Discovery of the Novel, Orally Active, and Selective LPA1 Receptor Antagonist ACT-1016-0707 as a Preclinical Candidate for the Treatment of Fibrotic Diseases von Lescop, Cyrille, Birker, Magdalena, Brotschi, Christine, Bürki, Cédric, Morrison, Keith, Froidevaux, Sylvie, Delahaye, Stéphane, Nayler, Oliver, Bolli, Martin H.

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Discovery of a Novel Orally Active, Selective LPA Receptor Type 1 Antagonist, 4‑(4-(2-Isopropylphenyl)-4-((2-methoxy-4-methylphenyl)carbamoyl)piperidin-1-yl)-4-oxobutanoic Acid, wi... von Lescop, Cyrille, Brotschi, Christine, Williams, Jodi T., Sager, Christoph P., Birker, Magdalena, Morrison, Keith, Froidevaux, Sylvie, Delahaye, Stéphane, Nayler, Oliver, Bolli, Martin H.

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Comparison of Macitentan and Bosentan on Right Ventricular Remodeling in a Rat Model of Non-vasoreactive Pulmonary Hypertension von Iglarz, Marc, Landskroner, Kyle, Bauer, Yasmina, Vercauteren, Magali, Rey, Markus, Renault, Berengère, Studer, Rolf, Vezzali, Enrico, Freti, Diego, Hadana, Hakim, Schläpfer, Manuela, Cattaneo, Christophe, Bortolamiol, Céline, Weber, Edgar, Whitby, Brian R, Delahaye, Stéphane, Wanner, Daniel, Steiner, Pauline, Nayler, Oliver, Hess, Patrick, Clozel, Martine

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Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors von Bezençon, Olivier, Bur, Daniel, Weller, Thomas, Richard-Bildstein, Sylvia, Remeň, Luboš, Sifferlen, Thierry, Corminboeuf, Olivier, Grisostomi, Corinna, Boss, Christoph, Prade, Lars, Delahaye, Stéphane, Treiber, Alexander, Strickner, Panja, Binkert, Christoph, Hess, Patrick, Steiner, Beat, Fischli, Walter

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Desensitization by progressive up-titration prevents first-dose effects on the heart: guinea pig study with ponesimod, a selective S1P1 receptor modulator von Rey, Markus, Hess, Patrick, Clozel, Martine, Delahaye, Stéphane, Gatfield, John, Nayler, Oliver, Steiner, Beat

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Effect of Liver Cirrhosis on the Pharmacokinetics, Metabolism, and Tolerability of Daridorexant, A Novel Dual Orexin Receptor Antagonist von Berger, Benjamin, Dingemanse, Jasper, Sabattini, Giancarlo, Delahaye, Stéphane, Duthaler, Urs, Muehlan, Clemens, Krähenbühl, Stephan

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PHARMACOLOGICAL CHARACTERIZATION OF APROCITENTAN, A DUAL ENDOTHELIN RECEPTOR ANTAGONIST, ALONE AND IN COMBINATION WITH BLOCKERS OF THE RENIN ANGIOTENSIN SYSTEM, IN TWO MODELS OF EX... von Trensz, Frederic, Bortolamiol, Celine, Kramberg, Markus, Wanner, Daniel, Hadana, Hakim, Rey, Markus, Strasser, Daniel S, Delahaye, Stephane, Hess, Patrick, Vezzali, Enrico, Mentzel, Ulrich, Menard, Joel, Clozel, Martine, Iglarz, Marc

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Evaluation of the cytochrome P450 2C19 and 3A4 inhibition potential of the complement factor 5a receptor 1 antagonist ACT‐1014‐6470 in vitro and in vivo von Anliker‐Ort, Marion, Dingemanse, Jasper, Delahaye, Stephane, Janů, Luboš, Anker, John, Berger, Benjamin, Kaufmann, Priska

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Influence of hepatic impairment on the pharmacokinetics and pharmacodynamics of the P2Y12 receptor antagonist selatogrel von Schilling, Uta, Hsin, Chih‐Hsuan, Delahaye, Stephane, Krause, Andreas, Wuelfrath, Hauke, Halabi, Atef, Dingemanse, Jasper

