Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma von Giulino-Roth, Lisa, van Besien, Herman J, Dalton, Tanner, Totonchy, Jennifer E, Rodina, Anna, Taldone, Tony, Bolaender, Alexander, Erdjument-Bromage, Hediye, Sadek, Jouliana, Chadburn, Amy, Barth, Matthew J, Dela Cruz, Filemon S, Rainey, Allison, Kung, Andrew L, Chiosis, Gabriela, Cesarman, Ethel

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A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors von Alvarez, Mariano J., Subramaniam, Prem S., Tang, Laura H., Grunn, Adina, Aburi, Mahalaxmi, Rieckhof, Gabrielle, Komissarova, Elena V., Hagan, Elizabeth A., Bodei, Lisa, Clemons, Paul A., Dela Cruz, Filemon S., Dhall, Deepti, Diolaiti, Daniel, Fraker, Douglas A., Ghavami, Afshin, Kaemmerer, Daniel, Karan, Charles, Kidd, Mark, Kim, Kyoung M., Kim, Hee C., Kunju, Lakshmi P., Langel, Ülo, Li, Zhong, Lee, Jeeyun, Li, Hai, LiVolsi, Virginia, Pfragner, Roswitha, Rainey, Allison R., Realubit, Ronald B., Remotti, Helen, Regberg, Jakob, Roses, Robert, Rustgi, Anil, Sepulveda, Antonia R., Serra, Stefano, Shi, Chanjuan, Yuan, Xiaopu, Barberis, Massimo, Bergamaschi, Roberto, Chinnaiyan, Arul M., Detre, Tony, Ezzat, Shereen, Frilling, Andrea, Hommann, Merten, Jaeger, Dirk, Kim, Michelle K., Knudsen, Beatrice S., Kung, Andrew L., Leahy, Emer, Metz, David C., Milsom, Jeffrey W., Park, Young S., Reidy-Lagunes, Diane, Schreiber, Stuart, Washington, Kay, Wiedenmann, Bertram, Modlin, Irvin, Califano, Andrea

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STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma von Adane, Biniam, Alexe, Gabriela, Seong, Bo Kyung A., Lu, Diana, Hwang, Elizabeth E., Hnisz, Denes, Lareau, Caleb A., Ross, Linda, Lin, Shan, Dela Cruz, Filemon S., Richardson, Melissa, Weintraub, Abraham S., Wang, Sarah, Iniguez, Amanda Balboni, Dharia, Neekesh V., Conway, Amy Saur, Robichaud, Amanda L., Tanenbaum, Benjamin, Krill-Burger, John M., Vazquez, Francisca, Schenone, Monica, Berman, Jason N., Kung, Andrew L., Carr, Steven A., Aryee, Martin J., Young, Richard A., Crompton, Brian D., Stegmaier, Kimberly

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Recurrent EML4–NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy von Church, Alanna J, Calicchio, Monica L, Nardi, Valentina, Skalova, Alena, Pinto, Andre, Dillon, Deborah A, Gomez-Fernandez, Carmen R, Manoj, Namitha, Haimes, Josh D, Stahl, Joshua A, Dela Cruz, Filemon S, Tannenbaum-Dvir, Sarah, Glade-Bender, Julia L, Kung, Andrew L, DuBois, Steven G, Kozakewich, Harry P, Janeway, Katherine A, Perez-Atayde, Antonio R, Harris, Marian H

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Dynamic network curvature analysis of gene expression reveals novel potential therapeutic targets in sarcoma von Elkin, Rena, Oh, Jung Hun, Dela Cruz, Filemon, Norton, Larry, Deasy, Joseph O., Kung, Andrew L., Tannenbaum, Allen R.

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A Bayesian active learning platform for scalable combination drug screens von Tosh, Christopher, Tec, Mauricio, White, Jessica B., Quinn, Jeffrey F., Ibanez Sanchez, Glorymar, Calder, Paul, Kung, Andrew L., Dela Cruz, Filemon S., Tansey, Wesley

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Lessons learned from 20 years of preclinical testing in pediatric cancers von Smith, Malcolm A., Houghton, Peter J., Lock, Richard B., Maris, John M., Gorlick, Richard, Kurmasheva, Raushan T., Li, Xiao-Nan, Teicher, Beverly A., Chuang, Jeffrey H., Dela Cruz, Filemon S., Dyer, Michael A., Kung, Andrew L., Lloyd, Michael W., Mossé, Yael P., Stearns, Timothy M., Stewart, Elizabeth A., Bult, Carol J., Erickson, Stephen W.

