Translesion Polymerases Drive Microhomology-Mediated Break-Induced Replication Leading to Complex Chromosomal Rearrangements von Sakofsky, Cynthia J., Ayyar, Sandeep, Deem, Angela K., Chung, Woo-Hyun, Ira, Grzegorz, Malkova, Anna

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Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis von Del Poggetto, Edoardo, Ho, I-Lin, Balestrieri, Chiara, Yen, Er-Yen, Zhang, Shaojun, Citron, Francesca, Shah, Rutvi, Corti, Denise, Diaferia, Giuseppe R, Li, Chieh-Yuan, Loponte, Sara, Carbone, Federica, Hayakawa, Yoku, Valenti, Giovanni, Jiang, Shan, Sapio, Luigi, Jiang, Hong, Dey, Prasenjit, Gao, Sisi, Deem, Angela K, Rose-John, Stefan, Yao, Wantong, Ying, Haoqiang, Rhim, Andrew D, Genovese, Giannicola, Heffernan, Timothy P, Maitra, Anirban, Wang, Timothy C, Wang, Linghua, Draetta, Giulio F, Carugo, Alessandro, Natoli, Gioacchino, Viale, Andrea

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Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis von Chen, Ziheng, Ho, I-Lin, Soeung, Melinda, Yen, Er-Yen, Liu, Jintan, Yan, Liang, Rose, Johnathon L., Srinivasan, Sanjana, Jiang, Shan, Edward Chang, Q., Feng, Ningping, Gay, Jason P., Wang, Qi, Wang, Jing, Lorenzi, Philip L., Veillon, Lucas J., Wei, Bo, Weinstein, John N., Deem, Angela K., Gao, Sisi, Genovese, Giannicola, Viale, Andrea, Yao, Wantong, Lyssiotis, Costas A., Marszalek, Joseph R., Draetta, Giulio F., Ying, Haoqiang

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Loss of ARID1A Promotes Epithelial-Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress von Tomihara, Hideo, Carbone, Federica, Perelli, Luigi, Huang, Justin K, Soeung, Melinda, Rose, Johnathon L, Robinson, Frederick S, Lissanu Deribe, Yonathan, Feng, Ningping, Takeda, Mitsunobu, Inoue, Akira, Poggetto, Edoardo Del, Deem, Angela K, Maitra, Anirban, Msaouel, Pavlos, Tannir, Nizar M, Draetta, Giulio F, Viale, Andrea, Heffernan, Timothy P, Bristow, Christopher A, Carugo, Alessandro, Genovese, Giannicola

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Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research von Inoue, Akira, Deem, Angela K, Kopetz, Scott, Heffernan, Timothy P, Draetta, Giulio F, Carugo, Alessandro

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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function von Viale, Andrea, Pettazzoni, Piergiorgio, Lyssiotis, Costas A., Ying, Haoqiang, Sánchez, Nora, Marchesini, Matteo, Carugo, Alessandro, Green, Tessa, Seth, Sahil, Giuliani, Virginia, Kost-Alimova, Maria, Muller, Florian, Colla, Simona, Nezi, Luigi, Genovese, Giannicola, Deem, Angela K., Kapoor, Avnish, Yao, Wantong, Brunetto, Emanuela, Kang, Ya’an, Yuan, Min, Asara, John M., Wang, Y. Alan, Heffernan, Timothy P., Kimmelman, Alec C., Wang, Huamin, Fleming, Jason B., Cantley, Lewis C., DePinho, Ronald A., Draetta, Giulio F.

