Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth von Sun, Ramon C., Denko, Nicholas C.

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Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect von Chen, Yijun, Cairns, Rob, Papandreou, Ioanna, Koong, Albert, Denko, Nicholas C

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Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism von Benej, Martin, Hong, Xiangqian, Vibhute, Sandip, Scott, Sabina, Wu, Jinghai, Graves, Edward, Le, Quynh-Thu, Koong, Albert C., Giaccia, Amato J., Yu, Bing, Chen, Shih-Ching, Papandreou, Ioanna, Denko, Nicholas C.

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption von Papandreou, Ioanna, Cairns, Rob A., Fontana, Lucrezia, Lim, Ai Lin, Denko, Nicholas C.

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Identification of a Protein Mediating Respiratory Supercomplex Stability von Chen, Yu-Chan, Taylor, Eric B., Dephoure, Noah, Heo, Jin-Mi, Tonhato, Aline, Papandreou, Ioanna, Nath, Nandita, Denko, Nicolas C., Gygi, Steven P., Rutter, Jared

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Hypoxia, HIF1 and glucose metabolism in the solid tumour von Denko, Nicholas C

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HILPDA Regulates Lipid Metabolism, Lipid Droplet Abundance, and Response to Microenvironmental Stress in Solid Tumors von VandeKopple, Matthew J, Wu, Jinghai, Auer, Erich N, Giaccia, Amato J, Denko, Nicholas C, Papandreou, Ioanna

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Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L von Papandreou, I, Lim, A L, Laderoute, K, Denko, N C

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XBP1 is essential for survival under hypoxic conditions and is required for tumor growth von ROMERO-RAMIREZ, Lorenzo, HONGBIN CAO, LE, Quynh-Thu, KOONG, Albert C, NELSON, Daniel, HAMMOND, Ester, LEE, Ann-Hwee, YOSHIDA, Hiderou, MORI, Kazutoshi, GLIMCHER, Laurie H, DENKO, Nicholas C, GIACCIA, Amato J

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Comparative analysis of the tumor microbiome, molecular profiles, and immune cell abundances by HPV status in mucosal head and neck cancers and their impact on survival von Upadhyay, Rituraj, Dhakal, Aastha, Wheeler, Caroline, Hoyd, Rebecca, Jagjit Singh, Malvenderjit, Karivedu, Vidhya, Bhateja, Priyanka, Bonomi, Marcelo, Valentin, Sasha, Gamez, Mauricio E., Konieczkowski, David J., Baliga, Sujith, Grecula, John C., Blakaj, Dukagjin M., Gogineni, Emile, Mitchell, Darrion L., Denko, Nicholas C., Spakowicz, Daniel, Jhawar, Sachin R.

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Investigating hypoxic tumor physiology through gene expression patterns von Denko, Nicholas C, Fontana, Lucrezia A, Hudson, Karen M, Sutphin, Patrick D, Raychaudhuri, Soumya, Altman, Russ, Giaccia, Amato J

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Hypoxic adaptation of mitochondria and its impact on tumor cell function von Benej, Martin, Papandreou, Ioanna, Denko, Nicholas C.

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CA IX Stabilizes Intracellular pH to Maintain Metabolic Reprogramming and Proliferation in Hypoxia von Benej, Martin, Svastova, Eliska, Banova, Radivojka, Kopacek, Juraj, Gibadulinova, Adriana, Kery, Martin, Arena, Simona, Scaloni, Andrea, Vitale, Monica, Zambrano, Nicola, Papandreou, Ioanna, Denko, Nicholas C., Pastorekova, Silvia

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Association between Tumor Microbiome and Hypoxia across Anatomic Subsites of Head and Neck Cancers von Dhakal, Aastha, Upadhyay, Rituraj, Wheeler, Caroline, Hoyd, Rebecca, Karivedu, Vidhya, Gamez, Mauricio E, Valentin, Sasha, Vanputten, Meade, Bhateja, Priyanka, Bonomi, Marcelo, Konieczkowski, David J, Baliga, Sujith, Mitchell, Darrion L, Grecula, John C, Blakaj, Dukagjin M, Denko, Nicholas C, Jhawar, Sachin R, Spakowicz, Daniel

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Slit2-Mediated Metabolic Reprogramming in Bone Marrow-Derived Macrophages Enhances Antitumor Immunity von Kaul, Kirti, Benej, Martin, Mishra, Sanjay, Ahirwar, Dinesh K, Yadav, Marshleen, Stanford, Kristin I, Jacob, Naduparambil K, Denko, Nicholas C, Ganju, Ramesh K

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Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy von Cairns, Rob A, Papandreou, Ioanna, Sutphin, Patrick D, Denko, Nicholas C

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Hypoxia Links ATR and p53 through Replication Arrest von Hammond, Ester M., Denko, Nicholas C., Dorie, Mary Jo, Abraham, Robert T., Giaccia, Amato J.

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Unanticipated metabolic plasticity in response to chronic hypoxia von Papandreou, Ioanna, Benej, Martin, Denko, Nicholas C.

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Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth von Echeverri Ruiz, Nancy P, Mohan, Vijay, Wu, Jinghai, Scott, Sabina, Kreamer, McKenzie, Benej, Martin, Golias, Tereza, Papandreou, Ioanna, Denko, Nicholas C

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Tumor Hypoxia Blocks Wnt Processing and Secretion through the Induction of Endoplasmic Reticulum Stress von Verras, Meletios, Papandreou, Ioanna, Lim, Ai Lin, Denko, Nicholas C.

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