PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain von Dawicki-McKenna, Jennine M., Langelier, Marie-France, DeNizio, Jamie E., Riccio, Amanda A., Cao, Connie D., Karch, Kelly R., McCauley, Michael, Steffen, Jamin D., Black, Ben E., Pascal, John M.

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In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates von Musunuru, Kiran, Chadwick, Alexandra C., Mizoguchi, Taiji, Garcia, Sara P., DeNizio, Jamie E., Reiss, Caroline W., Wang, Kui, Iyer, Sowmya, Dutta, Chaitali, Clendaniel, Victoria, Amaonye, Michael, Beach, Aaron, Berth, Kathleen, Biswas, Souvik, Braun, Maurine C., Chen, Huei-Mei, Colace, Thomas V., Ganey, John D., Gangopadhyay, Soumyashree A., Garrity, Ryan, Kasiewicz, Lisa N., Lavoie, Jennifer, Madsen, James A., Matsumoto, Yuri, Mazzola, Anne Marie, Nasrullah, Yusuf S., Nneji, Joseph, Ren, Huilan, Sanjeev, Athul, Shay, Madeleine, Stahley, Mary R., Fan, Steven H. Y., Tam, Ying K., Gaudelli, Nicole M., Ciaramella, Giuseppe, Stolz, Leslie E., Malyala, Padma, Cheng, Christopher J., Rajeev, Kallanthottathil G., Rohde, Ellen, Bellinger, Andrew M., Kathiresan, Sekar

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Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells von Fraietta, Joseph A., Nobles, Christopher L., Sammons, Morgan A., Lundh, Stefan, Carty, Shannon A., Reich, Tyler J., Cogdill, Alexandria P., Morrissette, Jennifer J. D., DeNizio, Jamie E., Reddy, Shantan, Hwang, Young, Gohil, Mercy, Kulikovskaya, Irina, Nazimuddin, Farzana, Gupta, Minnal, Chen, Fang, Everett, John K., Alexander, Katherine A., Lin-Shiao, Enrique, Gee, Marvin H., Liu, Xiaojun, Young, Regina M., Ambrose, David, Wang, Yan, Xu, Jun, Jordan, Martha S., Marcucci, Katherine T., Levine, Bruce L., Garcia, K. Christopher, Zhao, Yangbing, Kalos, Michael, Porter, David L., Kohli, Rahul M., Lacey, Simon F., Berger, Shelley L., Bushman, Frederic D., June, Carl H., Melenhorst, J. Joseph

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Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase von Schutsky, Emily K, DeNizio, Jamie E, Hu, Peng, Liu, Monica Yun, Nabel, Christopher S, Fabyanic, Emily B, Hwang, Young, Bushman, Frederic D, Wu, Hao, Kohli, Rahul M

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Functionally distinct roles for TET-oxidized 5-methylcytosine bases in somatic reprogramming to pluripotency von Caldwell, Blake A., Liu, Monica Yun, Prasasya, Rexxi D., Wang, Tong, DeNizio, Jamie E., Leu, N. Adrian, Amoh, Nana Yaa A., Krapp, Christopher, Lan, Yemin, Shields, Emily J., Bonasio, Roberto, Lengner, Christopher J., Kohli, Rahul M., Bartolomei, Marisa S.

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TET-TDG Active DNA Demethylation at CpG and Non-CpG Sites von DeNizio, Jamie E., Dow, Blaine J., Serrano, Juan C., Ghanty, Uday, Drohat, Alexander C., Kohli, Rahul M.

