Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies von Zuchero, Y. Joy Yu, Chen, Xiaocheng, Bien-Ly, Nga, Bumbaca, Daniela, Tong, Raymond K., Gao, Xiaoying, Zhang, Shuo, Hoyte, Kwame, Luk, Wilman, Huntley, Melanie A., Phu, Lilian, Tan, Christine, Kallop, Dara, Weimer, Robby M., Lu, Yanmei, Kirkpatrick, Donald S., Ernst, James A., Chih, Ben, Dennis, Mark S., Watts, Ryan J.

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Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants von Bien-Ly, Nga, Yu, Y Joy, Bumbaca, Daniela, Elstrott, Justin, Boswell, C Andrew, Zhang, Yin, Luk, Wilman, Lu, Yanmei, Dennis, Mark S, Weimer, Robby M, Chung, Inhee, Watts, Ryan J

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An anti-CD3/anti–CLL-1 bispecific antibody for the treatment of acute myeloid leukemia von Leong, Steven R., Sukumaran, Siddharth, Hristopoulos, Maria, Totpal, Klara, Stainton, Shannon, Lu, Elizabeth, Wong, Alfred, Tam, Lucinda, Newman, Robert, Vuillemenot, Brian R., Ellerman, Diego, Gu, Chen, Mathieu, Mary, Dennis, Mark S., Nguyen, Allen, Zheng, Bing, Zhang, Crystal, Lee, Genee, Chu, Yu-Waye, Prell, Rodney A., Lin, Kedan, Laing, Steven T., Polson, Andrew G.

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Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index von Junutula, Jagath R, Mallet, William, Raab, Helga, Clark, Suzanna, Bhakta, Sunil, Leipold, Douglas D, Weir, Sylvia, Chen, Yvonne, Simpson, Michelle, Tsai, Siao Ping, Dennis, Mark S, Lu, Yanmei, Meng, Y Gloria, Ng, Carl, Yang, Jihong, Lee, Chien C, Duenas, Eileen, Gorrell, Jeffrey, Katta, Viswanatham, Kim, Amy, McDorman, Kevin, Flagella, Kelly, Venook, Rayna, Ross, Sarajane, Spencer, Susan D, Lee Wong, Wai, Lowman, Henry B, Vandlen, Richard, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul

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Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent von Merchant, Mark, Ma, Xiaolei, Maun, Henry R, Zheng, Zhong, Peng, Jing, Romero, Mally, Huang, Arthur, Yang, Nai-ying, Nishimura, Merry, Greve, Joan, Santell, Lydia, Zhang, Yu-Wen, Su, Yanli, Kaufman, Dafna W, Billeci, Karen L, Mai, Elaine, Moffat, Barbara, Lim, Amy, Duenas, Eileen T, Phillips, Heidi S, Xiang, Hong, Young, Judy C, Vande Woude, George F, Dennis, Mark S, Reilly, Dorothea E, Schwall, Ralph H, Starovasnik, Melissa A, Lazarus, Robert A, Yansura, Daniel G

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Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge von Maun, Henry R., Vij, Rajesh, Walters, Benjamin T., Morando, Ashley, Jackman, Janet K., Wu, Ping, Estevez, Alberto, Chen, Xiaocheng, Franke, Yvonne, Lipari, Michael T., Dennis, Mark S., Kirchhofer, Daniel, Ciferri, Claudio, Loyet, Kelly M., Yi, Tangsheng, Eigenbrot, Charles, Lazarus, Robert A., Koerber, James T.

