Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection von Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

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Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL von Blombery, Piers, Lew, Thomas E., Dengler, Michael A., Thompson, Ella R., Lin, Victor S., Chen, Xiangting, Nguyen, Tamia, Panigrahi, Ashish, Handunnetti, Sasanka M., Carney, Dennis A., Westerman, David A., Tam, Constantine S., Adams, Jerry M., Wei, Andrew H., Huang, David C.S., Seymour, John F., Roberts, Andrew W., Anderson, Mary Ann

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p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin von Gutekunst, Matthias, Oren, Moshe, Weilbacher, Andrea, Dengler, Michael A, Markwardt, Christiane, Thomale, Jürgen, Aulitzky, Walter E, van der Kuip, Heiko

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Imaging of myocardial infarction using ultrasmall superparamagnetic iron oxide nanoparticles: a human study using a multi-parametric cardiovascular magnetic resonance imaging appro... von Yilmaz, Ali, Dengler, Michael A, van der Kuip, Heiko, Yildiz, Handan, Rösch, Sabine, Klumpp, Siegfried, Klingel, Karin, Kandolf, Reinhard, Helluy, Xavier, Hiller, Karl-Heinz, Jakob, Peter M, Sechtem, Udo

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BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association von Dengler, Michael A., Robin, Adeline Y., Gibson, Leonie, Li, Mark X., Sandow, Jarrod J., Iyer, Sweta, Webb, Andrew I., Westphal, Dana, Dewson, Grant, Adams, Jerry M.

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BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove von Li, Mark Xiang, Tan, Iris K. L., Ma, Stephen B., Hockings, Colin, Kratina, Tobias, Dengler, Michael A., Alsop, Amber E., Kluck, Ruth M., Dewson, Grant

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Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities von Grabow, Stephanie, Kueh, Andrew J., Ke, Francine, Vanyai, Hannah K., Sheikh, Bilal N., Dengler, Michael A., Chiang, William, Eccles, Samantha, Smyth, Ian M., Jones, Lynelle K., de Sauvage, Frederic J., Scott, Mark, Whitehead, Lachlan, Voss, Anne K., Strasser, Andreas

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Non-coding RNAs and ferroptosis: potential implications for cancer therapy von Balihodzic, Amar, Prinz, Felix, Dengler, Michael A., Calin, George A., Jost, Philipp J., Pichler, Martin

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Cisplatin Hypersensitivity of Testicular Germ Cell Tumors Is Determined by High Constitutive Noxa Levels Mediated by Oct-4 von GUTEKUNST, Matthias, MUELLER, Thomas, WEILBACHER, Andrea, DENGLER, Michael A, BEDKE, Jens, KRUCK, Stephan, OREN, Moshe, AULITZKY, Walter E, VAN DER KUIP, Heiko

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Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis von Dengler, Michael A, Staiger, Annette M, Gutekunst, Matthias, Hofmann, Ute, Doszczak, Malgorzata, Scheurich, Peter, Schwab, Matthias, Aulitzky, Walter E, van der Kuip, Heiko

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BAX mitochondrial integration is regulated allosterically by its α1−α2 loop von Dengler, Michael A., Gibson, Leonie, Adams, Jerry M.

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Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice von Pymm, Phillip, Adair, Amy, Chan, Li-Jin, Cooney, James P., Mordant, Francesca L., Allison, Cody C., Lopez, Ester, Haycroft, Ebene R., O’Neill, Matthew T., Tan, Li Lynn, Dietrich, Melanie H., Drew, Damien, Doerflinger, Marcel, Dengler, Michael A., Scott, Nichollas E., Wheatley, Adam K., Gherardin, Nicholas A., Venugopal, Hariprasad, Cromer, Deborah, Davenport, Miles P., Pickering, Raelene, Godfrey, Dale I., Purcell, Damian F. J., Kent, Stephen J., Chung, Amy W., Subbarao, Kanta, Pellegrini, Marc, Glukhova, Alisa, Tham, Wai-Hong