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Leukotrienes, a potential target for Covid-19 von Citron, Francesca, Perelli, Luigi, Deem, Angela K., Genovese, Giannicola, Viale, Andrea

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The Many Facets of Tumor Heterogeneity: Is Metabolism Lagging Behind? von Loponte, Sara, Lovisa, Sara, Deem, Angela K., Carugo, Alessandro, Viale, Andrea

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Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer von Yao, Wantong, Rose, Johnathon L., Wang, Wei, Seth, Sahil, Jiang, Hong, Taguchi, Ayumu, Liu, Jintan, Yan, Liang, Kapoor, Avnish, Hou, Pingping, Chen, Ziheng, Wang, Qiuyun, Nezi, Luigi, Xu, Zhaohui, Yao, Jun, Hu, Baoli, Pettazzoni, Piergiorgio F., Ho, I Lin, Feng, Ningping, Ramamoorthy, Vandhana, Jiang, Shan, Deng, Pingna, Ma, Grace J., Den, Peter, Tan, Zhi, Zhang, Shu Xing, Wang, Huamin, Wang, Y. Alan, Deem, Angela K., Fleming, Jason B., Carugo, Alessandro, Heffernan, Timothy P., Maitra, Anirban, Viale, Andrea, Ying, Haoqiang, Hanash, Samir, DePinho, Ronald A., Draetta, Giulio F.

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Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma von Puca, Francesca, Yu, Fei, Bartolacci, Caterina, Pettazzoni, Piergiorgio, Carugo, Alessandro, Huang-Hobbs, Emmet, Liu, Jintan, Zanca, Ciro, Carbone, Federica, Del Poggetto, Edoardo, Gumin, Joy, Dasgupta, Pushan, Seth, Sahil, Srinivasan, Sanjana, Lang, Frederick F, Sulman, Erik P, Lorenzi, Philip L, Tan, Lin, Shan, Mengrou, Tolstyka, Zachary P, Kachman, Maureen, Zhang, Li, Gao, Sisi, Deem, Angela K, Genovese, Giannicola, Scaglioni, Pier Paolo, Lyssiotis, Costas A, Viale, Andrea, Draetta, Giulio F

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SMARCB1 regulates the hypoxic stress response in sickle cell trait von Soeung, Melinda, Perelli, Luigi, Chen, Ziheng, Dondossola, Eleonora, Ho, I-Lin, Carbone, Federica, Zhang, Li, Khan, Hania, Le, Courtney N, Zhu, Cihui, Peoples, Michael D, Feng, Ningping, Jiang, Shan, Zacharias, Niki Millward, Minelli, Rosalba, Shapiro, Daniel D, Deem, Angela K, Gao, Sisi, Cheng, Emily H, Lucchetti, Donatella, Walker, Cheryl L, Carugo, Alessandro, Giuliani, Virginia, Heffernan, Timothy P, Viale, Andrea, Tannir, Nizar M, Draetta, Giulio F, Msaouel, Pavlos, Genovese, Giannicola

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Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer von Pettazzoni, Piergiorgio, Viale, Andrea, Shah, Parantu, Carugo, Alessandro, Ying, Haoqiang, Wang, Huamin, Genovese, Giannicola, Seth, Sahil, Minelli, Rosalba, Green, Tessa, Huang-Hobbs, Emmet, Corti, Denise, Sanchez, Nora, Nezi, Luigi, Marchesini, Matteo, Kapoor, Avnish, Yao, Wantong, Francesco, Maria E Di, Petrocchi, Alessia, Deem, Angela K, Scott, Kenneth, Colla, Simona, Mills, Gordon B, Fleming, Jason B, Heffernan, Timothy P, Jones, Philip, Toniatti, Carlo, DePinho, Ronald A, Draetta, Giulio F

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Epigenetic regulation of genomic integrity von Deem, Angela K, Li, Xuan, Tyler, Jessica K

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Arabidopsis thaliana plants possess a specific farnesylcysteine lyase that is involved in detoxification and recycling of farnesylcysteine von Crowell, Dring N, Huizinga, David H, Deem, Angela K, Trobaugh, Corey, Denton, Ryan, Sen, Stephanie E

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Prenylcysteine methylesterase in Arabidopsis thaliana von Deem, Angela K., Bultema, Rebecca L., Crowell, Dring N.

