Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness von Stokes, Barbara H., Dhingra, Satish K., Rubiano, Kelly, Mok, Sachel, Straimer, Judith, Gnadig, Nina F., Deni, Ioanna, Schindler, Kyra A., Bath, Jade R., Ward, Kurt E., Striepen, Josefine, Yeo, Tomas, Ross, Leila S., Legrand, Eric, Ariey, Frederic, Cunningham, Clark H., Souleymane, Issa M., Gansane, Adama, Nzoumbou-Boko, Romaric, Ndayikunda, Claudette, Kabanywanyi, Abdunoor M., Uwimana, Aline, Smith, Samuel J., Kolley, Olimatou, Ndounga, Mathieu, Warsame, Marian, Leang, Rithea, Nosten, Francois, Anderson, Timothy J. C., Rosenthal, Philip J., Menard, Didier, Fidock, David A.

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Genomic and Genetic Approaches to Studying Antimalarial Drug Resistance and Plasmodium Biology von Okombo, John, Kanai, Mariko, Deni, Ioanna, Fidock, David A.

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Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance von Small-Saunders, Jennifer L, Hagenah, Laura M, Wicht, Kathryn J, Dhingra, Satish K, Deni, Ioanna, Kim, Jonathan, Vendome, Jeremie, Gil-Iturbe, Eva, Roepe, Paul D, Mehta, Monica, Mancia, Filippo, Quick, Matthias, Eppstein, Margaret J, Fidock, David A

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Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose... von Barber, Bridget E, Fernandez, Melissa, Patel, Hardik Babubhai, Barcelo, Catalina, Woolley, Stephen D, Patel, Harilal, Llewellyn, Stacey, Abd-Rahman, Azrin N, Sharma, Sunil, Jain, Mukul, Ghoghari, Ashok, Di Resta, Ilaria, Fuchs, Aline, Deni, Ioanna, Yeo, Tomas, Mok, Sachel, Fidock, David A, Chalon, Stephan, Möhrle, Jörg J, Parmar, Deven, McCarthy, James S, Kansagra, Kevinkumar

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Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series von Palmer, Michael J, Deng, Xiaoyi, Watts, Shawn, Krilov, Goran, Gerasyuto, Aleksey, Kokkonda, Sreekanth, El Mazouni, Farah, White, John, White, Karen L, Striepen, Josefine, Bath, Jade, Schindler, Kyra A, Yeo, Tomas, Shackleford, David M, Mok, Sachel, Deni, Ioanna, Lawong, Aloysus, Huang, Ann, Chen, Gong, Wang, Wen, Jayaseelan, Jaya, Katneni, Kasiram, Patil, Rahul, Saunders, Jessica, Shahi, Shatrughan P, Chittimalla, Rajesh, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Wittlin, Sergio, Tumwebaze, Patrick K, Rosenthal, Philip J, Cooper, Roland A, Aguiar, Anna Caroline Campos, Guido, Rafael V. C, Pereira, Dhelio B, Mittal, Nimisha, Winzeler, Elizabeth A, Tomchick, Diana R, Laleu, Benoît, Burrows, Jeremy N, Rathod, Pradipsinh K, Fidock, David A, Charman, Susan A, Phillips, Margaret A

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Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum von Lawong, Aloysus, Gahalawat, Suraksha, Okombo, John, Striepen, Josefine, Yeo, Tomas, Mok, Sachel, Deni, Ioanna, Bridgford, Jessica L, Niederstrasser, Hanspeter, Zhou, Anwu, Posner, Bruce, Wittlin, Sergio, Gamo, Francisco Javier, Crespo, Benigno, Churchyard, Alisje, Baum, Jake, Mittal, Nimisha, Winzeler, Elizabeth, Laleu, Benoît, Palmer, Michael J, Charman, Susan A, Fidock, David A, Ready, Joseph M, Phillips, Margaret A

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Identification of Abundant and Evolutionarily Conserved Opioid Receptor Circular RNAs in the Nervous System Modulated by Morphine von Irie, Takeshi, Shum, Rebecca, Deni, Ioanna, Hunkele, Amanda, Le Rouzic, Valerie, Xu, Jin, Wilson, Roger, Fischer, Gregory W, Pasternak, Gavril W, Pan, Ying-Xian