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Bromodomain 4 inhibition leads to MYCN downregulation in Wilms tumor von Woods, Andrew D., Berlow, Noah E., Ortiz, Michael V., Dela Cruz, Filemon, Siddiquee, Armaan, Coutinho, Diego F., Purohit, Reshma, Freier, Katherine E. Tranbarger, Michalek, Joel E., Lathara, Melvin, Matlock, Kevin, Srivivasa, Ganapati, Royer‐Pokora, Brigitte, Veselska, Renata, Kung, Andrew L., Keller, Charles

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Pediatric Sarcoma Data Forms a Unique Cluster Measured via the Earth Mover’s Distance von Chen, Yongxin, Cruz, Filemon Dela, Sandhu, Romeil, Kung, Andrew L., Mundi, Prabhjot, Deasy, Joseph O., Tannenbaum, Allen

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A Transcriptome-Based Precision Oncology Platform for Patient-Therapy Alignment in a Diverse Set of Treatment-Resistant Malignancies von Mundi, Prabhjot S, Dela Cruz, Filemon S, Grunn, Adina, Diolaiti, Daniel, Mauguen, Audrey, Rainey, Allison R, Guillan, Kristina, Siddiquee, Armaan, You, Daoqi, Realubit, Ronald, Karan, Charles, Ortiz, Michael V, Douglass, Eugene F, Accordino, Melissa, Mistretta, Suzanne, Brogan, Frances, Bruce, Jeffrey N, Caescu, Cristina I, Carvajal, Richard D, Crew, Katherine D, Decastro, Guarionex, Heaney, Mark, Henick, Brian S, Hershman, Dawn L, Hou, June Y, Iwamoto, Fabio M, Jurcic, Joseph G, Kiran, Ravi P, Kluger, Michael D, Kreisl, Teri, Lamanna, Nicole, Lassman, Andrew B, Lim, Emerson A, Manji, Gulam A, McKhann, Guy M, McKiernan, James M, Neugut, Alfred I, Olive, Kenneth P, Rosenblat, Todd, Schwartz, Gary K, Shu, Catherine A, Sisti, Michael B, Tergas, Ana, Vattakalam, Reena M, Welch, Mary, Wenske, Sven, Wright, Jason D, Canoll, Peter, Hibshoosh, Hanina, Kalinsky, Kevin, Aburi, Mahalaxmi, Sims, Peter A, Alvarez, Mariano J, Kung, Andrew L, Califano, Andrea

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Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion-Driven Cancer von Slotkin, Emily K, Diolaiti, Daniel, Shukla, Neerav N, Dela Cruz, Filemon S, Clark, Jennifer J, Gundem, Gunes, Yellapantula, Venkata D, Levine, Max F, You, Daoqi, Ma, Peilin, Pachhal, Sagarika, Ibanez Sanchez, Glorymar, Benayed, Ryma, Jungbluth, Achim A, Smyth, Lillian M, Mauguen, Audrey, Gushterova, Irena, Ding, Hongxu, Spraggon, Lee, Darnell, Robert, Califano, Andrea, Ladanyi, Marc, Papaemmanuil, Elli, Kung, Andrew L, Hyman, David M, Roberts, Stephen S

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Solid tumor differentiation therapy - is it possible? von Cruz, Filemon Dela, Matushansky, Igor

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Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors von Coutinho, Diego F., Mundi, Prabhjot S., Marks, Lianna J., Burke, Chelsey, Ortiz, Michael V., Diolaiti, Daniel, Bird, Lauren, Vallance, Kelly L., Ibáñez, Glorymar, You, Daoqi, Long, Matthew, Rosales, Nestor, Grunn, Adina, Ndengu, Andoyo, Siddiquee, Armaan, Gaviria, Ervin S., Rainey, Allison R., Fazlollahi, Ladan, Hosoi, Hajime, Califano, Andrea, Kung, Andrew L., Dela Cruz, Filemon S.

