Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive Advanced Breast Cancer von André, Fabrice, Ciruelos, Eva, Rubovszky, Gabor, Campone, Mario, Loibl, Sibylle, Rugo, Hope S, Iwata, Hiroji, Conte, Pierfranco, Mayer, Ingrid A, Kaufman, Bella, Yamashita, Toshinari, Lu, Yen-Shen, Inoue, Kenichi, Takahashi, Masato, Pápai, Zsuzsanna, Longin, Anne-Sophie, Mills, David, Wilke, Celine, Hirawat, Samit, Juric, Dejan

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Cell Atlas of The Human Fovea and Peripheral Retina von Yan, Wenjun, Peng, Yi-Rong, van Zyl, Tavé, Regev, Aviv, Shekhar, Karthik, Juric, Dejan, Sanes, Joshua R.

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Alpelisib plus fulvestrant in PIK3CA-mutated, hormone receptor-positive advanced breast cancer after a CDK4/6 inhibitor (BYLieve): one cohort of a phase 2, multicentre, open-label,... von Rugo, Hope S, Lerebours, Florence, Ciruelos, Eva, Drullinsky, Pamela, Ruiz-Borrego, Manuel, Neven, Patrick, Park, Yeon Hee, Prat, Aleix, Bachelot, Thomas, Juric, Dejan, Turner, Nicholas, Sophos, Nickolas, Zarate, Juan Pablo, Arce, Christina, Shen, Yu-Ming, Turner, Stuart, Kanakamedala, Hemanth, Hsu, Wei-Chun, Chia, Stephen

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A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2- Metastatic Breast Cancer von Mayer, Ingrid A, Abramson, Vandana G, Formisano, Luigi, Balko, Justin M, Estrada, Mónica V, Sanders, Melinda E, Juric, Dejan, Solit, David, Berger, Michael F, Won, Helen H, Li, Yisheng, Cantley, Lewis C, Winer, Eric, Arteaga, Carlos L

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Clinical Acquired Resistance to KRASG12C Inhibition through a novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS-MAPK Reactivation von Tanaka, Noritaka, Lin, Jessica J., Li, Chendi, Ryan, Meagan B., Zhang, Junbing, Kiedrowski, Lesli A., Michel, Alexa G., Syed, Mohammed U., Fella, Katerina A., Sakhi, Mustafa, Baiev, Islam, Juric, Dejan, Gainor, Justin F., Klempner, Samuel J., Lennerz, Jochen K., Siravegna, Giulia, Bar-Peled, Liron, Hata, Aaron N., Heist, Rebecca S., Corcoran, Ryan B.

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Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity von Hafner, Marc, Mills, Caitlin E., Subramanian, Kartik, Chen, Chen, Chung, Mirra, Boswell, Sarah A., Everley, Robert A., Liu, Changchang, Walmsley, Charlotte S., Juric, Dejan, Sorger, Peter K.

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Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer von Pereira, Bernard, Chen, Christopher T., Goyal, Lipika, Walmsley, Charlotte, Pinto, Christopher J., Baiev, Islam, Allen, Read, Henderson, Laura, Saha, Supriya, Reyes, Stephanie, Taylor, Martin S., Fitzgerald, Donna M., Broudo, Maida Williams, Sahu, Avinash, Gao, Xin, Winckler, Wendy, Brannon, A. Rose, Engelman, Jeffrey A., Leary, Rebecca, Stone, James R., Campbell, Catarina D., Juric, Dejan

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Phase II study of ipilimumab and nivolumab in leptomeningeal carcinomatosis von Brastianos, Priscilla K., Strickland, Matthew R., Lee, Eudocia Quant, Wang, Nancy, Cohen, Justine V., Chukwueke, Ugonma, Forst, Deborah Anne, Eichler, April, Overmoyer, Beth, Lin, Nancy U., Chen, Wendy Y., Bardia, Aditya, Juric, Dejan, Dagogo-Jack, Ibiayi, White, Michael D., Dietrich, Jorg, Nayyar, Naema, Kim, Albert E., Alvarez-Breckenridge, Christopher, Mahar, Maura, Mora, Joana L., Nahed, Brian V., Jones, Pamela S., Shih, Helen A., Gerstner, Elizabeth R., Giobbie-Hurder, Anita, Carter, Scott L., Oh, Kevin, Cahill, Daniel P., Sullivan, Ryan J.

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CDK 4/6 Inhibitors Sensitize PIK3CA Mutant Breast Cancer to PI3K Inhibitors von Vora, Sadhna R., Juric, Dejan, Kim, Nayoon, Mino-Kenudson, Mari, Huynh, Tiffany, Costa, Carlotta, Lockerman, Elizabeth L., Pollack, Sarah F., Liu, Manway, Li, Xiaoyan, Lehar, Joseph, Wiesmann, Marion, Wartmann, Markus, Chen, Yan, Cao, Z. Alexander, Pinzon-Ortiz, Maria, Kim, Sunkyu, Schlegel, Robert, Huang, Alan, Engelman, Jeffrey A.

