A Brief History of Use of Animals in Biomedical Research and Perspective on Non-Animal Alternatives von Kinter, Lewis B, DeHaven, Ron, Johnson, David K, DeGeorge, Joseph J

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An Evaluation of the Impact of PD-1 Pathway Blockade on Reproductive Safety of Therapeutic PD-1 Inhibitors von Poulet, Frederique M., Wolf, Jayanthi J., Herzyk, Danuta J., DeGeorge, Joseph J.

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Exposure assessments in reproductive and developmental toxicity testing: An IQ-DruSafe industry survey on current practices and experiences in support of exposure-based high dose s... von Andrews, Paul A., McNerney, Mary Ellen, DeGeorge, Joseph J.

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Current nonclinical testing paradigms in support of safe clinical trials: An IQ Consortium DruSafe perspective von Butler, Lynne D., Guzzie-Peck, Peggy, Hartke, James, Bogdanffy, Matthew S., Will, Yvonne, Diaz, Dolores, Mortimer-Cassen, Elisabeth, Derzi, Mazin, Greene, Nigel, DeGeorge, Joseph J.

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Analysis of exposure margins in developmental toxicity studies for detection of human teratogens von Andrews, Paul A., Blanset, Diann, Costa, Priscila Lemos, Green, Martin, Green, Maia L., Jacobs, Abigail, Kadaba, Rajkumar, Lebron, Jose A., Mattson, Britta, McNerney, Mary Ellen, Minck, Daniel, Oliveira, Luana de Castro, Theunissen, Peter T., DeGeorge, Joseph J.

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Assessment of the clinical cardiac drug‐drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys... von Regan, Christopher P., Morissette, Pierre, Regan, Hillary K., Travis, Jeffery J., Gerenser, Pamela, Wen, Jianzhong, Fitzgerald, Kevin, Gruver, Shaun, DeGeorge, Joseph J., Sannajust, Frederick J.

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Scientific Knowledge and Technology, Animal Experimentation, and Pharmaceutical Development von Kinter, Lewis B, DeGeorge, Joseph J

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An Analysis of Pharmaceutical Experience with Decades of Rat Carcinogenicity Testing: Support for a Proposal to Modify Current Regulatory Guidelines von Sistare, Frank D., Morton, Daniel, Alden, Carl, Christensen, Joel, Keller, Douglas, Jonghe, Sandra De, Storer, Richard D., Reddy, M. Vijayaraj, Kraynak, Andrew, Trela, Bruce, Bienvenu, Jean-Guy, Bjurström, Sivert, Bosmans, Vanessa, Brewster, David, Colman, Karyn, Dominick, Mark, Evans, John, Hailey, James R., Kinter, Lewis, Liu, Matt, Mahrt, Charles, Marien, Dirk, Myer, James, Perry, Richard, Potenta, Daniel, Roth, Arthur, Sherratt, Philip, Singer, Thomas, Slim, Rabih, Soper, Keith, Fransson-Steen, Ronny, Stoltz, James, Turner, Oliver, Turnquist, Susan, van Heerden, Marjolein, Woicke, Jochen, DeGeorge, Joseph J.

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Regulatory Forum Commentary Counterpoint: Dose Selection for Tg.rasH2 Mouse Carcinogenicity Studies von Darbes, Jarig, Sistare, Frank D., DeGeorge, Joseph J.

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Role of chronic toxicology studies in revealing new toxicities von Galijatovic-Idrizbegovic, Alema, Miller, Judith E., Cornell, Wendy D., Butler, James A., Wollenberg, Gordon K., Sistare, Frank D., DeGeorge, Joseph J.

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An Industry Perspective on the Utility of Short-Term Carcinogenicity Testing in Transgenic Mice in Pharmaceutical Development von Storer, Richard D., Sistare, Frank D., Vijayaraj Reddy, M., Degeorge, Joseph J.

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Characterization of an investigative safety pharmacology model to assess comprehensive cardiac function and structure in chronically instrumented conscious beagle dogs von Regan, Christopher P., Stump, Gary L., Detwiler, Theodore J., Chen, Li, Regan, Hillary K., Gilberto, David B., DeGeorge, Joseph J., Sannajust, Frederick J.

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Safety Assessment of Drug Metabolites: Implications of Regulatory Guidance and Potential Application of Genetically Engineered Mouse Models that Express Human P450s von Powley, Mark W, Frederick, Clay B, Sistare, Frank D, DeGeorge, Joseph J

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Phenazin-5-ium hydrogen sulfate monohydrate von Degeorge, Joseph, Landee, Christopher P, Turnbull, Mark M

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Applications of Toxicogenomics to Nonclinical Drug Development: Regulatory Science Considerations von Sistare, Frank D., DeGeorge, Joseph J.

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Importance of Halogen···Halogen Contacts for the Structural and Magnetic Properties of CuX2(pyrazine-N,N′-dioxide)(H2O)2 (X = Cl and Br) von Schlueter, John A, Park, Hyunsoo, Halder, Gregory J, Armand, William R, Dunmars, Cortney, Chapman, Karena W, Manson, Jamie L, Singleton, John, McDonald, Ross, Plonczak, Alex, Kang, Jinhee, Lee, Chaghoon, Whangbo, Myung-Hwan, Lancaster, Tom, Steele, Andrew J, Franke, Isabel, Wright, Jack D, Blundell, Stephen J, Pratt, Francis L, deGeorge, Joseph, Turnbull, Mark M, Landee, Christopher P

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Carcinogenicity Testing and the Evaluation of Regulatory Requirements for Pharmaceuticals von Contrera, Joseph F, Jacobs, Abigail C, DeGeorge, Joseph J

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Interaction between amiodarone and hepatitis-C virus nucleotide inhibitors in human induced pluripotent stem cell-derived cardiomyocytes and HEK-293 Cav{sub 1.2} over-expressing ce... von Lagrutta, Armando

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Interaction between amiodarone and hepatitis-C virus nucleotide inhibitors in human induced pluripotent stem cell-derived cardiomyocytes and HEK-293 Cav1.2 over-expressing cells von Lagrutta, Armando, Zeng, Haoyu, Imredy, John, Balasubramanian, Bharathi, Dech, Spencer, Lis, Edward, Wang, Jixin, Zhai, Jin, DeGeorge, Joseph, Sannajust, Frederick

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A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity von Müller, Lutz, Mauthe, Robert J., Riley, Christopher M., Andino, Marta M., Antonis, David De, Beels, Chris, DeGeorge, Joseph, De Knaep, Alfons G.M., Ellison, Dean, Fagerland, Jane A., Frank, Rebecca, Fritschel, Betsy, Galloway, Sheila, Harpur, Ernie, Humfrey, Charles D.N., Jacks, Alexander S., Jagota, Nirdosh, Mackinnon, John, Mohan, Ganapathy, Ness, Daniel K., O’Donovan, Michael R., Smith, Mark D., Vudathala, Gopi, Yotti, Larry

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