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Albumin Binding as a General Strategy for Improving the Pharmacokinetics of Proteins von Dennis, Mark S, Zhang, Min, Meng, Y Gloria, Kadkhodayan, Miryam, Kirchhofer, Daniel, Combs, Dan, Damico, Lisa A

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An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer von Bhakta, Sunil, Crocker, Lisa M, Chen, Yvonne, Hazen, Meredith, Schutten, Melissa M, Li, Dongwei, Kuijl, Coenraad, Ohri, Rachana, Zhong, Fiona, Poon, Kirsten A, Go, Mary Ann T, Cheng, Eric, Piskol, Robert, Firestein, Ron, Fourie-O'Donohue, Aimee, Kozak, Katherine R, Raab, Helga, Hongo, Jo-Anne, Sampath, Deepak, Dennis, Mark S, Scheller, Richard H, Polakis, Paul, Junutula, Jagath R

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Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice von Brightbill, Hans D, Jeet, Surinder, Lin, Zhonghua, Yan, Donghong, Zhou, Meijuan, Tan, Martha, Nguyen, Allen, Yeh, Sherry, Delarosa, Donnie, Leong, Steven R, Wong, Terence, Chen, Yvonne, Ultsch, Mark, Luis, Elizabeth, Ramani, Sree Ranjani, Jackman, Janet, Gonzalez, Lino, Dennis, Mark S, Chuntharapai, Anan, DeForge, Laura, Meng, Y Gloria, Xu, Min, Eigenbrot, Charles, Lee, Wyne P, Refino, Canio J, Balazs, Mercedesz, Wu, Lawren C

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Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4 von Bumbaca, Daniela, Wong, Anne, Drake, Elizabeth, Reyes II, Arthur E., Lin, Benjamin C., Stephan, Jean-Philippe, Desnoyers, Luc, Shen, Ben-Quan, Dennis, Mark S.

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Function Blocking Antibodies to Neuropilin-1 Generated from a Designed Human Synthetic Antibody Phage Library von Liang, Wei-Ching, Dennis, Mark S., Stawicki, Scott, Chanthery, Yvan, Pan, Qi, Chen, Yongmei, Eigenbrot, Charles, Yin, JianPing, Koch, Alexander W., Wu, Xiumin, Ferrara, Napoleone, Bagri, Anil, Tessier-Lavigne, Marc, Watts, Ryan J., Wu, Yan

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Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice von Lo, Megan, Kim, Hok Seon, Tong, Raymond K., Bainbridge, Travis W., Vernes, Jean-Michel, Zhang, Yin, Lin, Yuwen Linda, Chung, Shan, Dennis, Mark S., Zuchero, Y. Joy Yu, Watts, Ryan J., Couch, Jessica A., Meng, Y. Gloria, Atwal, Jasvinder K., Brezski, Randall J., Spiess, Christoph, Ernst, James A.

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Bispecific antibodies for delivery into the brain von Watts, Ryan J, Dennis, Mark S

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Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation von Liao, Fan, Li, Aimin, Xiong, Monica, Bien-Ly, Nga, Jiang, Hong, Zhang, Yin, Finn, Mary Beth, Hoyle, Rosa, Keyser, Jennifer, Lefton, Katheryn B, Robinson, Grace O, Serrano, Javier Remolina, Silverman, Adam P, Guo, Jing L, Getz, Jennifer, Henne, Kirk, Leyns, Cheryl Eg, Gallardo, Gilbert, Ulrich, Jason D, Sullivan, Patrick M, Lerner, Eli Paul, Hudry, Eloise, Sweeney, Zachary K, Dennis, Mark S, Hyman, Bradley T, Watts, Ryan J, Holtzman, David M

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Relative Target Affinities of T-Cell-Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model von Mandikian, Danielle, Takahashi, Nene, Lo, Amy A, Li, Ji, Eastham-Anderson, Jeffrey, Slaga, Dionysos, Ho, Jason, Hristopoulos, Maria, Clark, Robyn, Totpal, Klara, Lin, Kedan, Joseph, Sean B, Dennis, Mark S, Prabhu, Saileta, Junttila, Teemu T, Boswell, C Andrew

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Peptide exosite inhibitors of factor VIIa as anticoagulants von Lazarus, Robert A, Dennis, Mark S, Eigenbrot, Charles, Skelton, Nicholas J, Ultsch, Mark H, Santell, Lydia, Dwyer, Mary A, O'Connell, Mark P

