Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy von Jiang, Hong, Hegde, Samarth, DeNardo, David G.

Volltext

A framework for advancing our understanding of cancer-associated fibroblasts von Sahai, Erik, Astsaturov, Igor, Cukierman, Edna, DeNardo, David G., Egeblad, Mikala, Evans, Ronald M., Fearon, Douglas, Greten, Florian R., Hingorani, Sunil R., Hunter, Tony, Hynes, Richard O., Jain, Rakesh K., Janowitz, Tobias, Jorgensen, Claus, Kimmelman, Alec C., Kolonin, Mikhail G., Maki, Robert G., Powers, R. Scott, Puré, Ellen, Ramirez, Daniel C., Scherz-Shouval, Ruth, Sherman, Mara H., Stewart, Sheila, Tlsty, Thea D., Tuveson, David A., Watt, Fiona M., Weaver, Valerie, Weeraratna, Ashani T., Werb, Zena

Volltext

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy von Jiang, Hong, Hegde, Samarth, Knolhoff, Brett L, Zhu, Yu, Herndon, John M, Meyer, Melissa A, Nywening, Timothy M, Hawkins, William G, Shapiro, Irina M, Weaver, David T, Pachter, Jonathan A, Wang-Gillam, Andrea, DeNardo, David G

Volltext

Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer von Hegde, Samarth, Krisnawan, Varintra E., Herzog, Brett H., Zuo, Chong, Breden, Marcus A., Knolhoff, Brett L., Hogg, Graham D., Tang, Jack P., Baer, John M., Mpoy, Cedric, Lee, Kyung Bae, Alexander, Katherine A., Rogers, Buck E., Murphy, Kenneth M., Hawkins, William G., Fields, Ryan C., DeSelm, Carl J., Schwarz, Julie K., DeNardo, David G.

Volltext

Macrophages as regulators of tumour immunity and immunotherapy von DeNardo, David G., Ruffell, Brian

Volltext

Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity von DeNardo, David G., Andreu, Pauline, Coussens, Lisa M.

Volltext

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-... von Nywening, Timothy M, MD, Wang-Gillam, Andrea, MD, Sanford, Dominic E, MD, Belt, Brian A, MA, Panni, Roheena Z, MD, Cusworth, Brian M, BA, Toriola, Adetunji T, MD, Nieman, Rebecca K, MS, Worley, Lori A, BS, Yano, Motoyo, MD, Fowler, Kathryn J, MD, Lockhart, A Craig, MD, Suresh, Rama, MD, Tan, Benjamin R, MD, Lim, Kian-Huat, MD, Fields, Ryan C, MD, Strasberg, Steven M, Prof, Hawkins, William G, Prof, DeNardo, David G, PhD, Goedegebuure, S Peter, PhD, Linehan, David C, Dr Prof

Volltext

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis von Ruhland, Megan K., Loza, Andrew J., Capietto, Aude-Helene, Luo, Xianmin, Knolhoff, Brett L., Flanagan, Kevin C., Belt, Brian A., Alspach, Elise, Leahy, Kathleen, Luo, Jingqin, Schaffer, Andras, Edwards, John R., Longmore, Gregory, Faccio, Roberta, DeNardo, David G., Stewart, Sheila A.

Volltext

Rethinking immune checkpoint blockade: ‘Beyond the T cell’ von Liu, Xiuting, Hogg, Graham D, DeNardo, David G

Volltext

Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression von DeNardo, David G, Coussens, Lisa M

Volltext

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses von MITCHEM, Jonathan B, BRENNAN, Donal J, HEWITT, Stephen, MALLYA UDUPI, Girish, GALLAGHER, William M, WEGNER, Craig, WEST, Brian L, WANG-GILLAM, Andrea, GOEDEGEBUURE, Peter, LINEHAN, David C, DENARDO, David G, KNOLHOFF, Brett L, BELT, Brian A, YU ZHU, SANFORD, Dominic E, BELAYGOROD, Larisa, CARPENTER, Danielle, COLLINS, Lynne, PIWNICA-WORMS, David

Volltext

Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance von Meyer, Melissa A., Baer, John M., Knolhoff, Brett L., Nywening, Timothy M., Panni, Roheena Z., Su, Xinming, Weilbaecher, Katherine N., Hawkins, William G., Ma, Cynthia, Fields, Ryan C., Linehan, David C., Challen, Grant A., Faccio, Roberta, Aft, Rebecca L., DeNardo, David G.

Volltext

Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis von SANFORD, Dominic E, BELT, Brian A, WANG-GILLAM, Andrea, EBERLEIN, Timothy J, DENARDO, David G, GOEDEGEBUURE, Simon Peter, LINEHAN, David C, PANNI, Roheena Z, MAYER, Allese, DESHPANDE, Anjali D, CARPENTER, Danielle, MITCHEM, Jonathan B, PLAMBECK-SUESS, Stacey M, WORLEY, Lori A, GOETZ, Brian D

Volltext

Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer von D'Amico, Lucia, Mahajan, Sahil, Capietto, Aude-Hélène, Yang, Zhengfeng, Zamani, Ali, Ricci, Biancamaria, Bumpass, David B, Meyer, Melissa, Su, Xinming, Wang-Gillam, Andrea, Weilbaecher, Katherine, Stewart, Sheila A, DeNardo, David G, Faccio, Roberta

Volltext

Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy von DeNardo, David G, Brennan, Donal J, Rexhepaj, Elton, Ruffell, Brian, Shiao, Stephen L, Madden, Stephen F, Gallagher, William M, Wadhwani, Nikhil, Keil, Scott D, Junaid, Sharfaa A, Rugo, Hope S, Hwang, E Shelley, Jirström, Karin, West, Brian L, Coussens, Lisa M

Volltext

The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis von Corsa, Callie A.S., Brenot, Audrey, Grither, Whitney R., Van Hove, Samantha, Loza, Andrew J., Zhang, Kun, Ponik, Suzanne M., Liu, Yuming, DeNardo, David G., Eliceiri, Kevin W., Keely, Patricia J., Longmore, Gregory D.

Volltext

Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer von Panni, Roheena Z., Sanford, Dominic E., Belt, Brian A., Mitchem, Jonathan B., Worley, Lori A., Goetz, Brian D., Mukherjee, Pinku, Wang-Gillam, Andrea, Link, Daniel C., DeNardo, David G., Goedegebuure, S. Peter, Linehan, David C.

Volltext

Polarized immune responses differentially regulate cancer development von Johansson, Magnus, DeNardo, David G, Coussens, Lisa M

Volltext

Recruitment of CCR2+ tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer von Grossman, Julie G, Nywening, Timothy M, Belt, Brian A, Panni, Roheena Z, Krasnick, Bradley A, DeNardo, David G, Hawkins, William G, Goedegebuure, S Peter, Linehan, David C, Fields, Ryan C

Volltext

Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors von Uzhachenko, Roman V., Bharti, Vijaya, Ouyang, Zhufeng, Blevins, Ashlyn, Mont, Stacey, Saleh, Nabil, Lawrence, Hunter A., Shen, Chengli, Chen, Sheau-Chiann, Ayers, Gregory D., DeNardo, David G., Arteaga, Carlos, Richmond, Ann, Vilgelm, Anna E.

Volltext