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Tumor genetic testing for patient selection in phase I clinical trials: the case of PI3K inhibitors von Juric, Dejan, Baselga, José

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Parallel Genomic Alterations of Antigen and Payload Targets Mediate Polyclonal Acquired Clinical Resistance to Sacituzumab Govitecan in Triple-Negative Breast Cancer von Coates, James T., Sun, Sheng, Leshchiner, Ignaty, Thimmiah, Nayana, Martin, Elizabeth E., McLoughlin, Daniel, Danysh, Brian P., Slowik, Kara, Jacobs, Raquel A., Rhrissorrakrai, Kahn, Utro, Filippo, Levovitz, Chaya, Denault, Elyssa, Walmsley, Charlotte S., Kambadakone, Avinash, Stone, James R., Isakoff, Steven J., Parida, Laxmi, Juric, Dejan, Getz, Gad, Bardia, Aditya, Ellisen, Leif W.

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CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer von Johnson, Shawn F., Cruz, Cristina, Greifenberg, Ann Katrin, Dust, Sofia, Stover, Daniel G., Chi, David, Primack, Benjamin, Cao, Shiliang, Bernhardy, Andrea J., Coulson, Rhiannon, Lazaro, Jean-Bernard, Kochupurakkal, Bose, Sun, Heather, Unitt, Christine, Moreau, Lisa A., Sarosiek, Kristopher A., Scaltriti, Maurizio, Juric, Dejan, Baselga, José, Richardson, Andrea L., Rodig, Scott J., D’Andrea, Alan D., Balmaña, Judith, Johnson, Neil, Geyer, Matthias, Serra, Violeta, Lim, Elgene, Shapiro, Geoffrey I.

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PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1 von Ebi, Hiromichi, Costa, Carlotta, Faber, Anthony C., Nishtala, Madhuri, Kotani, Hiroshi, Juric, Dejan, Pelle, Patricia Della, Song, Youngchul, Yano, Seiji, Mino-Kenudson, Mari, Benes, Cyril H., Engelman, Jeffrey A.

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Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers von Klotz, Remi, Thomas, Amal, Teng, Teng, Han, Sung Min, Iriondo, Oihana, Li, Lin, Restrepo-Vassalli, Sara, Wang, Alan, Izadian, Negeen, MacKay, Matthew, Moon, Byoung-San, Liu, Kevin J., Ganesan, Sathish Kumar, Lee, Grace, Kang, Diane S., Walmsley, Charlotte S., Pinto, Christopher, Press, Michael F., Lu, Wange, Lu, Janice, Juric, Dejan, Bardia, Aditya, Hicks, James, Salhia, Bodour, Attenello, Frank, Smith, Andrew D., Yu, Min

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Single-cell barcode analysis provides a rapid readout of cellular signaling pathways in clinical specimens von Giedt, Randy J., Pathania, Divya, Carlson, Jonathan C. T., McFarland, Philip J., del Castillo, Andres Fernandez, Juric, Dejan, Weissleder, Ralph

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FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma von Zhen, Yuanli, Liu, Kai, Shi, Lei, Shah, Simran, Xu, Qin, Ellis, Haley, Balasooriya, Eranga R., Kreuzer, Johannes, Morris, Robert, Baldwin, Albert S., Juric, Dejan, Haas, Wilhelm, Bardeesy, Nabeel

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EGFR Inhibition Potentiates FGFR Inhibitor Therapy and Overcomes Resistance in FGFR2 Fusion-Positive Cholangiocarcinoma von Wu, Qibiao, Zhen, Yuanli, Shi, Lei, Vu, Phuong, Greninger, Patricia, Adil, Ramzi, Merritt, Joshua, Egan, Regina, Wu, Meng-Ju, Yin, Xunqin, Ferrone, Cristina R, Deshpande, Vikram, Baiev, Islam, Pinto, Christopher J, McLoughlin, Daniel E, Walmsley, Charlotte S, Stone, James R, Gordan, John D, Zhu, Andrew X, Juric, Dejan, Goyal, Lipika, Benes, Cyril H, Bardeesy, Nabeel

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A First-in-Human, Phase I, Dose-Escalation Study of TAK-117, a Selective PI3Kα Isoform Inhibitor, in Patients with Advanced Solid Malignancies von Juric, Dejan, de Bono, Johann S, LoRusso, Patricia M, Nemunaitis, John, Heath, Elisabeth I, Kwak, Eunice L, Macarulla Mercadé, Teresa, Geuna, Elena, Jose de Miguel-Luken, Maria, Patel, Chirag, Kuida, Keisuke, Sankoh, Serap, Westin, Eric H, Zohren, Fabian, Shou, Yaping, Tabernero, Josep

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A risk analysis of alpelisib-induced hyperglycemia in patients with advanced solid tumors and breast cancer von Rodón, Jordi, Demanse, David, Rugo, Hope S, Burris, Howard A, Simó, Rafael, Farooki, Azeez, Wellons, Melissa F, André, Fabrice, Hu, Huilin, Vuina, Dragica, Quadt, Cornelia, Juric, Dejan

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A phase 1 study evaluating safety and pharmacokinetics of losatuxizumab vedotin (ABBV-221), an anti-EGFR antibody-drug conjugate carrying monomethyl auristatin E, in patients with... von Cleary, James M., Calvo, Emiliano, Moreno, Victor, Juric, Dejan, Shapiro, Geoffrey I., Vanderwal, Carol Ann, Hu, Beibei, Gifford, Maryella, Barch, David, Roberts-Rapp, Lisa, Ansell, Peter J., Xiong, Hao, Ocampo, Christopher, Tolcher, Anthony W.

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