An introduction to experimental surgical studies von Dempster, William James

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Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects von Dempster, Joshua M, Boyle, Isabella, Vazquez, Francisca, Root, David E, Boehm, Jesse S, Hahn, William C, Tsherniak, Aviad, McFarland, James M

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Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration von McFarland, James M., Ho, Zandra V., Kugener, Guillaume, Dempster, Joshua M., Montgomery, Phillip G., Bryan, Jordan G., Krill-Burger, John M., Green, Thomas M., Vazquez, Francisca, Boehm, Jesse S., Golub, Todd R., Hahn, William C., Root, David E., Tsherniak, Aviad

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Resilience, burnout and coping mechanisms in UK doctors: a cross-sectional study von McKinley, Nicola, McCain, R Scott, Convie, Liam, Clarke, Mike, Dempster, Martin, Campbell, William Jeffrey, Kirk, Stephen James

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Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal von Krill-Burger, J. Michael, Dempster, Joshua M., Borah, Ashir A., Paolella, Brenton R., Root, David E., Golub, Todd R., Boehm, Jesse S., Hahn, William C., McFarland, James M., Vazquez, Francisca, Tsherniak, Aviad

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A first-generation pediatric cancer dependency map von Dharia, Neekesh V., Kugener, Guillaume, Guenther, Lillian M., Malone, Clare F., Durbin, Adam D., Hong, Andrew L., Howard, Thomas P., Bandopadhayay, Pratiti, Wechsler, Caroline S., Fung, Iris, Warren, Allison C., Dempster, Joshua M., Krill-Burger, John M., Paolella, Brenton R., Moh, Phoebe, Jha, Nishant, Tang, Andrew, Montgomery, Philip, Boehm, Jesse S., Hahn, William C., Roberts, Charles W. M., McFarland, James M., Tsherniak, Aviad, Golub, Todd R., Vazquez, Francisca, Stegmaier, Kimberly

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Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection von Pardiñas, Antonio F., Holmans, Peter, Pocklington, Andrew J., Escott-Price, Valentina, Ripke, Stephan, Carrera, Noa, Legge, Sophie E., Bishop, Sophie, Cameron, Darren, Hamshere, Marian L., Han, Jun, Hubbard, Leon, Lynham, Amy, Mantripragada, Kiran, Rees, Elliott, MacCabe, James H., McCarroll, Steven A., Baune, Bernhard T., Breen, Gerome, Byrne, Enda M., Dannlowski, Udo, Eley, Thalia C., Hayward, Caroline, Martin, Nicholas G., McIntosh, Andrew M., Plomin, Robert, Porteous, David J., Wray, Naomi R., Caballero, Armando, Geschwind, Daniel H., Huckins, Laura M., Ruderfer, Douglas M., Santiago, Enrique, Sklar, Pamela, Stahl, Eli A., Won, Hyejung, Agerbo, Esben, Als, Thomas D., Andreassen, Ole A., Bækvad-Hansen, Marie, Mortensen, Preben Bo, Pedersen, Carsten Bøcker, Børglum, Anders D., Bybjerg-Grauholm, Jonas, Djurovic, Srdjan, Durmishi, Naser, Pedersen, Marianne Giørtz, Golimbet, Vera, Grove, Jakob, Hougaard, David M., Mattheisen, Manuel, Molden, Espen, Mors, Ole, Nordentoft, Merete, Pejovic-Milovancevic, Milica, Sigurdsson, Engilbert, Silagadze, Teimuraz, Hansen, Christine Søholm, Stefansson, Kari, Stefansson, Hreinn, Steinberg, Stacy, Tosato, Sarah, Werge, Thomas, Collier, David A., Rujescu, Dan, Kirov, George, Owen, Michael J., O’Donovan, Michael C., Walters, James T. R.

