Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors von Diamond, Jennifer R, Pitts, Todd M, Ungermannova, Dana, Nasveschuk, Christopher G, Zhang, Gan, Phillips, Andrew J, Bagby, Stacey M, Pafford, Jessica, Yacob, Betelehem W, Newton, Timothy P, Tentler, John J, Gittleman, Brian, Hartman, Sarah J, DeMattei, John A, Winkler, James D, Wendt, Michael K, Schiemann, William P, Eckhardt, S Gail, Liu, Xuedong, Piscopio, Anthony D

Volltext

First-in-Human Dose-Escalation Study of the Novel Oral Depsipeptide Class I-Targeting HDAC Inhibitor Bocodepsin (OKI-179) in Patients with Advanced Solid Tumors von Schreiber, Anna R, Kagihara, Jodi A, Corr, Bradley R, Davis, S Lindsey, Lieu, Christopher, Kim, Sunnie S, Jimeno, Antonio, Camidge, D Ross, Williams, Jud, Heim, Amy M, Martin, Anne, DeMattei, John A, Holay, Nisha, Triplett, Todd A, Eckhardt, S Gail, Litwiler, Kevin, Winkler, James, Piscopio, Anthony D, Diamond, Jennifer R

Volltext

Preparation of Pyrrolidine-Based PDE4 Inhibitors via Enantioselective Conjugate Addition of α-Substituted Malonates to Aromatic Nitroalkenes von Nichols, Paul J, DeMattei, John A, Barnett, Bradley R, LeFur, Nicole A, Chuang, Tsung-Hsun, Piscopio, Anthony D, Koch, Kevin

Volltext

Complete Relative Stereochemistry of Maitotoxin von Zheng, Wanjun, DeMattei, John A, Wu, Jiang-Ping, Duan, James J.-W, Cook, Laura R, Oinuma, Hitoshi, Kishi, Yoshito

Volltext

A Scaleable Synthesis of Fiduxosin von Haight, Anthony R, Bailey, Anne E, Baker, William S, Cain, Michael H, Copp, Richard R, DeMattei, John A, Ford, Kelley L, Henry, Rodger F, Hsu, Margaret C, Keyes, Robert F, King, Steven A, McLaughlin, Maureen A, Melcher, Laura M, Nadler, William R, Oliver, Patricia A, Parekh, Shyamal I, Patel, Hemant H, Seif, Louis S, Staeger, Mike A, Wayne, Gregory S, Wittenberger, Steven J, Zhang, Weijiang

Volltext

Abstract B007: OKI-179 is a novel, oral, class I specific histone deacetylase inhibitor in phase 1 clinical trials von Diamond, Jennifer R, Kagihara, Jodi A, Liu, Xuedong, Gordon, Gilad, Heim, Amy M, Winkler, James, DeMattei, John A, Piscopio, Anthony D, Eckhardt, S. Gail

Volltext

A highly diastereoselective vinylogous Mannich condensation and 1,4-conjugate addition of ( Z)-propenyl cuprate in the synthesis of an influenza neuraminidase inhibitor von Barnes, David M., Bhagavatula, Lakshmi, DeMattei, John, Gupta, Ashok, Hill, David R., Manna, Sukumar, McLaughlin, Maureen A., Nichols, Paul, Premchandran, Ramiya, Rasmussen, Michael W., Tian, Zhenping, Wittenberger, Steven J.

Volltext

Phase 1 study of OKI-179, an oral class 1-selective depsipeptide HDAC inhibitor, in patients with advanced solid tumors: Final results von Kagihara, Jodi A., Corr, Bradley, Pacheco, Jose Maria, Davis, S. Lindsey, Lieu, Christopher Hanyoung, Kim, Sunnie S., Jimeno, Antonio, Heim, Amy M., DeMattei, John A., Gordon, Gilad, Triplett, Todd A., Eckhardt, S. Gail, Winkler, James D., Piscopio, Anthony D., Diamond, Jennifer Robinson

Volltext

Allylation of Erythromycin Derivatives:  Introduction of Allyl Substituents into Highly Hindered Alcohols von Stoner, Eric J, Peterson, Matthew J, Allen, Michael S, DeMattei, John A, Haight, Anthony R, Leanna, M. Robert, Patel, Subhash R, Plata, Daniel J, Premchandran, Ramiya H, Rasmussen, Michael

Volltext

Synthesis of the C-13 Side Chain Precursors of the 9-Dihydrotaxane Analogue ABT-271 von Leanna, M. Robert, DeMattei, John A, Li, Wenke, Nichols, Paul J, Rasmussen, Michael, Morton, Howard E

Volltext

Asymmetric Synthesis of Calyculin C. 1. Synthesis of the C1−C25 Fragment von Scarlato, Gerard R, DeMattei, John A, Chong, Lee S, Ogawa, Anthony K, Lin, Mavis R, Armstrong, Robert W

Volltext

An Efficient Synthesis of the Taxane-Derived Anticancer Agent ABT-271 von DeMattei, John A., Leanna, M. Robert, Li, Wenke, Nichols, Paul J., Rasmussen, Michael W., Morton, Howard E.

Volltext

Asymmetric Synthesis of Calyculin C. 2. Synthesis of the C26−C37 Fragment and Model Wittig Couplings von Ogawa, Anthony K, DeMattei, John A, Scarlato, Gerard R, Tellew, John E, Chong, Lee S, Armstrong, Robert W

Volltext

ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE DERIVATIVES AS TLR7/8 AGONISTS AND USES THEREOF von KACHURA, Melissa, A, KIWAN, Radwan, CHIPMAN, Stewart, D, DEMATTEI, John

Volltext bestellen

ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE DERIVATIVES AS TLR7/8 AGONISTS AND USES THEREOF von KACHURA, Melissa, A, KIWAN, Radwan, CHIPMAN, Stewart, D, DEMATTEI, John

Volltext bestellen

ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE DERIVATIVES AS TLR7/8 AGONISTS AND USES THEREOF von KACHURA, Melissa A, KIWAN, Radwan, CHIPMAN, Stewart D, DEMATTEI, John

Volltext bestellen

ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE TLR7/8 AGONIST COMPOUNDS AND USES THEREOF von KACHURA, Melissa A, KIWAN, Radwan, CHIPMAN, Stewart D, DEMATTEI, John

Volltext bestellen

ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE TLR7/8 AGONIST COMPOUNDS AND USES THEREOF von KACHURA, Melissa A, KIWAN, Radwan, CHIPMAN, Stewart D, DEMATTEI, John

Volltext bestellen

Alkyl chain modified imidazoquinoline TLR7/8 agonist compounds and uses thereof von Kiwan, Radwan, Kachura, Melissa A, Demattei, John, Chipman, Stewart D

Volltext bestellen

Stereoselective methylations of bicyclic lactams derived from pyroglutamic acid von Armstrong, Robert W., DeMattei, John A.

Volltext