédéric, Porcar, Elodie, Ottavi, Anton, Destandau, Eugénie, Schwimmer, Christine, Moinot, Laetitia, Wallet, Cédrick, Allais, Florence, Savel, Hélène, Nedjaai, Naouel, Maugard, Anaïs, Lenzi, Nehza, Loulergue, Pierre, Bahuaud, Mathilde, Lainé, Fabrice, Laviolle, Bruno, Boissel, Nolwenn, Thébault, Elise, Vallée, David, Nicolas, Jean-François, Gilbert, Sophie, Dahel, Karima, Sagorny, Karen, Lucht, Frédéric, Paul, Stéphane, Haccourt Chanavat, Alice, Charra, Florent, Mutter, Catherine, Lambour, Monique, Muller, Caroline, Hutt-Clauss, Anne, Aranda, Olivia, Bernard, Louis, Gissot, Valérie, Hallouin-Bernard, Marie-Charlotte, Goudeau, Alain, Suzzoni, Steve, Auostin, Eva, Brick, Lysiane, Lopez-Zaragoza, Jose-Luis, Melic, Giovanna, Carvalho, Murial, Chesnel, Chrystel, Hocini, Hakim, Wiedemann, Aurélie, Hanot, Laurent, Rieux, Véronique, Puri, Adeep, Adeloye, Temitope, Boyce, Malcolm, Dennison, Jeremy, Loewenstein, Inge, Sahgal, Omar, van den Berg, Frans, Calvert, Wendy, Faldon, Mary, McClain, Bruce, Newell, Marie-Lousie, Molenberghs, Geert

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Safety, tolerability and pharmacokinetics of emodepside, a potential novel treatment for onchocerciasis (river blindness), in healthy male subjects von Gillon, Jean‐Yves, Dennison, Jeremy, Berg, Frans, Delhomme, Sophie, Dequatre Cheeseman, Karen, Peña Rossi, Claudia, Strub Wourgaft, Nathalie, Specht, Sabine, Pedrique, Belén, Monnot, Frédéric, Skrabs, Susanne, Rodriguez, Maria‐Luisa, Stass, Heino

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2831. Efficacy and Safety of Gepotidacin for Uncomplicated Urinary Tract Infection: Pooled Subgroup Analyses of the EAGLE-2 and EAGLE-3 Randomized Phase 3 Trials von Hooton, Thomas M, Perry, Caroline R, Janmohamed, Salim, Sheets, Amanda, Dennison, Jeremy, Millns, Helen, Jarvis, Emily, Huang, Chun

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A Novel Inhaled Dry-Powder Formulation of Ribavirin Allows for Efficient Lung Delivery in Healthy Participants and Those with Chronic Obstructive Pulmonary Disease in a Phase 1 Stu... von Dumont, Etienne F., Oliver, Amanda J., Ioannou, Chris, Billiard, Julia, Dennison, Jeremy, van den Berg, Frans, Yang, Shuying, Chandrasekaran, Vijayalakshmi, Young, Graeme C., Lahiry, Anirban, Starbuck, David C., Harrell, Andrew W., Georgiou, Alex, Hopchet, Nathalie, Gillies, Andy, Baker, Stephen J.

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2837. Impact of Regulatory Guidelines on Therapeutic, Clinical, and Microbiological Success Rates in Uncomplicated Urinary Tract Infection: Results from a Two Phase 3 Randomized Co... von Wagenlehner, Florian, Perry, Caroline R, Hooton, Thomas M, Scangarella-Oman, Nicole E, Millns, Helen, Jarvis, Emily, Dennison, Jeremy, Sheets, Amanda, Janmohamed, Salim

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2832. Gepotidacin Efficacy in E. coli Drug-Resistant Phenotypes: A Pooled Analysis of the EAGLE-2 and EAGLE-3 Randomized Controlled Trials in Uncomplicated Urinary Tract Infection von Hooton, Thomas M, Perry, Caroline R, Janmohamed, Salim, Sheets, Amanda, Dennison, Jeremy, Millns, Helen, Jarvis, Emily, Scangarella-Oman, Nicole E, Huang, Chun

