Gene editing as a therapeutic strategy for spinocerebellar ataxia type-3 von Déglon, N.

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Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado―Joseph disease von SIMOES, Ana T, GONCALVES, Nélio, KOEPPEN, Arnulf, DEGLON, Nicole, KÜGLER, Sebastian, DUARTE, Carlos Bandeira, DE ALMEIDA, Luís Pereira

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AAV5-miHTT gene therapy demonstrates suppression of mutant huntingtin aggregation and neuronal dysfunction in a rat model of Huntington’s disease von Miniarikova, J, Zimmer, V, Martier, R, Brouwers, C C, Pythoud, C, Richetin, K, Rey, M, Lubelski, J, Evers, M M, van Deventer, S J, Petry, H, Déglon, N, Konstantinova, P

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Gene transfer engineering for astrocyte-specific silencing in the CNS von Merienne, N, Delzor, A, Viret, A, Dufour, N, Rey, M, Hantraye, P, Déglon, N

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Formation of hippocampal mHTT aggregates leads to impaired spatial memory, hippocampal activation and adult neurogenesis von Schwab, LC, Richetin, K, Barker, RA, Deglon, N

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Viral vectors as tools to model and treat neurodegenerative disorders von Déglon, N., Hantraye, P.

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BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities von Quesseveur, G, David, D J, Gaillard, M C, Pla, P, Wu, M V, Nguyen, H T, Nicolas, V, Auregan, G, David, I, Dranovsky, A, Hantraye, P, Hen, R, Gardier, A M, Déglon, N, Guiard, B P

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Implication of the JNK pathway in a rat model of Huntington's disease von Perrin, V., Dufour, N., Raoul, C., Hassig, R., Brouillet, E., Aebischer, P., Luthi-Carter, R., Déglon, N.

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The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases von Ben Haim, Lucile, Ceyzériat, Kelly, Carrillo-de Sauvage, Maria Angeles, Aubry, Fabien, Auregan, Gwennaëlle, Guillermier, Martine, Ruiz, Marta, Petit, Fanny, Houitte, Diane, Faivre, Emilie, Vandesquille, Matthias, Aron-Badin, Romina, Dhenain, Marc, Déglon, Nicole, Hantraye, Philippe, Brouillet, Emmanuel, Bonvento, Gilles, Escartin, Carole

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In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects von Faideau, Mathilde, Kim, Jinho, Cormier, Kerry, Gilmore, Richard, Welch, Mackenzie, Auregan, Gwennaelle, Dufour, Noelle, Guillermier, Martine, Brouillet, Emmanuel, Hantraye, Philippe, Déglon, Nicole, Ferrante, Robert J., Bonvento, Gilles

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Preclinical Studies of Neurodegenerative Diseases von Deglon, N

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α-Synucleinopathy and Selective Dopaminergic Neuron Loss in a Rat Lentiviral-Based Model of Parkinson's Disease von Lo Bianco, C., J-L. Ridet, Schneider, B. L., Déglon, N., Aebischer, P.

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Emerging technologies to study glial cells (vol 68, pg 1692, 2020) von Hirbec, H., Deglon, N., Foo, L. C., Goshen, Grutzendler, J., Hangen, E., Escartin, C.

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Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina von KOSTIC, C, CHIODINI, F, ARSENIJEVIC, Y, SALMON, P, WIZNEROWICZ, M, DEGLON, N, HORNFELD, D, TRONO, D, AEBISCHER, P, SCHORDERET, D. F, MUNIER, F. L

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Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: Results of a phase I study von BLOCH, J, BACHOUD-LEVI, A. C, BRUGIERES, P, BOISSE, M.-F, BAUDIC, S, CESARO, P, HANTRAYE, P, AEBISCHER, P, PESCHANSKI, M, DEGLON, N, LEFAUCHEUR, J. P, WINKEL, L, PALFI, S, NGUYEN, J. P, BOURDET, C, GAURA, V, REMY, P

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Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease von Lo Bianco, C., Déglon, N., Pralong, W., Aebischer, P.

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Complete and Long-Term Rescue of Lesioned Adult Motoneurons by Lentiviral-Mediated Expression of Glial Cell Line-Derived Neurotrophic Factor in the Facial Nucleus von Hottinger, Andreas F, Azzouz, Mimoun, Deglon, Nicole, Aebischer, Patrick, Zurn, Anne D

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P.2.10 Hippocampal Cx43 hemichannel inactivation protects from glutamatergic stress-related behaviour von Portal, B., Manta, S., Rovera, R., Lorenzo, N., Rampon, C., Deglon, N., Haddjeri, N., Guiard, B.P.

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RNA interference as therapeutic strategy to counteract Huntington's disease von Deglon, Nicole

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Microtubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth von Deloulme, Jean-Christophe, Gory-Fauré, Sylvie, Mauconduit, Franck, Chauvet, Sophie, Jonckheere, Julie, Boulan, Benoit, Mire, Erik, Xue, Jing, Jany, Marion, Maucler, Caroline, Deparis, Agathe A., Montigon, Olivier, Daoust, Alexia, Barbier, Emmanuel L., Bosc, Christophe, Deglon, Nicole, Brocard, Jacques, Denarier, Eric, Le Brun, Isabelle, Pernet-Gallay, Karin, Vilgrain, Isabelle, Robinson, Phillip J., Lahrech, Hana, Mann, Fanny, Andrieux, Annie

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