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Antitumor efficacy of a bispecific antibody that targets HER2 and activates T cells von Junttila, Teemu T, Li, Ji, Johnston, Jennifer, Hristopoulos, Maria, Clark, Robyn, Ellerman, Diego, Wang, Bu-Er, Li, Yijin, Mathieu, Mary, Li, Guangmin, Young, Judy, Luis, Elizabeth, Lewis Phillips, Gail, Stefanich, Eric, Spiess, Christoph, Polson, Andrew, Irving, Bryan, Scheer, Justin M, Junttila, Melissa R, Dennis, Mark S, Kelley, Robert, Totpal, Klara, Ebens, Allen

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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma von Maun, Henry R., Jackman, Janet K., Choy, David F., Loyet, Kelly M., Staton, Tracy L., Jia, Guiquan, Dressen, Amy, Hackney, Jason A., Bremer, Meire, Walters, Benjamin T., Vij, Rajesh, Chen, Xiaocheng, Trivedi, Neil N., Morando, Ashley, Lipari, Michael T., Franke, Yvonne, Wu, Xiumin, Zhang, Juan, Liu, John, Wu, Ping, Chang, Diana, Orozco, Luz D., Christensen, Erin, Wong, Manda, Corpuz, Racquel, Hang, Julie Q., Lutman, Jeff, Sukumaran, Siddharth, Wu, Yan, Ubhayakar, Savita, Liang, Xiaorong, Schwartz, Lawrence B., Babina, Magda, Woodruff, Prescott G., Fahy, John V., Ahuja, Rahul, Caughey, George H., Kusi, Aija, Dennis, Mark S., Eigenbrot, Charles, Kirchhofer, Daniel, Austin, Cary D., Wu, Lawren C., Koerber, James T., Lee, Wyne P., Yaspan, Brian L., Alatsis, Kathila R., Arron, Joseph R., Lazarus, Robert A., Yi, Tangsheng

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Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme von Arguello, Annie, Mahon, Cathal S, Calvert, Meredith E K, Chan, Darren, Dugas, Jason C, Pizzo, Michelle E, Thomsen, Elliot R, Chau, Roni, Damo, Lorna A, Duque, Joseph, Fang, Meng, Giese, Tina, Kim, Do Jin, Liang, Nicholas, Nguyen, Hoang N, Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Ullman, Julie C, Wang, Junhua, Dennis, Mark S, Diaz, Dolores, Gunasekaran, Kannan, Henne, Kirk R, Lewcock, Joseph W, Sanchez, Pascal E, Troyer, Matthew D, Harris, Jeffrey M, Scearce-Levie, Kimberly, Shan, Lu, Watts, Ryan J, Thorne, Robert G, Henry, Anastasia G, Kariolis, Mihalis S

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CD98hc is a target for brain delivery of biotherapeutics von Chew, Kylie S., Wells, Robert C., Moshkforoush, Arash, Chan, Darren, Lechtenberg, Kendra J., Tran, Hai L., Chow, Johann, Kim, Do Jin, Robles-Colmenares, Yaneth, Srivastava, Devendra B., Tong, Raymond K., Tong, Mabel, Xa, Kaitlin, Yang, Alexander, Zhou, Yinhan, Akkapeddi, Padma, Annamalai, Lakshman, Bajc, Kaja, Blanchette, Marie, Cherf, Gerald Maxwell, Earr, Timothy K., Gill, Audrey, Huynh, David, Joy, David, Knight, Kristen N., Lac, Diana, Leung, Amy Wing-Sze, Lexa, Katrina W., Liau, Nicholas P. D., Becerra, Isabel, Malfavon, Mario, McInnes, Joseph, Nguyen, Hoang N., Lozano, Edwin I., Pizzo, Michelle E., Roche, Elysia, Sacayon, Patricia, Calvert, Meredith E. K., Daneman, Richard, Dennis, Mark S., Duque, Joseph, Gadkar, Kapil, Lewcock, Joseph W., Mahon, Cathal S., Meisner, René, Solanoy, Hilda, Thorne, Robert G., Watts, Ryan J., Zuchero, Y. Joy Yu, Kariolis, Mihalis S.

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