5,7-Dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: A Potent and Centrally-Selective Inhibitor of Acetylcholinesterase von Villalobos, Anabella, Butler, Todd W, Chapin, Douglas S, Chen, Yuhpyng L, DeMattos, Steven B, Ives, Jeffrey L, Jones, Shawn B, Liston, Dane R, Nagel, Arthur A

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5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improv... von Villalobos, A, Butler, T W, Chapin, D S, Chen, Y L, DeMattos, S B, Ives, J L, Jones, S B, Liston, D R, Nagel, A A, Nason, D M

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Agonist properties of a stable hexapeptide analog of neurotensin, NMeArg-Lys-Pro-Trp-tLeu-Leu (NT1) von Akunne, Hyacinth C., Demattos, Steven B., Whetzel, Steven Z., Wustrow, David J., Davis, Duff M., Wise, Lawrence D., Cody, Wayne L., Pugsley, Thomas A., Heffner, Thomas G.

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Agonist properties of a stable hexapeptide analog of neurotensin, NαMeArg-Lys-Pro-Trp-tLeu-Leu (NT1) von Akunne, Hyacinth C., Demattos, Steven B., Whetzel, Steven Z., Wustrow, David J., Davis, Duff M., Wise, Lawrence D., Cody, Wayne L., Pugsley, Thomas A., Heffner, Thomas G.

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Brain to Plasma Amyloid-β Efflux: A Measure of Brain Amyloid Burden in a Mouse Model of Alzheimer's Disease von DeMattos, Ronald B., Bales, Kelly R., Cummins, David J., Paul, Steven M., Holtzman, David M.

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Peripheral Anti-Aβ Antibody Alters CNS and Plasma Aβ Clearance and Decreases Brain Aβ Burden in a Mouse Model of Alzheimer's Disease von DeMattos, R B, Bales, K R, Cummins, D J, Dodart, J C, Paul, S M, Holtzman, D M

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Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model von Paul, Steven M, Dodart, Jean-Cosme, Bales, Kelly R, Gannon, Kimberley S, Greene, Stephen J, DeMattos, Ronald B, Mathis, Chantal, DeLong, Cynthia A, Wu, Su, Wu, Xin, Holtzman, David M

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Safety and biomarker effects of solanezumab in patients with Alzheimer’s disease von Farlow, Martin, Arnold, Steven E, van Dyck, Christopher H, Aisen, Paul S, Snider, B. Joy, Porsteinsson, Anton P, Friedrich, Stuart, Dean, Robert A, Gonzales, Celedon, Sethuraman, Gopalan, DeMattos, Ronald B, Mohs, Richard, Paul, Steven M, Siemers, Eric R

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Clusterin Promotes Amyloid Plaque Formation and is Critical for Neuritic Toxicity in a Mouse Model of Alzheimer's Disease von DeMattos, Ronald B., O'dell, Mark A., Parsadanian, Maia, Taylor, Jennie W., Judith A. K. Harmony, Bales, Kelly R., Paul, Steven M., Aronow, Bruce J., Holtzman, David M.

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ApoE and Clusterin Cooperatively Suppress Aβ Levels and Deposition: Evidence that ApoE Regulates Extracellular Aβ Metabolism In Vivo von DeMattos, Ronald B, Cirrito, John R, Parsadanian, Maia, May, Patrick C, O'Dell, Mark A, Taylor, Jennie W, Harmony, Judith A.K, Aronow, Bruce J, Bales, Kelly R, Paul, Steven M, Holtzman, David M

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In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life von Cirrito, John R, May, Patrick C, O'Dell, Mark A, Taylor, Jennie W, Parsadanian, Maia, Cramer, Jeffrey W, Audia, James E, Nissen, Jeffrey S, Bales, Kelly R, Paul, Steven M, DeMattos, Ronald B, Holtzman, David M

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A γ-secretase inhibitor decreases amyloid-β production in the central nervous system von Bateman, Randall J., Siemers, Eric R., Mawuenyega, Kwasi G., Wen, Guolin, Browning, Karen R., Sigurdson, Wendy C., Yarasheski, Kevin E., Friedrich, Stuart W., DeMattos, Ronald B., May, Patrick C., Paul, Steven M., Holtzman, David M.

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Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease von Siemers, Eric R, Friedrich, Stuart, Dean, Robert A, Gonzales, Celedon R, Farlow, Martin R, Paul, Steven M, Demattos, Ronald B

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Plaque‐associated disruption of CSF and plasma amyloid‐β (Aβ) equilibrium in a mouse model of Alzheimer's disease von DeMattos, Ronald B., Bales, Kelly R., Parsadanian, Maia, O'Dell, Mark A., Foss, Eric M., Paul, Steven M., Holtzman, David M.

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The Low Density Lipoprotein Receptor Regulates the Level of Central Nervous System Human and Murine Apolipoprotein E but Does Not Modify Amyloid Plaque Pathology in PDAPP Mice von Fryer, John D, Demattos, Ronald B, McCormick, Lynn M, O'Dell, Mark A, Spinner, Michael L, Bales, Kelly R, Paul, Steven M, Sullivan, Patrick M, Parsadanian, Maia, Bu, Guojun, Holtzman, David M

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Apolipoprotein E Markedly Facilitates Age-Dependent Cerebral Amyloid Angiopathy and Spontaneous Hemorrhage in Amyloid Precursor Protein Transgenic Mice von Fryer, John D, Taylor, Jennie W, DeMattos, Ronald B, Bales, Kelly R, Paul, Steven M, Parsadanian, Maia, Holtzman, David M

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Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposit... von Racke, Margaret M, Boone, Laura I, Hepburn, Deena L, Parsadainian, Maia, Bryan, Matthew T, Ness, Daniel K, Piroozi, Kathy S, Jordan, William H, Brown, Donna D, Hoffman, Wherly P, Holtzman, David M, Bales, Kelly R, Gitter, Bruce D, May, Patrick C, Paul, Steven M, DeMattos, Ronald B

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A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes von Liang, Yu, Lin, Suizhen, Beyer, Thomas P., Zhang, Youyan, Wu, Xin, Bales, Kelly R., DeMattos, Ronald B., May, Patrick C., Li, Shuyu Dan, Jiang, Xian‐Cheng, Eacho, Patrick I., Cao, Guoqing, Paul, Steven M.

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Aβ immunization and anti-Aβ antibodies: potential therapies for the prevention and treatment of Alzheimer’s disease von Holtzman, David M, Bales, Kelly R, Paul, Steven M, DeMattos, Ronald B

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Characterization of novel apoE isoform-dependent C-terminal specific proteolysis of Aβ1-42 by microglia von Liu, Feng, Lin, Suizhen, Chai, Xiyun, DeMattos, Ronald B, Paul, Steven M, Lilly, Eli

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