Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist von Pickford, P, Lucey, M, Rujan, R-M, McGlone, ER, Bitsi, S, Ashford, FB, Corrêa, IR, Hodson, DJ, Tomas, A, Deganutti, G, Reynolds, CA, Owen, BM, Tan, TM, Minnion, J, Jones, B, Bloom, SR

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Random glucose GWAS in 493,036 individuals provides insights into diabetes pathophysiology, complications and treatment stratification von Lagou, V, Jiang, L, Ulrich, A, Zudina, L, González, KSG, Balkhiyarova, Z, Faggian, A, Chen, S, Todorov, P, Sharapov, S, David, A, Marullo, L, Mägi, R, Rujan, R-M, Ahlqvist, E, Thorleifsson, G, Gao, H, Evangelou, E, Benyamin, B, Scott, R, Isaacs, A, Zhao, JH, Willems, SM, Johnson, T, Gieger, C, Grallert, H, Meisinger, C, Müller-Nurasyid, M, Strawbridge, RJ, Goel, A, Rybin, D, Albrecht, E, Jackson, AU, Stringham, HM, Corrêa, IR, Eric, F-E, Steinthorsdottir, V, Uitterlinden, AG, Munroe, PB, Brown, MJ, Julian, S, Holmen, O, Thorand, B, Hveem, K, Wilsgaard, T, Mohlke, KL, Kratzer, W, Mark, H, Koenig, W, Boehm, BO, Tan, TM, Tomas, A, Salem, V, Barroso, I, Tuomilehto, J, Boehnke, M, Florez, JC, Hamsten, A, Watkins, H, Njølstad, I, Wichmann, H-E, Caulfield, MJ, Khaw, K-T, Van Duijn, C, Hofman, A, Wareham, NJ, Langenberg, C, Whitfield, JB, Martin, NG, Montgomery, G, Scapoli, C, Tzoulaki, I, Elliott, P, Thorsteinsdottir, U, Stefansson, K, Brittain, EL, McCarthy, MI, Froguel, P, Sexton, PM, Wootten, D, Groop, L, Dupuis, J, Meigs, JB, Deganutti, G, Demirkan, A, Pers, TH, Reynolds, CA, Aulchenko, YS, Kaakinen, MA, Jones, B, Prokopenko, I, Glucose, OBOTM-AO, MAGIC, I-RTC

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Structure and dynamics of the active Gs-coupled human secretin receptor von Dong, Maoqing, Deganutti, Giuseppe, Piper, Sarah J., Liang, Yi-Lynn, Khoshouei, Maryam, Belousoff, Matthew J., Harikumar, Kaleeckal G., Reynolds, Christopher A., Glukhova, Alisa, Furness, Sebastian G. B., Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Sexton, Patrick M., Miller, Laurence J.

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Activation of the GLP-1 receptor by a non-peptidic agonist von Zhao, Peishen, Liang, Yi-Lynn, Belousoff, Matthew J., Deganutti, Giuseppe, Fletcher, Madeleine M., Willard, Francis S., Bell, Michael G., Christe, Michael E., Sloop, Kyle W., Inoue, Asuka, Truong, Tin T., Clydesdale, Lachlan, Furness, Sebastian G. B., Christopoulos, Arthur, Wang, Ming-Wei, Miller, Laurence J., Reynolds, Christopher A., Danev, Radostin, Sexton, Patrick M., Wootten, Denise

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First computation of Mueller Tang processes using a full NLL BFKL approach von Colferai, Dimitri, Deganutti, Federico, Raben, Timothy G., Royon, Christophe

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Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression von Wall, Mark J., Hill, Emily, Huckstepp, Robert, Barkan, Kerry, Deganutti, Giuseppe, Leuenberger, Michele, Preti, Barbara, Winfield, Ian, Carvalho, Sabrina, Suchankova, Anna, Wei, Haifeng, Safitri, Dewi, Huang, Xianglin, Imlach, Wendy, La Mache, Circe, Dean, Eve, Hume, Cherise, Hayward, Stephanie, Oliver, Jess, Zhao, Fei-Yue, Spanswick, David, Reynolds, Christopher A., Lochner, Martin, Ladds, Graham, Frenguelli, Bruno G.

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Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins von Liang, Yi-Lynn, Belousoff, Matthew J, Fletcher, Madeleine M, Zhang, Xin, Khoshouei, Maryam, Deganutti, Giuseppe, Koole, Cassandra, Furness, Sebastian G. B, Miller, Laurence J, Hay, Debbie L, Christopoulos, Arthur, Reynolds, Christopher A, Danev, Radostin, Wootten, Denise, Sexton, Patrick M

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Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy von Dal Maso, Emma, Zhu, Yue, Pham, Vi, Reynolds, Christopher A., Deganutti, Giuseppe, Hick, Caroline A., Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L., Wang, Ming-Wei, Sexton, Patrick M., Furness, Sebastian G.B., Wootten, Denise