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PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma von Giuliani, Virginia, Miller, Meredith A., Liu, Chiu-Yi, Hartono, Stella R., Class, Caleb A., Bristow, Christopher A., Suzuki, Erika, Sanz, Lionel A., Gao, Guang, Gay, Jason P., Feng, Ningping, Rose, Johnathon L., Tomihara, Hideo, Daniele, Joseph R., Peoples, Michael D., Bardenhagen, Jennifer P., Geck Do, Mary K., Chang, Qing E., Vangamudi, Bhavatarini, Vellano, Christopher, Ying, Haoqiang, Deem, Angela K., Do, Kim-Anh, Genovese, Giannicola, Marszalek, Joseph R., Kovacs, Jeffrey J., Kim, Michael, Fleming, Jason B., Guccione, Ernesto, Viale, Andrea, Maitra, Anirban, Emilia Di Francesco, M., Yap, Timothy A., Jones, Philip, Draetta, Giulio, Carugo, Alessandro, Chedin, Frederic, Heffernan, Timothy P.

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Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer von Inoue, Akira, Robinson, Frederick S., Minelli, Rosalba, Tomihara, Hideo, Rizi, Bahar Salimian, Rose, Johnathon L., Kodama, Takahiro, Srinivasan, Sanjana, Harris, Angela L., Zuniga, Andy M., Mullinax, Robert A., Ma, Xiaoyan, Seth, Sahil, Daniele, Joseph R., Peoples, Michael D., Loponte, Sara, Akdemir, Kadir C., Khor, Tin Oo, Feng, Ningping, Roszik, Jason, Sobieski, Mary M., Brunell, David, Stephan, Clifford, Giuliani, Virginia, Deem, Angela K., Shingu, Takashi, Deribe, Yonathan Lissanu, Menter, David G., Heffernan, Timothy P., Viale, Andrea, Bristow, Christopher A., Kopetz, Scott, Draetta, Giulio F., Genovese, Giannicola, Carugo, Alessandro

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Abstract 2136: Diversity across the pancreatic ductal adenocarcinoma disease spectrum revealed by network-anchored functional genomics von Srinivasan, Sanjana, Rose, Johnathon, Yao, Wantong, Seth, Sahil, Peoples, Michael, Machado, Annette, Li, Chieh-Yuan, Ho, I Lin, Lee, Jaewon J., Guerrera, Paola A., Kim, Eiru, Syed, Mustafa, Daniele, Joseph, Deem, Angela K., Kim, Michael, Bristow, Christopher A., Koay, Eugene, Genovese, Giannicola, Viale, Andrea, Heffernan, Timothy P., Maitra, Anirban, Hart, Traver, Carugo, Alessandro, Draetta, Giulio

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Syndecan1 is a critical mediator of macropinocytosis in pancreatic cancer von Yao, Wantong, Rose, Johnathon L., Wang, Wei, Seth, Sahil, Jiang, Hong, Taguchi, Ayumu, Liu, Jintan, Yan, Liang, Kapoor, Avnish, Hou, Pingping, Chen, Ziheng, Wang, Qiuyun, Nezi, Luigi, Xu, Zhaohui, Yao, Jun, Hu, Baoli, Pettazzoni, Piergiorgio F., Ho, I Lin, Feng, Ningping, Ramamoorthy, Vandhana, Jiang, Shan, Deng, Pingna, Ma, Grace J., Den, Peter, Tan, Zhi, Zhang, Shu Xing, Wang, Huamin, Wang, Alan Y., Deem, Angela K., Fleming, Jason B., Carugo, Alessandro, Heffernan, Timothy P., Maitra, Anirban, Viale, Andrea, Ying, Haoqiang, Hanash, Samir, DePinho, Ronald A., Draetta, Giulio F.

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Abstract 77: Recapitulating metastatic colorectal cancer in somatic mutation models for investigating the tumor immune microenvironment in minimal residual disease von Mohamed, Alaa M., Soeung, Melinda, Alshenaifi, Jumanah, Fowlkes, Natalie, Manyam, Ganiraju, Davis, Jennifer, Anderson, Amanda, Norton, Will, Deem, Angela K., Gao, Sisi, Khanduri, Isha, Bistow, Christopher, Carbone, Federica, Napolitano, Stefania, Huang, Justin, Maru, Dipen M., Menter, David G., Draetta, Giulio F., Genovese, Giannicola, Kopetz, Scott

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