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Amenamevir: Studies of Potential CYP3A‐Mediated Pharmacokinetic Interactions With Midazolam, Cyclosporine, and Ritonavir in Healthy Volunteers von Adeloye, Temitope, Sahgal, Omair, Puri, Adeep, Warrington, Steve, Endo, Takamasa, Dennison, Jeremy, Johnston, Atholl

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Amenamevir: Studies of Potential CYP2C8‐ and CYP2B6‐Mediated Pharmacokinetic Interactions With Montelukast and Bupropion in Healthy Volunteers von Dennison, Jeremy, Puri, Adeep, Warrington, Steven, Endo, Takamasa, Adeloye, Temitope, Johnston, Atholl

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P31 Efficacy and safety of oral gepotidacin in the treatment of uncomplicated urinary tract infection: results of two randomized, multicentre Phase 3 trials (EAGLE-2 and EAGLE-3) von Wagenlehner, Florian, Perry, Caroline R, Hooton, Thomas M, Scangarella-Oman, Nicole E, Millns, Helen, (Ed) Feng, Hwa-ping, Powell, Marcy, Jarvis, Emily, Dennison, Jeremy, Sheets, Amanda, Butler, Deborah, Breton, John, Janmohamed, Salim

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The British Society for Antimicrobial Chemotherapy Resistance Surveillance Project: a successful collaborative model von White, Anthony R.

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Processing of pro‐tumor necrosis factor‐α by venom metalloproteinases: A hypothesis explaining local tissue damage following snake bite von Moura‐da‐Silva, Ana Maria, Laing, Gavin David, Paine, Mark John Ingraham, Dennison, Jeremy Michael Thomas Jonathan, Politi, Vincenzo, Crampton, Julian Moray, Theakston, Robert David Geoffrey

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Long-term nutrient reductions lead to the unprecedented recovery of a temperate coastal region von Lefcheck, Jonathan S., Orth, Robert J., Dennison, William C., Wilcox, David J., Murphy, Rebecca R., Keisman, Jennifer, Gurbisz, Cassie, Hannam, Michael, Landry, J. Brooke, Moore, Kenneth A., Patrick, Christopher J., Testa, Jeremy, Weller, Donald E., Batiuk, Richard A.

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Rise of Ruppia in Chesapeake Bay: Climate change-driven turnover of foundation species creates new threats and management opportunities von Hensel, Marc J S, Patrick, Christopher J, Orth, Robert J, Wilcox, David J, Dennison, William C, Gurbisz, Cassie, Hannam, Michael P, Landry, J Brooke, Moore, Kenneth A, Murphy, Rebecca R, Testa, Jeremy M, Weller, Donald E, Lefcheck, Jonathan S

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Ecological Forecasting and the Science of Hypoxia in Chesapeake Bay von TESTA, JEREMY M., CLARK, J. BLAKE, DENNISON, WILLIAM C., DONOVAN, E. CAROLINE, FISHER, ALEXANDER W., NI, WENFEI, PARKER, MATTHEW, SCAVIA, DONALD, SPITZER, SUZANNE E., WALDROP, ANTHONY M., VARGAS, VANESSA M.D., ZIEGLER, GREGORY

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Abstract 1534 Identification of ERAD-dependent degrons for the endoplasmic reticulum lumen von Dortch, Jeremy, Sharninghausen, Rachel, Hwang, Jiwon, Dennison, Devon, Baldridge, Ryan

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Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift von Zhang, Yang, Garcia-Ibanez, Laura, Ulbricht, Carolin, Lok, Laurence S. C., Pike, Jeremy A., Mueller-Winkler, Jennifer, Dennison, Thomas W., Ferdinand, John R., Burnett, Cameron J. M., Yam-Puc, Juan C., Zhang, Lingling, Alfaro, Raul Maqueda, Takahama, Yousuke, Ohigashi, Izumi, Brown, Geoffrey, Kurosaki, Tomohiro, Tybulewicz, Victor L. J., Rot, Antal, Hauser, Anja E., Clatworthy, Menna R., Toellner, Kai-Michael

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