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Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations von Lorenzini, Tiziana, Fliegauf, Manfred, Klammer, Nils, Proietti, Michele, Bulashevska, Alla, Schejter, Yael D., Atschekzei, Faranaz, Stepensky, Polina, Pedroza, Luis A., van der Flier, Michiel, Martínez-Gallo, Mónica, Svec, Peter, Fischer, Ute, Ip, Winnie, Geha, Raif, Chou, Janet, Alosaimi, Mohammed, Weintraub, Lauren, Dos Santos Vilela, Maria Marluce, Holzinger, Dirk, Seidl, Maximilian, Lougaris, Vassilios, Plebani, Alessandro, Abolhassani, Hassan, Thaventhiran, James E., Warnatz, Klaus, Grimbacher, Bodo, Ashford, Sofie, Bacchelli, Chiara, Batista, Joana, Bibi, Shahnaz, Boardman, Barbara, Booth, Claire, Breen, Gerome, Burns, Siobhan O., Burren, Oliver S., Carss, Keren, Chambers, John, Cooper, Nichola, Davies, E.G., Dempster, John, Dewhurst, Eleanor F., Drewe, Elizabeth, Duarte, Daniel, Edgar, J. David M., Egner, William, El-Shanawany, Tariq, Erwood, Marie, Fox, James, Frontini, Mattia, Furnell, Abigail, Gaspar, H. Bobby, Gleadall, Nicholas S., Grigoriadou, Sofia, Hackett, Scott, Hague, Rosie, Haimel, Matthias, Hayman, Grant, Hu, Fengyuan, Huissoon, Aarnoud P., Jolles, Stephen, Kasanicki, Mary A., Kelleher, Peter, Klein, Nigel, Kreuzhuber, Roman, Kuijpers, Taco W., Kumararatne, Dinakantha, Allen, Hana Lango, Linger, Rachel, Lorenzo, Lorena E., Maimaris, Jesmeen, Martin, Jennifer, McDermott, Elizabeth M., Meacham, Stuart, Morrisson, Valerie, Nasir, Iman, Nejentsev, Sergey, Papadia, Sofia, Ponsford, Mark J., Quinn, Ellen, Quinti, Isabella, Rayner-Matthews, Paula J., Samani, Nilesh, Sanchis-Juan, Alba, Savic, Sinisa, Simpson, Michael A., Smith, Kenneth G.C., Thaventhiran, James E., Tilly, Tobias, Titterton, Catherine, Tuna, Salih, Urniaz, Rafal, von Ziegenweidt, Julie, Watt, Christopher, Welch, Steven B., Whitehorn, Deborah, Wood, Yvette, Workman, Sarita, Worth, Austen, Young, Timothy

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Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans von Tuijnenburg, Paul, Jansen, Machiel H., Carss, Keren J., Baxendale, Helen, Chandra, Anita, Seneviratne, Suranjith L., Oksenhendler, Eric, Tool, Anton T.J., Whitehorn, Deborah, Turro, Ernest, Thaventhiran, James E., Kuijpers, Taco W., Adhya, Zoe, Anantharachagan, Ariharan, Arumugakani, Gururaj, Bacchelli, Chiara, Baxendale, Helen, Bibi, Shahnaz, Booth, Claire, Browning, Michael, Burns, Siobhan, Clifford, Hayley, Cooper, Nichola, Davies, Sophie, Devlin, Lisa, Edgar, David, Egner, William, Ghurye, Rohit, Gilmour, Kimberley, Goddard, Sarah, Gordins, Pavel, Hackett, Scott, Hague, Rosie, Hayman, Grant, Jolles, Stephen, Jones, Julie, Kelleher, Peter, Klein, Nigel, Kuijpers, Taco, Kumararatne, Dinakantha, Laffan, James, Lango Allen, Hana, Lear, Sara, Longhurst, Hilary, Maimaris, Jesmeen, McDermott, Elizabeth, Morrisson, Valerie, Nasir, Iman, Noorani, Sadia, Oksenhendler, Eric, Ponsford, Mark, Qasim, Waseem, Quinn, Ellen, Quinti, Isabella, Samarghitean, Crina, Savic, Sinisa, Seneviratne, Suranjith, Simeoni, Ilenia, Staples, Emily, Steele, Cathal, Thaventhiran, James, Thomas, Moira, Thrasher, Adrian, Worth, Austen, Yong, Patrick, Bradley, John, Hammerton, Tracey, Ouwehand, Willem, Raymond, F Lucy, Veltman, Marijke, Clements-Brod, Naomi, Davis, John, Dewhurst, Eleanor, Erwood, Marie, Frary, Amy, Linger, Rachel, Papadia, Sofia, Rehnstrom, Karola, Astle, William, Attwood, Antony, Bleda, Marta, Carss, Keren, Daugherty, Louise, Deevi, Sri, Graf, Stefan, Greene, Daniel, Halmagyi, Csaba, Matser, Vera, Meacham, Stuart, Megy, Karyn, Shamardina, Olga, Titterton, Catherine, Tuna, Salih, Turro, Ernest, von Ziegenweldt, Julie, Furnell, Abigail, Staines, Simon, Stephens, Jonathan, Whitehorn, Deborah, Watt, Christopher