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Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia von Moujalled, Donia M., Brown, Fiona C., Chua, Chong Chyn, Dengler, Michael A., Pomilio, Giovanna, Anstee, Natasha S., Litalien, Veronique, Thompson, Ella, Morley, Thomas, MacRaild, Sarah, Tiong, Ing S., Morris, Rhiannon, Dun, Karen, Zordan, Adrian, Shah, Jaynish, Banquet, Sebastien, Halilovic, Ensar, Morris, Erick, Herold, Marco J., Lessene, Guillaume, Adams, Jerry M., Huang, David C. S., Roberts, Andrew W., Blombery, Piers, Wei, Andrew H.

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Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias von Thijssen, Rachel, Diepstraten, Sarah T., Moujalled, Donia, Chew, Edward, Flensburg, Christoffer, Shi, Melissa X., Dengler, Michael A., Litalien, Veronique, MacRaild, Sarah, Chen, Maoshan, Anstee, Natasha S., Reljić, Boris, Gabriel, Sarah S., Djajawi, Tirta M., Riffkin, Chris D., Aubrey, Brandon J., Chang, Catherine, Tai, Lin, Xu, Zhen, Morley, Thomas, Pomilio, Giovanna, Bruedigam, Claudia, Kallies, Axel, Stroud, David A., Bajel, Ashish, Kluck, Ruth M., Lane, Steven W., Schoumacher, Marie, Banquet, Sébastien, Majewski, Ian J., Strasser, Andreas, Roberts, Andrew W., Huang, David C.S., Brown, Fiona C., Kelly, Gemma L., Wei, Andrew H.

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The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner von Meinhardt, Anna-Lena, Munkhbaatar, Enkhtsetseg, Höckendorf, Ulrike, Dietzen, Michelle, Dechant, Marta, Anton, Martina, Jacob, Anne, Steiger, Katja, Weichert, Wilko, Brcic, Luka, McGranahan, Nicholas, Branca, Caterina, Kaufmann, Thomas, Dengler, Michael A., Jost, Philipp J.

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Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma von Dengler, Michael A., Teh, Charis E., Thijssen, Rachel, Gangoda, Lahiru, Lan, Ping, Herold, Marco J., Gray, Daniel H., Kelly, Gemma L., Roberts, Andrew W., Adams, Jerry M.

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Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target von Iyer, Sweta, Uren, Rachel T., Dengler, Michael A., Shi, Melissa X., Uno, Etsuko, Adams, Jerry M., Dewson, Grant, Kluck, Ruth M.

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Characterization of a novel human BFL-1-specific monoclonal antibody von Gangoda, Lahiru, Teh, Charis E., Dengler, Michael A., Best, Sarah A., Weeden, Clare E., Tai, Lin, Lee, Erinna F., Fairlie, Walter D., Sutherland, Kate D., Harrison, Leonard C., Gray, Daniel H., Strasser, Andreas, Herold, Marco J.

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The Flavonoid Brusatol Induces Apoptosis in Aggressive Lymphoma Cells and Exhibits Synergistic Effect with Venetoclax von Szmyra, Marta M., Haingartner, Sandra, Jantscher, Sonja, Pansy, Katrin, Uhl, Barbara, Greinix, Hildegard T., Neumeister, Peter, Bernhart, Eva, Beham-Schmid, Christine, Dengler, Michael A., Klösch, Burkhard, Deutsch, Alexander J.A.

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BAX-Mutated Clonal Hematopoiesis in Patients on Long-Term Venetoclax for Relapsed/Refractory Chronic Lymphocytic Leukemia von Blombery, Piers, Thompson, Ella R, Chen, Xiangting, Nguyen, Tamia, Anderson, Mary Ann, Westerman, David Alan, Seymour, John F., Tam, Constantine S., Dengler, Michael A, Huang, David C.S., Wei, Andrew, Roberts, Andrew W

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