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CYP3A4 Catalyzes the Rearrangement of the Dual Orexin Receptor Antagonist Daridorexant to 4‐Hydroxypiperidinol Metabolites von Treiber, Alexander, Aissaoui, Hamed, Delahaye, Stéphane, Glutz, Sven, Grimont, Julien, Müller, Claus, Seeland, Swen, Siefken, Valérie, Boss, Christoph

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The endothelin receptor antagonist macitentan for the treatment of pulmonary arterial hypertension: A cross‐species comparison of its cytochrome P450 induction pattern von Treiber, Alexander, Delahaye, Stephane, Seeland, Swen, Gnerre, Carmela

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Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug–Drug Interactions von de Kanter, Ruben, Sidharta, Patricia N., Delahaye, Stéphane, Gnerre, Carmela, Segrestaa, Jerome, Buchmann, Stephan, Kohl, Christopher, Treiber, Alexander

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Desensitization by Progressive Up-Titration Prevents First-Dose Effects on the Heart: Guinea Pig Study with Ponesimod, a Selective S1P.sub.1 Receptor Modulator von Rey, Markus, Hess, Patrick, Clozel, Martine, Delahaye, Stéphane, Gatfield, John, Nayler, Oliver, Steiner, Beat

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New classes of potent and bioavailable human renin inhibitors von Remeň, L’uboš, Bezençon, Olivier, Richard-Bildstein, Sylvia, Bur, Daniel, Prade, Lars, Corminboeuf, Olivier, Boss, Christoph, Grisostomi, Corinna, Sifferlen, Thierry, Strickner, Panja, Hess, Patrick, Delahaye, Stéphane, Treiber, Alexander, Weller, Thomas, Binkert, Christoph, Steiner, Beat, Fischli, Walter

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Reaction of Trimethylchlorosilane in Spin-On Silicalite-1 Zeolite Film von Eslava, Salvador, Delahaye, Stephane, Baklanov, Mikhail R, Iacopi, Francesca, Kirschhock, Christine E. A, Maex, Karen, Martens, Johan A

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Discovery and Characterization of a New Class of C5aR1 Antagonists Showing In Vivo Activity von Hubler, Francis, Renneberg, Dorte, Siendt, Hervé, Stamm, Simon, Hilpert, Kurt, Caroff, Eva, Delahaye, Stephane, Froidevaux, Sylvie, Murphy, Mark J.

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Macitentan does not interfere with hepatic bile salt transport von Treiber, Alexander, Äänismaa, Päivi, de Kanter, Ruben, Delahaye, Stephane, Treher, Marianne, Hess, Patrick, Sidharta, Patricia

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Discovery of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers von Renneberg, Dorte, Hubler, Francis, Rey, Markus, Hess, Patrick, Delahaye, Stephane, Gatfield, John, Iglarz, Marc, Hilpert, Kurt

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Identification of a New Chemical Class of Antimalarials von Brunner, Ralf, Aissaoui, Hamed, Boss, Christoph, Bozdech, Zbynek, Brun, Reto, Corminboeuf, Olivier, Delahaye, Stephane, Fischli, Christoph, Heidmann, Bibia, Kaiser, Marcel, Kamber, Jolanda, Meyer, Solange, Papastogiannidis, Petros, Siegrist, Romain, Voss, Till, Welford, Richard, Wittlin, Sergio, Binkert, Christoph

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Abstract 2718: Preclinical development of humanized CD39 and CD73 blocking antibodies targeting the ATP/adenosine immune checkpoint pathway for cancer immunotherapy von Perrot, Ivan, Paoli, Marc Giraudon, Augier, Séverine, Blemont, Marilyne Royannez, Gaudin, Marion, Bosco, Frédéric, Courtois, Rachel, Delahaye, Stephane, Jecko, Diana, Gourdin, Nicolas, Agu, Maryline Salin, Perrier, Cyril, Ricaut, Paul, Docquier, Aurélie, Chanteux, Stéphanie, Rossi, Benjamin, Représa, Agnès, Denis, Caroline, Remark, Romain, Bonnafous, Cécile, Gauthier, Laurent, Morel, Ariane, Bonnefoy, Nathalie, Bastid, Jérémy, Morel, Yannis, Paturel, Carine

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