Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct von Gehrlein, Alexandra, Udayar, Vinod, Anastasi, Nadia, Morella, Martino L., Ruf, Iris, Brugger, Doris, von der Mark, Sophia, Thoma, Ralf, Rufer, Arne, Heer, Dominik, Pfahler, Nina, Jochner, Anton, Niewoehner, Jens, Wolf, Luise, Fueth, Matthias, Ebeling, Martin, Villaseñor, Roberto, Zhu, Yanping, Deen, Matthew C., Shan, Xiaoyang, Ehsaei, Zahra, Taylor, Verdon, Sidransky, Ellen, Vocadlo, David J., Freskgård, Per-Ola, Jagasia, Ravi

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Chemical Tools for Monitoring and Targeting Collagen Cross-linking von Deen, Matthew C, Boll, Linus B, Wennemers, Helma

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Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo von Deen, Matthew C, Gilormini, Pierre-André, Vocadlo, David J

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A Direct Fluorescent Activity Assay for Glycosyltransferases Enables Convenient High‐Throughput Screening: Application to O‐GlcNAc Transferase von Alteen, Matthew G., Gros, Christina, Meek, Richard W., Cardoso, David A., Busmann, Jil A., Sangouard, Gontran, Deen, Matthew C., Tan, Hong‐Yee, Shen, David L., Russell, Cecilia C., Davies, Gideon J., Robinson, Phillip J., McCluskey, Adam, Vocadlo, David J.

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A Fixable Fluorescence‐Quenched Substrate for Quantitation of Lysosomal Glucocerebrosidase Activity in Both Live and Fixed Cells von Zhu, Sha, Deen, Matthew C., Zhu, Yanping, Gilormini, Pierre‐André, Chen, Xi, Davis, Oliver B., Chin, Marcus Y., Henry, Anastasia G., Vocadlo, David J.

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A versatile fluorescence-quenched substrate for quantitative measurement of glucocerebrosidase activity within live cells von Deen, Matthew C, Zhu, Yanping, Gros, Christina, Na, Na, Gilormini, Pierre-André, Shen, David L, Bhosale, Sandeep, Anastasi, Nadia, Wang, RuiQi, Shan, Xiaoyang, Harde, Eva, Jagasia, Ravi, Lynn, Francis C, Vocadlo, David J

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Quantifying lysosomal glycosidase activity within cells using bis-acetal substrates von Cecioni, Samy, Ashmus, Roger A., Gilormini, Pierre-André, Zhu, Sha, Chen, Xi, Shan, Xiaoyang, Gros, Christina, Deen, Matthew C., Wang, Yang, Britton, Robert, Vocadlo, David J.

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Pharmacological Chaperones for GCase that Switch Conformation with pH Enhance Enzyme Levels in Gaucher Animal Models von Santana, Andrés G., Robinson, Kyle, Vickers, Chelsea, Deen, Matthew C., Chen, Hong‐Ming, Zhou, Stephen, Dai, Ben, Fuller, Maria, Boraston, Alisdair B., Vocadlo, David J., Clarke, Lorne A., Withers, Stephen G.

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Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates von Bhosale, Sandeep, Kandalkar, Sachin, Gilormini, Pierre-André, Akintola, Oluwafemi, Rowland, Rhianna, Adabala, Pal John Pal, King, Dustin, Deen, Matthew C., Chen, Xi, Davies, Gideon J., Vocadlo, David J., Bennet, Andrew J.

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A Fluorogenic Disaccharide Substrate for α‑Mannosidases Enables High-Throughput Screening and Identification of an Inhibitor of the GH92 Virulence Factor from Streptococcus pneumon... von Bhosale, Sandeep, Deen, Matthew C., Proceviat, Cameron, Hettle, Andrew, Winter, Dana K., Brockerman, Jacob, Levene, Marina, Bennet, Andrew J., Spino, Claude, Boraston, Alisdair B., Vocadlo, David J.

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Directed evolution of a remarkably efficient Kdnase from a bacterial neuraminidase von Shamsi Kazem Abadi, Saeideh, Deen, Matthew C, Watson, Jacqueline N, Shidmoossavee, Fahimeh S, Bennet, Andrew J

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Selective Fluorogenic β‑Glucocerebrosidase Substrates for Convenient Analysis of Enzyme Activity in Cell and Tissue Homogenates von Deen, Matthew C, Proceviat, Cameron, Shan, Xiaoyang, Wu, Liang, Shen, David L, Davies, Gideon J, Vocadlo, David J

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Pharmacological Inhibition of O‑GlcNAcase Enhances Autophagy in Brain through an mTOR-Independent Pathway von Zhu, Yanping, Shan, Xiaoyang, Safarpour, Farzaneh, Erro Go, Nancy, Li, Nancy, Shan, Alice, Huang, Mina C, Deen, Matthew, Holicek, Viktor, Ashmus, Roger, Madden, Zarina, Gorski, Sharon, Silverman, Michael A, Vocadlo, David J

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A Fixable Fluorescence‐Quenched Substrate for Quantitation of Lysosomal Glucocerebrosidase Activity in Both Live and Fixed Cells von Zhu, Sha, Deen, Matthew C., Zhu, Yanping, Gilormini, Pierre‐André, Chen, Xi, Davis, Oliver B., Chin, Marcus Y., Henry, Anastasia G., Vocadlo, David J.

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Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2 von Ging, Kathi, Frick, Lukas, Schlachetzki, Johannes, Armani, Andrea, Zhu, Yanping, Gilormini, Pierre-André, Dhingra, Ashutosh, Böck, Desirée, Marques, Ana, Deen, Matthew, Chen, Xi, Serdiuk, Tetiana, Trevisan, Chiara, Sellitto, Stefano, Pisano, Claudio, Glass, Christopher K., Heutink, Peter, Yin, Jiang-An, Vocadlo, David J., Aguzzi, Adriano

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Pharmacological Chaperones for GCase that Switch Conformation with pH Enhance Enzyme Levels in Gaucher Animal Models von Santana, Andrés G., Robinson, Kyle, Vickers, Chelsea, Deen, Matthew C., Chen, Hong‐Ming, Zhou, Stephen, Dai, Ben, Fuller, Maria, Boraston, Alisdair B., Vocadlo, David J., Clarke, Lorne A., Withers, Stephen G.

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A Direct Fluorescent Activity Assay for Glycosyltransferases Enables Convenient High‐Throughput Screening: Application to O‐GlcNAc Transferase von Alteen, Matthew G., Gros, Christina, Meek, Richard W., Cardoso, David A., Busmann, Jil A., Sangouard, Gontran, Deen, Matthew C., Tan, Hong‐Yee, Shen, David L., Russell, Cecilia C., Davies, Gideon J., Robinson, Phillip J., McCluskey, Adam, Vocadlo, David J.

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An Efficient and Accessible Hectogram-Scale Synthesis for the Selective O‑GlcNAcase Inhibitor Thiamet‑G von Holicek, Viktor, Deen, Matthew, Bhosale, Sandeep, Ashmus, Roger A., Vocadlo, David J.

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SUBSTRATES FOR IMAGING GLUCOCEREBROSIDASE ACTIVITY von DEEN, Matthew, VOCADLO, David, ZHU, Sha

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SUBSTRATES FOR IMAGING GLUCOCEREBROSIDASE ACTIVITY von DEEN, Matthew, VOCADLO, David, ZHU, Sha

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