Heterogeneity of kinase inhibitor resistance mechanisms in GIST von Liegl, B, Kepten, I, Le, C, Zhu, M, Demetri, GD, Heinrich, MC, Fletcher, CDM, Corless, CL, Fletcher, JA

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KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway von Bauer, S, Duensing, A, Demetri, G D, Fletcher, J A

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Hypertension as a potential biomarker of efficacy in patients with gastrointestinal stromal tumor treated with sunitinib von George, S., Reichardt, P., Lechner, T., Li, S., Cohen, D.P., Demetri, G.D.

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Clinical evaluation of continuous daily dosing of sunitinib malate in patients with advanced gastrointestinal stromal tumour after imatinib failure von George, S, Blay, J.Y, Casali, P.G, Le Cesne, A, Stephenson, P, DePrimo, S.E, Harmon, C.S, Law, C.N.J, Morgan, J.A, Ray-Coquard, I, Tassell, V, Cohen, D.P, Demetri, G.D

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Clinical outcomes and safety with trabectedin therapy in patients with advanced soft tissue sarcomas following failure of prior chemotherapy: results of a worldwide expanded access... von Samuels, B.L., Chawla, S., Patel, S., von Mehren, M., Hamm, J., Kaiser, P.E., Schuetze, S., Li, J., Aymes, A., Demetri, G.D.

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Phase III study of nilotinib versus best supportive care with or without a TKI in patients with gastrointestinal stromal tumors resistant to or intolerant of imatinib and sunitinib von Reichardt, P., Blay, J.-Y., Gelderblom, H., Schlemmer, M., Demetri, G.D., Bui-Nguyen, B., McArthur, G.A., Yazji, S., Hsu, Y., Galetic, I., Rutkowski, P.

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A multicenter phase II study of pazopanib in patients with advanced gastrointestinal stromal tumors (GIST) following failure of at least imatinib and sunitinib von Ganjoo, K.N., Villalobos, V.M., Kamaya, A., Fisher, G.A., Butrynski, J.E., Morgan, J.A., Wagner, A.J., D'Adamo, D., McMillan, A., Demetri, G.D., George, S.

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Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma von Gronchi, A., Bui, B.N., Bonvalot, S., Pilotti, S., Ferrari, S., Hohenberger, P., Hohl, R.J., Demetri, G.D., Le Cesne, A., Lardelli, P., Pérez, I., Nieto, A., Tercero, J.C., Alfaro, V., Tamborini, E., Blay, J.Y.

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A phase I–II study of everolimus (RAD001) in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors von Schöffski, P., Reichardt, P., Blay, J.-Y., Dumez, H., Morgan, J.A., Ray-Coquard, I., Hollaender, N., Jappe, A., Demetri, G.D.

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Neo-adjuvant chemotherapy for primary high-grade extremity soft tissue sarcoma von Grobmyer, S. R., Maki, R. G., Demetri, G. D., Mazumdar, M., Riedel, E., Brennan, M. F., Singer, S.

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Trabectedin is a feasible treatment for soft tissue sarcoma patients regardless of patient age: a retrospective pooled analysis of five phase II trials von Cesne, A L, Judson, I, Maki, R, Grosso, F, Schuetze, S, Mehren, M V, Chawla, S P, Demetri, G D, Nieto, A, Tanovic, A, Blay, J-Y

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Phase II and Pharmacokinetic Study of Ecteinascidin 743 in Patients With Progressive Sarcomas of Soft Tissues Refractory to Chemotherapy von GARCIA-CARBONERO, R, SUPKO, J. G, MATULONIS, U, MAKI, R. G, LOPEZ, T, PUCHALSKI, T. A, SANCHO, M. A, GOMEZ, J, GUZMAN, C, JIMENO, J, DEMETRI, G. D, MANOLA, J, SEIDEN, M. V, HARMON, D, RYAN, D. P, QUIGLEY, M. T, MERRIAM, P, CANNIFF, J, GOSS, G

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Ecteinascidin-743 (ET-743) for Chemotherapy-Naive Patients With Advanced Soft Tissue Sarcomas: Multicenter Phase II and Pharmacokinetic Study von GARCIA-CARBONERO, R, SUPKO, J. G, QUIGLEY, M. T, LOPEZ, T, SANCHO, M. A, JIMENO, J, GUZMAN, C, DEMETRI, G. D, MAKI, R. G, MANOLA, J, RYAN, D. P, HARMON, D, PUCHALSKI, T. A, GOSS, G, SEIDEN, M. V, WAXMAN, A

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KIT activation is a ubiquitous feature of gastrointestinal stromal tumors von RUBIN, Brian P, SINGER, Samuel, DEMETRI, George D, FLETCHER, Christopher D. M, FLETCHER, Jonathan A, TSAO, Connie, DUENSING, Anette, LUX, Marcia L, RUIZ, Robert, HIBBARD, Michele K, CHEN, Chang-Jie, SHENG XIAO, TUVESON, David A

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Protein kinase C-θ regulates KIT expression and proliferation in gastrointestinal stromal tumors von Ou, W-b, Zhu, M-j, Demetri, G D, Fletcher, C D M, Fletcher, J A

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Growth modulation index as metric of clinical benefit assessment among advanced soft tissue sarcoma patients receiving trabectedin as a salvage therapy von Penel, N., Demetri, G.D., Blay, J.Y., Cousin, S., Maki, R.G., Chawla, S.P., Judson, I., von Mehren, M., Schöffski, P., Verweij, J., Casali, P., Rodenhuis, S., Schütte, H.J., Cassar, A., Gomez, J., Nieto, A., Zintl, P., Pontes, M.J., Le Cesne, A.

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KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance von Zhu, M-J, Ou, W-B, Fletcher, C D M, Cohen, P S, Demetri, G D, Fletcher, J A

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Anaemia and its functional consequences in cancer patients: current challenges in management and prospects for improving therapy von Demetri, G D

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Long-term follow-up results of the multicenter phase II trial of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of standard tyrosine kin... von Ben-Ami, E., Barysauskas, C.M., von Mehren, M., Heinrich, M.C., Corless, C.L., Butrynski, J.E., Morgan, J.A., Wagner, A.J., Choy, E., Yap, J.T., Van den Abbeele, A.D., Solomon, S.M., Fletcher, J.A., Demetri, G.D., George, S.

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Granulocyte Colony-Stimulating Factor and Its Receptor von Demetri, George D., Griffin, James D.

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