Receptor occupancy assessment and interpretation in terms of quantitative systems pharmacology: nivolumab case study von Shchelokov, Dmitry, Demin, Jr, Oleg

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480 Translational PK/RO model of tetravalent bispecific antibody CTX8371: receptor occupancy estimation, PD1 loss and bispecific binding-related avidity increase in low doses von Musatovac, Veronika, Demin, Oleg, Demin, Oleg

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1167 Prediction of first-in-human dose for HPN536, a T-cell engager targeting mesothelin: MABEL vs mechanistic translational PK/RO/PA modeling von Demin, Oleg, Shchelokov, Dmitry

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273 Application of pharmacokinetic-pharmacodynamic modeling to select the optimal dose of ALX148, a CD47 blocker von Demin, Oleg, Vasileva, Elena

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Studying the Progression of Amyloid Pathology and Its Therapy Using Translational Longitudinal Model of Accumulation and Distribution of Amyloid Beta von Karelina, Tatiana, Demin, Oleg, Demin, Oleg, Duvvuri, Sridhar, Nicholas, Timothy

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A mathematical model of multisite phosphorylation of tau protein von Stepanov, Alexander, Karelina, Tatiana, Markevich, Nikolai, Demin, Oleg, Nicholas, Timothy

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The Edinburgh human metabolic network reconstruction and its functional analysis von Goryanin, Igor, Ma, Hongwu, Sorokin, Anatoly, Mazein, Alexander, Selkov, Alex, Selkov, Evgeni, Demin, Oleg

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Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach von Karelina, Tatiana A, Zhudenkov, Kirill V, Demin, Oleg O, Svetlichny, Dmitry V, Agoram, Balaji, Fairman, David, Demin, Oleg V

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CYTOCON: The manually curated database of human in vivo cell and molecule concentrations von Leonov, Vladislav, Mogilevskaya, Ekaterina, Gerasimuk, Elita, Gizzatkulov, Nail, Demin, Oleg

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Correction: A mathematical model of multisite phosphorylation of tau protein von Stepanov, Alexander, Karelina, Tatiana, Markevich, Nikolai, Demin, Oleg, Nicholas, Timothy

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Monoclonal antibody therapy efficacy can be boosted by combinations with other treatments: Predictions using an integrated Alzheimer’s Disease Platform von Karelina, Tatiana, Lerner, Stepan, Stepanov, Alexandr, Meerson, Mark, Demin, Oleg

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338 Comparison of lymphodepleting chemotherapy regimens as preconditioning for T-cell therapies von Demin, Oleg, Kolesova, Galina, Ramos-Hernandez, Natalia, Faitg, Thomas, Zajic, Stefan, Cucurull-Sanchez, Lourdes

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1280 Modeling of direct (EGFR- based) and ADCC cytotoxic effect of Cetuximab on the basis of literature available in vitro data von Demin, Oleg, Smirnov, Sergey, Diakonova, Alexandra, Roskoshnaia, Anna, Bajaj, Gaurav, Adams, Homer, Gupta, Manish, Thalhauser, Craig

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Modeling of celiac disease immune response and the therapeutic effect of potential drugs von Demin, Oleg O, Smirnov, Sergey V, Sokolov, Victor V, Cucurull-Sanchez, Lourdes, Pichardo-Almarza, Cesar, Flores, M Victoria, Benson, Neil, Demin, Oleg V

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Analysis of the efficacy of SGLT2 inhibitors using semi-mechanistic model von Demin, Jr, Oleg, Yakovleva, Tatiana, Kolobkov, Dmitry, Demin, Oleg

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Abstract 5488: Prediction of target receptor occupancy for ALX148, a CD47 blocker, using mechanistic PK/RO modeling von Vasileva, Elena, Demin, Oleg

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Abstract 2233: Prediction and comparison of PD-1 receptor occupancy in the tumor after treatment with immune checkpoint inhibitors von Shchelokov, Dmitry, Demin, Oleg

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874 A quantitative systems pharmacology model of head and neck squamous cell carcinoma: a tool for evaluating treatment outcomes for combination therapies von Diakonova, Alexandra, Smirnov, Sergey, Roskoshnaia, Anna, Borisov, Ivan, Demin, Oleg, Bajaj, Gaurav, Adams, Homer, Jure-Kunkel, Maria, Gupta, Manish, Thalhauser, Craig

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Two heads are better than one: current landscape of integrating QSP and machine learning von Zhang Tongli, Androulakis, Ioannis P, Bonate, Peter, Cheng, Limei, Helikar Tomáš, Parikh Jaimit, Rackauckas Christopher, Subramanian Kalyanasundaram, Cho, Carolyn R, Borisov, Ivan, Broderick, Gordon, Damian Valeriu, Dariolli Rafael, Demin Oleg, Ellinwood, Nicholas, Fey, Dirk, Gulati Abhishek, Helikar Tomas, Jordie Eric, Musante, Cynthia, Saez-Rodriguez, Julio, Sobie, Eric

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Abstract 687: Implementation of inter-patient variability in semi-mechanistic model of melanoma treatment with vemurafenib von Shchelokov, Dmitry, Demin, Oleg, Demin, Oleg

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