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Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the UK von Shields, Adrian M, Anantharachagan, Ariharan, Arumugakani, Gururaj, Baker, Kenneth, Bahal, Sameer, Baxendale, Helen, Bermingham, William, Bhole, Malini, Boules, Evon, Bright, Philip, Chopra, Charu, Cliffe, Lucy, Cleave, Betsy, Dempster, John, Devlin, Lisa, Dhalla, Fatima, Diwakar, Lavanya, Drewe, Elizabeth, Duncan, Christopher, Dziadzio, Magdalena, Elcombe, Suzanne, Elkhalifa, Shuayb, Gennery, Andrew, Ghanta, Harichandrana, Goddard, Sarah, Grigoriadou, Sofia, Hackett, Scott, Hayman, Grant, Herriot, Richard, Herwadkar, Archana, Huissoon, Aarnoud, Jain, Rashmi, Jolles, Stephen, Johnston, Sarah, Khan, Sujoy, Laffan, James, Lane, Peter, Leeman, Lucy, Lowe, David M, Mahabir, Shanti, Lochlainn, Dylan James Mac, McDermott, Elizabeth, Misbah, Siraj, Moghaddas, Fiona, Morsi, Hadeil, Murng, Sai, Noorani, Sadia, O'Brien, Rachael, Patel, Smita, Price, Arthur, Rahman, Tasneem, Seneviratne, Suranjith, Shrimpton, Anna, Stroud, Catherine, Thomas, Moira, Townsend, Katie, Vaitla, Prashantha, Verma, Nisha, Williams, Anthony, Burns, Siobhan O, Savic, Sinisa, Richter, Alex G

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A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas von Cervia, Lisa D, Shibue, Tsukasa, Borah, Ashir A, Gaeta, Benjamin, He, Linh, Leung, Lisa, Li, Naomi, Moyer, Sydney M, Shim, Brian H, Dumont, Nancy, Gonzalez, Alfredo, Bick, Nolan R, Kazachkova, Mariya, Dempster, Joshua M, Krill-Burger, John Michael, Piccioni, Federica, Udeshi, Namrata D, Olive, Meagan E, Carr, Steven A, Root, David E, McFarland, James M, Vazquez, Francisca, Hahn, William C

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Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer von Bondeson, Daniel P, Paolella, Brenton R, Asfaw, Adhana, Rothberg, Michael V, Skipper, Thomas A, Langan, Carly, Mesa, Gabriel, Gonzalez, Alfredo, Surface, Lauren E, Ito, Kentaro, Kazachkova, Mariya, Colgan, William N, Warren, Allison, Dempster, Joshua M, Krill-Burger, John M, Ericsson, Maria, Tang, Andrew A, Fung, Iris, Chambers, Emily S, Abdusamad, Mai, Dumont, Nancy, Doench, John G, Piccioni, Federica, Root, David E, Boehm, Jesse, Hahn, William C, Mannstadt, Michael, McFarland, James M, Vazquez, Francisca, Golub, Todd R

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Autosomal Dominant STAT6 Gain of Function Causes Severe Atopy Associated with Lymphoma von Minskaia, Ekaterina, Maimaris, Jesmeen, Jenkins, Persephone, Albuquerque, Adriana S., Hong, Ying, Eleftheriou, Despina, Gilmour, Kimberly C., Grace, Richard, Moreira, Fernando, Grimbacher, Bodo, Morris, Emma C., Burns, Siobhan O.

