Integrated pathway analysis of malignant rhabdoid tumour identifies key SMARCB1-pathways and therapeutic opportunities von Finetti, M.A, Selby, M.P, Del Carpio Pons, A, Wong, J.P, Bashton, M, Cranston, R.E, Barker, J, Crosier, S, Smith, A, Ramli, R.A, Grabovska, Y, Bailey, S, Huang, P.H, Clifford, S.C, Williamson, D

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413 Next-generation sequencing identifies the mechanism of tumourigenesis caused by loss of SMARCB1 in malignant rhabdoid tumours von Finetti, M.A, Selby, M, del Carpio Pons, A, Wood, J, Skalkoyannis, B, Smith, A, Crosier, S, Bailey, S, Clifford, S, Williamson, D

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470: Mechanism of tumourigenesis caused by loss of SMARCB1 in malignant rhabdoid tumors von Finetti, M, Del Carpio Pons, A, Wood, J, Skalkoyannis, B, Selby, M, Smith, A, Crosier, S, Bailey, S, Clifford, S, Williamson, D

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A PHYSIOLOGICAL DOSE OF ESTRADIOL IN A MURINE OSTEOARTHRITIS MODEL PARTIALLY RESCUES THE PHENOTYPE OF THE HEALTHY JOINT von Corciulo, C., Scheffler, J.M., Humeniuk, P., Pons, A. del Carpio, Stubelius, A., Von Mentzer, U., Drevinge, C., Barrett, A., Poutanen, M., Ohlsson, C., Lagerquist, M.K., Islander, U.

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137 - Integrated pathway analysis of malignant rhabdoid tumour identifies key SMARCB1-pathways and therapeutic opportunities von Finetti, M.A., Selby, M.P., Del Carpio Pons, A., Wong, J.P., Bashton, M., Cranston, R.E., Barker, J., Crosier, S., Smith, A., Ramli, R.A., Grabovska, Y., Bailey, S., Huang, P.H., Clifford, S.C., Williamson, D.

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Physiological levels of estradiol limit murine osteoarthritis progression von Corciulo, Carmen, Scheffler, Julia M, Humeniuk, Piotr, Del Carpio Pons, Alicia, Stubelius, Alexandra, Von Mentzer, Ula, Drevinge, Christina, Barrett, Aidan, Wüstenhagen, Sofia, Poutanen, Matti, Ohlsson, Claes, Lagerquist, Marie K, Islander, Ulrika

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FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis von Leslie, Jack, Millar, Ben Jm, Del Carpio Pons, Alicia, Burgoyne, Rachel A, Frost, Joseph D, Barksby, Ben S, Luli, Saimir, Scott, Jon, Simpson, A John, Gauldie, Jack, Murray, Lynne A, Finch, Donna K, Carruthers, Alan M, Ferguson, John, Sleeman, Matthew A, Rider, David, Howarth, Rachel, Fox, Christopher, Oakley, Fiona, Fisher, Andrew J, Mann, Derek A, Borthwick, Lee A

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ERα Signaling in a Subset of CXCL12‐Abundant Reticular Cells Regulates Trabecular Bone in Mice von Scheffler, Julia M, Gustafsson, Karin L, Barrett, Aidan, Corciulo, Carmen, Drevinge, Christina, Del Carpio Pons, Alicia M, Humeniuk, Piotr, Engdahl, Cecilia, Gustafsson, Jan‐Åke, Ohlsson, Claes, Carlsten, Hans, Lagerquist, Marie K., Islander, Ulrika

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Pulsed administration for physiological estrogen replacement in mice [version 1; peer review: 2 approved] von Corciulo, Carmen, Scheffler, Julia M, Gustafsson, Karin L, Drevinge, Christina, Humeniuk, Piotr, del Carpio Pons, Alicia M, Poutanen, Matti, Ohlsson, Claes, Lagerquist, Marie K, Islander, Ulrika

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Fibroblasts Promote Inflammation and Pain via IL-1α Induction of the Monocyte Chemoattractant Chemokine (C-C Motif) Ligand 2 von Paish, Hannah L., Kalson, Nicholas S., Smith, Graham R., del Carpio Pons, Alicia, Baldock, Thomas E., Smith, Nicholas, Swist-Szulik, Katarzyna, Weir, David J., Bardgett, Michelle, Deehan, David J., Mann, Derek A., Borthwick, Lee A.

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Profiling of innate and adaptive immune cells during influenza virus infection reveals sex bias in invariant natural killer T (iNKT) cells von Humeniuk, Piotr, Barrett, Aidan, Axelsson, Hannes, Corciulo, Carmen, Drevinge, Christina, Pons, Alicia Del Carpio, Angeletti, Davide, Scheffler, Julia M., Islander, Ulrika

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Chronic, Active Inflammation in Patients With Failed Total Knee Replacements Undergoing Revision Surgery von Paish, Hannah L., Baldock, Thomas Edward, Gillespie, Colin S., del Carpio Pons, Alicia, Mann, Derek A., Deehan, David J., Borthwick, Lee A., Kalson, Nicholas S.