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A recurrent novel MGA-NUTM1 fusion identifies a new subtype of high-grade spindle cell sarcoma von Diolaiti, Daniel, Dela Cruz, Filemon S, Gundem, Gunes, Bouvier, Nancy, Boulad, Mathieu, Zhang, Yanming, Chou, Alexander J, Dunkel, Ira J, Sanghvi, Rashesh, Shah, Minita, Geiger, Heather, Rahman, Sadia, Felice, Vanessa, Wrzeszczynski, Kazimierz O, Darnell, Robert B, Antonescu, Cristina R, French, Christopher A, Papaemmanuil, Elli, Kung, Andrew L, Shukla, Neerav

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Implementation of next generation sequencing into pediatric hematology-oncology practice: moving beyond actionable alterations von Oberg, Jennifer A, Glade Bender, Julia L, Sulis, Maria Luisa, Pendrick, Danielle, Sireci, Anthony N, Hsiao, Susan J, Turk, Andrew T, Dela Cruz, Filemon S, Hibshoosh, Hanina, Remotti, Helen, Zylber, Rebecca J, Pang, Jiuhong, Diolaiti, Daniel, Koval, Carrie, Andrews, Stuart J, Garvin, James H, Yamashiro, Darrell J, Chung, Wendy K, Emerson, Stephen G, Nagy, Peter L, Mansukhani, Mahesh M, Kung, Andrew L

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Cancer stem cells in pediatric sarcomas von Dela Cruz, Filemon S

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A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma von Dela Cruz, Filemon S, Diolaiti, Daniel, Turk, Andrew T, Rainey, Allison R, Ambesi-Impiombato, Alberto, Andrews, Stuart J, Mansukhani, Mahesh M, Nagy, Peter L, Alvarez, Mariano J, Califano, Andrea, Forouhar, Farhad, Modzelewski, Beata, Mitchell, Chelsey M, Yamashiro, Darrell J, Marks, Lianna J, Glade Bender, Julia L, Kung, Andrew L

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Translational Strategies for Repotrectinib in Neuroblastoma von O'Donohue, Tara J, Ibáñez, Glorymar, Coutinho, Diego Ferreira, Mauguen, Audrey, Siddiquee, Armaan, Rosales, Nestor, Calder, Paul, Ndengu, Andoyo, You, Daoqi, Long, Matthew, Roberts, Stephen S, Kung, Andrew L, Dela Cruz, Filemon S

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Roadmap for the next generation of Children’s Oncology Group rhabdomyosarcoma trials von Metts, Jonathan L., Aye, Jamie M., Crane, Jacquelyn N., Oberoi, Sapna, Balis, Frank M., Bhatia, Smita, Bona, Kira, Carleton, Bruce, Dasgupta, Roshni, Dela Cruz, Filemon S., Greenzang, Katie A., Kaufman, Jonathan L., Linardic, Corinne M., Parsons, Susan K., Robertson‐Tessi, Mark, Rudzinski, Erin R., Soragni, Alice, Stewart, Elizabeth, Weigel, Brenda J., Wolden, Suzanne L., Weiss, Aaron R., Venkatramani, Rajkumar, Heske, Christine M.

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Prospective pan-cancer germline testing using MSK-IMPACT informs clinical translation in 751 patients with pediatric solid tumors von Fiala, Elise M., Jayakumaran, Gowtham, Mauguen, Audrey, Kennedy, Jennifer A., Bouvier, Nancy, Kemel, Yelena, Fleischut, Megan Harlan, Maio, Anna, Salo-Mullen, Erin E., Sheehan, Margaret, Arnold, Angela G., Latham, Alicia, Carlo, Maria I., Cadoo, Karen, Murkherjee, Semanti, Slotkin, Emily K., Trippett, Tanya, Glade Bender, Julia, Meyers, Paul A., Wexler, Leonard, Dela Cruz, Filemon S., Cheung, Nai-Kong, Basu, Ellen, Kentsis, Alex, Ortiz, Michael, Francis, Jasmine H., Dunkel, Ira J., Khakoo, Yasmin, Gilheeney, Stephen, Farouk Sait, Sameer, Forlenza, Christopher J., Sulis, Maria, Karajannis, Matthias, Modak, Shakeel, Gerstle, Justin T., Heaton, Todd E., Roberts, Stephen, Yang, Ciyu, Jairam, Sowmya, Vijai, Joseph, Topka, Sabine, Friedman, Danielle N., Stadler, Zsofia K., Robson, Mark, Berger, Michael F., Schultz, Nikolaus, Ladanyi, Marc, O’Reilly, Richard J., Abramson, David H., Ceyhan-Birsoy, Ozge, Zhang, Liying, Mandelker, Diana, Shukla, Neerav N., Kung, Andrew L., Offit, Kenneth, Zehir, Ahmet, Walsh, Michael F.

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