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APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA von Schutsky, Emily K, Nabel, Christopher S, Davis, Amy K F, DeNizio, Jamie E, Kohli, Rahul M

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Exploiting Substrate Promiscuity To Develop Activity-Based Probes for Ten-Eleven Translocation Family Enzymes von Ghanty, Uday, DeNizio, Jamie E, Liu, Monica Yun, Kohli, Rahul M

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Both tails and the centromere targeting domain of CENP-A are required for centromere establishment von Logsdon, Glennis A, Barrey, Evelyne J, Bassett, Emily A, DeNizio, Jamie E, Guo, Lucie Y, Panchenko, Tanya, Dawicki-McKenna, Jennine M, Heun, Patrick, Black, Ben E

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Selectivity and Promiscuity in TET-Mediated Oxidation of 5‑Methylcytosine in DNA and RNA von DeNizio, Jamie E, Liu, Monica Yun, Leddin, Emmett M, Cisneros, G. Andrés, Kohli, Rahul M

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BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia von Kong, Weimin, Dimitri, Alexander, Wang, Wenliang, Jung, In-Young, Ott, Christopher J, Fasolino, Maria, Wang, Yan, Kulikovskaya, Irina, Gupta, Minnal, Yoder, Todd, DeNizio, Jamie E, Everett, John K, Williams, Erik F, Xu, Jun, Scholler, John, Reich, Tyler J, Bhoj, Vijay G, Haines, Kathleen M, Maus, Marcela V, Melenhorst, J. Joseph, Young, Regina M, Jadlowsky, Julie K, Marcucci, Katherine T, Bradner, James E, Levine, Bruce L, Porter, David L, Bushman, Frederic D, Kohli, Rahul M, June, Carl H, Davis, Megan M, Lacey, Simon F, Vahedi, Golnaz, Fraietta, Joseph A

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Direct enzymatic sequencing of 5-methylcytosine at single-base resolution von Wang, Tong, Fowler, Johanna M., Liu, Laura, Loo, Christian E., Luo, Meiqi, Schutsky, Emily K., Berríos, Kiara N., DeNizio, Jamie E., Dvorak, Ashley, Downey, Nick, Montermoso, Saira, Pingul, Bianca Y., Nasrallah, MacLean, Gosal, Walraj S., Wu, Hao, Kohli, Rahul M.

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Tuning Hsp104 specificity to selectively detoxify α-synuclein von Mack, Korrie L., Kim, Hanna, Barbieri, Edward M., Lin, JiaBei, Braganza, Sylvanne, Jackrel, Meredith E., DeNizio, Jamie E., Yan, Xiaohui, Chuang, Edward, Tariq, Amber, Cupo, Ryan R., Castellano, Laura M., Caldwell, Kim A., Caldwell, Guy A., Shorter, James

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Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine von Liu, Monica Yun, Torabifard, Hedieh, Crawford, Daniel J, DeNizio, Jamie E, Cao, Xing-Jun, Garcia, Benjamin A, Cisneros, G Andrés, Kohli, Rahul M

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Harnessing natural DNA modifying activities for editing of the genome and epigenome von DeNizio, Jamie E, Schutsky, Emily K, Berrios, Kiara N, Liu, Monica Yun, Kohli, Rahul M

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The expanding scope and impact of epigenetic cytosine modifications von Liu, Monica Yun, DeNizio, Jamie E, Schutsky, Emily K, Kohli, Rahul M

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Identification and interrogation of combinatorial histone modifications von Karch, Kelly R, Denizio, Jamie E, Black, Ben E, Garcia, Benjamin A

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DNA Methyltransferases Demonstrate Reduced Activity against Arabinosylcytosine: Implications for Epigenetic Instability in Acute Myeloid Leukemia von Nabel, Christopher S, DeNizio, Jamie E, Carroll, Martin, Kohli, Rahul M

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HJURP Uses Distinct CENP-A Surfaces to Recognize and to Stabilize CENP-A/Histone H4 for Centromere Assembly von Bassett, Emily A., DeNizio, Jamie, Barnhart-Dailey, Meghan C., Panchenko, Tanya, Sekulic, Nikolina, Rogers, Danielle J., Foltz, Daniel R., Black, Ben E.

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DAXX co-folds with H3.3/H4 using high local stability conferred by the H3.3 variant recognition residues von DeNizio, Jamie E, Elsässer, Simon J, Black, Ben E

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