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Molecular Signature for Receptor Engagement in the Metabolic Peptide Hormone Amylin von Bower, Rebekah L, Yule, Lauren, Rees, Tayla A, Deganutti, Giuseppe, Hendrikse, Erica R, Harris, Paul W. R, Kowalczyk, Renata, Ridgway, Zachary, Wong, Amy G, Swierkula, Katarzyna, Raleigh, Daniel P, Pioszak, Augen A, Brimble, Margaret A, Reynolds, Christopher A, Walker, Christopher S, Hay, Debbie L

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Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor von Pham, Vi, Zhu, Yue, Dal Maso, Emma, Reynolds, Christopher A, Deganutti, Giuseppe, Atanasio, Silvia, Hick, Caroline A, Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L, Furness, Sebastian G. B, Wang, Ming-Wei, Wootten, Denise, Sexton, Patrick M

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Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor von Deganutti, Giuseppe, Barkan, Kerry, Preti, Barbara, Leuenberger, Michele, Wall, Mark, Frenguelli, Bruno G, Lochner, Martin, Ladds, Graham, Reynolds, Christopher A

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Selective activation of Gαob by an adenosine A 1 receptor agonist elicits analgesia without cardiorespiratory depression von Wall, Mark J, Hill, Emily, Huckstepp, Robert, Barkan, Kerry, Deganutti, Giuseppe, Leuenberger, Michele, Preti, Barbara, Winfield, Ian, Carvalho, Sabrina, Suchankova, Anna, Wei, Haifeng, Safitri, Dewi, Huang, Xianglin, Imlach, Wendy, La Mache, Circe, Dean, Eve, Hume, Cherise, Hayward, Stephanie, Oliver, Jess, Zhao, Fei-Yue, Spanswick, David, Reynolds, Christopher A, Lochner, Martin, Ladds, Graham, Frenguelli, Bruno G

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Selective Cyclooxygenase-2 Inhibitor Rofecoxib (Vioxx) Induces Expression of Cell Cycle Arrest Genes and Slows Tumor Growth in Human Pancreatic Cancer von Tseng, William W, Deganutti, Adriana, Chen, May N, Saxton, Romaine E, Liu, Carson D

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Structure and Dynamics of Adrenomedullin Receptors AM 1 and AM 2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins von Liang, Yi-Lynn, Belousoff, Matthew J, Fletcher, Madeleine M, Zhang, Xin, Khoshouei, Maryam, Deganutti, Giuseppe, Koole, Cassandra, Furness, Sebastian G B, Miller, Laurence J, Hay, Debbie L, Christopoulos, Arthur, Reynolds, Christopher A, Danev, Radostin, Wootten, Denise, Sexton, Patrick M

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First computation of Mueller Tang processes using the full NLL BFKL approach von Colferai, Dimitri, Deganutti, Federico, Raben, Timothy G, Royon, Christophe

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Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor von Deganutti, Giuseppe, Barkan, Kerry, Preti, Barbara, Leuenberger, Michele, Wall, Mark, Frenguelli, Bruno G, Lochner, Martin, Ladds, Graham, Reynolds, Christopher A

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Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression von Wall, Mark J, Hill, Emily, Huckstepp, Robert, Barkan, Kerry, Deganutti, Giuseppe, Leuenberger, Michele, Preti, Barbara, Winfield, Ian, Carvalho, Sabrina, Suchankova, Anna, Wei, Haifeng, Safitri, Dewi, Huang, Xianglin, Imlach, Wendy, La Mache, Circe, Dean, Eve, Hume, Cherise, Hayward, Stephanie, Oliver, Jess, Zhao, Fei-Yue, Spanswick, David, Reynolds, Christopher A, Lochner, Martin, Ladds, Graham, Frenguelli, Bruno G

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Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression von Wall, Mark J, Hill, Emily, Huckstepp, Robert, Barkan, Kerry, Deganutti, Giuseppe, Leuenberger, Michele, Preti, Barbara, Winfield, Ian, Carvalho, Sabrina, Suchankova, Anna, Wei, Haifeng, Safitri, Dewi, Huang, Xianglin, Imlach, Wendy, La Mache, Circe, Dean, Eve, Hume, Cherise, Hayward, Stephanie, Oliver, Jess, Zhao, Fei-Yue, Spanswick, David, Reynolds, Christopher A, Lochner, Martin, Ladds, Graham, Frenguelli, Bruno G

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Catalogue of Rainfall Events with Shallow Landslides and New Rainfall Thresholds in Italy von Brunetti, Maria Teresa, Peruccacci, Silvia, Antronico, Loredana, Bartolini, Devis, Deganutti, Andrea Maria, Gariano, Stefano Luigi, Iovine, Giulio, Luciani, Silvia, Luino, Fabio, Melillo, Massimo, Palladino, Michela Rosa, Parise, Mario, Rossi, Mauro, Turconi, Laura, Vennari, Carmela, Vessia, Giovanna, Viero, Alessia, Guzzetti, Fausto

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