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Association of efficacy and immune-related adverse events (irAEs) in patients with NSCLC receiving immune-checkpoint inhibitors (ICIs) von Riudavets Melia, M., Gabriela Sullivan, I., Barba Joaquín, A., Anguera Palacios, G., del Carpio, L.P., Molto Valiente, C., Camacho Arellano, S.D., Moron Asensio, S., Gomila Pons, P., Andres Granyó, M., Castillo Villegas, D., Facundo Molas, C., Garcia Planella, E., González Blanco, C., Barnadas Molins, A., Gich Saladich, I., Majem Tarruella, M.

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A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty von Dixon, David, Coates, Jonathon, del Carpio Pons, Alicia, Horabin, Joanna, Walker, Andrew, Abdul, Nicole, Kalson, Nicholas S., Brewster, Nigel T., Weir, David J., Deehan, David J., Mann, Derek A., Borthwick, Lee A.

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Brain metastases in colorectal cancer: prognostic factors and survival analysis von Del Carpio Huerta, Luis, Virgili Manrique, Anna Cristina, Szafranska, Justyna, Martin-Richard, Marta, Paez Lopez-Bravo, David, Sebio Garcia, Ana, Espinosa Mariscal, Iñigo, Gomila Pons, Paula, Andres Granyo, Marta, Barba Joaquin, Andres, Barnadas Molins, Agusti, Tobeña Puyal, Maria

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Abstract 408: Investigating the biology of atypical teratoid/rhabdoid tumors by whole genome CRISPR/Cas9 screening von Selby, Matthew P., Finetti, Martina A., Bashton, Matthew, Cranston, Ruth E., Grabovska, Yura, Del-Carpio-Pons, Alicia, Smith, Amanda, Bailey, Simon, Clifford, Steven C., Williamson, Daniel

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1409PAssociation of efficacy and immune-related adverse events (irAEs) in patients with NSCLC receiving immune-checkpoint inhibitors (ICIs) von Riudavets Melia, M, Gabriela Sullivan, I, Barba Joaquín, A, Anguera Palacios, G, del Carpio, L P, Molto Valiente, C, Camacho Arellano, S D, Moron Asensio, S, Gomila Pons, P, Andres Granyó, M, Castillo Villegas, D, Facundo Molas, C, Garcia Planella, E, González Blanco, C, Barnadas Molins, A, Gich Saladich, I, Majem Tarruella, M

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P1.01-63 Correlation Between Immune-Related Adverse Events and Efficacy of Immune-Checkpoint Inhibitors in Patients with Non-Small Cell Lung Cancer von Riudavets Melià, M., Gabriela Sullivan, I., Barba Joaquín, A., Anguera Palacios, G., Del Carpio Huerta, L., Moltó Valiente, C., Camacho Arellano, S.D., Moron Asensio, S., Gomila Pons, P., Andrés Granyó, M., Castillo Villegas, D., Facundo Molas, C., Garcia Planella, E., González Blanco, C., Genua Trullos, I., Tuneu Valls, L., Stantonyonge Sesnic, N., Barnadas Molins, A., Gich Saladich, I., Majem Tarruella, M.

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AT-18INVESTIGATING THE BIOLOGY OF ATYPICAL TERATOID/RHABDOID TUMORS BY WHOLE GENOME CRISPR/CAS9 SCREENING von Selby, Matthew P., Finetti, Martina A., Bashton, Matthew, Cranston, Ruth E., Del-Carpio-Pons, Alicia, Bailey, Simon, Clifford, Steven C., Williamson, Daniel

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ATRT-23. SMARCB1-DEPENDENCIES IN ATYPICAL TERATOID/RHABDOID TUMOURS: A STRATEGY FOR PRE-CLINICAL THERAPEUTIC TARGET IDENTIFICATION IN THE ABSENCE OF ACTIONABLE MUTATIONS von Finetti, Martina Anna, Selby, Matthew p, Pons, Alicia del-Carpio, Batting, Sarah, Wood, James A, Barker, James M, Smith, Amanda, Crosier, Stephen, Bashton, Matthew, Pickles, Jessica C, Fairchild, Amy R, Avery, Aimee, O’Hare, Patricia, Pizer, Barry, Brennan, Bernadette, Lowis, Stephen, Hargrave, Darren, Jacques, Thomas S, Bailey, Simon, Clifford, Steven C, Williamson, Daniel

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