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Practical challenges for functional validation of STAT1 gain of function genetic variants von Albuquerque, Adriana S, Maimaris, Jesmeen, McKenna, Alexander J, Lambourne, Jonathan, Moreira, Fernando, Workman, Sarita, Megy, Karyn, Simeoni, Ilenia, Lango Allen, Hana, Morris, Emma C, Burns, Siobhan O

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Early versus delayed weight-bearing following operatively treated ankle fracture (WAX): a non-inferiority, multicentre, randomised controlled trial von Bretherton, Christopher Patrick, Achten, Juul, Jogarah, Vidoushee, Petrou, Stavros, Peckham, Nicholas, Achana, Felix, Appelbe, Duncan, Kearney, Rebecca, Claireux, Harry, Bell, Philip, Griffin, Xavier L, McAndrew, Andrew, Jacobs, Neal, Forder, Justin, Hester, Thomas, Cross, Charlotte, Bateman, Tony, Kieffer, Will, Barton, Tristan, Walter, Richard, Savva, Nick, Marsland, Daniel, Rose, Barry, Beech, Zine, Koc, Togay, Armstead, Bethany, Ollivere, Ben, Diamond, Owen, Teoh, Kar, Magill, Paul, Mangwani, Jitendra, Hodgson, Paul, Ray, Robbie, Dhinsa, Baljinder, Majeed, Haroon, Wong-Chung, John, Young, Jonathan, Lagare, Agnes, Soogumbur, Akash, Morozova, Albina, Hunt, Alexander, Adamson, Amanda, Dempster, Angie, McCormack, Ann, Arif, Azra, Vye, Charlotte, Dojode, Chetan, Brown, Chloe, Haines, Christina, To, Christopher, Brennan, Ciaran, Winson, Dan, McGough, Elizabeth, Jessup-Dunton, Ellen, Bintcliffe, Fiona, Thompson, Fiona, Omogra, Gabriel, Scott, Georgia, Samuel, Helen, Fraig, Hossam, Burokiene, Ina, Odysseos-Beaumont, Isabel, Rand, James, Edkins, Janet, Barrett-Lee, Joe, McFall, John, Wahed, Karim, Herbert, Kate, Death, Kelly, Beddard, Laura, Dupley, Leanne, Bryce, Leeann, Wright, Lianne, Bailey, Lucy, Maling, Lucy, Raad, Marjan, Morris, Matt, Williams, Matthew, Labidi, May, Holmes, Natalie, Staines, Nikki, Matthews, Paul A, McCormac, Philip, Easow, Rashmi, Matthews, Scott, Kapoor, Smriti, Harris, Sophie, Wagland, Susan, Cobb, Timothy, White, Tracey

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Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection von Pardiñas, Antonio F., Holmans, Peter, Pocklington, Andrew J., Escott-Price, Valentina, Ripke, Stephan, Carrera, Noa, Legge, Sophie E., Bishop, Sophie, Cameron, Darren, Hamshere, Marian L., Han, Jun, Hubbard, Leon, Lynham, Amy, Mantripragada, Kiran, Rees, Elliott, MacCabe, James H., McCarroll, Steven A., Baune, Bernhard T., Breen, Gerome, Byrne, Enda M., Dannlowski, Udo, Eley, Thalia C., Hayward, Caroline, Martin, Nicholas G., McIntosh, Andrew M., Plomin, Robert, Porteous, David J., Wray, Naomi R., Caballero, Armando, Geschwind, Daniel H., Huckins, Laura M., Ruderfer, Douglas M., Santiago, Enrique, Sklar, Pamela, Stahl, Eli A., Won, Hyejung, Agerbo, Esben, Als, Thomas D., Andreassen, Ole A., Bækvad-Hansen, Marie, Mortensen, Preben Bo, Pedersen, Carsten Bøcker, Børglum, Anders D., Bybjerg-Grauholm, Jonas, Djurovic, Srdjan, Durmishi, Naser, Pedersen, Marianne Giørtz, Golimbet, Vera, Grove, Jakob, Hougaard, David M., Mattheisen, Manuel, Molden, Espen, Mors, Ole, Nordentoft, Merete, Pejovic-Milovancevic, Milica, Sigurdsson, Engilbert, Silagadze, Teimuraz, Hansen, Christine Søholm, Stefansson, Kari, Stefansson, Hreinn, Steinberg, Stacy, Tosato, Sarah, Werge, Thomas, Collier, David A., Rujescu, Dan, Kirov, George, Owen, Michael J., O’Donovan, Michael C., Walters, James T. R.