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Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3 von Calic, Petar P.S., Ashton, Trent D., Mansouri, Mahta, Loi, Katie, Jarman, Kate E., Qiu, Deyun, Lehane, Adele M., Roy, Sayantan, Rao, Gunturu P., Maity, Bikash, Wittlin, Sergio, Crespo, Benigno, Gamo, Franciso-Javier, Deni, Ioanna, Fidock, David A., Chowdury, Mrittika, de Koning-Ward, Tania F., Cowman, Alan F., Jackson, Paul F., Baud, Delphine, Brand, Stephen, Laleu, Benoît, Sleebs, Brad E.

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Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome von Deni, Ioanna, Stokes, Barbara H., Ward, Kurt E., Fairhurst, Kate J., Pasaje, Charisse Flerida A., Yeo, Tomas, Akbar, Shirin, Park, Heekuk, Muir, Ryan, Bick, Daniella S., Zhan, Wenhu, Zhang, Hao, Liu, Yi Jing, Ng, Caroline L., Kirkman, Laura A., Almaliti, Jehad, Gould, Alexandra E., Duffey, Maëlle, O'Donoghue, Anthony J., Uhlemann, Anne-Catrin, Niles, Jacquin C., da Fonseca, Paula C.A., Gerwick, William H., Lin, Gang, Bogyo, Matthew, Fidock, David A.

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The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance von Murithi, James M., Deni, Ioanna, Pasaje, Charisse Flerida A., Okombo, John, Bridgford, Jessica L., Gnädig, Nina F., Edwards, Rachel L., Yeo, Tomas, Mok, Sachel, Burkhard, Anna Y., Coburn-Flynn, Olivia, Istvan, Eva S., Sakata-Kato, Tomoyo, Gomez-Lorenzo, Maria G., Cowell, Annie N., Wicht, Kathryn J., Le Manach, Claire, Kalantarov, Gavreel F., Dey, Sumanta, Duffey, Maëlle, Laleu, Benoît, Lukens, Amanda K., Ottilie, Sabine, Vanaerschot, Manu, Trakht, Ilya N., Gamo, Francisco-Javier, Wirth, Dyann F., Goldberg, Daniel E., Odom John, Audrey R., Chibale, Kelly, Winzeler, Elizabeth A., Niles, Jacquin C., Fidock, David A.

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Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome von Xie, Stanley C., Metcalfe, Riley D., Mizutani, Hirotake, Puhalovich, Tanya, Hanssen, Eric, Morton, Craig J., Du, Yawei, Dogovski, Con, Huang, Shih-Chung, Ciavarri, Jeffrey, Hales, Paul, Griffin, Robert J., Cohen, Lawrence H., Chuang, Bei-Ching, Wittlin, Sergio, Deni, Ioanna, Yeo, Tomas, Ward, Kurt E., Barry, Daniel C., Liu, Boyin, Gillett, David L., Crespo-Fernandez, Benigno F., Ottilie, Sabine, Mittal, Nimisha, Churchyard, Alisje, Ferguson, Daniel, Aguiar, Anna Caroline C., Guido, Rafael V. C., Baum, Jake, Hanson, Kirsten K., Winzeler, Elizabeth A., Gamo, Francisco-Javier, Fidock, David A., Baud, Delphine, Parker, Michael W., Brand, Stephen, Dick, Lawrence R., Griffin, Michael D. W., Gould, Alexandra E., Tilley, Leann

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Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum von Lawong, Aloysus, Gahalawat, Suraksha, Okombo, John, Striepen, Josefine, Yeo, Tomas, Mok, Sachel, Deni, Ioanna, Bridgford, Jessica L., Niederstrasser, Hanspeter, Zhou, Anwu, Posner, Bruce, Wittlin, Sergio, Gamo, Francisco Javier, Crespo, Benigno, Churchyard, Alisje, Baum, Jake, Mittal, Nimisha, Winzeler, Elizabeth, Laleu, Benoît, Palmer, Michael J., Charman, Susan A., Fidock, David A., Ready, Joseph M., Phillips, Margaret A.

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