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Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the United Kingdom von Shields, Adrian M, Anantharachagan, Ariharan, Arumugakani, Gururaj, Baker, Kenneth, Bahal, Sameer, Baxendale, Helen, Bermingham, William, Bhole, Malini, Boules, Evon, Bright, Philip, Chopra, Charu, Cliffe, Lucy, Cleave, Betsy, Dempster, John, Devlin, Lisa, Dhalla, Fatima, Diwakar, Lavanya, Drewe, Elizabeth, Duncan, Christopher, Dziadzio, Magdalena, Elcombe, Suzanne, Elkhalifa, Shuayb, Gennery, Andrew, Ghanta, Harichandrana, Goddard, Sarah, Grigoriadou, Sofia, Hackett, Scott, Hayman, Grant, Herriot, Richard, Herwadkar, Archana, Huissoon, Aarnoud, Jain, Rashmi, Jolles, Stephen, Johnston, Sarah, Khan, Sujoy, Laffan, James, Lane, Peter, Leeman, Lucy, Lowe, David M, Mahabir, Shanti, Mac Lochlainn, Dylan James, McDermott, Elizabeth, Misbah, Siraj, Moghaddas, Fiona, Morsi, Hadeil, Murng, Sai, Noorani, Sadia, O’Brien, Rachael, Patel, Smita, Price, Arthur, Rahman, Tasneem, Seneviratne, Suranjith, Shrimpton, Anna, Stroud, Catherine, Thomas, Moira, Townsend, Katie, Vaitla, Prashantha, Verma, Nisha, Williams, Anthony, Burns, Siobhan O, Savic, Sinisa, Richter, Alex G

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Abstract P3-09-01: A ubiquitination cascade regulating the integrated stress response and survival in carcinomas von Cervia, Lisa D, Shibue, Tsukasa, Gaeta, Benjamin, Borah, Ashir A, Leung, Lisa, Li, Naomi, Dumont, Nancy, Gonzalez, Alfredo, Bick, Nolan, Kazachkova, Mariya, Dempster, Joshua M, Krill-Burger, John M, Piccioni, Federica, Udeshi, Namrata D, Olive, Meagan E, Carr, Steven A, Root, David E, McFarland, James M, Vazquez, Francisca, Hahn, William C

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Abstract LB-100: Systematic target prioritization and validation from genome-scale loss-of-function screens in large panels of human cancer cell lines von Shibue, Tsukasa, Krill-Burger, John M., Paolella, Brenton R., Gaeta, Benjamin, Asfaw, Adhana, Dempster, Joshua M., McFarland, James M., Root, David E., Boehm, Jesse S., Tsherniak, Aviad, Hahn, William C., Vazquez, Francisca

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Abstract 1950: A ubiquitination cascade regulates the integrated stress response and epithelial cancer survival von Cervia, Lisa D., Shibue, Tsukasa, Gaeta, Benjamin, Borah, Ashir, Leung, Lisa, Li, Naomi, Dumont, Nancy, Gonzalez, Alfredo, Bick, Nolan, Kazachkova, Mariya, Dempster, Joshua, Krill-Burger, John M., Udeshi, Namrata, Olive, Meagan, Carr, Steven A., Root, David E., Piccioni, Federica, McFarland, James M., Vazquez, Francisca, Hahn, William C.

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